Stable One-Dimensional Dissipative Solitons in Complex Cubic-Quintic Ginzburg-Landau Equation

The generation and nonlinear dynamics of one-dimensional optical dissipative solitonic pulses are examined. The variational method is extended to complex dissipative systems, in order to obtain steady state solutions of the (1 + 1)-dimensional complex cubic-quintic Ginzburg-Landau equation. A stability criterion is established fixing a domain of dissipative parameters for stable steady state solutions. Following numerical simulations, evolution of any input pulse from this domain leads to stable dissipative temporal solitons. Analytical predictions are confirmed by numerical evolution of input temporal pulses towards stable dissipative solitons

MILOPrOductIOn Of vIabLe Miscanthus gigantheus rhIzOMes at fertILe and degraded sOIL

abstract ArAndjelovic, M., G. drAzic, j. MilovAnovic and S. AlekSic, 2014. Miloproduction of viable Miscanthus gigantheus rhizomes at fertile and degraded soil. Bulg. J. Agric. Sci., 20: 1189-1194 expanding supplies of home grown biomass and facilitation of the development and competitiveness of a supply chain in an sustainable manner, presents a core of government's strategy, for energy development in republic of Serbia. Growing agroenergy corps may be one of the solutions according to analysis that were carried out. one of these corps that was found to be especially amenable due to its potentially high productivity and cultivation on degraded terrain is Miscanthus giganteus. The possibility of producing after mentioned plant for the biomass supply chain, at very low cost is the main aim of this study. due to its sterility Miscanthus giganteus can only by propagated by vegetative division. Potential of production of viable rhizome on terrains with different rate of fertility was followed by method of experiments on the field. 6 parameters that were following growth of the rhizome and planting survival rate were monitored. According to the results, main factors that affect production of viable rhizomes are age of mother plants, and biotic effects of weed vegetation. Size of rhizomes and nursery fertilization shoved significantly smaller effect. This study concentrates on available data regarding the potential directions by which Miscanthus material could achieve maximum production, by high density planting

Prospects for Observations of Pulsars and Pulsar Wind Nebulae with CTA

The last few years have seen a revolution in very-high gamma-ray astronomy (VHE; E>100 GeV) driven largely by a new generation of Cherenkov telescopes (namely the H.E.S.S. telescope array, the MAGIC and MAGIC-II large telescopes and the VERITAS telescope array). The Cherenkov Telescope Array (CTA) project foresees a factor of 5 to 10 improvement in sensitivity above 0.1 TeV, extending the accessible energy range to higher energies up to 100 TeV, in the Galactic cut-off regime, and down to a few tens GeV, covering the VHE photon spectrum with good energy and angular resolution. As a result of the fast development of the VHE field, the number of pulsar wind nebulae (PWNe) detected has increased from one PWN in the early '90s to more than two dozen firm candidates today. Also, the low energy threshold achieved and good sensitivity at TeV energies has resulted in the detection of pulsed emission from the Crab Pulsar (or its close environment) opening new and exiting expectations about the pulsed spectra of the high energy pulsars powering PWNe. Here we discuss the physics goals we aim to achieve with CTA on pulsar and PWNe physics evaluating the response of the instrument for different configurations.Comment: accepted for publication in Astroparticle Physic

Acceleration and radiation of ultra-high energy protons in galaxy clusters

Clusters of galaxies are believed to be capable to accelerate protons at accretion shocks to energies exceeding 10^18 eV. At these energies, the losses caused by interactions of cosmic rays with photons of the Cosmic Microwave Background Radiation (CMBR) become effective and determine the maximum energy of protons and the shape of the energy spectrum in the cutoff region. The aim of this work is the study of the formation of the energy spectrum of accelerated protons at accretion shocks of galaxy clusters and of the characteristics of their broad band emission. The proton energy distribution is calculated self-consistently via a time-dependent numerical treatment of the shock acceleration process which takes into account the proton energy losses due to interactions with the CMBR. We calculate the energy distribution of accelerated protons, as well as the flux of broad-band emission produced by secondary electrons and positrons via synchrotron and inverse Compton scattering processes. We find that the downstream and upstream regions contribute almost at the same level to the emission. For the typical parameters characterising galaxy clusters, the synchrotron and IC peaks in the spectral energy distributions appear at comparable flux levels. For an efficient acceleration, the expected emission components in the X-ray and gamma-ray band are close to the detection threshold of current generation instruments, and will be possibly detected with the future generation of detectors.Comment: 9 pages, 13 figures, submitted to Astronomy & Astrophysic

The near-infrared detection of PSR B0540-69 and its nebula

The ~1700 year old PSR B0540-69 in the LMC is considered the twin of the Crab pulsar because of its similar spin parameters, magnetic field, and energetics. Its optical spectrum is fit by a power-law, ascribed to synchrotron radiation, like for the young Crab and Vela pulsars. nIR observations, never performed for PSR B0540-69, are crucial to determine whether the optical power-law spectrum extends to longer wavelengths or a new break occurs, like it happens for both the Crab and Vela pulsars in the mIR, hinting at an even more complex particle energy and density distribution in the pulsar magnetosphere. We observed PSR B0540-69 in the J, H, and Ks bands with the VLT to detect it, for the first time, in the nIR and characterise its optical-to-nIR spectrum. To disentangle the pulsar emission from that of its pulsar wind nebula (PWN), we obtained high-spatial resolution adaptive optics images with NACO. We could clearly identify PSR B0540-69 in our J, H, and Ks-band images and measure its flux (J=20.14, H=19.33, Ks=18.55, with an overall error of +/- 0.1 magnitudes in each band). The joint fit to the available optical and nIR photometry with a power-law spectrum gives a spectral index alpha=0.70 +/-0.04. The comparison between our NACO images and HST optical ones does not reveal any apparent difference in the PWN morphology as a function of wavelength. The PWN optical-to-nIR spectrum is also fit by a single power-law, with spectral index alpha=0.56+/- 0.03, slightly flatter than the pulsar's. Using NACO at the VLT, we obtained the first detection of PSR B0540-69 and its PWN in the nIR. Due to the small angular scale of the PWN (~4") only the spatial resolution of the JWST will make it possible to extend the study of the pulsar and PWN spectrum towards the mid-IR.Comment: 11 pages, 10 figures, Accepted for publication on Astronomy and Astrophysic

White Matter Deficits Assessed by Diffusion Tensor Imaging and Cognitive Dysfunction in Psychostimulant Users With Comorbid Human Immunodeficiency Virus Infection

Background Psychostimulant drug use is commonly associated with drug-related infection, including the human immunodeficiency virus (HIV). Both psychostimulant use and HIV infection are known to damage brain white matter and impair cognition. To date, no study has examined white matter integrity using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) in chronic psychostimulant users with comorbid HIV infection, and determined the relationship of white matter integrity to cognitive function. Methods Twenty-one subjects (mean age 37.5 ± 9.0 years) with a history of heavy psychostimulant use and HIV infection (8.7 ± 4.3 years) and 22 matched controls were scanned on a 3T MRI. Fractional anisotropy (FA) values were calculated with DTI software. Four regions of interest were manually segmented, including the genu of the corpus callosum, left and right anterior limbs of the internal capsule, and the anterior commissure. Subjects also completed a neurocognitive battery and questionnaires about physical and mental health. Results The psychostimulant using, HIV positive group displayed decreased white matter integrity, with significantly lower FA values for all white matter tracts (p < 0.05). This group also exhibited decreased cognitive performance on tasks that assessed cognitive set-shifting, fine motor speed and verbal memory. FA values for the white matter tracts correlated with cognitive performance on many of the neurocognitive tests. Conclusions White matter integrity was thus impaired in subjects with psychostimulant use and comorbid HIV infection, which predicted worsened cognitive performance on a range of tests. Further study on this medical comorbidity is required

When will 'open science' become simply 'science'?

Open science describes the practice of carrying out scientific research in a completely transparent manner, and making the results of that research available to everyone. Isn’t that just ‘science’

Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study

BACKGROUND: The genes encoding proteins in the thrombomodulin-protein C pathway are promising candidate genes for stroke susceptibility because of their importance in thrombosis regulation and inflammatory response. Several published studies have shown that the Ala455Val thrombomodulin polymorphism is associated with ischemic heart disease, but none has examined the association with stroke. Using data from the Stroke Prevention in Young Women Study, we sought to determine the association between the Ala455Val thrombomodulin polymorphism and the occurrence of ischemic stroke in young women. METHODS: All 59 hospitals in the greater Baltimore-Washington area participated in a population-based case-control study of stroke in young women. We compared 141 cases of first ischemic stroke (44% black) among women 15 to 44 years of age with 210 control subjects (35% black) who were identified by random digit dialing and frequency matched to the cases by age and geographical region of residence. Data on historical risk factors were collected by standardized interview. Genotyping of the thrombomodulin Ala455Val polymorphism was performed by pyrosequencing. RESULTS: The A allele (frequency = 0.85) was associated with stroke under the recessive model. After adjustment for age, race, cigarette smoking, hypertension, and diabetes, the AA genotype, compared with the AV and VV genotypes combined, was significantly associated with stroke (odds ratio 1.9, 95% CI 1.1–3.3). The AA genotype was more common among black than white control subjects (81% versus 68%) but there was no significant interaction between the risk genotype and race (adjusted odds ratio 2.7 for blacks and 1.6 for whites). A secondary analysis removing all probable (n = 16) and possible (n = 15) cardioembolic strokes demonstrated an increased association (odds ratio 2.2, 95% CI 1.2–4.2). CONCLUSIONS: Among women aged 15 to 44 years, the AA genotype is more prevalent among blacks than whites and is associated with increased risk of early onset ischemic stroke. Removing strokes potentially related to cardioembolic phenomena increased this association. Further studies are needed to determine whether this polymorphism is functionally related to thrombomodulin expression or whether the association is due to population stratification or linkage to a nearby functional polymorphism

A unifying mathematical framework for experimental TCR-pMHC kinetic constants

Receptor binding and triggering are central in Immunology as T cells activated through their T cell receptors (TCR) by protein antigens orchestrate immune responses. In order to understand receptor-ligand interactions, many groups working with different experimental techniques and assays have generated a vast body of knowledge during the last decades. However, in recent years a type of assays, referred to as two-dimensional or membrane-to-membrane, has questioned our current understanding of the role of different kinetic constants (for instance, on- versus off-rate constants) on TCR-ligand interaction and subsequent T cell activation. Here we present a general mathematical framework that provides a unifying umbrella to relate fundamental and effective (or experimentally determined) kinetic constants, as well as describe and compare state-of-the-art experimental methods. Our framework is able to predict the correlations between functional output, such as 1/EC50, and effective kinetic constants for a range of different experimental assays (in two and three dimensions). Furthermore, our approach can be applied beyond Immunology, and serve as a “translation method” for the biochemical characterization of receptor-ligand interactions