552 research outputs found
Development of hematopoietic stem cell activity in the mouse embryo.
The precise time of appearance of the first hematopoietic stem cell activity in the developing mouse embryo is unknown. Recently the aorta-gonad-mesonephros region of the developing mouse embryo has been shown to possess hematopoietic colony-forming activity (CFU-S) in irradiated recipient mice. To determine whether the mouse embryo possesses definitive hematopoietic stem cell activity in the analogous AGM region and to determine the order of appearance of stem cells in the yolk sac, AGM region, and liver, we transferred these embryonic tissues into adult irradiated recipients. We report here the long-term, complete, and functional hematopoietic repopulation of primary and serial recipients with AGM-derived cells. We observe potent hematopoietic stem cell activity in the AGM region before the appearance of yolk sac and liver stem cell activity and discuss a model for the maturation of stem cell activity in mouse embryogenesis
Theory, Simulation and Nanotechnological Applications of Adsorption on a Surface with Defects
Theory of adsorption on a surface with nanolocal defects is proposed. Two
efficacy parameters of surface modification for nanotechnological purposes are
introduced, where the modification is a creation of nanolocal artificial
defects. The first parameter corresponds to applications where it is necessary
to increase the concentration of certain particles on the modified surface. And
the second one corresponds to the pattern transfer with the help of particle
self-organization on the modified surface. The analytical expressions for both
parameters are derived with the help of the thermodynamic and the kinetic
approaches for two cases: jump diffusion and free motion of adsorbed particles
over the surface. The possibility of selective adsorption of molecules is shown
with the help of simulation of the adsorption of acetylene and benzene
molecules in the pits on the graphite surface. The process of particle
adsorption from the surface into the pit is theoretically studied by molecular
dynamic technique. Some possible nanotechnological applications of adsorption
on the surface with artificial defects are considered: fabrication of sensors
for trace molecule detection, separation of isomers, and pattern transfer.Comment: 12 pages, 2 Postscript figures. Submitted to Surface Science (1998
Azimuthal Correlations in the Target Fragmentation Region of High Energy Nuclear Collisions
Results on the target mass dependence of proton and pion pseudorapidity
distributions and of their azimuthal correlations in the target rapidity range
are presented. The data have been taken with the
Plastic-Ball detector set-up for 4.9 GeV p + Au collisions at the Berkeley
BEVALAC and for 200 GeV/ p-, O-, and S-induced reactions on
different nuclei at the CERN-SPS. The yield of protons at backward rapidities
is found to be proportional to the target mass. Although protons show a typical
``back-to-back'' correlations, a ``side-by-side'' correlation is observed for
positive pions, which increases both with target mass and with impact parameter
of a collision. The data can consistently be described by assuming strong
rescattering phenomena including pion absorption effects in the entire excited
target nucleus.Comment: 7 pages, figures included, complete postscript available at
ftp://qgp.uni-muenster.de/pub/paper/azi-correlations.ps submitted to Phys.
Lett.
A new heparan sulfate from the mollusk nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of plasmodium falciparum
Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Pf-iEs. In this context, we evaluated a new heparan sulfate (HS) from Nodipecten nodosus for antimalarial activity and inhibition of P. falciparum cytoadhesion and rosetting. Parasite inhibition was measured by SYBR green using a cytometer. HS was assessed in rosetting and cytoadhesion assays under static and flow conditions using CHO and HLEC cells expressing ICAM1 and CSA, respectively. This HS inhibited merozoite invasion similar to heparin. Moreover, mollusk HS decreased cytoadherence of P. falciparum to CSA (chondroitin sulfate A) and ICAM-1 (intercellular adhesion molecule-1) on the surface of endothelial cells under static and flow conditions. In addition, this glycan efficiently disrupted rosettes. These findings support a potential use for mollusk HS as adjunct therapy for severe malaria114CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIRO - FAPERJFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPnão temnão tem2012/16525-2; 2017/18611-7; 2010/18571-6; 2015/20774-
Phase diagrams of classical spin fluids: the influence of an external magnetic field on the liquid-gas transition
The influence of an external magnetic field on the liquid-gas phase
transition in Ising, XY, and Heisenberg spin fluid models is studied using a
modified mean field theory and Gibbs ensemble Monte Carlo simulations. It is
demonstrated that the theory is able to reproduce quantitatively all
characteristic features of the field dependence of the critical temperature
T_c(H) for all the three models. These features include a monotonic decrease of
T_c with rising H in the case of the Ising fluid as well as a more complicated
nonmonotonic behavior for the XY and Heisenberg models. The nonmonotonicity
consists in a decrease of T_c with increasing H at weak external fields, an
increase of T_c with rising H in the strong field regime, and the existence of
a minimum in T_c(H) at intermediate values of H. Analytical expressions for
T_c(H) in the large field limit are presented as well. The magnetic para-ferro
phase transition is also considered in simulations and described within the
mean field theory.Comment: 14 pages, 12 figures (to be submitted to Phys. Rev. E
Thermal history of the string universe
Thermal history of the string universe based on the Brandenberger and Vafa's
scenario is examined. The analysis thereby provides a theoretical foundation of
the string universe scenario. Especially the picture of the initial oscillating
phase is shown to be natural from the thermodynamical point of view. A new tool
is employed to evaluate the multi state density of the string gas. This
analysis points out that the well-known functional form of the multi state
density is not applicable for the important region , and derives a
correct form of it.Comment: 39 pages, no figures, use revtex.sty, aps.sty, aps10.sty &
preprint.st
Towards the Theory of Cosmological Phase Transitions
We discuss recent progress (and controversies) in the theory of finite
temperature phase transitions. This includes the structure of the effective
potential at a finite temperature, the infrared problem in quantum statistics
of gauge fields, the theory of formation of critical and subcritical bubbles
and the theory of bubble wall propagation.Comment: 50 p
Charge conservation and time-varying speed of light
It has been recently claimed that cosmologies with time dependent speed of
light might solve some of the problems of the standard cosmological scenario,
as well as inflationary scenarios. In this letter we show that most of these
models, when analyzed in a consistent way, lead to large violations of charge
conservation. Thus, they are severly constrained by experiment, including those
where is a power of the scale factor and those whose source term is the
trace of the energy-momentum tensor. In addition, early Universe scenarios with
a sudden change of related to baryogenesis are discarded.Comment: 4 page
Quintessence arising from exponential potentials
We demonstrate how exponential potentials that could arise in the early
Universe as a result of Kaluza-Klein type compactifications of string theory,
can lead to cosmological solutions which correspond to the currently observed
accelerating Universe. The idea is simple, relying solely on the known scaling
properties associated with exponential potentials. In particular we show that
the existence of stable attractor solutions implies that the results hold for a
wide range of coupling constants and initial conditions.Comment: 4 pages, 3 figures, published versio
The COMPASS Experiment at CERN
The COMPASS experiment makes use of the CERN SPS high-intensitymuon and
hadron beams for the investigation of the nucleon spin structure and the
spectroscopy of hadrons. One or more outgoing particles are detected in
coincidence with the incoming muon or hadron. A large polarized target inside a
superconducting solenoid is used for the measurements with the muon beam.
Outgoing particles are detected by a two-stage, large angle and large momentum
range spectrometer. The setup is built using several types of tracking
detectors, according to the expected incident rate, required space resolution
and the solid angle to be covered. Particle identification is achieved using a
RICH counter and both hadron and electromagnetic calorimeters. The setup has
been successfully operated from 2002 onwards using a muon beam. Data with a
hadron beam were also collected in 2004. This article describes the main
features and performances of the spectrometer in 2004; a short summary of the
2006 upgrade is also given.Comment: 84 papes, 74 figure
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