Convolutional neural network for malware detection in IoT Network

[EN] The network has exploded in popularity in the twenty-first century in the last few years, becoming one of the most extensively utilized and prominent technologies. Nowadays, cyberattacks occurring and the variety, size, and intensity of cyberattacks are increasing. In this work, the machine learning method is used to predict Intrusion in the Internet of Things. Attacks on networks connected to smart cities or on intelligent transportation systems endanger the security of these networks. Studies show that IoT attacks can cost the network millions of dollars. DDoS attacks by malicious botnets and nodes on the IoT network are among the most malicious attacks on the network and can disable IoT application servers

Perancangan Dan Implementasi Kontroler Knowledge Based-PI Pada Pengaturan Kecepatan Motor Induksi 3 Fasa

Tugas Akhir ini membahas desain dan implementasi kontroler Knowledge Based-PI untuk pengaturan kecepatan motor induksi 3 fasa yang diberikan efek pembebanan melalui sebuah rem elekromagnetik. Rem elektromagnetik terdiri dari beberapa kumparan yang diberi input tegangan DC melalui sebuah auto transformator (0-240V) yang telah disearahkan. Prinsip dasar rem elektromagnetik menggunakan hukum Faraday dan hukum Lenz. Kedua hukum ini menimbulkan arus eddy yang melingkar dan menginduksi medan magnet sehingga dapat memberikan gaya lawan terhadap arah gaya pergerakan. Oleh karena itu dibutuhkan sebuah kontroler agar kecepatan motor tetap konstan sesuai Set Point dengan tingkatan pembebanan yang berbeda-beda. Kontroler Knowledge Based-PI dapat menjadi solusi dari permasalahan ini dengan cara membentuk sebuah direktori parameter kontrol PI (Proportional Integrator) untuk berbagai kondisi pembebanan yang dimuat ke dalam sebuah fungsi look-up table. Metode knowledge base bekerja berdasarkan pengambilan dan pencocokan data (appropriate). Adanya hubungan langsung antara input dan output, maka diperoleh banyak kemungkinan keputusan aksi kontrol. Penggunaan kontroler knowledge based-PI dapat mengurangi Error Steady State serta memberikan kemudahan dalam menentukan berbagai macam model sesuai dengan variasi pembebanan

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection

Streptococcus pneumoniae accounts for more deaths worldwide than any other single pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. Life-threatening acute cardiac complications are more common in pneumococcal infection compared to other bacterial infections. Distinctively, these arise despite effective antibiotic therapy. Here, we describe a novel mechanism of myocardial injury, which is triggered and sustained by circulating pneumolysin (PLY). Using a mouse model of invasive pneumococcal disease (IPD), we demonstrate that wild type PLY-expressing pneumococci but not PLY-deficient mutants induced elevation of circulating cardiac troponins (cTns), well-recognized biomarkers of cardiac injury. Furthermore, elevated cTn levels linearly correlated with pneumococcal blood counts (r=0.688, p=0.001) and levels were significantly higher in non-surviving than in surviving mice. These cTn levels were significantly reduced by administration of PLY-sequestering liposomes. Intravenous injection of purified PLY, but not a non-pore forming mutant (PdB), induced substantial increase in cardiac troponins to suggest that the pore-forming activity of circulating PLY is essential for myocardial injury in vivo. Purified PLY and PLY-expressing pneumococci also caused myocardial inflammatory changes but apoptosis was not detected. Exposure of cultured cardiomyocytes to PLY-expressing pneumococci caused dose-dependent cardiomyocyte contractile dysfunction and death, which was exacerbated by further PLY release following antibiotic treatment. We found that high PLY doses induced extensive cardiomyocyte lysis, but more interestingly, sub-lytic PLY concentrations triggered profound calcium influx and overload with subsequent membrane depolarization and progressive reduction in intracellular calcium transient amplitude, a key determinant of contractile force. This was coupled to activation of signalling pathways commonly associated with cardiac dysfunction in clinical and experimental sepsis and ultimately resulted in depressed cardiomyocyte contractile performance along with rhythm disturbance. Our study proposes a detailed molecular mechanism of pneumococcal toxin-induced cardiac injury and highlights the major translational potential of targeting circulating PLY to protect against cardiac complications during pneumococcal infections

Efficacy of tranexamic acid administration in traumatic brain injury patients: A review

BackgroundAnti-fibrinolytic medications decrease traumatic intracranial haemorrhage (ICH). Tranexamic acid (TXA) is an anti-fibrinolytic, which recently has shown effectiveness in management of traumatic haemorrhage‎.AimsTo summarize the randomized control trials (RCTs) that evaluate the efficacy of tranexamic acid administration in traumatic brain ‎injury (TBI) patients‎.‎Methods An electronic literature review, including PubMed, Google Scholar, and EBSCO that examining RCTs, observational, and experimental studies which study the efficacy of TXA administration in (TBI) patients.ResultsThe current review included 7 randomized studies reported the efficacy of TXA in management of TBI. TXA limit secondary brain injury by preventing the expansion of ICH. Administration of TXA exhibited a tendency to decrease head trauma-related mortality.ConclusionTXA significantly lower the risk of ICU expansion m and prevent brain injury related deaths

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac