35 research outputs found
Characterization of the Secreted Acid Phosphatase SapS Reveals a Novel Virulence Factor of Staphylococcus aureus That Contributes to Survival and Virulence in Mice
- Author
- Publication venue
- Saarländische Universitäts- und Landesbibliothek
- Publication date
- 14/11/2022
- Field of study
Staphylococcus aureus possesses a large arsenal of immune-modulating factors, enabling it
to bypass the immune system’s response. Here, we demonstrate that the acid phosphatase SapS is
secreted during macrophage infection and promotes its intracellular survival in this type of immune
cell. In animal models, the SA564 sapS mutant demonstrated a significantly lower bacterial burden
in liver and renal tissues of mice at four days post infection in comparison to the wild type, along
with lower pathogenicity in a zebrafish infection model. The SA564 sapS mutant elicits a lower
inflammatory response in mice than the wild-type strain, while S. aureus cells harbouring a functional
sapS induce a chemokine response that favours the recruitment of neutrophils to the infection site.
Our in vitro and quantitative transcript analysis show that SapS has an effect on S. aureus capacity to
adapt to oxidative stress during growth. SapS is also involved in S. aureus biofilm formation. Thus,
this study shows for the first time that SapS plays a significant role during infection, most likely
through inhibiting a variety of the host’s defence mechanisms
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
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- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
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- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
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- Al-Dahdouh Mosheer
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- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
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- Alkchr Hayat Ben Hasan Mohamed A A
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- Alsaid Hamza
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- Alsoudani Ali
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- Altair Mawadda
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- Alvarez Matias
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- Yousri Mohamed
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- Youssef Arkan
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- Yue Tiffany
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- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Aali Amirali
- Abbas Qamar
- Abbasi Behzad
- Abbasi-Kangevari Mohsen
- Abbasi-Kangevari Zeinab
- Abbastabar Hedayat
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed Abdelwahab
- Abdoli Gholamreza
- Abdulkader Rizwan Suliankatchi
- Abdulkadir Hanan Abdulkadir
- Abedi Aidin
- Abegaz Kedir Hussein
- Abidi Hassan
- Aboagye Richard Gyan
- Abolhassani Hassan
- Absalan Abdorrahim
- Abtew Yonas Derso
- Abu-Gharbieh Eman
- Achappa Basavaprabhu
- Acheson Alistair R
- Acuna Juan Manuel
- Addison Daniel
- Addo Isaac Yeboah
- Adegboye Oyelola A
- Adesina Miracle Ayomikun
- Adnan Mohammad
- Adnani Qorinah Estiningtyas Sakilah
- Advani Shailesh M
- Afrin Sumia
- Afzal Muhammad Sohail
- Aggarwal Manik
- Ahinkorah Bright Opoku
- Ahmad Araz Ramazan
- Ahmad Rizwan
- Ahmad Sajjad
- Ahmad Sohail
- Ahmadi Sepideh
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Aiman Wajeeha
- Ajami Marjan
- Akalu Gizachew Taddesse
- Akbarzadeh-Khiavi Mostafa
- Aklilu Addis
- Akonde Maxwell
- Akunna Chisom Joyqueenet
- Al-Hanawi Mohammed Khaled
- Al-Maweri Sadeq Ali Ali
- Al-Raddadi Rajaa M
- Al-Rifai Rami H Hani
- Al-Sabah Salman Khalifah
- Al-Tammemi Ala'a B
- Alahdab Fares
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Alessy Saleh Ali
- Algammal Abdelazeem M
- Alhassan Robert Kaba
- Ali Adel Hajj
- Ali Beriwan Abdulqadir
- Ali Hiwa Abubaker
- Ali Liaqat
- Ali Syed Shujait
- Alimohamadi Yousef
- Alipour Vahid
- Aljunid Syed Mohamed
- Alkhayyat Motasem
- Almustanyir Sami
- Alonso Nivaldo
- Alqalyoobi Shehabaldin
- Altawalah Haya
- Alvis-Guzman Nelson
- Amare Firehiwot
- Ameyaw Edward Kwabena
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amusa Ganiyu Adeniyi
- Ancuceanu Robert
- Anderson Jason A
- Animut Yaregal Animut
- Anoushiravani Amir
- Anoushirvani Ali Arash
- Ansari-Moghaddam Alireza
- Ansha Mustafa Geleto
- Antony Benny
- Antwi Maxwell Hubert
- Anwar Sumadi Lukman
- Anwer Razique
- Anyasodor Anayochukwu Edward
- Arab-Zozani Morteza
- Arabloo Jalal
- Aremu Olatunde
- Argaw Ayele Mamo
- Ariffin Hany
- Aripov Timur
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- Waheed Yasir
- Walde Mandaras Tariku
- Wamai Richard G
- Wang Cong
- Wang Fang
- Wang Ning
- Wang Yu
- Ward Paul
- Waris Abdul
- Westerman Ronny
- Wickramasinghe Nuwan Darshana
- Woldemariam Melat
- Woldu Berhanu
- Xiao Hong
- Xu Rixing
- Xu Suowen
- Xu Xiaoyue
- Yadav Lalit
- Yang Lin
- Yazdanpanah Fereshteh
- Yeshaw Yigizie
- Yismaw Yazachew
- Yonemoto Naohiro
- Younis Mustafa Z
- Yousefi Zabihollah
- Yousefian Fatemeh
- Yu Chuanhua
- Yu Yong
- Yunusa Ismaeel
- Zahir Mazyar
- Zaki Nazar
- Zaman Burhan Abdullah
- Zangiabadian Moein
- Zare Fariba
- Zare Iman
- Zareshahrabadi Zahra
- Zarrintan Armin
- Zastrozhin Mikhail Sergeevich
- Zeineddine Mohammad A
- Zhang Dongyu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhou Linghui
- Zodpey Sanjay
- Zoladl Mohammad
- Šekerija Mario
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
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- Abatli SJ
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- Abd Razak RB
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- Abdelhady DS
- Abdelhafez MOM
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- Abdelmoumen R
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- Abdunomonovich DA
- Abib SDCV
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- Zreeg DAS
- Zurikat RO
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- Zvizdic Z
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Aali A
- Ab Khan M
- Abbas Q
- Abbasi B
- Abbasi-Kangevari M
- Abbasi-Kangevari Z
- Abbastabar H
- Abd-Elsalam S
- Abdelmasseh M
- Abdelwahab AA
- Abdoli G
- Abdulkader RS
- Abdulkadir HA
- AbdulmuhsinMohammad K
- Abedi A
- Abegaz KH
- Abidi H
- Aboagye RG
- Abolhassani H
- Absalan A
- Abtew YD
- Abu-Gharbieh E
- Achappa B
- Acheson AR
- Acuna JM
- Addison D
- Addo IY
- Adegboye OA
- Adesina MA
- Adnan M
- Adnani QES
- Advani SM
- Afrin S
- Afzal MS
- Aggarwal M
- Ahinkorah BO
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- Ahmadi S
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- Ahmed LA
- Ahmed MB
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- Ajami M
- Akalu GT
- Akbarzadeh-Khiavi M
- Aklilu A
- Akonde M
- Akunna CJ
- Al Hamad H
- Al Montasir A
- Al-Hanawi MK
- Al-Maweri SAA
- Al-Raddadi RM
- Al-Rifai RHH
- Al-Sabah SK
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- Publication venue
- Publication date
- 20/08/2022
- Field of study
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub M.
- A. Adam M.
- A. Nassar M.
- A. Nemer A.
- Aahlin E. K.
- Ab Rahim M. F.
- Abad Gurumeta A.
- Abad-Motos A.
- Abang Jamari D. Z. H.
- Abantanga F.
- Abarca S.
- Abazid E.
- Abbas A.
- Abbas K.
- Abbas M. M.
- Abbasy J.
- Abbosh A.
- Abd B.
- Abd Karim M. F. S.
- Abd Wahab H. H.
- Abdalei A.
- Abdalla Ahmed Elkamel A.
- Abdallah A.
- AbdAllah M. S. M.
- Abdel Malik A. B.
- Abdelhady Mousa H.
- Abdelhady S.
- Abdelhakim A.
- Abdelkader M.
- Abdelkawy S.
- Abdelkhalek M.
- Abdellatif E.
- Abdelmaksoud Tawakel N.
- Abdelmohsen N.
- Abdelmotaleb I.
- Abdelrazek A.
- Abdelsalam I.
- Abdelshakour M.
- Abdelwahed A. M.
- Abdou A.
- Abdou A. O.
- Abdou H.
- Abdul Aziz M. R.
- Abdul Aziz N.
- Abdulgawad Almogy M.
- Abdulla M. A.
- Abdullah M. T.
- Abdullahi L.
- Abdullayev S.
- Abed S.
- Abello D.
- Abiola O.
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- Abo-khammash A.
- Abou Chaar M. K.
- Abou El. soud M. R.
- Abouelsoad N.
- Abraham J.
- Abreu da Silva A.
- Abu Ahammala A. B.
- Abu Al Amrain M.
- Abu Al-saleem H.
- Abu Alamrain A.
- Abu Alqumboz A.
- Abu Ataya A.
- Abu hallalah M. F. K.
- Abu Jamie N.
- Abu Jayyab I.
- Abu shua'ib R.
- Abu Zainah B.
- Abu-Nimeh S.
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- Yates C.
- Ye G.
- Yeen Chin L.
- Yemez K.
- Yenidunya N.
- Yenli E.
- Yeo J.
- Yeoh A.
- Yepez R.
- Yesilsancak M.
- Yildirim R.
- Yildiz A.
- Yilmaz D.
- Yip C. W.
- Ylatoma Diaz E. A.
- Yong S. Q.
- Yoong A.
- Yorke J.
- Yotsov T.
- You L.
- Younes E.
- Younes M.
- Yousry B.
- Yozgatli T. K.
- Yu K.
- Yue S. Y. P.
- Yuksel O.
- Yunes A.
- Yusuf B.
- Zabiyaka M.
- Zachariah S. K.
- Zafar S. N.
- Zaffaroni G.
- Zahra B.
- Zahran D.
- Zakaria A. D.
- Zakaria M.
- Zakaria O.
- Zakaria Z.
- Zambrana Campos V.
- Zammit M.
- Zanini N.
- Zara V. J.
- Zarti H.
- Zarzycki P.
- Zatecky J.
- Zattoni D.
- Zavala G.
- Zawahrah H.
- Zeiton A.
- Zeko A.
- Zeng Z.
- Zeromskas P.
- Zhang G.
- Zhivkov E.
- Zid E.
- Zidan A. M.
- Zielasek C.
- Zilinskas J.
- Zimmermann B.
- Ziprin P.
- Zizzo M.
- Zografos G.
- Zoikas A.
- Zorrilla Matilla L. P.
- Zoulamoglou M.
- Zreeg D.
- Zub-Pokrowiecka A.
- Zubiaurre V.
- Zuhdy M.
- Zuikyte D.
- Zuloaga Fernandez del Valle C. J.
- Zulu S.
- Zumbakys
- Zupan D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- A. Mohammed Kalakwa
- A. Nemer Ayoub
- Abantanga Francis A.
- Abatli Safa' Jamal
- Abbas Wisam
- Abbo Olivier
- Abdelbaqi Reem
- Abdelhady Dina Sobhy
- Abdelhafez Mohammad Omar Mohammad
- Abdelhamid Sultan S.
- Abdelmaksoud Sherif
- Abdelmoumen Roua
- Abdelmutalib Fakereldeen
- Abdul-Mumin Alhassan
- Abduljawad Fatima Mousa
- Abdullah Fizan
- Abdullah Mohd Yusof bin
- Abdulraheem Nurudeen
- Abdulrahman Alaa
- Abdulsalam Moruf Adekunle
- Abdunomonovich Dekhkonboev Avazjon
- Aboelela Ahmed
- Abouheba Mohamed
- Abrahamsson Kate
- Abrunhosa Matias Marcia
- Abu-Nejmah Fawzi
- Abuajaila Abdulsalam
- Abuattaya Adham Ashraf
- Abubakar Auwal M
- Abueideh Ahmad
- Abuhayyeh Husam Aldean
- Abuhlega Ma'aly A.
- Abukhalaf Sadi
- Abumunshar Ali Abdelhay
- Acuna Gaston
- Adams Stephen
- Adamu Sani
- Adanan Mohd Fitri Shukri bin Mohamed
- Adawi Ihda
- Adawi Samer
- Adawy Ahmad
- Ade-Ajayi Niyi
- Adegboyega Rilwan
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adhiwidjaja Cathline Freya
- Adofo-Ansong Nana
- Agboola Titiloye Hannah
- Agelebe Efeturi
- Aguilar Aguilar Faye
- Aguilar Gargurevich Prince Pamela
- Aguirre-Lopez Pastor
- Agulham Miguel Angelo
- Ahmad Hira
- Ahmad Zahidah Adlynee Haji
- Ahmed Hazem
- Ahmed Mahmoud Abdelfattah
- Ajai Olalekan Temitope
- Ajao Emmanuel Akinlabi
- Ajiboye Olalekan S.
- Ajrami Yara
- Ajwa Ahmad Elian Abu
- Akan M. Eren
- Akhbari Melika
- Akhter Nadeem
- Akova Fatih
- Al-Attar Hala M.
- Al-Halbouni Layana
- Al-Mamun Abdullah
- Al-Mayoof Ali Farooq
- Al-Momani Hashem M.
- Al-Mouakeh Ahmad
- Al-Rayyes Maisara
- Al-saleem Hasan Subhi Hasan Abu
- Al-Salhi Ashraf Ayman
- Al-Shwaikh Samar H.
- Al-Slaibi Ibrahim
- Al-Taher Raed Nael
- Al-Taher Raed Nael
- Al-Tammam Hiba
- Alakaloko Felix
- Alamrain Abdulwhhab Ayman Abu
- Alanguia Chipana Cathy Lee
- Alattas Khalid
- Alberto Carlos
- Albozidi Aya
- Alcántara Elvyn
- ALDIRAWI MOHAMMED A. M.
- Alebbini Mohanad Mutasem
- Alfoghi Mabroka
- Algabri Hayder Nadhim Obaid
- Alglaib Mohammed Meftah
- Alhamid Ahmad
- Alhamid Aos
- Alhassan Priscilla
- Ali Hassan
- Ali Karim Osamy
- Ali Liza
- Ali Mansour
- Alijla Sharif
- Alijla Sharif S.
- Aliwisat Ahmad Hasan
- Aljaboo Hajir
- Aljadidi Wesal Omar F. Saied
- Aljarad Ziad
- Alkareem Raghad mohammad abdu
- Almada Suad Ahmed
- Almadhoun Walaa
- Almasri Murad
- Almeida Aguiar Arthur
- Almeida Giovana
- Almengar Inas
- Almohamady Hisham
- Almosaibli Mohammad
- Almusleh Tasneem Fathi Hasan
- Alnaeri Ali
- Alnahhal Khaled
- Alonso Verónica
- Alosta Hasan Mustafa
- Alqarajeh Firas
- Alqor Mohammad Omar Ibrahim
- Alsaadi Nijmeh Nasser
- Alsaggaf Ameen
- Alsaied Amer
- Alser Mohammed
- Alser Osaid H.
- Alshaikhkhalil Haya Abdulnasser Ali
- Alshehri Abdullah
- Altaweel Ahmed
- Altın Merve
- Altokhais Tariq
- Altomi Mohamed
- Alturki Fahad
- Alvarado Zelada Jackelyne
- Alves Dutra da Silva Érika
- Alwadia Soha Marwan Salem
- Alwaggaa Nouriyah Ali
- Alzamari Ainaa Ata Mohammad
- Alzate Gallego Edgar
- Alzeer Asmahan Mohammad Suliman
- Alzerei Sulaiman T.
- Alzraikat Sayel H.
- Alzubair Afnan
- Alzughayyar Tareq Z.
- Amad Mohamed
- Amado Fernando
- Amaechi Chukwubinyelum
- Amah Christopher Chim
- Amarin Justin Z.
- Amarin Marzouq
- Ambriz-González Gabriela
- Ameh Emmanuel
- Amjad Muhammad Bin
- Amoabin Afua Amoabin
- Anatole Nzanzu
- Anatole Nzanzu Kipata
- Anaya Dominguez Marlene
- Anaya Firas
- Andrade Jerhy
- Andreussi Lorna
- Anicama Elias Rocio
- Annajjar Mohammad hasan
- Anntinea Jessmine
- Antunes Amanda
- Antunez-Mora Alexandra
- Anyomih Theophilus Teddy Kojo
- Anzelewicz Stefan
- Apaza Leon Jose Luis
- Appeadu-Mensah William
- Arabiat Esraa
- Arafa Mohamed Ahmed
- Arafat Hasan
- Aragão Liliana
- Arancibia Gutiérrez Elsa
- Aranda Sánchez Cristian Irela
- Arar Ahmad Samih
- Arauco Jenny
- Arbab Hana
- Arboleda Jenny
- Aremo Anuoluwapo
- Arnadóttir Helena
- Arnaud Alexis P
- Arnold Marion
- Arnoletto Lucia Beatriz
- Arrmali Saddam
- Arrmalli Lina Ali
- Arshad Muhammad
- Arthur Felicity
- Arul Suren
- Ashour Dina Ayman
- Ashour Yara shareef
- Aslan Yakup
- Aspirot Ann
- Assi Ahmadfateh
- Assi Muath Abdelrahem Fuad
- Astudillo Miguel
- Atatri Yazid yousef mahmoud
- Atta Ahmed
- Attia Alaa Mobarak
- Avile Romina
- Avolio Luigi
- Awad Hadeel
- Aydin Emrah
- Aykut Merve
- Ayque Rosas Fernando
- Aziz Dayang Anita Abdul
- Ba'baa' Basheer
- Badr Helmy
- Baertschiger Reto
- Bagbio Dominic
- Bah Abdoulie
- Bai Qiang
- Bai Yu Zuo
- Baistrocchi Valentina
- Bakar Ainal Huda Abu
- Baker Wisam
- Ballouhey Quentin
- Balousha Abrar ghassan
- Bamanga Ahmed
- Baniowda Muath A. M.
- Bao Xiaozhou
- Barauskas Vidmantas
- Barbosa Patricia Reis
- Baseggio Natalia
- Bashir Fatma
- Bashir Muhammad Kashif
- Bassan Gonçalves Paulo César
- Bataineh Ziad A.
- Batal Mohammad Mohannad
- Bazozi Hana Milad
- Beasley Spencer
- Becker Karin
- Belmino Gadelha Aluísio Augusto
- Benaskeur Yousra-Imane
- Beres Alana
- Berková Klára
- Bernaus Marianela
- Berrocal Anaya Waldo
- Berzanskis Mindaugas
- Beshtawi Doha mustafa saleh
- Beşir Ahmet
- Bianchin Ezequiel
- Bibas Fatma
- Biber Elna
- Bischoff Cristiano
- Bismarck Sylvester von
- Blain Otilia Eva
- Blanc Thomas
- Blazquez-Gomez Eva
- Bobadilla Morales Lucina
- Bode Christopher
- Bonnard Arnaud
- Boonthai Ampaipan
- Borbonet Daniel
- Bouhadiba Nordeen
- Bowder Alex
- Bracho Blanchet Eduardo
- Bradshaw Kate
- Bragagnini Paolo
- Brahmamdam Pavan
- Bravo Mauro Nicolas
- Bright Benedict Paul
- Brito Quevedo Luz Mery
- Broch Aline
- Brolin Santis Isolan Paola Maria
- Brunero Marco
- Bruxel Carla Luisa
- Bsisu Isam
- Bucaram Elena
- Bueno Mazzuca Rafael
- Bueno Motter Sarah
- Bujarimin Ahmad Shafiee bin
- Bulnes Mendizabal David
- Burks Stephen S.
- Burns Kate
- Butler Marilyn
- Bvulani Bruce
- C. Nwosu David
- Caamal Lorenzo Juvencio
- Calancea Calin
- Calderon Moore Antonio
- Calderón Arancibia José Alfredo
- Calistus Nwachukwu
- Cama Jitoko
- Camamra Kajali
- Cameron Fraser
- Camp Lauren
- Canözer Ali
- Caouette-Laberge Louise
- Cardenas Alva Loreley Raquel
- Cardenas Ruiz Velasco Juan Jose
- Carrasco Ana Lucia
- Carrasco-Ortega Cesar
- Carrillo Isabel
- Casado Francis Tanise
- Casal Beloy Isabel
- Caseb Paloma
- Casquero Victor
- Castañeda Espinosa Sergio
- Castaño Avila Daniela
- Castedo Camacho Fabiola Ruth
- Cavaiuolo Silvia
- Cañapataña Sahuanay Veronica Raquel
- Cepeda Rodrigo
- Cesur İlknur Banlı
- Chan Jonathan
- Chang Jeremy
- Charras Maria Delia
- Chaudary Ali Raza
- Chaudhry Muhammad Amjad
- Chauhan Nirav
- Chavez Galvez Patricia
- Chen Lulu
- Chen Rui
- Cheung Maija
- Chipalavela Rossana Francisco
- Chiriboga Elena
- Chitiavi Soita Wycliffe
- Chitnis Milind
- Cho Seok Hyeon
- Choo Candy SC
- Chukwu Isaac
- Chukwuemeka Anyanwu Lofty-John
- Chung Jae Hee
- Cletus Cyril
- Coghill Griffin
- Collins Nwokoro
- Colombo de Holanda Felipe
- Contreras Carla Sofia
- Coon John
- Cordonnier Annelien
- Cornelli Fabio
- Cornwall Hannah
- Corona C. Rivera Jorge Román
- Corona Rivera Alfredo
- Correa Leite Mila Torii
- Correa Armandou
- Correa Catalina
- Corrêa Costa Eduardo
- Cosoreanu Vlad
- Costas-Chavarri Ainhoa
- Cripovich Alejandrina
- Cunningham Aaron
- Czauderna Piotr
- Cáceres Aucatoma Freud
- Cárdenas Barón José de Jesús
- Cömert Hatice Sonay Yalçın
- da Silva Augusto Maria Lucia
- Dagilytė Rūta
- Dahman Nesrine Ben Hadj
- Dajia Wang
- Dalek Noor Fa'izatul Rahil Ambok
- Dallegre Maria Belen
- Dalloul Hisham
- Damiani Andrea
- Dammagh Nagham Mohammed Al
- Dania Bouguermouh
- Darras Osama Majed
- Darwish Ahmed S
- Darwish Ammar
- Dass Anthony
- Dassonville Martine
- Davenport Kate
- David Kuria
- Davies Justine
- Davis Jenna Kylene
- de Assis Silva Murilo
- de Azevedo Belesa Flavia
- de Campos Vieira Abib Simone
- de Deus Passos Leles Kamila
- de Guzman Johann
- de Souza Santos Ferreira Mariana
- Dedeke Florence
- Defago Victor Hugo
- Defert Coralie
- Delefortrie Thomas
- Delforge Xavier
- Delft Dirk von
- Delgado Malaga Florangel Patricia
- Delgado Quinteros Edgar Fernando
- Dellenmark Blom Michaela
- Dendusic Nejra
- Derbew Miliard
- Derks Terry
- Deya Corazone
- Deyab Abdelaziz
- Di Siervi Oscar
- Diaz Castañeda Flor de Maria
- Diaz Echegaray Marlene
- Diaz Gomez Jose Manuel
- Diaz Leon Cesar
- Dieudonné Lemfuka
- Dimatatac Doris Mae
- Djordjevic Ivona
- Dogar Sohail
- Doheim Mohamed Fahmy
- Dominguez Danny
- Donglai Hu
- Dornellas do Nascimento Suely
- dos Santos Dias André Iván Bradley
- Dosselman Luke J.
- Douiri Abdel
- Drah Weam
- Dube Andile Maqhawe
- Duchesne Camille
- Duggan Eileen
- Duote Cai
- Dure Carolina
- Dávila Perez Roberto
- Ebeido Annan
- Egbuchulem Ifeanyichukwu Kelvin
- Ejinkeonye Eze Chukwuemeka
- Ekenze Sebastian Okwuchukwu
- Ekwunife Okechukwu Hyginus
- El-Ghazaly Mohammed
- Elassall Gena Mohamed Hamed
- Elayeb Abdallah
- Elebute Olumide Abiodun
- Elewaily Mohamed
- Elfiky Mahmoud
- Elgammudi Mala
- Elghazaly Shrouk Mahmoud
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine Ali
- Elhattab Ahmad
- Elisante Joseph
- Elkaloush Abdullahn Abdousalam
- Elkhazmi Ebtesam Othman Abdulsalam
- Elmenam Mohamed Abd
- Elmzyyen Aya Mahmoud
- Elrais Safa Abdal
- Elsadek Menan Ahmed
- Elsaied Adham
- Elshaer Omar Adly
- Elsherbiny Mohamed
- Elsiraffy Omar Ossama
- Elstad Maria
- Elzohiri Mohamed
- Elzowawi Fathi
- Emam Omar Sameh
- Emil Sherif
- Enbaya Manal Ben
- Ensar Nicholas
- Erdem Melisa
- Eren Elif
- Ergenekon Ebru
- Eroğlu Egemen
- Erturk Nazile
- Erçin Seçil
- Eshkabilov Shukurali
- Espineda Beda
- Essa Tarek Mohamed
- Essamilghi Kamila Almabrouk Mohammed
- Ezidiegwu Ugochukwu S
- Ezomike Uchechukwu Obiora
- Faboya Omolara Moronkeji
- Fachin Camila
- Fadhle Muhamed Jassim
- Faks Vivian
- Falah Eyad Hassan
- Farag Eman mohamed
- Fares Jehad
- Farha Mervat Sufian Abu
- Farion-Aguiar Luiz
- Fawzy Omar Moustafa
- Fayez Mohamed
- Fazli Mohamad Rafi
- Feldens Leticia
- Felix Michael
- Ferdousi Tamanna
- Fernandes de Oliveira Darli
- Fernandes de Souza Rachel
- Fernandez Ferrer Marianelly
- Fernandez Portilla Emilio
- Fernandez Wilson Miriam Daniela
- Ferraz Schopf Luciano
- Flores Carbajal Lenny
- Ford Kat
- Forero Ladino Angelica Maria
- Fouda Mohamed Fayez
- Fouly Mariam Albatoul Nageh
- Fouquet-Languillat Virginie
- Fourcade Laurent
- Fowler Kathryn L
- Fox Sarah
- Franco Helena
- Furtado Meyer Karine
- Furtado Mariana
- Féliz Erick
- Gabriel Comba
- Gad Dalia
- Gadepalli Samir
- Gai A.
- Galdeano Marcelo
- Gall Caroline Le
- Gamage Tharanga
- Gamboa Kcomt Segundo
- Gao Zhigang
- Gao Zhou Chong
- Garcia Martinez Humberto
- Garcia Isidora
- Garcia Virginia
- Garcia-Aparicio Luis
- García Miriam
- Gargum Sondas Ali
- Garnier Hanna
- Garrett-Cox Robin
- Gasana Georges
- Gatzinsky Vladimir
- Gavrila Bogdan
- Gavrilovska-Brzanov Aleksandra
- Gee Oliver
- Gerus Sylwester
- Geze Şükran
- Ghabayen Amir Talat Sheda
- Ghallab Alaa
- Ghaly Khaled Abd elrahman
- Ghanem Waleed H.
- Ghayth Sumayyah
- Ghazzawi Ihsan
- Ghilardi Silva Ximena
- Ghorab Islam Abdelmonem
- Ghosh Dhruv
- Gilardi Jose
- Girão Tauffer Mariana
- Goddard Lucy
- Goebel Peter
- Gohil Hetal
- Gomes Adriano Luis
- Gomez Juanita
- Gomez Oscar
- Gondal Mudassir Fayaz
- Gonzales Brandy
- Gonzalez Cortez Luis Fernando
- Gonzalez Daniel Emilio
- Gonzalez Joann
- González Ojeda Alejandro
- Gonçalves Borges Carolina
- Gonçalves da Cunha
- Gonçalves Victor
- Gosain Ankush
- Grabowski Andrzej
- Granéli Christina
- Greenberg Jodie
- Grella Maria Giovanna
- Grosos Céline
- Grottling Emma
- Grynberg Lucie
- Guadagno Elena
- Guayelema Marisol
- Guazzotti Marinella
- Guerin Florent
- Guimarães Patricia
- Guinsburg Ruth
- Guisse Carmen
- Gurgel do Amaral Antonio Cipriano
- Gurskas Pranas
- Gutarra Palomino Andrea
- Gutierrez Maldonado Joan Elizabeth
- Habiba Alouani
- Hagander Lars
- Hagander Lars
- Haidari Sayed Aman
- Haider Naveed
- Hajajreh Ma'alem sameer
- Hakan Nilay
- Halabi Yasmeen Adly
- Hall Nigel
- Hall Timothy
- Hameed Soban
- Hamidi Nadia
- Hamidovic Ajla
- Hamill James
- Hamilton April
- Hammato Abdalkarim Yhya
- Hammond Philip
- Hammouri Ahmad G.
- Hamzah Siti Nur Aien binti Hamid
- Han Yijiang
- Hanifah Nur Atiqah binti Mohd
- Haraux Elodie
- Harilal Shamaman
- Harper Luke
- Hasan Samiul
- Hasan Samiul
- Hasanain Doaa Khalil
- Hashim Hidayah Hayati binti
- Hashim Imran
- Hashim Sophia
- Hassan Majd Yousef Mohammed
- Hassan Mohamed Abada
- Hassan Mohd Razin bin
- Hassan Zulfitri bin Md
- Herappe Mellado Dorihela
- Herdan Mohamed Omar
- Hernández Córdova Karina
- Herrera Pesara Luciana Martina
- Herrera Carina
- Herrera Laura
- Hery Géraldine
- Hinostroza Daniel
- Hisham Intisar
- Hodgman Erica
- Honhar Medhavi
- Horacio Bonavia
- Horozic Dzan
- Hospital Sonia Inamuco
- Huang Liuming
- Huang Shungen
- Huang Ting
- Huaytalla Quiroz Natalia
- Huespe Enrique
- Hukic Lamija
- Huq Umama
- Hussain Syeda Ra'ana
- Hussein Omar Ghazi
- Hussein Sara Al
- Hussien Muaad
- Hwang In ji
- Hyeon Cho Seok
- Hyman Gabriella
- Ibarra Daniel
- Ibrahim Eman Abouzeid Abouzeid
- Ibrahim Fowzia
- Ibrahim Mahmoud abdelshakour
- Ibukunolu Ogundele
- Igoche Matthias
- Ihediwa George
- İmamoğlu Mustafa
- Ionescu Sebastian
- Iracelay Susana
- Iriondo Martí
- Ishak Shareena
- Ismail Enas Musa
- Ismavel Vijay Anand
- Itangishaka Innocent
- Ivanov Monica
- Jabaiti Mohammad S.
- Jabang John N.
- Jaber Dania
- Jacobson Jillian
- Jain Sunil
- Jaiteh Musa
- Jallow Cherno S.
- Jalo Iliya
- Jamal Muhammad Umer
- Jamie Najlaa Abu
- Jamie Yasmin Mohammed Khalil Abu
- Jaramillo Martha
- Jauri Cesar
- Jayaratnam Sridharan
- Jayyab Mustafa abu
- Jester Ingo
- Jimenez Morejon Vinicio
- Joda Ali Egab
- Joharifard Shahrzad
- Johnson Stephanie
- Jones Brendan
- Jones Ceri
- Jones Matthew
- Jonuzi Asmir
- Jooma Uzair
- Joubeh Sharehan
- Jovcheski Laze
- Jr Acimar
- Juhasz Laszlo
- Julio Lapalma
- Junes Maria del Carmen
- Junjie Chen
- Junyi Wang
- Juricic Mélodie
- Jusabani Mubashir
- Jyun Keily Wong Yue
- Jáuregui Lorena
- Jérémie Niyonkuru
- Kader Şebnem
- Kalicińsk Piotr
- Kamel Tarek mohamed
- Kamilovski Marjan
- Kannessan Hemasutha a/p
- Kano Yar
- Kapihya Chisengo
- Karabulut Ramazan
- Karakus Suleyman Cuneyt
- Karamustafic Azra
- Karavdic Kenan
- Karim Sabbir
- Karim Safina
- Kaya Hatice
- Kayed Yara Imad Omar
- Kayibanda Emmanuel
- Kchiche Nahla
- Kelay Arun
- Keleş Elif
- Keshtgar Alireza
- Khaled Ala
- Khalel Wegden ibrahim almabrouk
- Khalid Hazlina Mohd.
- Khamag Omar
- Khatatba Lara Zahi Adel
- Khattak Muhammad Adnan Khan
- Khlevner Julie
- Khodor Cury Edson
- Khorana Jiraporn
- Kihiko David
- Kim Hyun-Young
- King Sebastian
- Knorr Brenner Nicole
- Knorr Christian
- Knurowska Agata
- Kohaut Jules
- Koipapi Sengua
- Korlacki Wojciech
- Kostic Ana
- Koszutski Tomasz
- Kowalewsk Grzegorz
- Krause Hardy
- Krayem Yousef
- Krisanova Dasha
- Krishnaswami Sanjay
- Kufeji Dorothy
- Kukkady Askar
- Kumar Vijay
- Kumolalo Felix O.
- Kunfah Sheba Mary Pognaa
- Kurian Merina
- Kurt Gökmen
- Kwasau Henang
- Laberge Jean-Martin
- Labonia Carla
- Ladipo-Ajayi Oluwaseun
- Lahlooh Raghad abdullateef
- Lakhoo Kokila
- Lander Tony
- Landivar Cino Enrique
- Langer Monica
- Langley Jason
- Lapouble Francisco
- Lara Sandra
- Laraqui Hossini Samia
- Latiff Zarina Abdul
- Lawal Taiwo
- Lawalbarau Abdullahi
- Layas Tesneem
- Laymouna Moustafa A.
- Leal Paola Osses
- Leather Andrew J. M.
- Lechmiannandan Abhirrami
- Ledesma Peraza Jesmarina
- Lee Ju yeon
- Lee Sanghoon
- Leech Mary
- Lerma Sergio
- Letic Emina
- Levard Guillaume
- Levitt Marc
- Leyba Marcos Federico
- León Frutos Francisco Javier
- Li Haijing
- Li Shungen
- Li Zhongrong
- Liang Liang
- Liljesthrom Karen
- Lim Felicia
- Lin Nicole
- Lindert Judith
- Lino Urquizo Marcelo Mauricio
- Liu Yang
- Liubsys Arunas
- Liukitithara Sirima
- Ljuhar Damir
- Llap Unchón Genaro
- Lobos Pablo
- Lodhia Jay
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- Reda Ahmed
- Rehman Wajeeh ur
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- Ruan Weiwei
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- Ruiz de Temiño Bravo Mercedes
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- Saad Mahmoud M.
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- Saleem Ayesha
- Saleem Muhammad
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- Sharabati Mutassem
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- Sharif Randa Alamen M
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- Türkyılmaz Zafer
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- Ugwunne Chuka A
- Ulasi Ikechukwu
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- Vacek Jonathan
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- Vanis Nedim
- Vaquila Justo
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- Vellusamy V Muthualhagi M
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- Venkatraman Soundappan Sannappa
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- Vida Lucian
- Vidal Cristian R. Zalles
- Vierboom Liam
- Villalba Villalba Araceli
- Villegas Silva Raúl
- Vinskaite Asta
- Vos Corné de
- Vosoughi Armin
- Wafa Tamer
- Walker Gregor
- Wang Jinhu
- Wang Peng
- Waseem Basma
- Weeratunga Naveen
- Weiszewsk Alicja
- Wen Gang
- Werneck Raposo Juliana
- Wester Tomas
- Wijekoon Naveen
- Wilke Alexandra
- Williams Isabelle
- Williams Omolara
- Williams Regan
- Win Win Sabai Phyu
- Wishah Bisan D. M.
- Wishah Nidal
- Wissanji Hussein
- Wolak Przemyslaw
- Wolny Agnieszka
- Wong Janice
- Wong Marilyn
- Wright Naomi Jane
- Wu Guowei
- Wyrzykowski Dariusz
- Xiaodong Guo
- Xie Hua
- Yacoub Mina A.
- Yaghi Bashar
- Yaghi Dua Hasan
- Yalcinkaya Ali
- Yang Hee-Beom
- Yanis Ahmad H.
- Yanowsky Reyes Guillermo
- Yao Yang
- Yapo Benjamin
- Yarza Fernández Jessica
- Yeniay Aslı Öztürk
- Yola Mariya Mukhtar
- Yong Feng
- Youn Joong Kee
- Yousuf Hina
- Yu Mengnan
- Yu Raisa
- Yuen Quah Soong
- Yuldashev Rustam Z.
- Yunus Aayenah
- Za'nouneh Faris J. Abu
- Zaghlol Louay Y.
- Zahari Dato' Dr Zakaria bin
- Zain Mostafa
- Zaman Azrina SK
- Zanellato Josiane Bernartt
- Zarwawi Ahmad Zulhisyam bin
- Zea-Salazar Luis Enrique
- Zeinelabdeen Ali
- Zhao Xiaoxia
- Zhu Jianming
- Zhu Libin
- Zidan Mazen
- Zivanovic Dragoljub
- Zottis Barcelos Fabricio
- Zreeg Dafer abdulhakim . S.
- Zurikat Rajai O.
- Zvizdic Nada
- Zvizdic Zlatan
- Çekiç Bahanur
- Çelik Müge
- Özçelik Zerrin
- Şeref Kıvanç
- Šafus Antonín
- Škvařil Jan
- Štichhauer Radek
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)
- Author
- Aadil Hussain
- Abbes Salem
- Abdelbaset Buhmaida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbasit Buhmeida
- Abdelbasit Buhmeida
- Abdellatif Bouazzaoui
- Abdelwahab Noorwali
- Abdulah E. A. Mathkoor
- Abdulazeez Sayyed
- Abdulla A. Alharthi
- Abdullah Al-Harbi
- Abdullah Alashwal
- Abdullah M. Gari
- Abdullraheem Rozi
- Abdulmonem Al-Mutawa
- Abdulmonem Al-Mutawa
- Abdulrahman M. S. Sibiani
- Abeer A. Al-refai
- Abid Qureshi
- Abrar Al Qahtani
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chudhary
- Adel Abuzenada
- Adel Abuzenada
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Al-Ammari
- Adel Al-Ammari
- Adel Al-Johari
- Adel Al-Johari
- Adel E. El-Tarras
- Adel Galal Ahmed El-Shemi
- Adel Galal Ahmed El-Shemi
- Adel Galal El-Shemi
- Adel M. Abu Zenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel Mohammed Abuzenadah
- Adil Jamal
- Adnan Merdad
- Adnan Merdad
- Afnan Bahamaid
- Afnan Bandah
- Afnan Bandah
- Afnan Bandah
- Afnan O. Bahmaid
- Ahmad A. T. Naqvi
- Ahmad Ashshi
- Ahmad Ashshi
- Ahmad J. Al Sayyad
- Ahmad J. Al Sayyad
- Ahmed Al-Sayyad
- Ahmed Al-Sayyad
- Ahmed Ateya
- Ahmed M. Ashshi
- Ahmed M. Isa
- Ahmed M. Z. Darwish
- Ahmed Rebai
- Ahmed Rebai
- Ahmed Rebai
- Ahmed S. Masmoudi
- Aisha A. Alyamani
- Aisha Alyamani
- Aisha Hassan Elaimi
- Alaa A. Albogmi
- Alaa A. Albogmi
- Alaa A. Alboogmi
- Alaa Al-Ahmadi
- Alaa Al-Ahmadi
- Alaa Al-Ahmadi
- Alaa Alamandi
- Alaa K. Kamel
- Alaa O. Magrabi
- Alagiri Srinivasan
- Alastair D. Burt
- Albert J. Fornace
- Ali Al-Muraikhi
- Ali Al-Sahwan
- Ali Mobasheri
- Ali Sawan
- Alia M. Aldahlawi
- Alistair G. Rust
- Amal Awad
- Amal M. Mohamed
- Amal M. Nour
- Amanuel T. Gebreslasie
- Amein Al-Ali
- Ameur Cherif
- Ameur Cherif
- Amr Abdelfattah
- Anas M. M. Oun
- Andrey Ptitsyn
- Angel Carracedo
- Angel Carracedo
- Angie Ambers
- Anne Goodeve
- Areeg Faggad
- Asad M. Ilyas
- Asho Ali
- Ashok Agarwa
- Ashok Agarwal
- Ashok Agarwal
- Ashok Agarwal
- Ashok Agarwal
- Ashraf Ali
- Ashraf Ali
- Ashraf Dallol
- Ashraf Dallol
- Ashraf Dallol
- Ashraf Dallol
- Ashraf Dallol
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- Ashraf Dallol
- Ashraf Dallol
- Ashraf Dallol
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- Assad El Gerzawy
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- Gauthaman Kalamegam
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- Hans-Juergen Schulten
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- Hans-Juergen Schulten
- Hans-Juergen Schulten
- Hans-Juergen Schulten
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- Ibtessam R. Hussein
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- Iftikhar A. Tayubi
- Iftikhar A. Tayubi
- Iftikhar A. Tayubi
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- Jaudah Al-Maghrabi
- Jaudah Al-Maghrabi
- Jaudah Al-Maghrabi
- Jaudah Al-Maghrabi
- Jaudah Al-Maghrabi
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- Mahmood Rasool
- Mahmood Rasool
- Mahmood Rasool
- Mahmood Rasool
- Mahmood Rasool
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- Mahmood Rasool
- Mahmood Rasool
- Mahmood Rasool
- Mahmood Rasool
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- Mahmoud Al-Ahwal
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- Mamdooh A. Gari
- Mamdooh A. Gari
- Mamdooh A. Gari
- Mamdooh Gari
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- Mamdooh Gari
- Mamdooh Gari
- Mamdooh Gari
- Mamdooh Gari
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- Manish Tripathi
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- Mansour Al-Enazi
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- Marwa I. Shehab
- Marwa I. Shehab
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- Mauro Santibanez-Koref
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- Mazen M. Gari
- Md I. Hassan
- Mehdi Zarrei
- Mehenaz Hanbazazh
- Metwally M. Montaser
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- Mikhlid H. Almutairi
- Mohamad I. Lone
- Mohamad I. Lone
- Mohamad Saka
- Mohamed Boudjelal
- Mohamed H. Alqahtani
- Mohamed M. M. Ibrahim
- Mohamed Nabil Alama
- Mohammad A. Al Karaawi
- Mohammad A. Alzohairy
- Mohammad A. Aziz
- Mohammad A. Jafri
- Mohammad A. Jafri
- Mohammad A. Jafri
- Mohammad A. Jafri
- Mohammad A. Kamal
- Mohammad A. Kamal
- Mohammad Al-Qahtani
- Mohammad Al-Qahtani
- Mohammad Al-Qahtani
- Mohammad Athar
- Mohammad H. Al Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad I. Lone
- Mohammad Khalid Alwasiyah
- Mohammad Khalid Alwasiyah
- Mohammad Khalid Alwasiyah
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. S. Jarullah
- Mohammad Sarwar Jamal
- Mohammed Abbas
- Mohammed Abbas
- Mohammed Abuzinadah
- Mohammed Al Qahtani
- Mohammed Al Qahtani
- Mohammed Al Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Aldress
- Mohammed Alqahtani
- Mohammed Bangash
- Mohammed Bangash
- Mohammed Bangash
- Mohammed Bangash
- Mohammed Basalamah
- Mohammed Basalamah
- Mohammed Elanbari
- Mohammed F. Elshal
- Mohammed H. Al Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Alkaf
- Mohammed H. Alkaf
- Mohammed H. Alkaf
- Mohammed H. Alqahtani
- Mohammed H. AlQahtani
- Mohammed H. AlQahtani
- Mohammed H. AlQahtani
- Mohammed H. AlQahtani
- Mohammed Imran Nasser
- Mohammed M. Abbas
- Mohammed M. Abbas
- Mohammed M. Abbas
- Mohammed M. Abbas
- Mohammed M. F. Al-Halbosiy
- Mohammed M. Jan
- Mohammed Sarwar Jamal
- Mohd A. Beg
- Mohd A. Beg
- Mohd A. Beg
- Mohd A. Beg
- Mohd Rehan
- Mohd Suhail
- Mohiuddin K. Warsi
- Mohiuddin K. Warsi
- Mohiuddin M. Taher
- Mohmmad Shoab Mansuri
- Mohmmed H. Alkaff
- Mohtashim Lohani
- Mona Al-Sharif
- Mona Al-Sharif
- Mona El-Ruby
- Mona Mekkawy
- Mona Saleh
- Monika Stoljarova
- Moumni Imen
- Mouna Medhioub
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- Mourad Assidi
- Mourad Assidi
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- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
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- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Msadok Azouz
- Msadok Azouz
- Mughees Uddin Siddiqui
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Al-Qahtani
- Muhammad Al-Qatani
- Muhammad Bilal
- Muhammad Faheem
- Muhammad Faheem
- Muhammad Faheem
- Muhammad Faheem
- Muhammad Faheem
- Muhammad I. Naseer
- Muhammad I. Naseer
- Muhammad I. Naseer
- Muhammad I. Naseer
- Muhammad I. Naseer
- Muhammad I. Naseer
- Muhammad I. Nasser
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- Peter Natesan Pushparaj
- Peter Natesan Pushparaj
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- Peter Natesan Pushparaj
- Peter Natesan Pushparaj
- Peter Natesan Pushparaj
- Peter Natesan Pushparaj
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- Rola F. Turki
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- Rukhsana Satar
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- Saadiah Alfakeeh
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- Sachiyo Mimaki
- Sadananda Acharya
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- Safia S. Messaoudi
- Sahar A. F. Hammoudah
- Sahar Hakamy
- Sahar Hakamy
- Sahar Hakamy
- Sahar Hakamy
- Saher Hakamy
- Sahira Lary
- Saif Ahmad
- Sajid Mehmood
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Saleh Alasiri
- Saleh Baeesa
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- Sarah A. Batwa
- Sathish Periyasamy
- Satoshi Serada
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- Seyed E. Hasnain
- Shadi Al-Khayyat
- Shahida Khan
- Shahnawaz D. Jadeja
- Shakeel A. Ansari
- Shakeel A. Ansari
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- Shakeel Ansari
- Shereen A. Turkistany
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
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- Steven C. Clifford
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- Sudhir Kumar
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- Sudhir Kumar
- Sudhir Kumar
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- Sulman Basit
- Susan Walker
- Syed A. Hassan
- Syed A. Hassan
- Syed Asif Hassan
- Syed Hassan
- Syed K. Zaidi
- Syed Kashif Zaidi
- Syed Kashif Zaidi
- Taha A. Abdel-Meguid
- Taha Abduallah Kumosani
- Taha Abduallah Kumosani
- Taha Abdullah Kumosani
- Taha Abo Almagd
- Taha Kumosani
- Takahiko Nishigaki
- Takis Athanasopoulos
- Taoufik Nedjadi
- Taoufik Nedjadi
- Tatsuhiro Shibata
- Tej P. Singh
- Tetsuji Naka
- Toshirou Nishida
- Touhami Mahjoub
- Touhami Mahjoub
- Touhami Mahjoub
- Tsuyoshi Takahashi
- Vera Chayeb
- Vikram Gopalakrishna Pillai
- Vladimir B. Bajic
- Wafaey Gomaa
- Waseem Ahmad
- Waseem Ahmad
- Waseem Ahmad
- Waseem Ahmad
- Wassim Almawi
- Wassim Y. Almawi
- Wejdan Al-Qahtani
- Wejdan Al-Qahtani
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- Wided Malah
- Yogesh S. Marfatia
- Yosr Z. Haffani
- Yosr Z. Haffani
- Youjin Na
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- Yousif A. Abutalib
- Youssri Ahmed
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- Zeenat Mirza
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Aali A.
- Abbas Q.
- Abbasi B.
- Abbasi-Kangevari M.
- Abbasi-Kangevari Z.
- Abbastabar H.
- Abd-Elsalam S.
- Abdelmasseh M.
- Abdelwahab A.A.
- Abdoli G.
- Abdulkadir H.A.
- Abedi A.
- Abegaz K.H.
- Abidi H.
- Aboagye R.G.
- Abolhassani H.
- Absalan A.
- Abtew Yo.D.
- Abu-Gharbieh E.
- Abubaker Ali H.
- Achappa B.
- Acheson A.R.
- Acuna J.M.
- Addison D.
- Addo I.Y.
- Adegboye O.A.
- Adesina M.A.
- Adnan M.
- Adnani Q.E.S.
- Advani S.M.
- Afrin S.
- Afzal M.S.
- Aggarwal M.
- Ahinkorah B.O.
- Ahmad A.R.
- Ahmad R.
- Ahmad S.
- Ahmad S.
- Ahmadi S.
- Ahmed Rashid T.
- Ahmed H.
- Ahmed L.A.
- Ahmed M.B.
- Aiman W.
- Ajami M.
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- Ukke G.G.
- Ullah I.
- Ullah S.
- Ullah S.
- Unnikrishnan B.
- Vacante M.
- Vaezi M.
- Valadan Tahbaz S.
- Valdez P.R.
- Vardavas C.
- Varthya S.B.
- Vaziri S.
- Velazquez D.Z.
- Veroux M.
- Villeneuve P.J.
- Violante F.S.
- Vladimirov S.K.
- Vlassov V.
- Vo B.
- Vos T.
- Vu L.G.
- Wadood A.W.
- Waheed Y.
- Walde M.T.
- Wamai R.G.
- Wang C.
- Wang F.
- Wang N.
- Wang Y.
- Ward P.
- Waris A.
- Westerman R.
- Wickramasinghe N.D.
- Woldemariam M.
- Woldu B.
- Xiao H.
- Xu R.
- Xu S.
- Xu X.
- Yadav L.
- Yahyazadeh Jabbari S.H.
- Yang L.
- Yazdanpanah F.
- Yeshaw Y.
- Yismaw Y.
- Yonemoto N.
- Younis M.Z.
- Yousefi Z.
- Yousefian F.
- Yu C.
- Yu Y.
- Yunusa I.
- Zahir M.
- Zaki N.
- Zaman B.A.
- Zangiabadian M.
- Zare F.
- Zare I.
- Zareshahrabadi Z.
- Zarrintan A.
- Zastrozhin M.S.
- Zeineddine M.A.
- Zhang D.
- Zhang J.
- Zhang Y.
- Zhang Z.J.
- Zhou L.
- Zodpey S.
- Zoladl M.
- Šekerija M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden
Investigating Pathogenicity and Virulence of Staphylococcus pettenkoferi: An Emerging Pathogen
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 19/12/2021
- Field of study
Staphylococcus pettenkoferi is a coagulase-negative Staphylococcus identified in 2002 that has been implicated in human diseases as an opportunistic pathogenic bacterium. Its multiresistant character is becoming a major health problem, yet the pathogenicity of S. pettenkoferi is poorly characterized. In this study, the pathogenicity of a S. pettenkoferi clinical isolate from diabetic foot osteomyelitis was compared with a Staphylococcus aureus strain in various in vitro and in vivo experiments. Growth kinetics were compared against S. aureus, and bacteria survival was assessed in the RAW 264.7 murine macrophage cell line, the THP-1 human leukemia monocytic cell line, and the HaCaT human keratinocyte cell line. Ex vivo analysis was performed in whole blood survival assays and in vivo assays via the infection model of zebrafish embryos. Moreover, whole-genome analysis was performed. Our results show that S. pettenkoferi was able to survive in human blood, human keratinocytes, murine macrophages, and human macrophages. S. pettenkoferi demonstrated its virulence by causing substantial embryo mortality in the zebrafish model. Genomic analysis revealed virulence factors such as biofilm-encoding genes (e.g., icaABCD; rsbUVW) and regulator-encoding genes (e.g., agr, mgrA, sarA, saeS) well characterized in S. aureus. This study thus advances the knowledge of this under-investigated pathogen and validates the zebrafish infection model for this bacterium