Doing Marginalized Motherhood: Identities and Practices among Incarcerated Women in Mexico

This study examines the mothering practices and identities of incarcerated women in Mexico. Data gathered from repeated life-story interviews with 12 women, were analyzed to describe mothering practices in the different phases of incarcerated women’s’ lives. We argue that knowledge of the Latin American context is crucial to understand their experiences of motherhood. In a society based on familism and marianismo identities that suffers from a lack of welfare institutions, motherhood provided a way for socially and economically excluded women to escape destructive family environments and gain autonomy. Motherhood also provided a way to cope with the stigma of delinquency. Using the framework of Southern Criminology, we explore the importance of marginalized motherhood in this tradition. The results reveal the tragic paradox of motherhood for incarcerated women and the importance of studying marginalized mothering beyond the Global North

Formación universitaria en Administración Pública y capacidades burocráticas en Argentina (1990-2017)

This work aims to reflect on the link between the bureaucratic capacities probably involved in the management of States that are recognized in two currents: neoliberal and neo-developmentalist and the development of the training offer in Administration and Public Management in Argentina during the last twenty-seven years, from questioning ourselves: what would be those capacities in each case? And what training offers would feed those capabilities? The work postulates that this training field is defined by the promises regarding their graduation profiles and the scope for them designed, at the same time that it is constituted as an institutionally consolidated horizon for the formation of state bureaucracies.Este trabajo tiene como objetivo reflexionar acerca del vínculo entre las capacidades burocráticas probablemente involucradas en la gestión de Estados que se reconocen en dos corrientes: neoliberal y neodesarrollista y el desarrollo de la oferta de formación en Administración y Gestión Pública en Argentina durante los últimos veintisiete años, a partir de interrogarnos: ¿cuáles serían esas capacidades en cada caso? y ¿qué ofertas formativas alimentarían esas capacidades? El trabajo postula que este campo de formación se define por las promesas en torno a sus perfiles de egreso y los alcances para ellos diseñados, al mismo tiempo que se constituye como un horizonte consolidado institucionalmente para la formación de las burocracias estatales. El trabajo propone un esquema de comparación entre carreras y niveles de formación que posibilita formular hipótesis acerca del comportamiento del sistema académico respecto de las necesidades de formación para la gestión públic

Políticas públicas y procesos de enseñanza desde una mirada federal

Este número especial de la Revista Pilquen Sección Ciencias Sociales de la UNCo, que presenta un dossier sobre Administración Pública, responde a la convocatoria realizada oportunamente por la Red Universitaria de Carreras de Administración y Política Pública (RUCAPP

Extrapulmonary small cell sarcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

<p>Abstract</p> <p>Background</p> <p>Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type.</p> <p>Case presentation</p> <p>We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed small cell carcinoma. Serial PET/CT scans of the entire body failed to reveal any extracranial [¹⁸F]2-fluoro-2-deoxy-D-glucose (FDG) avid lesions at either diagnosis or follow-up.</p> <p>Conclusion</p> <p>Chemotherapy may show a transient response in the treatment of EPSCC. Further studies are needed to help identify optimal treatment strategies. Combination PET/CT technology may be a useful tool to monitor EPSCC and assess for an occult primary malignancy.</p

Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP

The human adenovirus type 5 (HAdV-5) E1A 13S oncoprotein is a potent regulator of gene expression and is used extensively as a model for transcriptional activation. It possesses two independent transcriptional activation domains located in the N-terminus/conserved region (CR) 1 and CR3. The protein acetyltransferase p300 was previously identified by its association with the N-terminus/CR1 portion of E1A and this association is required for oncogenic transformation by E1A. We report here that transcriptional activation by 13S E1A is inhibited by co-expression of sub-stoichiometric amounts of the smaller 12S E1A isoform, which lacks CR3. Transcriptional inhibition by E1A 12S maps to the N-terminus and correlates with the ability to bind p300/CBP, suggesting that E1A 12S is sequestering this limiting factor from 13S E1A. This is supported by the observation that the repressive effect of E1A 12S is reversed by expression of exogenous p300 or CBP, but not by a CBP mutant lacking actyltransferase activity. Furthermore, we show that transcriptional activation by 13S E1A is greatly reduced by siRNA knockdown of p300 and that CR3 binds p300 independently of the well-characterized N-terminal/CR1-binding site. Importantly, CR3 is also required to recruit p300 to the adenovirus E4 promoter during infection. These results identify a new functionally significant interaction between E1A CR3 and the p300/CBP acetyltransferases, expanding our understanding of the mechanism by which this potent transcriptional activator functions

Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells

BACKGROUND: Cervical carcinomas are second most frequent type of women cancer. Success in diagnostics of this disease is due to the use of Pap-test (cytological smear analysis). However Pap-test gives significant portion of both false-positive and false-negative conclusions. Amendments of the diagnostic procedure are desirable. Aetiological role of papillomaviruses in cervical cancer is established while the role of cellular gene alterations in the course of tumor progression is less clear. Several research groups including us have recently named the protein p16(INK4a )as a possible diagnostic marker of cervical cancer. To evaluate whether the specificity of p16(INK4a )expression in dysplastic and neoplastic cervical epithelium is sufficient for such application we undertook a broader immunochistochemical registration of this protein with a highly p16(INK4a)-specific monoclonal antibody. METHODS: Paraffin-embedded samples of diagnostic biopsies and surgical materials were used. Control group included vaginal smears of healthy women and biopsy samples from patients with cervical ectopia. We examined 197 samples in total. Monoclonal antibody E6H4 (MTM Laboratories, Germany) was used. RESULTS: In control samples we did not find any p16(INK4a)-positive cells. Overexpression of p16(INK4a )was detected in samples of cervical dysplasia (CINs) and carcinomas. The portion of p16(INK4a)-positive samples increased in the row: CIN I – CIN II – CIN III – invasive carcinoma. For all stages the samples were found to be heterogeneous with respect to p16(INK4a)-expression. Every third of CINs III and one invasive squamous cell carcinoma (out of 21 analyzed) were negative. CONCLUSIONS: Overexpression of the protein p16(INK4a )is typical for dysplastic and neoplastic epithelium of cervix uteri. However p16(INK4a)-negative CINs and carcinomas do exist. All stages of CINs and carcinomas analyzed are heterogeneous with respect to p16(INK4a )expression. So p16(INK4a)-negativity is not a sufficient reason to exclude a patient from the high risk group. As far as normal cervical epithelium is p16(INK4a)-negative and the ratio p16(INK4a)-positive/ p16(INK4a)-negative samples increases at the advanced stages application of immunohisto-/cytochemical test for p16(INK4a )may be regarded as a supplementary test for early diagnostics of cervical cancer