Seconds-scale coherence in a tweezer-array optical clock

Optical clocks based on atoms and ions achieve exceptional precision and accuracy, with applications to relativistic geodesy, tests of relativity, and searches for dark matter. Achieving such performance requires balancing competing desirable features, including a high particle number, isolation of atoms from collisions, insensitivity to motional effects, and high duty-cycle operation. Here we demonstrate a new platform based on arrays of ultracold strontium atoms confined within optical tweezers that realizes a novel combination of these features by providing a scalable platform for isolated atoms that can be interrogated multiple times. With this tweezer-array clock, we achieve greater than 3 second coherence times and record duty cycles up to 96%, as well as stability commensurate with leading platforms. By using optical tweezer arrays --- a proven platform for the controlled creation of entanglement through microscopic control --- this work further promises a new path toward combining entanglement enhanced sensitivities with the most precise optical clock transitions

A CLASSIFICATION OF THE MURINE LEUKEMIA VIRUSES : NEUTRALIZATION OF PSEUDOTYPES OF FRIEND SPLEEN FOCUS-FORMING VIRUS BY TYPE-SPECIFIC MURINE ANTISERA

Coinfection of neonatal BALB/c mice with helper-dependent Friend spleen focus-forming virus (SFFV), as contained in the Friend virus (FV) complex, and antigenically distinct Moloney leukemia virus (MolLV) resulted in the recovery of a MolLV pseudotype of SFFV, abbreviated SFFV(MolLV). The antigenic alteration of SFFV was observed by following its neutralization kinetics in vitro by specific Friend or Moloney typing antiserum. Effective pseudotype production was accomplished only when N-tropic LLV-F (the natural helper virus in the FV complex) was inhibited in B-type mice coinfected with an NB-tropic MolLV or other murine leukemia virus (MuLV) preparation. SFFV pseudotypes could not be prepared by using murine viruses other than leukemia viruses. SFFV prepared after two serial passages in the presence of MolLV was effectively neutralized by Moloney antiserum, but not by Friend typing antiserum; therefore, the envelope of the pseudotype virus, SFFV(MolLV), is homogeneous. Pseudotype virus was antigenically stable in the absence of continued mixed infection of BALB/c mice with SFFV(MolLV) and MolLV. However, SFFV(MolLV) was easily converted back to the LLV-F type after only one passage in BALB/c mice coinfected with NB-tropic LLV-F. The antigenic interconversion between LLV-F and MolLV types demonstrated that SFFV is defective with respect to the expression of neutralizable envelope antigens. Analysis of the neutralizable envelope antigens of nine SFFV(MuLV) pseudotypes by a panel of seven typing antisera made possible a "type-specific" SFFV(MuLV) envelope classification. Two major categories have been identified which correspond to the Gross (G) and Friend-Moloney-Rauscher (FMR) subgroups. Further, the FMR subgroup was divided into four types on the basis of distinct neutralization patterns. These results indicated that the specificity observed by cytotoxic G vs. FMR antisera is different from that observed by neutralization kinetics. We therefore suggest that the specific antigens revealed by virus neutralization tests be referred to as type specific

Return to Driving and a Clinical Measure of Reaction Time

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147100/1/pmr2156.pd

MECHANISMS OF GENETIC RESISTANCE TO FRIEND VIRUS LEUKEMIA IN MICE : I. ROLE OF89Sr-SENSITIVE EFFECTOR CELLS RESPONSIBLE FOR REJECTION OF BONE MARROW ALLOGRAFTS

Resistance to malignant erythropoiesis induced by Friend spleen focus-forming virus and resistance to marrow stem cell allografts are under genetic control. Strains of mice, e.g., C57BL/6 and B10.D2, which are homozygous for resistance at the Fv-2 locus, are also good rejectors of most bone marrow allografts. 89Sr, a bone-seeking isotope, irradiates marrow but not other lymphoid organs and abrogates resistance to marrow allografts without suppressing T- or B-cell functions. Thus, marrow-dependent effector cells (M cells) seem to resist allogeneic stem cells. To test if the genetic resistance to Friend virus (FV) is also mediated by M cells, B6 mice were treated with 89Sr using a dosage schedule known to abrogate resistance to allogeneic marrow cells. 9 days after FV infection of such mice, the spleens showed malignant erythroblastosis which could not be suppressed by prior hypertransfusion, a procedure which suppresses physiologic erythropoiesis. Such 89Sr-treated B6 mice also supported extensive virus replication, while control mice did not. FV markedly suppressed the ability of 89Sr-treated B6 mice to produce antisheep red blood cell (SRBC) antibodies, a feature seen normally only in genetically susceptible mice. Thus, 89Sr-treated B6 mice behaved in these respects as if they were susceptible to FV. When increasing doses of 89Sr were administered to B6 mice, a dose-related loss of resistance to FV was seen. Therefore, it appears that 89Sr-sensitive M cells mediate the genetic resistance to FV. The results of experiments with 89Sr indicated that genetically resistant mice would be expected to possess target cells which are susceptible to transformation by FV. To verify this corollary, bone marrow cells from B10.D2 (Fv-2rr) mice were transplanted into previously infected and lethally irradiated DBA/2 (Fv-2ss) recipients which share the same H-2d alleles. 5–15 days later, the spleens of DBA/2 primary recipients yielded transformed cells which were capable of producing splenic tumor colonies upon transplantation into adult, unirradiated B10.D2 secondary recipients. Various control experiments clearly indicated that the tumor colonies so induced were of B10.D2 marrow origin. This indicated that B10.D2 stem cells could be transformed when allowed to interact with FV in the spleens of susceptible DBA/2 mice. However, 30 days after transplantation of B10.D2 bone marrow cells into DBA/2 recipients, no transformed cells were detected. Apparently, in the 30-day interval precursors in the B10.D2 marrow gave rise to mature M cells which resisted the leukemic process. Since M cells recognize hybrid or hemopoietic histocompatability antigens expressed on primitive normal and transformed hematopoietic cells, we suggest that M cells may exert surveillance by rejecting leukemic cells. Thus, marrow transplantation from genetically resistant donors may provide a new mode of treatment for leukemia, by providing precursors of M cells and other immunocompetent cell types

Poster 90 Effect of Exercise on a Novel Clinical Test for Reaction Time

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146913/1/pmr2s171a.pd

Constraining MeV-scale axion-like particles with Fermi-LAT observations of SN 2023ixf

The Fermi-LAT observations of SN 2023ixf, a Type II supernova in the nearby Pinwheel Galaxy, Messier 101 (M101), presents us with an excellent opportunity to constrain MeV-scale Axion-Like Particles (ALPs). By examining the photon decay signature from heavy ALPs that could be produced in the explosion, we improve the existing constraints on the ALP-photon coupling by up to a factor of $\sim 2$ for masses $m_a \lesssim 3$ MeV, with the exact value depending mostly on plasma properties of the collapsing core. This study demonstrates the relevance of core-collapse supernovae, also beyond the Magellanic Clouds, as probes of fundamental physics.Comment: 7 pages, 2 figure

Investigating the Role of Feedback and Motivation in Clinical Reaction Time Assessment

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146854/1/pmr21092.pd

Effect of Concussion on Clinically Measured Reaction Time in 9 NCAA Division I Collegiate Athletes: A Preliminary Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147005/1/pmr2212.pd