79 research outputs found
CMBPol Mission Concept Study: Probing Inflation with CMB Polarization
We summarize the utility of precise cosmic microwave background (CMB) polarization measurements as probes of the physics of inflation. We focus on the prospects for using CMB measurements to differentiate various inflationary mechanisms. In particular, a detection of primordial B-mode polarization would demonstrate that inflation occurred at a very high energy scale, and that the inflaton traversed a super-Planckian distance in field space. We explain how such a detection or constraint would illuminate aspects of physics at the Planck scale. Moreover, CMB measurements can constrain the scale-dependence and non-Gaussianity of the primordial fluctuations and limit the possibility of a significant isocurvature contribution. Each such limit provides crucial information on the underlying inflationary dynamics. Finally, we quantify these considerations by presenting forecasts for the sensitivities of a future satellite experiment to the inflationary parameters
Climate threats to coastal infrastructure and sustainable development outcomes
Climate hazards pose increasing threats to development outcomes across the world’s coastal regions by impacting infrastructure service delivery. Using a high-resolution dataset of 8.2 million households in Bangladesh’s coastal zone, we assess the extent to which infrastructure service disruptions induced by flood, cyclone and erosion hazards can thwart progress towards the Sustainable Development Goals (SDGs). Results show that climate hazards potentially threaten infrastructure service access to all households, with the poorest being disproportionately threatened in 69% of coastal subdistricts. Targeting adaptation to these climatic threats in one-third (33%) of the most vulnerable areas could help to safeguard 50–85% of achieved progress towards SDG 3, 4, 7, 8 and 13 indicators. These findings illustrate the potential of geospatial climate risk analyses, which incorporate direct household exposure and essential service access. Such high-resolution analyses are becoming feasible even in data-scarce parts of the world, helping decision-makers target and prioritize pro-poor development
CMBPol Mission Concept Study: Probing Inflation with CMB Polarization
We summarize the utility of precise cosmic microwave background (CMB)
polarization measurements as probes of the physics of inflation. We focus on
the prospects for using CMB measurements to differentiate various inflationary
mechanisms. In particular, a detection of primordial B-mode polarization would
demonstrate that inflation occurred at a very high energy scale, and that the
inflaton traversed a super-Planckian distance in field space. We explain how
such a detection or constraint would illuminate aspects of physics at the
Planck scale. Moreover, CMB measurements can constrain the scale-dependence and
non-Gaussianity of the primordial fluctuations and limit the possibility of a
significant isocurvature contribution. Each such limit provides crucial
information on the underlying inflationary dynamics. Finally, we quantify these
considerations by presenting forecasts for the sensitivities of a future
satellite experiment to the inflationary parameters.Comment: 107 pages, 14 figures, 17 tables; Inflation Working Group
contribution to the CMBPol Mission Concept Study; v2: typos fixed and
references adde
Anomalous Dimensions and Non-Gaussianity
We analyze the signatures of inflationary models that are coupled to strongly
interacting field theories, a basic class of multifield models also motivated
by their role in providing dynamically small scales. Near the squeezed limit of
the bispectrum, we find a simple scaling behavior determined by operator
dimensions, which are constrained by the appropriate unitarity bounds.
Specifically, we analyze two simple and calculable classes of examples:
conformal field theories (CFTs), and large-N CFTs deformed by relevant
time-dependent double-trace operators. Together these two classes of examples
exhibit a wide range of scalings and shapes of the bispectrum, including nearly
equilateral, orthogonal and local non-Gaussianity in different regimes. Along
the way, we compare and contrast the shape and amplitude with previous results
on weakly coupled fields coupled to inflation. This signature provides a
precision test for strongly coupled sectors coupled to inflation via irrelevant
operators suppressed by a high mass scale up to 1000 times the inflationary
Hubble scale.Comment: 40 pages, 10 figure
CMB-S4 Science Book, First Edition
This book lays out the scientific goals to be addressed by the
next-generation ground-based cosmic microwave background experiment, CMB-S4,
envisioned to consist of dedicated telescopes at the South Pole, the high
Chilean Atacama plateau and possibly a northern hemisphere site, all equipped
with new superconducting cameras. CMB-S4 will dramatically advance cosmological
studies by crossing critical thresholds in the search for the B-mode
polarization signature of primordial gravitational waves, in the determination
of the number and masses of the neutrinos, in the search for evidence of new
light relics, in constraining the nature of dark energy, and in testing general
relativity on large scales
Victim, perpetrator, and offense characteristics in filicide and filicide-suicide
The purpose of this paper is to provide a critical review of most recent studies of parental and stepparental filicide. A detailed review of the literature revealed the importance of certain demographic, environmental, and psychosocial factors in the commission of child homicide. Our findings indicate that filicides perpetrated by genetic parents and stepparents differ considerably in terms of underlying motivational factors. Data in the literature suggest that biological parents are more likely to choose methods of killing which produce quick and painless death, whereas stepparents frequently kill their wards by beating. Research results demonstrate the victims of maternal filicides to be significantly younger than the victims of paternal filicides. Additionally, filicide–suicide is most often associated with parental psychopathology. Genetic fathers are at the greatest risk of death by suicide after the commission of familicide. These findings are discussed in relation to theoretical frameworks explaining the occurrence of child murder. Further, limitations of reviewed studies and directions for future research are presented
CMB-S4: Forecasting Constraints on Primordial Gravitational Waves
CMB-S4---the next-generation ground-based cosmic microwave background (CMB)
experiment---is set to significantly advance the sensitivity of CMB
measurements and enhance our understanding of the origin and evolution of the
Universe, from the highest energies at the dawn of time through the growth of
structure to the present day. Among the science cases pursued with CMB-S4, the
quest for detecting primordial gravitational waves is a central driver of the
experimental design. This work details the development of a forecasting
framework that includes a power-spectrum-based semi-analytic projection tool,
targeted explicitly towards optimizing constraints on the tensor-to-scalar
ratio, , in the presence of Galactic foregrounds and gravitational lensing
of the CMB. This framework is unique in its direct use of information from the
achieved performance of current Stage 2--3 CMB experiments to robustly forecast
the science reach of upcoming CMB-polarization endeavors. The methodology
allows for rapid iteration over experimental configurations and offers a
flexible way to optimize the design of future experiments given a desired
scientific goal. To form a closed-loop process, we couple this semi-analytic
tool with map-based validation studies, which allow for the injection of
additional complexity and verification of our forecasts with several
independent analysis methods. We document multiple rounds of forecasts for
CMB-S4 using this process and the resulting establishment of the current
reference design of the primordial gravitational-wave component of the Stage-4
experiment, optimized to achieve our science goals of detecting primordial
gravitational waves for at greater than , or, in the
absence of a detection, of reaching an upper limit of at CL.Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note:
text overlap with arXiv:1907.0447
BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis
Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
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