Nivel de resolución de problemas aditivos en los estudiantes del segundo grado de la Institución Educativa N.° 88025-Coishco

El presente trabajo de Investigación tuvo como objetivo determinar el nivel de resolución de problemas aditivos en los estudiantes del segundo grado de la Institución Educativa N° 88025 “Ramón Castilla” del distrito de Coishco, en el año 2019. El estudio de tipo descriptivo, considero un diseño descriptivo simple, donde el tamaño de muestra considerado fueron niños y niñas de segundo grado con un total de 32 estudiantes, para la recolección de información se utilizó como instrumento una prueba de comprobación con un total de 20 ítems para evaluarla resolución de problemas. Los resultados indican que la dimensión Problemas de cantidad, presenta 3,59 puntos como promedio; Problemas de Regularidad, equivalencia y cambio 3,72 puntos; Problemas de Forma, movimiento y localización 2,66 puntos; Problemas de Gestión de datos e incertidumbre 2,63 puntos todas las dimensiones ubicadas el nivel proceso; mientras que, la variable Resolución de problemas aditivos 12,59 puntos como promedio ubicándose en el nivel proceso. Con lo cual se concluyó que el nivel de resolución de problemas en los estudiantes sujetos de la muestra no es el adecuado, lo cual repercute en el logro de competencias del área de Matemáticas

Muestreo compresivo utilizando Orthogonal Matching Pursuit (OMP)

Muestreo Compresivo es una rama emergente del procesamiento de señales, basada en el hecho de que un número pequeño de proyecciones lineales no adaptativas sobre una señal compresible, contienen suficiente información para reconstruirla y procesarla. En este artículo se presentan los resultados obtenidos al evaluar cinco matrices de medición para la realización de Muestreo Compresivo en un sistema que utiliza el algoritmo Orthogonal Matching Pursuit (OMP), para la recuperación de la señal original. Las matrices de medición están implicadas tanto en el proceso de muestreo-compresión de la señal, como en la reconstrucción de la misma

Diseño de una estrategia didáctica basada en la simbología Pasto para desarrollar el pensamiento geométrico

El entorno que rodea a los niños y las niñas está lleno de formas geométricas, por esta razón, saber distribuir los objetos en el espacio es una de las tantas razones de la enseñanza de la geometría en los escenarios escolares. La presente investigación se enmarca en el desarrollo del pensamiento geométrico, y tiene como objetivo el diseñar el planteamiento de una estrategia didáctica que permita a los estudiantes de grado quinto de la Institución Educativa Agroindustrial Los Pastos el fortalecimiento de los procesos geométricos a partir de elementos simbólicos propios de su cultura. Para esto, se utiliza el estudio y la aplicación del Modelo de Razonamiento Geométrico de Van Hiele, buscando facilitar una mejor comprensión y aplicación de la geometría. El diseño metodológico en el cual se fundamenta esta investigación es de tipo descriptivo e interpretativo. Los instrumentos empleados para la recolección de la información fueron el cuestionario, que permitió identificar las causas de las dificultades en el aprendizaje del proceso geométrico y la entrevista semiestructurada para poder responder a las necesidades individuales y colectivas planteadas por los investigadores. El grupo focal fue el grado quinto de básica primaria de la Institución Educativa Agroindustrial Los Pastos. Por último, se concluye que el planteamiento de la estrategia didáctica pretende generar un cambio en la práctica metodológica del docente impactando en los procesos de enseñanza y aprendizaje significativo en la población objeto del estudio

Plan de responsabilidad social empresarial distribuidora Triple A.

Tablas: Formato de evaluación Impacto empresa Distribuidora Triple A, Formato de recursos financieros y decisiones de inversión, Plan de Responsabilidad Social Empresarial Distribuidora Triple A, Plan de comunicaciones a los interesados (stakeholders) tanto internos como externos de la Distribuidora Triple A. Figuras: Mapa genérico de Stakeholders Distribuidora Triple A, Matriz de relaciones (influencia vs. Impacto). Enlace video YouTubeEl objetivo del trabajo presentado a continuación es proponer la elaboración de un Plan de Responsabilidad Social Empresarial para la distribuidora Triple A, considerando la situación actual de la organización y la necesidad de que esta cuente con las herramientas de planeación necesarias para el correcto direccionamiento de su personal hacia el cumplimiento de los objetivos corporativos. La importancia del Plan de Responsabilidad Social propuesto radica en la necesidad de establecer la misión, la visión y los valores corporativos que identificarán a la organización frente a sus diferentes grupos de interés y que guiarán el actuar de los empleados y directivas con respecto a los intereses del negocio. Así mismo, incluye el establecimiento de un Código de Conducta que servirá como marco de referencia de cómo actuar frente a diferentes situaciones. Igualmente, la identificación, descripción y evaluación de los stakeholders que tienen relación con la organización, apoyados en herramientas gerenciales como la Matriz de relación (influencia vs impacto), para finalmente proponer el modelo de gestión de RSE más idóneo para la organización. El Plan de Responsabilidad Social Empresarial puede considerarse, por lo tanto, un lineamiento de carácter ético que le permitirá a la organización actuar de la mejor manera posible frente a los diferentes aspectos de su entorno, tanto a nivel interno como externo, permitiéndole mejorar su imagen corporativa, el nivel de compromiso de sus colaboradores y su capacidad para posicionarse en el mercado y garantizar su crecimiento económico.The objective of the work presented below is to propose the preparation of a Corporate Social Responsibility Plan for the Triple A distributor, considering the current situation of the organization and the need for it to have the planning tools necessary for the correct addressing of its personnel towards the fulfillment of corporate objectives. The importance of the proposed Social Responsibility Plan lies in the need to establish the mission, vision and corporate values that will identify the organization vis-à-vis its different interest groups and that will guide the actions of employees and directives with respect to the interests of the business. It also includes the establishment of a code of Conduct that will serve as a reference framework for how to act in relation to different situations. Equally the identification, description and evaluation of the stakeholders that have a relationship with the organization, supported by management tools such as the Relationship Matrix (influence vs. impact), to finally propose the most appropriate CSR management model for the organization. The Corporate Social Responsibility Plan can be considered, therefore, a guideline of ethical character that will allow the organization to act in the best possible way in front of the different aspects of its environment, both internally and externally, allowing it to improve its image company, the level of commitment of its employees and its ability to position itself in the market and guarantee its economic growth

Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases

Multiple factors have been shown to alter intestinal microbial diversity. It remains to be seen, however, how multiple collective pressures impact the activity in the gut environment and which, if any, is positioned as a dominant driving factor determining the final metabolic outcomes. Here, we describe the results of a metabolome-wide scan of gut microbiota in 18 subjects with systemic lupus erythematosus (SLE) and 17 healthy control subjects and demonstrate a statistically significant difference (p < 0.05) between the two groups. Healthy controls could be categorized (p < 0.05) based on their body mass index (BMI), whereas individuals with SLE could not. We discuss the prevalence of SLE compared with BMI as the dominant factor that regulates gastrointestinal microbial metabolism and provide plausible explanatory causes. Our results uncover novel perspectives with clinical relevance for human biology. In particular, we rank the importance of various pathophysiologies for gut homeostasis.The present investigation was funded by the Spanish Ministry of Economy and Competitiveness and the Federal Ministry of Education and Research (BMBF) within the ERA NET PathoGenoMics2 program, grant number 0315441A. This work was further funded by grants BFU2008-04501-E, BFU2008-04398-E, SAF2009-13032-C02-01, SAF2012-31187 and CSD2007-00005, BIO2011-25012, AGL2010-14952 and AGL2006-11697/ALI from the Spanish Ministry of Economy and Competitiveness, and Prometeo/2009/092 from Generalitat Valenciana (Spain). The authors gratefully acknowledge the financial support provided by the European Regional Development Fund (ERDF)

The "case concerning the application of the convention on the prevention and punishment of the crime of genocide (Bosnia and eHrzegovina v. Serbia and Montenegro)" released on february 26, 2007. Genocide and state responsibility

El fallo de la Corte Internacional de Justicia sobre la “Aplicación de la Convención para la Prevención y la Sanción del Delito de Genocidio (Bosnia y Herzegovina v. Serbia y Montenegro)” representa un hito en el ámbito internacional, por cuanto contiene el primer análisis que realiza ese cuerpo colegiado sobre la responsabilidad internacional de un Estado por el “delito” de Genocidio. Además, da luces sobre derechos y obligaciones que trascienden la teoría clásica de las relaciones interestatales, para adentrarse en la teoría de las obligaciones de medio como la de prevención del Genocidio. Sólo un estudio contextualizado del fallo revela lo reprochable de acudir a conceptos como “control total” para descartar la configuración del crimen en oportunidades en las cuales, acudiendo a los elementos del genocidio previamente delineados por la doctrina y jurisprudencia internacionales, fue innegablemente perpetrado. No obstante, no podemos desconocer el acierto de Corte al darle una mayor alcance a las obligaciones derivadas de la Convención contra el Genocidio, puesto que admite como sujeto activo no sólo al individuo sino también al Estado. Por eso, aunque la sala se quedó corta, el fallo es un asomo de innovación que probablemente conducirá, cuando el estado del arte lo permita, a fallos más justos.The ruling of the International Court of Justice on the “Case concerning the application of the Convention on the Prevention and Punishment of the Crime of Genocide (Bosnia and Herzegovina v. Serbia and Montenegro)” is crucial in the international arena, inasmuch as it contains the first jurisdictional analysis on the international responsibility of a State of the crime of Genocide. In addition, it sheds lights on the issue of the rights and obligations that result from the Convention against Genocide, and that of obligations of means like the prevention of Genocide. Only a contextualized study of the ruling reveals the Court’s peculiar use of concepts: this Tribunal resorts to concepts like “total control” to discard the configuration of the crime in opportunities in which, according to the elements of the genocide previously delineated by the international doctrine and jurisprudence, was undeniably perpetrated. However, we cannot ignore that the Court has advanced in extending the reach to the obligations derived from the Convention against Genocide. Therefore, though much is still to be done, the ruling is a hint of innovation that will probably lead, when the state-of-the-art allows it, to something closer to justice

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

Thrombosis is a common, life-threatening consequence of systemic infection; however, the underlying mechanisms that drive the formation of infection-associated thrombi are poorly understood. Here, using a mouse model of systemic Salmonella Typhimurium infection, we determined that inflammation in tissues triggers thrombosis within vessels via ligation of C-type lectin-like receptor-2 (CLEC-2) on platelets by podoplanin exposed to the vasculature following breaching of the vessel wall. During infection, mice developed thrombi that persisted for weeks within the liver. Bacteria triggered but did not maintain this process, as thrombosis peaked at times when bacteremia was absent and bacteria in tissues were reduced by more than 90% from their peak levels. Thrombus development was triggered by an innate, TLR4-dependent inflammatory cascade that was independent of classical glycoprotein VI-mediated (GPVI-mediated) platelet activation. After infection, IFN-ã release enhanced the number of podoplanin-expressing monocytes and Kupffer cells in the hepatic parenchyma and perivascular sites and absence of TLR4, IFN-ã, or depletion of monocytic-lineage cells or CLEC-2 on platelets markedly inhibited the process. Together, our data indicate that infection-driven thrombosis follows local inflammation and upregulation of podoplanin and platelet activation. The identification of this pathway offers potential therapeutic opportunities to control the devastating consequences of infection-driven thrombosis without increasing the risk of bleeding

Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes: data from a nationwide multicenter survey in Brazil

Background: To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D).Methods: This multicenter study was conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. Data were obtained from 3,591 patients (56.0% female, 57.1% Caucasian). Insulin regimens were classified as follows: group 1, conventional therapy (CT) (intermediate human insulin, one to two injections daily); group 2 (three or more insulin injections of intermediate plus regular human insulin); group 3 (three or more insulin injections of intermediate human insulin plus short-acting insulin analogues); group 4, basal-bolus (one or two insulin injections of long-acting plus short-acting insulin analogues or regular insulin); and group 5, basal-bolus with continuous subcutaneous insulin infusion (CSII). Groups 2 to 5 were considered IT groups.Results: We obtained complete data from 2,961 patients. Combined intermediate plus regular human insulin was the most used therapeutic regimen. CSII was used by 37 (1.2%) patients and IT by 2,669 (90.2%) patients. More patients on IT performed self-monitoring of blood glucose and were treated at the tertiary care level compared to CT patients (p < 0.001). the majority of patients from all groups had HbA1c levels above the target. Overweight or obesity was not associated with insulin regimen. Logistic regression analysis showed that economic status, age, ethnicity, and level of care were associated with IT (p < 0.001).Conclusions: Given the prevalence of intensive treatment for T1D in Brazil, more effective therapeutic strategies are needed for long term-health benefits.Farmanguinhos/Fundacao Oswaldo Cruz/National Health MinistryBrazilian Diabetes SocietyFundacao do Amparo a Pesquisa do Estado do Rio de JaneiroConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estado Rio de Janeiro, Unit Diabet, BR-20551030 Rio de Janeiro, BrazilBaurus Diabet Assoc, São Paulo, BrazilFed Univ São Paulo State, Diabet Unit, São Paulo, BrazilFed Univ Hosp Porto Alegre, Porto Alegre, BrazilUniv Hosp São Paulo, Diabet Unit, São Paulo, BrazilUniv Fed Rio de Janeiro, Rio de Janeiro, BrazilUniv Fed Ceara, Fortaleza, Ceara, BrazilSanta Casa Misericordia, Belo Horizonte, MG, BrazilSanta Casa Misericordia São Paulo, São Paulo, BrazilUniv Fed Amazonas, Manaus, Amazonas, BrazilHosp Geral de Bonsucesso, Rio de Janeiro, BrazilHosp Univ Clementino Fraga Filho IPPMG, Rio de Janeiro, BrazilUniv Hosp São Paulo, São Paulo, BrazilFac Ciencias Med Santa Casa São Paulo, São Paulo, BrazilUniv São Paulo, Inst Crianca, Hosp Clin, São Paulo, BrazilUniv São Paulo, Fac Med Ribeirao Preto, Hosp Clin, Ribeirao Preto, BrazilAmbulatorio Fac Estadual Med Sao Jose Rio Preto, Ribeirao Preto, BrazilEscola Paulista Med, Ctr Diabet, Ribeirao Preto, BrazilClin Endocrinol Santa Casa Belo Horizonte, Belo Horizonte, MG, BrazilUniv Estadual Londrina, Londrina, BrazilUniv Fed Parana, Hosp Clin, Porto Alegre, RS, BrazilInst Crianca Com Diabet Rio Grande Sul, Rio Grande Do Sul, RS, BrazilGrp Hosp Conceicao, Inst Crianca Com Diabet, Porto Alegre, RS, BrazilHosp Univ Santa Catarina, Florianopolis, SC, BrazilInst Diabet Endocrinol Joinville, Joinville, BrazilHosp Reg Taguatinga, Brasilia, DF, BrazilHosp Geral Goiania, Goiania, Go, BrazilCtr Diabet & Endocrinol Estado Bahia, Goiania, Go, BrazilUniv Fed Maranhao, Sao Luis, BrazilCtr Integrado Diabet & Hipertensao Ceara, Fortaleza, Ceara, BrazilUniv Fed Sergipe, Aracaju, BrazilHosp Univ Alcides Carneiro, Campina Grande, BrazilHosp Univ Joao de Barros Barreto, Belem, Para, BrazilFed Univ São Paulo State, Diabet Unit, São Paulo, BrazilUniv Hosp São Paulo, Diabet Unit, São Paulo, BrazilUniv Hosp São Paulo, São Paulo, BrazilEscola Paulista Med, Ctr Diabet, Ribeirao Preto, BrazilWeb of Scienc

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities