The Influence of Northern Hemisphere Teleconnections on the Geography of Pacific Tropical Cyclone Genesis

The research in this thesis used statistical and spatial analysis methods to test the influence of six Northern Hemisphere teleconnection patterns on the latitude and longitude components of tropical cyclogenesis occurring in the eastern and western North Pacific Ocean basins for the period 1979-2016. The Pacific-North American (PNA), West Pacific (WP), El Niño Southern Oscillation (ENSO), Pacific Decadal Oscillation (PDO), Madden-Julian Oscillation (MJO), and Quasi-Biennial Oscillation (QBO) teleconnection patterns were examined independently and in combination for association with variations in cyclogenesis geography. Four of the six teleconnection patterns were found to exert an influence on cyclogenesis latitude and/or longitude in their respective areas of dominance during independent testing; the PNA and WP patterns were not found to be significant explanatory variables for cyclogenesis latitude or longitude. Overall, the teleconnection patterns explained a greater portion of the variance in cyclogenesis latitude than longitude for both the eastern and western North Pacific basins. Patterns of cyclogenesis cluster shifting in positive, neutral, and negative phases of each teleconnection were identified for the study area using kernel density analysis. Furthermore, the teleconnection combination analysis was used to test the influence of multiple teleconnection patterns on the geography of tropical cyclones in positive and negative phases. Although the analysis provided statistically significant results, the combination analysis was inefficient at explaining variance in cyclogenesis geography

A Randomized Controlled Multicenter US Food and Drug Administration Trial of the Safety and Efficacy of the Minerva Endometrial Ablation System: One-Year Follow-Up Results

AbstractStudy ObjectiveTo assess the safety and effectiveness of the Minerva Endometrial Ablation System for the treatment of heavy menstrual bleeding in premenopausal women.DesignMulticenter, randomized, controlled, international study (Canadian Task Force classification I).SettingThirteen academic and private medical centers.PatientsPremenopausal women (n = 153) suffering from heavy menstrual bleeding (PALM-COEIN: E, O).InterventionPatients were treated using the Minerva Endometrial Ablation System or rollerball ablation.Measurements and Main ResultsAt 1-year post-treatment, study success (alkaline hematin ≤80 mL) was observed in 93.1% of Minerva subjects and 80.4% of rollerball subjects with amenorrhea reported by 71.6% and 49% of subjects, respectively. The mean procedure times were 3.1 minutes for Minerva and 17.2 minutes for rollerball. There were no intraoperative adverse events and/or complications reported.ConclusionThe results of this multicenter randomized controlled trial demonstrate that at the 12-month follow-up, the Minerva procedure produces statistically significantly higher rates of success, amenorrhea, and patient satisfaction as well as a shorter procedure time when compared with the historic criterion standard of rollerball ablation. Safety results were excellent and similar for both procedures