6 research outputs found
Trisomy 9 syndrome in a neonate with unusual features
- Publication venue
- The Egyptian Society of Human Genetics
- Publication date
- 13/11/2009
- Field of study
Aim of the Work: To report a newborn infant with multiple congenital anomalies and apparent complete trisomy 9 in the blood. Review will be included.Methods: Clinical examination, TORCH screening, echocardiography, skeletal survey, ultrasound head and abdomen were done. In addition chromosomal analysis of a peripheral blood sample using GTG, CBG banding and FISH techniques were employed.Results: Multiple congenital anomalies including craniofacial features, centralnervous, cardiovascular, skeletal, gastric and urogenital systems becauseof chromosomal abnormality which indicated: 47, XY, inv (9) (p12;q13) + inv(9) (p12;q13) mat. Conclusion: Our case could be a new case of apparently complete trisomy 9syndrome with unusual findings.Key Words: Trisomy 9, congenital anomalies, karyotype, FIS
Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abady GG
- Abbasi-Kangevari M
- Abbasifard M
- Abd-Allah F
- Abedi V
- Abu-Rmeileh NM
- Abualhasan A
- Abushouk A
- Adebayo OM
- Agarwal G
- Agasthi P
- Ahinkorah BO
- Ahmad S
- Ahmadi S
- Aji B
- Akbarpour S
- Akinyemi RO
- Al Hamad H
- Al Montasir A
- Al-Raddadi RM
- Alahdab F
- Alif SM
- Alipour V
- Aljunid SM
- Almustanyir S
- Alvis-Guzman N
- Ancuceanu R
- Anderlini D
- Anderson JA
- Ansar A
- Antonazzo IC
- Arabloo J
- Arnlov J
- Artanti KD
- Aryan Z
- Asgari S
- Ashraf T
- Athar M
- Atreya A
- Ausloos M
- Bach XT
- Baig AA
- Baltatu OC
- Banach M
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barone MTU
- Basu S
- Bazmandegan G
- Beghi E
- Beheshti M
- Bejot Y
- Bell AW
- Bennett DA
- Bensenor IM
- Bezabhe WM
- Bezabih YM
- Bhagavathula AS
- Bhardwaj P
- Bhattacharyya K
- Bijani A
- Bikbov B
- Bin Zaman S
- Birhanu MM
- Bisignano C
- Boloor A
- Bonny A
- Brauer M
- Brenner H
- Bryazka D
- Butt ZA
- Campos-Nonato IR
- Cantu-Brito C
- Carrero JJ
- Castaneda-Orjuela CA
- Catapano AL
- Chakraborty PA
- Charan J
- Choudhari SG
- Chowdhury EK
- Chu D-T
- Chung S-C
- Colozza D
- Costa VM
- Costanzo S
- Criqui MH
- D'Amico E
- Dadras O
- Dagnew B
- Dai X
- Dalal K
- Damasceno AAM
- Dandona L
- Dandona R
- Davletov K
- De La Cruz-Gongora V
- Desai R
- Dhamnetiya D
- Dharmaratne SD
- Dhimal M
- Dhimal ML
- Diaz D
- Dichgans M
- Dokova K
- dos Santos FLC
- Doshi R
- Douiri A
- Duncan BB
- Eftekharzadeh S
- Ekholuenetale M
- El Nahas N
- El-Jaafary S
- Elgendy IY
- Elhadi M
- Endres M
- Endries AY
- Erku DA
- Faraon EJA
- Farooque U
- Farzadfar F
- Feigin VL
- Feroze AH
- Filip I
- Fischer F
- Flood D
- Gad MM
- Gaidhane S
- Gela JD
- Ghashghaee A
- Gheshlagh RG
- Ghith N
- Ghozali G
- Ghozy S
- Gialluisi A
- Giampaoli S
- Giang TV
- Gilani SA
- Gill PS
- Gnedovskaya E
- Golechha M
- Goulart AC
- Guo Y
- Gupta R
- Gupta VB
- Gupta VK
- Gyanwali P
- Hafezi-Nejad N
- Hamidi S
- Hanif A
- Hankey GJ
- Hanson SW
- Hargono A
- Hashi A
- Hassan TS
- Hassen HY
- Havmoeller RJ
- Hay S
- Hayat K
- Hegazy M
- Herteliu C
- Holla R
- Hostiuc S
- Househ M
- Huang J
- Humayun A
- Hwang B-F
- Iacoviello L
- Iavicoli I
- Ibitoye SE
- Ilesanmi OS
- Ilic IM
- Ilic MD
- Iqbal U
- Irvani SSN
- Islam SMS
- Ismail NE
- Iso H
- Isola G
- Iwagami M
- Jabbari SHY
- Jacob L
- Jain V
- Jang S-I
- Jayapal SK
- Jayaram S
- Jayawardena R
- Jeemon P
- Jha RP
- Johnson CO
- Johnson WD
- Jonas JB
- Jonasson JM
- Joseph N
- Jozwiak JJ
- Jurisson M
- Kalani R
- Kalhor R
- Kalkonde Y
- Kamath A
- Kamiab Z
- Kan FP
- Kanchan T
- Kandel H
- Kandel SN
- Karch A
- Katoto PDMC
- Kayode GA
- Keshavarz P
- Khader YS
- Khan EA
- Khan IA
- Khan M
- Khan MAB
- Khatib MN
- Khubchandani J
- Kim GR
- Kim MS
- Kim YJ
- Kisa A
- Kisa S
- Kivimaki M
- Kolte D
- Koolivand A
- Koyanagi A
- Krishan K
- Krishnamoorthy V
- Krishnamurthi R
- Kumar GA
- Kusuma D
- La Vecchia C
- Lacey B
- Lak HM
- Lallukka T
- Lasrado S
- Lavados PM
- Laxminarayana SLK
- Leonardi M
- Li B
- Li S
- Lin H
- Lin R-T
- Linh GV
- Liu X
- Lo WD
- Lorkowski S
- Lucchetti G
- Magnani FG
- Mahajan PB
- Majeed A
- Makki A
- Malekzadeh R
- Malik AA
- Manafi N
- Mansournia MA
- Mantovani LG
- Martini S
- Mazzaglia G
- Mehndiratta MM
- Menezes RG
- Meretoja A
- Mersha AG
- Miazgowski B
- Miazgowski T
- Michalek IM
- Mirrakhimov EM
- Moghaddam SS
- Mohammad Y
- Mohammadian-Hafshejani A
- Mohammed S
- Mokdad AH
- Mokhayeri Y
- Molokhia M
- Moni MA
- Moradzadeh R
- Morawska L
- Morze J
- Murray CJL
- Muruet W
- Musa KI
- Nagarajan AJ
- Naghavi M
- Nascimento BR
- Negoi RI
- Norrving B
- Noubiap JJ
- Nwatah VE
- Oancea B
- Odukoya OO
- Olagunju AT
- Orru H
- Owolabi MO
- Padubidri JR
- Pana A
- Parekh T
- Park E-C
- Pathak M
- Peres MFP
- Perianayagam A
- Piradov MA
- Podder V
- Polinder S
- Postma MJ
- Pourshams A
- Radfar A
- Rafiei A
- Raggi A
- Rahim F
- Rahimi-Movaghar V
- Rahman M
- Rahman MA
- Rahmani AM
- Rajai N
- Ranasinghe P
- Rao CR
- Rao SJ
- Rathi P
- Rawaf DL
- Rawaf S
- Razek HMAE
- Reitsma MB
- Renjith V
- Renzaho AMN
- Rezapour A
- Rodriguez JAB
- Roever L
- Romoli M
- Roth GA
- Rynkiewicz A
- Sacco S
- Sadeghi M
- Sahebkar A
- Saif-Ur-Rahman K
- Salah R
- Salih YA
- Salman RA-S
- Samaei M
- Samy AM
- Santos IS
- Santric-Milicevic MM
- Sarrafzadegan N
- Sathian B
- Sattin D
- Saute RL
- Schiavolin S
- Schlaich MP
- Schmidt MI
- Schutte AE
- Sepanlou SG
- Seylani A
- Sha F
- Shahabi S
- Shaikh MA
- Shannawaz M
- Shawon MSR
- Sheikh A
- Sheikhbahaei S
- Shibuya K
- Siabani S
- Silva DAS
- Singh JA
- Singh JK
- Skryabin VY
- Skryabina AA
- Sobaih BH
- Stark BA
- Stortecky S
- Stranges S
- Swamy SN
- Tadesse EG
- Tahbaz SV
- Tarigan IU
- Temsah M-H
- Teuschl Y
- Thrift AG
- Tonelli M
- Tovani-Palone MR
- Trang HN
- Tripathi M
- Truong-Minh P
- Tsegaye GW
- Ullah A
- Unim B
- Unnikrishnan B
- Vakilian A
- Vasankari TJ
- Venketasubramanian N
- Vervoort D
- Vo B
- Volovici V
- Vosoughi K
- Wafa HA
- Waheed Y
- Wang Y
- Wijeratne T
- Winkler AS
- Wolfe CDA
- Woodward M
- Wu JH
- Xu X
- Yadav L
- Yadollahpour A
- Yamagishi K
- Yatsuya H
- Yonemoto N
- Yu C
- Yunusa I
- Zaman MS
- Zamanian M
- Zand R
- Zandifar A
- Zastrozhin MS
- Zastrozhina A
- Zhang Y
- Zhang Z-J
- Zhong C
- Zuniga YMH
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/10/2021
- Field of study
Background:
Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels.
Methods:
We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level.
Findings:
In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]).
Interpretation:
The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
Funding:
Bill & Melinda Gates Foundation
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
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- Angus C
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- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
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- Skou ST
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- Stein DJ
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- Straif K
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- Sudaryanto A
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- Sultan I
- Swope CB
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- Tabb KM
- Tabuchi T
- Tadakamadla SK
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- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
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- Umeokonkwo CD
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- Unnikrishnan B
- Upadhyay E
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- Valdez PR
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- Vasankari TJ
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- Veisani Y
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- Venketasubramanian N
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- Whiteford HA
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- Wickramasinghe ND
- Wiens KE
- Wijeratne T
- Wilner LB
- Wilson S
- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
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- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 17/10/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3·5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
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- Adelson JD
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- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
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- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
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- Dichgans M
- Didarloo A
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- Publication venue
- Publication date
- 01/01/2020
- Field of study