Una experiencia de formación colaborativa y práctica real entre la universidad y un centro educativo generando un espacio CSCL

Esta experiencia refleja la respuesta que le hemos dado en la necesidad de contextualizar los procesos de enseñanza en la formación de maestros y la fundamental coordinación de los trabajos que se realizan en la universidad para llevar a cabo nuestra labor. La unión de dos asignaturas troncales en el plan de estudios de magisterio (Didáctica General y Nuevas Tecnologías aplicadas a la Educación), junto con la participación de un Centro Escolar (C.P. Vicente Aleixandre de Valladolid), ha posibilitado la interconexión de contenidos teóricos de ambas asignaturas y la perspectiva práctica que aporta el Colegio. Todo ello tomando como eje un entorno colaborativo de trabajo en red, Basic Support for Cooperative Work (BSCW) que nos ha permitido generar una dinámica de formación CSCL (Computer Support for Colaborative Learnin). En este trabajo se incluye una descripción del proyecto con su intrincado cúmulo de relaciones e interconexiones, así como la valoración del primer año de trabajo.This experience shows the answer that we give to the need of relating theory and practice in maestriʹs formation. The union of two main subjects of study in the curriculum (Didáctica General y Nuevas Tecnologías aplicadas a la Educación) , along with the participation of an school (C.P. Vicente Aleixandre) , has made the interconnection of theoretic contentses of both subjects of study and the practical perspective that the School contributes . All of it taking like axle a collaborative surroundings of net work, Basic Support for Cooperative Work (BSCW), that has permitted us generating a dynamics of formation (Computer Supported Collaborative Learning). In this work a description of project with his intricate relational accumulation and interface are included, as well as the evaluation of first year of workEsta experiência reflete a resposta que nós temos dado à necessidade de contextualizar os processos de ensino na formação de professores e a fundamental coordenação dos trabalhos que realizam‐se na universidade para levar a cabo nosso labor. A união de duas disciplinas troncais no plano de estudos de Magistério (Didática Geral e Novas Tecnologías aplicadas à Educação) junto com a participação de um Centro Escolar (C. P. Vicente Aleixandre de Valladolid), tem possibilitado a interconexão dos conteúdos teóricos de ambas disciplinas e a perspectiva prática que aporta o Colégio. Tudo isto tomando como eixo um meio colaborativo de trabalho em rede, Basic Support for Cooperativ Work (BSCW) que permitiu‐nos gerar uma dinâmica de formação CSCL (Computer Support for Colaborative Learning). Neste trabalho se inclui uma descrição do projeto com seu enredado conjunto de relações e interconexões, bem como a valoração do primeiro ano de trabalho

Orquestando Comunidades, Ubicuidades, Tiempos y Espacios: Experiencias Internacionales en el Uso de Tecnología Educativa

In this brief introduction we frame the special issue on “Orchestrating communities, ubicuity, time and space: International experiences in the use of educational technology.“ It constitutes the result of the “International experiences in the use of Educational Technology” panel session celebrated within the XXI University Conference on Educational Technology (XXI Jornadas Universitarias de Tecnología Educativa) (JUTE) in Valladolid, Spain in 2013. Every article has gone through a double-blind peer review process with the aim of ensuring not only the quality of the issue but also the adaptation of the initial presentations given in the aforementioned panel session to the rules of scientific publications. This issue brings together five of the works presented in the panel to address a number of relevant challenges in the field of Educational Technology. The topics accomplished by the articles spin around the (mis-)uses of technology in the national accreditation process of teachers in the United States; the tensions derived from the use, re-use and sharing of Open Educational Resources (OER´s) in Europe; an interpretive proposal to orchestrate the evaluation of complex technology-enhanced learning settings, and finally; a experience in the collective generation of documentaries at the Galiano Islands (Canada).En esta breve introducción enmarcamos el número especial titulado “Orquestando comunidades, ubicuidades, tiempos y espacio:experiencias internacionales en el uso de tecnología educativa.” Constituye el resultado de la mesa de comunicaciones titulada “International experiences in the use of Educational Technology”, que se celebró en junio de 2013, dentro de las XXI Jornadas Universitarias de Tecnología Educativa (JUTE), en Valladolid, España. Cada artículo se ha sometido a un proceso de revisión doble ciego no solo con la intención de garantizar la calidad de este número, sino con la de velar por la adaptación de las presentaciones realizadas en las JUTE a las características de los artículos científicos. Este número especial aglutina cinco de los trabajos presentados en la mencionada mesa, con la intención de abordar algunos de los retos a los que se enfrenta actualmente el campo de la Tecnología Educativa. Los temas planteados van desde los (ab)usos de la tecnología dentro del proceso de acreditación de maestros en USA y las tensiones derivadas de la utilización de recursos educativos abiertos en europa, hasta una propuesta interpretativa para favorecer la orquestación de la evaluación de escenarios educativos complejos mediados por TIC, pasando por una experiencia creativa de elaboración colectiva de documentales en las Islas Galiano (Canadá)

Influence of different cooling techniques on the surface roughness in milling operations of carbon steels

Comunicació presentada al 22rd International Congress on Project Management and Engineering CIDIP 2018 (Madrid, 11-13 July 2018)In machining processes the use of coolants and lubricants in the cutting zone is critical to reduce cutting forces, facilitate the chip removal and improve the surface quality of the workpiece. However, the influence of different coolant/lubricant techniques on the surface finish depends on many factors, such as the geometry of the cutting tool, material of the workpiece, cutting conditions, and so on. This paper studies the effect of different lubrication techniques such as: internal coolant, external coolant, dry cutting, air coolant and MQL lubrication (Minimum Quantity Lubrication) on the surface finish and the advantages and disadvantages of these systems for milling carbon steels. The study fundamentally analyzes the variations in roughness due to the built-up edge (BUE) and the minimum chip thickness in relation to the type of lubrication / cooling used.En los procesos de mecanizado la refrigeración / lubricación de la zona de corte es fundamental para conseguir menores fuerzas de corte, facilitar el arranque de viruta y mejorar la calidad superficial de la pieza. Sin embargo, la influencia de las diferentes técnicas en el acabado superficial depende de muchos factores, como la geometría de la herramienta de corte, material de la pieza de trabajo, condiciones de corte, etc. En esta comunicación se estudia el efecto de diferentes técnicas de lubricación como: lubricación interna, externa, en seco, con aire y con MQL (Minimum Quantity Lubrication) sobre el acabado superficial y se presentan las ventajas e inconvenientes de estos sistemas para el fresado de aceros al carbono. El estudio analiza fundamentalmente las variaciones de rugosidad debidas al efecto de filo recrecido (Built-up Edge, BUE) y del espesor mínimo de viruta en relación con el tipo de lubricación / refrigeración emplead

A high-throughput screening identifies microRNA inhibitors that influence neuronal maintenance and/or response to oxidative stress

Oxidative stress; Small RNA sequencing; NeurodegenerationEstrés oxidativo; Secuenciación de ARN pequeño; NeurodegeneraciónEstrès oxidatiu; Seqüenciació d'ARN petit; NeurodegeneracióSmall non-coding RNAs (sncRNAs), including microRNAs (miRNAs) are important post-transcriptional gene expression regulators relevant in physiological and pathological processes. Here, we combined a high-throughput functional screening (HTFS) platform with a library of antisense oligonucleotides (ASOs) to systematically identify sncRNAs that affect neuronal cell survival in basal conditions and in response to oxidative stress (OS), a major hallmark in neurodegenerative diseases. We considered hits commonly detected by two statistical methods in three biological replicates. Forty-seven ASOs targeting miRNAs (miRNA-ASOs) consistently decreased cell viability under basal conditions. A total of 60 miRNA-ASOs worsened cell viability impairment mediated by OS, with 36.6% commonly affecting cell viability under basal conditions. In addition, 40 miRNA-ASOs significantly protected neuronal cells from OS. In agreement with cell viability impairment, damaging miRNA-ASOs specifically induced increased free radical biogenesis. miRNAs targeted by the detrimental ASOs are enriched in the fraction of miRNAs downregulated by OS, suggesting that the miRNA expression pattern after OS contributes to neuronal damage. The present HTFS highlighted potentially druggable sncRNAs. However, future studies are needed to define the pathways by which the identified ASOs regulate cell survival and OS response and to explore the potential of translating the current findings into clinical applications.This work was supported by the Spanish Ministry of Economy and Competitiveness and FEDER funds (SAF2014-60551-R and SAF2017-88452-R). We acknowledge the support of the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership and the Centro de Excelencia Severo Ochoa 2013-2017 (SEV-2012-0208). We acknowledge the support of the Spanish Ministry of Science Innovation and Universities, Maria Maeztu Unit of Excellence Programme. We thank the staff of the Genomics Unit for the preparation of sRNA libraries and sequencing and the staff of the Biomolecular Screening and Protein Technologies Unit for their help in the setting up the high-throughput screening

Spatial Analysis of the Relationship between Mortality from Cardiovascular and Cerebrovascular Disease and Drinking Water Hardness

Previously published scientific papers have reported a negative correlation between drinking water hardness and cardiovascular mortality. Some ecologic and case–control studies suggest the protective effect of calcium and magnesium concentration in drinking water. In this article we present an analysis of this protective relationship in 538 municipalities of Comunidad Valenciana (Spain) from 1991–1998. We used the Spanish version of the Rapid Inquiry Facility (RIF) developed under the European Environment and Health Information System (EUROHEIS) research project. The strategy of analysis used in our study conforms to the exploratory nature of the RIF that is used as a tool to obtain quick and flexible insight into epidemiologic surveillance problems. This article describes the use of the RIF to explore possible associations between disease indicators and environmental factors. We used exposure analysis to assess the effect of both protective factors—calcium and magnesium—on mortality from cerebrovascular (ICD-9 430–438) and ischemic heart (ICD-9 410–414) diseases. This study provides statistical evidence of the relationship between mortality from cardiovascular diseases and hardness of drinking water. This relationship is stronger in cerebrovascular disease than in ischemic heart disease, is more pronounced for women than for men, and is more apparent with magnesium than with calcium concentration levels. Nevertheless, the protective nature of these two factors is not clearly established. Our results suggest the possibility of protectiveness but cannot be claimed as conclusive. The weak effects of these covariates make it difficult to separate them from the influence of socioeconomic and environmental factors. We have also performed disease mapping of standardized mortality ratios to detect clusters of municipalities with high risk. Further standardization by levels of calcium and magnesium in drinking water shows changes in the maps when we remove the effect of these covariates

Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is required

The objective in this paper is to compare the cumulative incidence and incidence density of therapy-related acute myeloid leukaemia in two cohorts of patients with multiple sclerosis treated with mitoxantrone, and with previously reported data in the literature. Six new cases of acute myeloid leukaemia were observed by prospectively following two Spanish series of 142 and 88 patients with worsening relapsing multiple sclerosis and secondary-progressive disease treated with mitoxantrone. A literature review shows 32 further cases of acute myeloid leukaemia reported, 65.6% of which are therapy-related acute promyelocytic leukaemia. Five cases in the cohorts fulfilled the diagnostic criteria for acute promyelocytic leukaemia, and one patient was diagnosed with pre-B-acute lymphoblastic leukaemia. Acute myeloid leukaemia latency after mitoxantrone discontinuation was 1 to 45 months. The accumulated incidence and incidence density was 2.82% and 0.62%, respectively, in the Valencian cohort, and 2.27% and 0.44% in the Catalonian cohort. In the only seven previously reported series, the accumulated incidence varied from 0.15% to 0.80%. The real incidence of acute myeloid leukaemia after mitoxantrone therapy in the multiple sclerosis population could be higher as evidenced by the growing number of cases reported. Haematological monitoring should continue for at least 5 years after the last dose of mitoxantrone. These data stress the necessity of re-evaluating this ris

A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men

Background Genetic polymorphisms in the RAS gene family are associated with different diseases, which may include alcohol-related disorders. Previous studies showed an association of the allelic variant rs26907 in RASGRF2 gene with higher alcohol intake. Additionally, the rs61764370 polymorphism in the KRAS gene is located in a binding site for the let-7 micro-RNA family, which is potentially involved in alcohol-induced inflammation. Therefore, this study was designed to explore the association between these two polymorphisms and susceptibility to alcoholism or alcoholic liver disease (ALD). Methods We enrolled 301 male alcoholic patients and 156 healthy male volunteers in this study. Polymorphisms were genotyped by using TaqMan® PCR assays for allelic discrimination. Allelic and genotypic frequencies were compared between the two groups. Logistic regression analysis was performed to analyze the inheritance model. Results The A allele of the RASGRF2 polymorphism (rs26907) was significantly more prevalent among alcoholic patients with cirrhosis (23.2%) compared to alcoholic patients without ALD (14.2%). This difference remained significant in the group of patients with alcohol dependence (28.8% vs. 14.3%) but not in those with alcohol abuse (15.1% vs. 14.4%). Multivariable logistic regression analysis showed that the A allele of this polymorphism (AA or GA genotype) was associated with alcoholic cirrhosis both in the total group of alcoholics (odds ratio [OR]: 2.33, 95% confidence interval [CI]: 1.32–4.11; P = 0.002) and in the group of patients with alcohol dependence (OR: 3.1, 95% CI: 1.50–6.20; P = 0.001). Allelic distributions of the KRAS polymorphism (rs61764370) did not differ between the groups. Conclusions To our knowledge, this genetic association study represents the first to show an association of the RASGRF2 G>A (rs26907) polymorphism with ALD in men, particularly in the subgroup of patients with AD. The findings suggest the potential relevance of the RAS gene family in alcoholism and ALD

Minimal residual disease evaluation by flow cytometry is a complementary tool to cytogenetics for treatment decisions in acute myeloid leukaemia

For PETHEMA Programa para el Estudio de la Terapéutica en Hemopatías Malignas Cooperative Study Group.The clinical utility of minimal residual disease (MRD) analysis in acute myeloid leukaemia (AML) is not yet defined. We analysed the prognostic impact of MRD level at complete remision after induction therapy using multiparameter flow cytometry in 306 non-APL AML patients. First, we validated the prognostic value of MRD-thresholds we have previously proposed (≥0.1%; ≥0.01-0.1%; and <0.01), with a 5-year RFS of 38%, 50% and 71%, respectively (p = 0.002). Cytogenetics is the most relevant prognosis factor in AML, however intermediate risk cytogenetics represent a grey zone that require other biomarkers for risk stratification, and we show that MRD evaluation discriminate three prognostic subgroups (p = 0.03). Also, MRD assessments yielded relevant information on favourable and adverse cytogenetics, since patients with favourable cytogenetics and high MRD levels have poor prognosis and patients with adverse cytogenetics but undetectable MRD overcomes the adverse prognosis. Interestingly, in patients with intermediate or high MRD levels, intensification with transplant improved the outcome as compared with chemotherapy, while the type of intensification therapy did not influenced the outcome of patients with low MRD levels. Multivariate analysis revealed age, MRD and cytogenetics as independent variables. Moreover, a scoring system, easy in clinical practice, was generated based on MRD level and cytogenetics.This work was supported in part by Spanish grants from Fondo de Investigación Sanitaria-ISCIII (FIS 00/0023-03, PI12/02321), DGCYT (SAF 94- 0308, SAF2001-1687), Conserjería de Educación de Castilla y León (HUS416A12), and Red Temática de Investigación Cooperativa en Cáncer (RTICC-ISCIII) (RD12/0036/0069).Peer Reviewe

Defining the importance of landscape metrics for large branchiopod biodiversity and conservation: the case of the Iberian Peninsula and Balearic Islands

The deficiency in the distributional data of invertebrate taxa is one of the major impediments acting on the bias towards the low awareness of its conservation status. The present study sets a basic framework to understand the large branchiopods distribution in the Iberian Peninsula and Balearic Islands. Since the extensive surveys performed in the late 1980s, no more studies existed updating the information for the whole studied area. The present study fills the gap, gathering together all available information on large branchiopods distribution since 1995, and analysing the effect of human population density and several landscape characteristics on their distribution, taking into consideration different spatial scales (100 m, 1 km and 10 km). In overall, 28 large branchiopod taxa (17 anostracans, 7 notostracans and 4 spinicaudatans) are known to occur in the area. Approximately 30% of the sites hosted multiple species, with a maximum of 6 species. Significant positive co-occurring species pairs were found clustered together, forming 4 different associations of large branchiopod species. In general, species clustered in the same group showed similar responses to analysed landscape characteristics, usually showing a better fit at higher spatial scales.Brazilian Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq [401045/2014-5]Spanish Ministry of Education, Culture and Sport [FPU014/06783]info:eu-repo/semantics/publishedVersio