13 research outputs found
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Hip Arthroplasty after Previous Arthrodesis
Total hip arthroplasty after previous arthrodesis has been associated with increased complications and decreased survivorship of the prosthesis. We evaluated pain, function, and the factors influencing survivorship of total hip arthroplasties after previous arthrodesis between 1985 and 2000 and compared these results with those obtained in prior years with the same procedure and in the same institution. We retrospectively reviewed 30 patients who had previous spontaneous or surgical arthrodesis. The minimum followup was 2 years (mean, 10.4 years; range 2–20.5 years). Seven failures were identified (23%). The overall survival free of failure was 86% at 5 years and 75% at 10 years. At last followup, 27 of the 30 patients (91%) had no or slight pain, 26 (87%) had a limp, and 18 (61%) needed a gait aid. Surgical arthrodesis, age younger than 50 years at the time of arthroplasty, and length of arthrodesis less than 30 years independently predicted failure. Conversion of arthrodesis to hip arthroplasty reliably decreases pain and improves function, but many patients will limp and require a gait aid. Our outcomes were similar to those after revision rather than after primary hip arthroplasty
Superior isolation of antigen-specific brain infiltrating T cells using manual homogenization technique
A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling
The energetically optimal cadence decreases after prolonged cycling exercise
This study investigated the change in the energetically optimal cadence after prolonged cycling. The energetically optimal cadence (EOC) was determined in 14 experienced cyclists by pulmonary gas exchange at six different cadences (100-50 rpm at 10 rpm intervals). The determination of the EOC was repeated after a prolonged cycling exercise of 55 min duration, where cadence was fixed either at high (>95 rpm) or low (<55 rpm) pedalling rates. The EOC decreased after prolonged cycling exercise at a high as well as at a low fixed cadence (P < 0.01). According to the generalized muscle equations of Hill, this indicates that most likely more type I muscle fibres contribute to muscular power output after fatiguing cycling exercise compared to cycling in the beginning of an exercise bout. We suggest that the determination of EOC might be a potential non-invasive method to detect the qualitative changes in activated muscle fibres, which needs further investigation