Effect of multimorbidity on survival of patients diagnosed with heart failure: A retrospective cohort study in Singapore

10.1136/bmjopen-2017-021291BMJ Open85e021291

Comparing methods for mapping cis acting polymorphisms using allelic expression ratios

Genome wide association studies frequently reveal associations between disease susceptibility and polymorphisms outside coding regions. Such associations cannot always be explained by linkage disequilibrium with changes affecting the transcription products. This has stimulated the interest in characterising sequence variation influencing gene expression levels, in particular in changes acting in cis. Differences in transcription between the two alleles at an autosomal locus can be used to test the association between candidate polymorphisms and the modulation of gene expression in cis. This type of approach requires at least one transcribed polymorphism and one candidate polymorphism. In the past five years, different methods have been proposed to analyse such data. Here we use simulations and real data sets to compare the power of some of these methods. The results show that when it is not possible to determine the phase between the transcribed and potentially cis acting allele there is some advantage in using methods that estimate phased genotype and effect on expression simultaneously. However when the phase can be determined, simple regression models seem preferable because of their simplicity and flexibility. The simulations and the analysis of experimental data suggest that in the majority of situations, methods that assume a lognormal distribution of the allelic expression ratios are both robust to deviations from this assumption and more powerful than alternatives that do not make these assumptions

Measurement of the Ratio of Branching Fractions B (B ¯ 0 →d∗+τ- ν ¯ τ) / B (B ¯ 0 →d∗+μ- ν ¯ μ)

he branching fraction ratio R(D∗)≡B(B¯0→D∗+τ-ν¯τ)/B(B¯0→D∗+μ-ν¯μ) is measured using a sample of proton-proton collision data corresponding to 3.0fb-1 of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode τ-→μ-ν¯μντ. The semitauonic decay is sensitive to contributions from non-standard-model particles that preferentially couple to the third generation of fermions, in particular, Higgs-like charged scalars. A multidimensional fit to kinematic distributions of the candidate B¯0 decays gives R(D∗)=0.336±0.027(stat)±0.030(syst). This result, which is the first measurement of this quantity at a hadron collider, is 2.1 standard deviations larger than the value expected from lepton universality in the standard model

Observation of J /ψp Resonances Consistent with Pentaquark States in Λb0 →j /ψK-p Decays

Observations of exotic structures in the J/ψp channel, which we refer to as charmonium-pentaquark states, in Λb0→J/ψK-p decays are presented. The data sample corresponds to an integrated luminosity of 3fb-1 acquired with the LHCb detector from 7 and 8 TeV pp collisions. An amplitude analysis of the three-body final state reproduces the two-body mass and angular distributions. To obtain a satisfactory fit of the structures seen in the J/ψp mass spectrum, it is necessary to include two Breit-Wigner amplitudes that each describe a resonant state. The significance of each of these resonances is more than 9 standard deviations. One has a mass of 4380±8±29MeV and a width of 205±18±86MeV, while the second is narrower, with a mass of 4449.8±1.7±2.5MeV and a width of 39±5±19MeV. The preferred JP assignments are of opposite parity, with one state having spin 3/2 and the other 5/2

Measurement of matter–antimatter differences in beauty baryon decays

Differences in the behaviour of matter and antimatter have been observed in K and B meson decays, but not yet in any baryon decay. Such differences are associated with the non-invariance of fundamental interactions under the combined charge-conjugation and parity transformations, known as CP violation. Here, using data from the LHCb experiment at the Large Hadron Collider, we search for CP-violating asymmetries in the decay angle distributions of Lambda(0)(b) baryons decaying to p pi(-) pi(+) pi(-) and p pi(-) K+K- final states. These four-body hadronic decays are a promising place to search for sources of CP violation both within and beyond the standard model of particle physics. We find evidence for CP violation in Lambda(0)(b) to p pi(-) pi(+) pi(-) decays with a statistical significance corresponding to 3.3 standard deviations including systematic uncertainties. This represents the first evidence for CP violation in the baryon sector