Hydrographic Study of Peirce Island Wastewater Treatment Plant Effluent in the Piscataqua River of Portsmouth, New Hampshire: Report of Findings from the December 10 – 14, 2012 Study Period

In order to assist the New Hampshire Department of Environmental Services (NHDES) evaluate the impact of treated wastewater effluent from Peirce Island Wastewater Treatment Plant (WWTP) to the Lower Piscataqua River and Portsmouth Harbor a hydrographic dye study was conducted in December 2012 in Portsmouth, NH. Eight (8) shellfish cages with American oysters (Crassostrea virginica) and blue mussels (Mytilus edulis) were deployed both upstream and downstream of the Peirce Island WWTP in the Piscataqua River, Little Harbor, and the entrance of Little Bay. Eight (8) mini CTDs that monitor conductivity/salinity, temperature, and depth, and six (6) moored fluorometers, which measure dye tagged effluent from the Peirce Island WWTP were attached to the subsurface cages. A fifty (50) gallon mixture of Rhodamine WT dye and distilled water was injected into WWTP on December 11, 2012 for a half tidal cycle (approximately 12.4 hours). Additionally, boat tracking fluorometers connected with a mobile geographic information system (GIS) were used to measure dye levels on the surface in situ and in real time. Microbiological analyses of fecal coliform (FC), male-specific coliphage (MSC), Norovirus (NoV) genogroup I (GI) and genogroup II (GII), and Adenovirus (AdV) were conducted on WWTP influent and effluent composite samples collected with automated samplers to determine the WWTP efficiency in reducing indicator bacteria and viruses. Microbiological sampling and testing of oysters and mussels from the eight (8) sentinel cages was conducted to assess the impact of WWTP effluent on shellfish growing areas and growing area classifications. Prior to conducting the study, the assumption was that the FDA’s recommended minimum dilution of 1000:1was not applicable in this situation because the recommended dilution is based on a WWTP having at least secondary treatment. The microbiological findings in shellfish samples, wastewater samples from the Peirce Island WWTP, and the results of the dye study, confirm that a minimum of 1,000:1 dilution with respect to Peirce Island WWTP is currently not applicable for this WWTP. The FDA and NHDES recommend continued MSC testing of wastewater samples from the WWTP before and after the WWTP upgrade. The FDA and NHDES recommend a future field study after the WWTP upgrade in order to delineate the 1,000:1 dilution zone

Health related quality of life and psychological variables among a sample of asthmatics in Ile-Ife South-Western Nigeria

Background: Assessment of health related quality of life (HRQL) has become central to assessing the selfperceived impact of physical and mental impairment on patient’s health. Studies have reported a high rate of psychological disturbances among asthmatics; however, the impact of these psychological factors on HRQL remains unexplored. Objectives: To assess the health related quality of life among a sample of asthmatics and to identify the psychological and clinical variables that affect quality of life among asthmatics. Method: A total of 81 patients attending the clinic were assessed using the Mini-Asthma Quality of Life questionnaire (Mini-AQLQ), and the Hospital Anxiety and Depression Scale (HADS). Sociodemographic and clinical variables were also obtained from the patients, the lung function was assessed using Peak Expiratory Flow Rate (PEFR). Results: Mean age of all the patients was 35.22 (SD±14.36) with a mean duration of asthma symptoms of 17.5 (SD±14.4) years. Mean peak expiratory flow was 336 l/min (SD±74.12). Anxiety was present in 44.4% of respondents, while 40% of respondents reported the presence of depressive symptoms, 48.1% of the respondents reported low scores on the asthma quality of life questionnaire. Poor quality of life was associated with the presence of psychological symptoms, female sex, and lower educational level. Conclusion: Psychosocial variables are just as important as clinical variables as determinants of health related quality of life among asthmatics.Keywords: quality of life; asthma; anxiety; depression; psychosocia

Knowledge Distillation Under Ideal Joint Classifier Assumption

Knowledge distillation is a powerful technique to compress large neural networks into smaller, more efficient networks. Softmax regression representation learning is a popular approach that uses a pre-trained teacher network to guide the learning of a smaller student network. While several studies explored the effectiveness of softmax regression representation learning, the underlying mechanism that provides knowledge transfer is not well understood. This paper presents Ideal Joint Classifier Knowledge Distillation (IJCKD), a unified framework that provides a clear and comprehensive understanding of the existing knowledge distillation methods and a theoretical foundation for future research. Using mathematical techniques derived from a theory of domain adaptation, we provide a detailed analysis of the student network's error bound as a function of the teacher. Our framework enables efficient knowledge transfer between teacher and student networks and can be applied to various applications

Perturbations of moving membranes in AdS_7

We study the stability of uniformly moving membrane-like objects in seven dimensional Anti-de Sitter space. This is approached by a linear perturbation analysis and a search for growing modes. We examine both analytic and numerical configurations previously found in [1].Comment: 20 pages, 6 figure

The relation between 13CO(2-1) line width in molecular clouds and bolometric luminosity of associated IRAS sources

We search for evidence of a relation between properties of young stellar objects (YSOs) and their parent molecular clouds to understand the initial conditions of high-mass star formation. A sample of 135 sources was selected from the Infrared Astronomical Satellite (IRAS) Point Source Catalog, on the basis of their red color to enhance the possibility of discovering young sources. Using the Kolner Observatorium fur SubMillimeter Astronomie (KOSMA) 3-m telescope, a single-point survey in 13CO(2-1) was carried out for the entire sample, and 14 sources were mapped further. Archival mid-infrared (MIR) data were compared with the 13CO emissions to identify evolutionary stages of the sources. A 13CO observed sample was assembled to investigate the correlation between 13CO line width of the clouds and the luminosity of the associated YSOs. We identified 98 sources suitable for star formation analyses for which relevant parameters were calculated. We detected 18 cores from 14 mapped sources, which were identified with eight pre-UC HII regions and one UC HII region, two high-mass cores earlier than pre-UC HII phase, four possible star forming clusters, and three sourceless cores. By compiling a large (360 sources) 13CO observed sample, a good correlation was found between the 13CO line width of the clouds and the bolometric luminosity of the associated YSOs, which can be fitted as a power law: lg(dV13/km/s)=-0.023+0.135lg(Lbol/Lsolar). Results show that luminous (>10^3Lsolar) YSOs tend to be associated with both more massive and more turbulent (dV13>2km/s) molecular cloud structures.Comment: Accepted by Astronomy and Astrophysics; this version: sent to publisher; 13 pages, 4 figures, 2 tables, 1 online appendi

The Breakdown of Alfven's Theorem in Ideal Plasma Flows

This paper presents both rigorous results and physical theory on the breakdown of magnetic flux conservation for ideal plasmas, by nonlinear effects. Our analysis is based upon an effective equation for magnetohydrodynamic (MHD) modes at length-scales $>\ell,$ with smaller scales eliminated, as in renormalization-group methodology. We prove that flux-conservation can be violated for an arbitrarily small length-scale $\ell,$ and in the absence of any non-ideality, but only if singular current sheets and vortex sheets both exist and intersect in sets of large enough dimension. This result gives analytical support to and rigorous constraints on theories of fast turbulent reconnection. Mathematically, our theorem is analogous to Onsager's result on energy dissipation anomaly in hydrodynamic turbulence. As a physical phenomenon, the breakdown of magnetic-flux conservation in ideal MHD is similar to the decay of magnetic flux through a narrow superconducting ring, by phase-slip of quantized flux lines. The effect should be observable both in numerical MHD simulations and in laboratory plasma experiments at moderately high magnetic Reynolds numbers.Comment: 38 pages, 1 figur

The role of bone sialoprotein in the tendon-bone insertion

© 2016 International Society of Matrix Biology. Tendons/ligaments insert into bone via a transitional structure, the enthesis, which is susceptible to injury and difficult to repair. Fibrocartilaginous entheses contain fibrocartilage in their transitional zone, part of which is mineralized. Mineral-associated proteins within this zone have not been adequately characterized. Members of the Small Integrin Binding Ligand N-linked Glycoprotein (SIBLING) family are acidic phosphoproteins expressed in mineralized tissues. Here we show that two SIBLING proteins, bone sialoprotein (BSP) and osteopontin (OPN), are present in the mouse enthesis. Histological analyses indicate that the calcified zone of the quadriceps tendon enthesis is longer in Bsp-/- mice, however no difference is apparent in the supraspinatus tendon enthesis. In an analysis of mineral content within the calcified zone, micro-CT and Raman spectroscopy reveal that the mineral content in the calcified fibrocartilage of the quadriceps tendon enthesis are similar between wild type and Bsp-/- mice. Mechanical testing of the patellar tendon shows that while the tendons fail under similar loads, the Bsp-/- patellar tendon is 7.5% larger in cross sectional area than wild type tendons, resulting in a 16.5% reduction in failure stress. However, Picrosirius Red staining shows no difference in collagen organization. Data collected here indicate that BSP is present in the calcified fibrocartilage of murine entheses and suggest that BSP plays a regulatory role in this structure, influencing the growth of the calcified fibrocartilage in addition to the weakening of the tendon mechanical properties. Based on the phenotype of the Bsp-/- mouse enthesis, and the known in vitro functional properties of the protein, BSP may be a useful therapeutic molecule in the reattachment of tendons and ligaments to bone

A solution to the misrepresentations of CO2-equivalent emissions of short-lived climate pollutants under ambitious mitigation

While cumulative carbon dioxide (CO2) emissions dominate anthropogenic warming over centuries, temperatures over the coming decades are also strongly affected by short-lived climate pollutants (SLCPs), complicating the estimation of cumulative emission budgets for ambitious mitigation goals. Using conventional Global Warming Potentials (GWPs) to convert SLCPs to “CO2-equivalent” emissions misrepresents their impact on global temperature. Here we show that peak warming under a range of mitigation scenarios is determined by a linear combination of cumulative CO2 emissions to the time of peak warming and non-CO2 radiative forcing immediately prior to that time. This may be understood by expressing aggregate non-CO2 forcing as cumulative CO2 forcing-equivalent (CO2-fe) emissions. We show further that contributions to CO2-fe emissions are well approximated by a new usage of GWP, denoted GWP*, which relates cumulative CO2 emissions to date with the current rate of emission of SLCPs. GWP* accurately indicates the impact of emissions of both long-lived and short-lived pollutants on radiative forcing and temperatures over a wide range of timescales, including under ambitious mitigation when conventional GWPs fail. Measured by GWP*,implementing the Paris Agreement would reduce the expected rate of warming in 2030 by 28% relative to a No Policy scenario. Expressing mitigation efforts in terms of their impact on future cumulative emissions aggregated using GWP* would relate them directly to contributions to future warming, better informing both burden-sharing discussions and long-term policies and measures in pursuit of ambitious global temperature goals

Global Validation of the AO Spine Upper Cervical Injury Classification.

STUDY DESIGN Global Cross Sectional Survey. OBJECTIVE To determine the classification accuracy, interobserver reliability, and intraobserver reproducibility of the AO Spine Upper Cervical Injury Classification System based on an international group of AO Spine members. SUMMARY OF BACKGROUND DATA Previous upper cervical spine injury classifications have primarily been descriptive without incorporating a hierarchical injury progression within the classification system. Further, upper cervical spine injury classifications have focused on distinct anatomical segments within the upper cervical spine. The AO Spine Upper Cervical Injury Classification System incorporates all injuries of the upper cervical spine into a single classification system focused on a hierarchical progression from isolated bony injuries (type A) to fracture dislocations (type C). METHODS A total of 275 AO Spine members participated in a validation aimed at classifying 25 upper cervical spine injuries via computed tomography (CT) scans according to the AO Spine Upper Cervical Classification System. The validation occurred on two separate occasions, three weeks apart. Descriptive statistics for percent agreement with the gold-standard were calculated and Pearson's chi square test evaluated significance between validation groups. Kappa coefficients (ƙ) determined the interobserver reliability and intraobserver reproducibility. RESULTS The accuracy of AO Spine members to appropriately classify upper cervical spine injuries was 79.7% on assessment 1 (AS1) and 78.7% on assessment 2 (AS2). The overall intraobserver reproducibility was substantial (ƙ=0.70), while the overall interobserver reliability for AS1 and AS2 was substantial (ƙ=0.63 and ƙ=0.61, respectively). Injury location had higher interobserver reliability (AS1: ƙ = 0.85 and AS2: ƙ=0.83) than the injury type (AS1: ƙ=0.59 and AS2: 0.57) on both assessments. CONCLUSION The global validation of the AO Spine Upper Cervical Injury Classification System demonstrated substantial interobserver agreement and intraobserver reproducibility. These results support the universal applicability of the AO Spine Upper Cervical Injury Classification System