33 research outputs found
Identification and Characterization of Paramyosin from Cyst Wall of Metacercariae Implicated Protective Efficacy against Clonorchis sinensis Infection
- Author
- A Loukas
- A Ribeiro de Jesus
- AF Petavy
- B Sripa
- C Liang
- C Strube
- Chenhui Zhou
- Chi Liang
- D Rassy
- DH Lai
- DP McManus
- Erika Martins Braga
- F Ge
- Fangli Lu
- GN Gobert
- GN Gobert
- HJ Rim
- HR Shin
- Huali Lei
- J Deng
- J Keiser
- J Mulvenna
- J Mulvenna
- J Vazquez-Talavera
- J Wei
- Jin Xu
- Jingtao Men
- JS Lee
- KJ Livak
- LP Farias
- M Cancela
- M Jiz
- ND Young
- PC Fan
- QP Zhao
- R Perez-Sanchez
- R Sachdeva
- R Schirmbeck
- R Toledo
- S Mazumder
- T Erban
- TJ Park
- W Castro-Borges
- Wenjun Chen
- X Wang
- X Wang
- Xiaoli Lv
- Xiaoyun Wang
- Xifeng Zhang
- Xinbing Yu
- Xuchu Hu
- Xuerong Li
- Yanli Tian
- Z Faghiri
- Z Zhou
- Zhongdao Wu
- ZR Lun
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Human clonorchiasis has been increasingly prevalent in recent years and results in a threat to the public health in epidemic regions, motivating current strategies of vaccines to combat Clonorchis sinensis (C. sinensis). In this study, we identified C. sinensis paramyosin (CsPmy) from the cyst wall proteins of metacercariae by proteomic approaches and characterized the expressed recombinant pET-26b-CsPmy protein (101 kDa). Bioinformatics analysis indicated that full-length sequences of paramyosin are conserved in helminthes and numerous B-cell/T-cell epitopes were predicted in amino acid sequence of CsPmy. Western blot analysis showed that CsPmy was expressed at four life stages of C. sinensis, both cyst wall proteins and soluble tegumental components could be probed by anti-CsPmy serum. Moreover, immunolocalization results revealed that CsPmy was specifically localized at cyst wall and excretory bladder of metacercaria, as well as the tegument, oral sucker and vitellarium of adult worm. Both immunoblot and immunolocalization results demonstrated that CsPmy was highly expressed at the stage of adult worm, metacercariae and cercaria, which could be supported by real-time PCR analysis. Both recombinant protein and nucleic acid of CsPmy showed strong immunogenicity in rats and induced combined Th1/Th2 immune responses, which were reflected by continuous high level of antibody titers and increased level of IgG1/IgG2a subtypes in serum. In vaccine trials, comparing with control groups, both CsPmy protein and DNA vaccine exhibited protective effect with significant worm reduction rate of 54.3% (p<0.05) and 36.1% (p<0.05), respectively. In consistence with immune responses in sera, elevated level of cytokines IFN-Îł and IL-4 in splenocytes suggested that CsPmy could induce combined cellular immunity and humoral immunity in host. Taken together, CsPmy could be a promising vaccine candidate in the prevention of C. sinensis regarding its high immunogenicity and surface localization
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC
- Author
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- Uchida MA
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- Usher T
- Uzunyan S
- Vagins MR
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- Valencia E
- Valentim R
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- Wu W
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- Yankelevich A
- Yershov N
- Yonehara K
- Yoon YS
- Young T
- Yu B
- Yu H
- Yu H
- Yu J
- Yu Y
- Yuan W
- Zaki R
- Zalesak J
- Zambelli L
- Zamorano B
- Zani A
- Zazueta L
- Zeller GP
- Zennamo J
- Zeug K
- Zhang C
- Zhang S
- Zhang Y
- Zhao M
- Zhivun E
- Zhu G
- Zimmerman ED
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 16/07/2022
- Field of study
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6Â Ă Â 6Â Ă Â 6Â m 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7Â m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
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- A Brzezinski
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- U Heinz
- U Laufs
- U Schönbeck
- UN Das
- V Adam-Vizi
- V Adam-Vizi
- V Atanasiu
- V Braun
- V Braun
- V Calabrese
- V Campuzano
- V Campuzano
- V Curcin
- V Emilsson
- V Fellman
- V Gabutti
- V Gordeuk
- V Hower
- V Hvidberg
- V Irazusta
- V Irazusta
- V Kaushal
- V Lahera
- V Prinz
- V Shulaev
- V Siffrin
- V Srinivasan
- VA Kostyuk
- VB O'Donnell
- VD Longo
- VE O'Collins
- VE Steele
- VH Haase
- VL Kinnula
- VL Kinnula
- VM Campese
- VM Victor
- VM Victor
- VN Anisimov
- VR Gordeuk
- VR Gordeuk
- VR Taqueti
- W Aerbajinai
- W Breuer
- W Craelius
- W Davis Jr
- W Dichtl
- W Dröge
- W Dröge
- W Hu
- W Kalt
- W Kong
- W Li
- W Ma
- W Mair
- W Makropoulos
- W Ondo
- W Tungwiwat
- WA Cass
- WB Dunn
- WB Ershler
- WB Kannel
- WI Leong
- WJ Jo
- WK Adkins
- WL Neeley
- WM Campana
- WR Farwell
- WR Markesbery
- WR Markesbery
- WS Jeong
- WS Yang
- WW Huber
- WW Wong
- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-ĂstĂŒn
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
- Author
- Abecasis GR
- Adair LS
- Afaq S
- Afzal U
- Ahluwalia TS
- Ahmad S
- Alfred T
- Amin N
- Bakker SJL
- Baldassarre D
- Balkau B
- Bandinelli S
- Barata L
- Barroso I
- Bartz TM
- Beilby J
- Bergman RN
- Bergmann S
- Bielak LF
- Bien SA
- Biffar R
- Blangero J
- Boehnke M
- Boerwinkle E
- Boger CA
- Bonnefond A
- Bonnycastle LL
- Boomsma DI
- Borecki IB
- Bottinger E
- Bouchard C
- Braga D
- Bragg J
- Bruinenberg M
- Buckley BM
- Buyske S
- Cadby G
- Campbell H
- Chambers JC
- Chasman DI
- Chen YDI
- Chines PS
- Chittani M
- Chu AY
- Coggeshall S
- Collins FS
- Cooper RS
- Corre T
- Cucca F
- Cupples LA
- Curran JE
- Cusi D
- Czajkowski J
- de Borst GJ
- de Craen AJM
- de Faire U
- de Geus EJC
- Dedoussis G
- Delgado GE
- Deloukas P
- den Ruijter HM
- Deng X
- Direk N
- Eicher JD
- Eiriksdottir G
- Eriksson AL
- Eriksson J
- Esko T
- Faul JD
- Feitosa MF
- Ferrucci L
- Fischer K
- Fisher VA
- Ford I
- Forrester T
- Fox CS
- Franks PW
- Frayling TM
- Froguel P
- Gertow K
- Gigante B
- Glorioso N
- Gong J
- Gordon-Larsen P
- Gorski M
- Grabe HJ
- Graff M
- Grallert H
- Grammer TB
- Grarup N
- Gudnason V
- Hadley D
- Haiman CA
- Haitjema S
- Hallmans G
- Hamsten A
- Hansen T
- Harder MN
- Harris TB
- Hartman CA
- Hassinen M
- Hastie ND
- Hayward C
- Heard-Costa NL
- Heath AC
- Heid IM
- Hernandez D
- Hindorff L
- Hirschhorn JN
- Hocking LJ
- Hollensted M
- Holmen OL
- Homuth G
- Horikoshi M
- Hottenga JJ
- Huang J
- Huang T
- Huffman JE
- Hung J
- Hunter DJ
- Hutri-Kahonen N
- Hveem K
- Ingelsson E
- Jackson AU
- James AL
- Jansson JO
- Jarvelin MR
- Jhun MA
- Johnson AD
- Jorgensen ME
- Jukema W
- Juonala M
- Justesen JM
- Justice AE
- Kahonen M
- Kanoni S
- Kardia SLR
- Karlsson M
- Kilpelainen TO
- Kinnunen L
- Kivimaki M
- Kleber ME
- Koistinen HA
- Kolcic I
- Kolovou G
- Komulainen P
- Kooner JS
- Kooperberg C
- Kramer BK
- Kuh D
- Kumari M
- Kutalik Z
- Kuusisto J
- Kvaloy K
- Laakso M
- Lakka TA
- Langenberg C
- Launer LJ
- Le Marchand L
- Leander K
- Lee NR
- Lehtimaki T
- Lim E
- Lim U
- Lind L
- Lindgren CM
- Linneberg A
- Liu CT
- Lobbens S
- Loh M
- Loos RJF
- Lorentzon M
- Luan J
- Luben R
- Lubke G
- Ludolph-Donislawski A
- Lupoli S
- Lyytikainen LP
- Madden PAF
- Mahajan A
- Mangino M
- Manichaikul A
- Mannikko R
- Marchini J
- Marques-Vidal P
- Marten J
- Martin NG
- Marz W
- McCarthy MI
- McKenzie CA
- McKnight B
- Mellstrom D
- Menni C
- Metspalu A
- Middelberg RPS
- Mohlke KL
- Montgomery GW
- Morris AP
- Mueller-Nurasyid M
- Musk AW
- Narisu N
- Nauck M
- Navarro P
- Ngwa JS
- Nolte IM
- North KE
- Ohlsson C
- Oldehinkel AJ
- Olden M
- Ong KK
- Padmanabhan S
- Palmer LJ
- Pasterkamp G
- Pedersen O
- Perez J
- Perusse L
- Pervjakova N
- Peters A
- Peters U
- Peyser PA
- Pisinger C
- Polasek O
- Porteous DJ
- Psaty BM
- Qi L
- Qi QB
- Raitakari OT
- Rankinen T
- Rao DC
- Rasmussen-Torvik LJ
- Rauramaa R
- Rawal R
- Renstrom F
- Rice T
- Ridker PM
- Rose LM
- Rudan I
- Sanna S
- Sarti C
- Sarzynski MA
- Sattar N
- Savonen K
- Schlessinger D
- Scholtens S
- Schurmann C
- Scott RA
- Sennblad B
- Siemelink MA
- Silbernagel G
- Slagboom PE
- Smith AV
- Smith BH
- Smith JA
- Snieder H
- Sorensen TIA
- Spector TD
- Staessen JA
- Stancakova A
- Stott DJ
- Strachan DP
- Strauch K
- Strawbridge RJ
- Stringham HM
- Sung YJ
- Swertz MA
- Swift AJ
- Tanaka T
- Taylor KD
- Tayo BO
- Teumer A
- Thorand B
- Thuillier D
- Tiemeier H
- Tremoli E
- Trompet S
- Tuomilehto J
- Tyrrell J
- Uitterlinden AG
- Van der Harst P
- van der Laan SW
- van der Most PJ
- van Duijn CM
- Van Vliet-Ostaptchouk JV
- Vandenput L
- Vedantam SL
- Verweij N
- Vestergaard H
- Vink JM
- Vitart V
- Vohl MC
- Vollenweider P
- Volzke H
- Vonk JM
- Waeber G
- Waldenberger M
- Wareham NJ
- Weir DR
- Westendorp RGJ
- Whitfield JB
- Wild S
- Willemsen G
- Wilson JF
- Winkler TW
- Wolffenbuttel BHR
- Wong A
- Wright AF
- Wu J
- Wu Y
- Xue L
- Yengo L
- Young K
- Zhang WH
- Zhao JH
- Zhao W
- Zillikens MC
- Zimmermann ME
- Zubair N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/10/2022
- Field of study
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
- Abi B
- Abud A Abed
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adamowski M
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
- Aimard B
- Alba J Bazo
- Ali-Mohammadzadeh B
- Alion T
- Allison K
- Alonso MJ Rodriguez
- AlRashed M
- Alt C
- Alton A
- Alvarez R
- Amedo P
- Anderson J
- Andreopoulos C
- Andreotti M
- Andrews M
- Andrianala F
- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Arellano L
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Astiz IL De Icaza
- Aurisano A
- Aushev V
- Autiero D
- Ayala-Torres M
- Azfar F
- Babicz M
- Back A
- Back H
- Back JJ
- Backhouse C
- Bagaturia I
- Bagby L
- Balashov N
- Balasubramanian S
- Baldi P
- Baller B
- Bambah B
- Barao F
- Barenboim G
- Barker G
- Barkhouse W
- Barnes C
- Barr G
- Barros A
- Barros N
- Barrow JL
- Basharina-Freshville A
- Bashyal A
- Basque V
- Batchelor C
- Battat J
- Battisti F
- Bay F
- Bazetto MCQ
- Beacom JF
- Bechetoille E
- Behera B
- Beigbeder C
- Bellantoni L
- Bellettini G
- Bellini V
- Beltramello O
- Benekos N
- Berg R Van
- Berger J
- Berkman S
- Bermeo L Gomez
- Bernardini P
- Berner RM
- Bersani A
- Bertolucci S
- Betancourt M
- Bevan A
- Bezawada Y
- Bezerra TS
- Bhardwaj A
- Bhatnagar V
- Bhattacharjee M
- Bhattarai D
- Bhuller S
- Bhuyan B
- Biagi S
- Bian J
- Biassoni M
- Biery K
- Bilki B
- Bishai M
- Bitadze A
- Blake A
- Blaszczyk F
- Blazey G
- Blucher E
- Boissevain J
- Bolognesi S
- Bolton T
- Bomben L
- Bonesini M
- Bongrand M
- Bonilla E Rodriguez
- Bonilla-Diaz C
- Bonini F
- Bonis I De
- Booth A
- Boran F
- Bordoni S
- Borkum A
- Bostan N
- Bour P
- Bourgeois C
- Boyden D
- Bracinik J
- Braga D
- Brailsford D
- Branca A
- Brandt A
- Bremer J
- Breton D
- Brew C
- Brice SJ
- Brizzolari C
- Bromberg C
- Brooke J
- Bross A
- Brunetti G
- Brunetti M
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- Budd H
- Bueno L Molina
- Butorov I
- Cagnoli I
- Cai T
- Caicedo DA Martinez
- Caiulo D
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- Calafiura P
- Calcutt J
- Calin M
- Calvez S
- Calvo E
- Caminata A
- Campanelli M
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- Carniti P
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- Castillo A
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- Cattadori C
- Cavalier F
- Cavallaro G
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- Cerati G
- Cervelli A
- Chagas E Batista das
- Chalifour M
- Chappell A
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- Chatterjee A
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- Chong PS
- Christensen A
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- Christodoulou G
- Chukanov A
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- Cocco AG
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- Collaboration DUNE
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- Delgado M Ramirez
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- Deptuch GW
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- Dharmapalan R
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- Dwyer D
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- Ereditato A
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between data and simulation
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
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- Zimmerman ED
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- Zwaska R
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation
Design, construction and operation of the ProtoDUNE-SP Liquid Argon TPC
- Author
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- Abud AA
- Acciarri R
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- Adames MR
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- Zeller GP
- Zennamo J
- Zetina LMM
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- Zhu G
- Zilberman P
- Zimmerman ED
- Zito M
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'IOP Publishing'
- Publication date
- 04/08/2021
- Field of study
The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 Ă 6 Ă 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful operation between 2018 and 2020 demonstrates the effectiveness of the single-phase far detector design. This paper describes the design, construction, assembly and operation of the detector components
Searching for solar KDAR with DUNE
- Author
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- Cavanna F
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- Chalifour M
- Chappell A
- Chardonnet E
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- Chatterjee A
- Chattopadhyay S
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- Chen M
- Chen Y
- Chen Z
- Cheon Y
- Cherdack D
- Chi C
- Childress S
- Chiriacescu A
- Chisnall G
- Cho K
- Choate S
- Chokheli D
- Chong PS
- Choubey S
- Christensen A
- Christian D
- Christodoulou G
- Chukanov A
- Chung M
- Church E
- Cicero V
- Clarke P
- Coan TE
- Cocco AG
- Coelho JAB
- Conley E
- Conley R
- Conrad JM
- Convery M
- Copello S
- Corwin L
- Cremaldi L
- Cremonesi L
- Crespo-AnadĂłn JI
- Crisler M
- Cristaldo E
- Cross R
- Cudd A
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- Cui Y
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- da Motta H
- Dalager O
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- David Q
- Davies GS
- Davini S
- Dawson J
- De Bonis I
- de GouvĂȘa A
- De Holanda PC
- De Jong P
- De Lurgio P
- de Oliveira MAL
- De Roeck A
- De Romeri V
- De Souza G
- de Souza HV
- De K
- Debbins P
- Decowski MP
- Deisting A
- Del Campo AO
- Delbart A
- Delepine D
- Delgado M
- Delgado MAR
- Dell'Acqua A
- DeMuth DM
- Dennis S
- Densham C
- Deptuch GW
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- Dolinski MJ
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- Douillet D
- Drake G
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- Duchesneau D
- Duffy K
- DUNE Collaboration
- Dunne P
- Durkin T
- Duyang H
- Dvornikov O
- Dwyer DA
- Dyshkant AS
- DĂaz JS
- Eads M
- Earle A
- Edmunds D
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- Ereditato A
- Erjavec T
- Escobar CO
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- Ezeribe AC
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- Fajardo LSG
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- Farnese C
- Farzan Y
- Fedoseev D
- Felix J
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- Fernandez-Martinez E
- Ferraro F
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- Filip P
- Filthaut F
- Fiorentini A
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- Fitzpatrick RS
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- Furic IK
- Furmanski AP
- Gabrielli A
- Gago A
- Gallagher H
- Gallas A
- Gallego-Ros A
- Gallice N
- Galymov V
- Gamberini E
- Gamble T
- Ganacim F
- Gandhi R
- Gandrajula R
- Gao F
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- Garcia-Gamez D
- GarcĂa-Peris MĂ
- Gardiner S
- Gastler D
- Gauvreau J
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- Gent S
- Ghorbani-Moghaddam Z
- Giammaria P
- Giammaria T
- Gibin D
- Gil-Botella I
- Gilligan S
- Girerd C
- Giri AK
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- Gollapinni S
- Gollwitzer K
- Gomes RA
- Gonnella F
- Gonzalez-Cuevas JA
- Gonzalez-Lopez M
- Goodman MC
- Goodwin O
- Goswami S
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- Hadavand H
- Haenni R
- Hahn A
- Haiston J
- Hamacher-Baumann P
- Hamernik T
- Hamilton P
- Han J
- Harris DA
- Hartnell J
- Harton J
- Hasegawa T
- Hasnip C
- Hatcher R
- Hatfield KW
- Hatzikoutelis A
- Hayes C
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- Hazen E
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- Heavey A
- Heeger KM
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- Hertel L
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- Hillier SJ
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- Hourlier A
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- Hronek MS
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- Marshall J
- Marteau J
- Martin-Albo J
- Martinez N
- Martynenko S
- Mascagna V
- Mason K
- Mastbaum A
- Masud M
- Matichard F
- Matsuno S
- Matthews J
- Mauger C
- Mauri N
- Mavrokoridis K
- Mawby I
- Mazza R
- Mazzacane A
- Mazzucato E
- McAskill T
- McCluskey E
- McConkey N
- McFarland KS
- McGrew C
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- Miedema T
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- Reitzner SD
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- Sandberg V
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- Sapienza P
- Sarasty C
- Sarcevic I
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- Schellman H
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- Shoemaker I
- Shooltz D
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- Siegel H
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- Siyeon K
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- Smith A
- Smith E
- Smith P
- Smolik J
- Smy M
- Snider EL
- Snopok P
- Snowden-Ifft D
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- Solomey N
- Solovov V
- Sondheim WE
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- Sousa A
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- Szelc AM
- Söldner-Rembold S
- Tanaka HA
- Tapper A
- Tariq S
- Tatar E
- Tayloe R
- Teklu AM
- Tenti M
- Terao K
- Ternes CA
- Terranova F
- Terrazas IC
- Testera G
- Thakore T
- Thea A
- Thompson JL
- Thorn C
- Timm SC
- Tishchenko V
- Todd J
- Tomassetti L
- Tonazzo A
- Torbunov D
- Torti M
- Tortola M
- Tortorici F
- Tosi N
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- Toups M
- Touramanis C
- Travaglini R
- Trevor J
- Trilov S
- Tripathi A
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- Tsamalaidze Z
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- Tufanli S
- Tull C
- Tyley E
- Tzanov M
- Uboldi L
- Uchida MA
- Urheim J
- Usher T
- Uzunyan S
- Vagins MR
- Vahle P
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- Valencia E
- Valentim R
- Vallari Z
- Vallazza E
- Valle JWF
- Vallecorsa S
- Van Berg R
- Van de Water RG
- Varanini F
- Vargas D
- Varner G
- Vasel J
- Vasina S
- Vasseur G
- Vaughan N
- Vaziri K
- Vazquez WP
- Ventura S
- Verdugo A
- Vergani S
- Vermeulen MA
- Verzocchi M
- Vicenzi M
- Vignoli C
- Vilela C
- Villanueva AC
- Viren B
- Vrba T
- Wachala T
- Waldron AV
- Wallbank M
- Wallis C
- Wang H
- Wang J
- Wang L
- Wang MHLS
- Wang Y
- Wang Y
- Warburton K
- Warner D
- Wascko MO
- Waters D
- Watson A
- Weatherly P
- Weber A
- Weber M
- Wei H
- Weinstein A
- Wenman D
- Wetstein M
- White A
- Whitehead LH
- Whittington D
- Wilking MJ
- Wilkinson C
- Williams Z
- Wilson F
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- Wisniewski W
- Wolcott J
- Wongjirad T
- Wood A
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- Worcester E
- Worcester M
- Wret C
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- Wu W
- Xiao Y
- Xie F
- Yandel E
- Yang G
- Yang K
- Yang S
- Yang T
- Yankelevich A
- Yershov N
- Yonehara K
- Young T
- Yu B
- Yu H
- Yu H
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- Yuan W
- Zaki R
- Zalesak J
- Zambelli L
- Zamorano B
- Zani A
- Zazueta L
- Zeller GP
- Zennamo J
- Zetina LMM
- Zeug K
- Zhang C
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- Zhivun E
- Zhu G
- Zilberman P
- Zimmerman ED
- Zito M
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- Publication date
- Field of study
Low exposure long-baseline neutrino oscillation sensitivity of the DUNE experiment
- Author
- Abi B
- Abud AA
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
- Aimard B
- Alba JLB
- Ali-Mohammadzadeh B
- Alion T
- Allison K
- Alonso MJR
- AlRashed M
- Alt C
- Alton A
- Amedo P
- Anderson J
- Andreopoulos C
- Andreotti M
- Andrews MP
- Andrianala F
- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Astiz ILDI
- Aurisano A
- Aushev V
- Autiero D
- Ayala-Torres M
- Azfar F
- Back A
- Back H
- Back JJ
- Backhouse C
- Bagaturia I
- Bagby L
- Balashov N
- Balasubramanian S
- Baldi P
- Baller B
- Bambah B
- Barao F
- Barenboim G
- Barker GJ
- Barkhouse W
- Barnes C
- Barr G
- Barros A
- Barros N
- Barrow JL
- Basharina-Freshville A
- Bashyal A
- Basque V
- Battat JBR
- Battisti F
- Bay F
- Beacom JF
- Bechetoille E
- Behera B
- Belchior E
- Bellantoni L
- Bellettini G
- Bellini V
- Beltramello O
- Benekos N
- Berg RV
- Berger J
- Berkman S
- Bermeo LVG
- Bernardini P
- Berner RM
- Bertolucci S
- Betancourt M
- Bevan A
- Bezawada Y
- Bezerra TJC
- Bhardwaj A
- Bhatnagar V
- Bhattacharjee M
- Bhuller S
- Bhuyan B
- Biagi S
- Bian J
- Biassoni M
- Biery K
- Bilki B
- Bishai M
- Bitadze A
- Blake A
- Blaszczyk FDM
- Blazey GC
- Blucher E
- Boissevain J
- Bolognesi S
- Bolton T
- Bomben L
- Bonesini M
- Bongrand M
- Bonilla ER
- Bonilla-Diaz C
- Bonini F
- Bonis ID
- Booth A
- Boran F
- Bordoni S
- Borkum A
- Bostan N
- Bour P
- Bourgeois C
- Boyden D
- Bracinik J
- Braga D
- Brailsford D
- Branca A
- Brandt A
- Bremer J
- Brew C
- Brice SJ
- Brizzolari C
- Bromberg C
- Brooke J
- Bross A
- Brunetti G
- Brunetti M
- Buchanan N
- Budd H
- Bueno LM
- Butorov I
- Cagnoli I
- Caicedo DAM
- Caiulo D
- Calabrese R
- Calafiura P
- Calcutt J
- Calin M
- Calvez S
- Calvo E
- Caminata A
- Campanelli M
- Caratelli D
- Carini G
- Carlus B
- Carneiro MF
- Carniti P
- Carranza H
- Carroll T
- Castillo A
- Castromonte C
- Catano-Mur E
- Cattadori C
- Cavalier F
- Cavanna F
- Centro S
- Cerati G
- Cervelli A
- Chalifour M
- Chappell A
- Chardonnet E
- Charitonidis N
- Chatterjee A
- Chattopadhyay S
- Chen H
- Chen M
- Chen Y
- Chen Z
- Cheon Y
- Cherdack D
- Chi C
- Childress S
- Chiriacescu A
- Chisnall G
- Cho K
- Choate S
- Chokheli D
- Chong PS
- Christensen A
- Christian D
- Christodoulou G
- Chukanov A
- Chung M
- Church E
- Cicero V
- Clarke P
- Coan TE
- Cocco AG
- Coelho JAB
- Collaboration DUNE
- Colton N
- Conley E
- Conley R
- Conrad JM
- Convery M
- Copello S
- Cremaldi L
- Cremonesi L
- Crespo-AnadĂłn JI
- Crisler M
- Cristaldo E
- Cross R
- Cudd A
- Cuesta C
- Cui Y
- Cussans D
- Dalager O
- David C
- David Q
- Davies GS
- Davini S
- Dawson J
- De K
- Debbins P
- Decowski MP
- Deisting A
- Delbart A
- Delepine D
- Delgado M
- Delgado MAR
- Dell'Acqua A
- DeMuth DM
- Dennis S
- Densham C
- Deptuch GW
- Devi R
- Dharmapalan R
- Dias M
- Diaz F
- Ding P
- Distefano C
- Diurba R
- Diwan M
- Djurcic Z
- Doering D
- Dolan S
- Dolek F
- Dolinski MJ
- Domine L
- Domizio SD
- Douglas D
- Douillet D
- Drake G
- Drielsma F
- Duarte L
- Duchesneau D
- Duffy K
- Dunne P
- Duyang H
- Dvornikov O
- Dwyer DA
- Dyshkant AS
- DĂaz JS
- Eads M
- Earle A
- Edmunds D
- Eisch J
- Emberger L
- Emery S
- Ereditato A
- Erjavec T
- Escobar CO
- Eurin G
- Evans JJ
- Ewart E
- Ezeribe AC
- Fahey K
- Fajardo LSG
- Falcone A
- Fani' M
- Farnese C
- Farzan Y
- Fedoseev D
- Felix J
- Feng Y
- Fernandez-Martinez E
- Ferraro F
- Fields L
- Filip P
- Filthaut F
- Fiorentini A
- Fiorini M
- Fitzpatrick RS
- Flanagan W
- Fleming B
- Flight R
- Fogarty S
- Foreman W
- Forero DV
- Forero JFC
- Fowler J
- Fox W
- Franc J
- Francis K
- Franco D
- Freeman J
- Freestone J
- Fried J
- Friedland A
- Fuess S
- Furic IK
- Furmanski AP
- Gabrielli A
- Gago A
- Gallagher H
- Gallas A
- Gallego-Ros A
- Gallice N
- Galymov V
- Gamberini E
- Gamble T
- Ganacim F
- Gandhi R
- Gandrajula R
- Gao F
- Gao S
- Garcia-Gamez D
- GarcĂa-Peris MĂ
- Gardiner S
- Gastler D
- Gauvreau J
- Ge G
- Geffroy N
- Gelli B
- Gendotti A
- Gent S
- Ghorbani-Moghaddam Z
- Giammaria P
- Giammaria T
- Gibin D
- Gil-Botella I
- Gilligan S
- Girerd C
- Giri AK
- Giulio LD
- Gnani D
- Gogota O
- Gold M
- Gollapinni S
- Gollwitzer K
- Gomes RA
- Gonnella F
- Gonzalez-Cuevas JA
- Gonzalez-Diaz D
- Gonzalez-Lopez M
- Goodman MC
- Goodwin O
- Goswami S
- Gotti C
- Goudzovski E
- GouvĂȘa AD
- Grace C
- Gran R
- Granados E
- Granger P
- Grant A
- Grant C
- Gratieri D
- Green P
- Greenler L
- Greer J
- Grenard J
- Griffith WC
- Groh M
- Grudzinski J
- Grzelak K
- Gu W
- Guardincerri E
- Guarino V
- Guarise M
- Guenette R
- Guerard E
- Guerzoni M
- Guffanti D
- Guglielmi A
- Guo B
- Gupta V
- Guthikonda KK
- Gutierrez R
- Guzowski P
- Guzzo MM
- Gwon S
- Ha C
- Habig A
- Hadavand H
- Haenni R
- Hahn A
- Haiston J
- Hamacher-Baumann P
- Hamernik T
- Hamilton P
- Han J
- Harris DA
- Hartnell J
- Hartnett T
- Harton J
- Hasegawa T
- Hasnip C
- Hatcher R
- Hatfield KW
- Hatzikoutelis A
- Hayes C
- Hayrapetyan K
- Hays J
- Hazen E
- He M
- Heavey A
- Heeger KM
- Heise J
- Henry S
- Herner K
- Hewes J
- Hill T
- Hillier SJ
- Himmel A
- Hinkle E
- Hirsch LR
- Ho J
- Hoff J
- Holanda PCD
- Holin A
- Hoppe E
- Horton-Smith GA
- Hostert M
- Hourlier A
- Howard B
- Howell R
- Hristova I
- Hronek MS
- Huang J
- Iles G
- Ilic N
- Iliescu AM
- Illingworth R
- Ingratta G
- Ioannisian A
- Irwin B
- Isenhower L
- Itay R
- Jackson CM
- Jain V
- James E
- Jang W
- Jargowsky B
- Jediny F
- Jena D
- Jeong YS
- JesĂșs-Valls C
- Ji X
- Jiang L
- Jiménez S
- Jipa A
- Johnson R
- Johnston N
- Jones B
- Jones SB
- Jong PD
- Judah M
- Jung CK
- Junk T
- Jwa Y
- Kabirnezhad M
- Kaboth A
- Kadenko I
- Kaira D
- Kakorin I
- Kalitkina A
- Kamiya F
- Kaneshige N
- Karagiorgi G
- Karaman G
- Karcher A
- Karolak M
- Karyotakis Y
- Kasai S
- Kasetti SP
- Kashur L
- Kazaryan N
- Kearns E
- Keener P
- Kelly KJ
- Kemp E
- Kemularia O
- Ketchum W
- Kettell SH
- Khabibullin M
- Khotjantsev A
- Khvedelidze A
- Kim D
- King B
- Kirby B
- Kirby M
- Klein J
- Koehler K
- Koerner LW
- Koh DH
- Kohn S
- Koller PP
- Kolupaeva L
- Korablev D
- Kordosky M
- Kosc T
- Kose U
- KosteleckĂœ VA
- Kothekar K
- Kreczko L
- Krennrich F
- Kreslo I
- Kropp W
- Kudenko Y
- Kudryavtsev VA
- Kulagin S
- Kumar J
- Kumar P
- Kumar R
- Kunze P
- Kurita N
- Kuruppu C
- Kus V
- Kutter T
- Kvasnicka J
- Kwak D
- Lambert A
- Land BJ
- Lane CE
- Lang K
- Langford T
- Langstaff M
- Larkin J
- Lasorak P
- Last D
- Lastoria C
- Laundrie A
- Laurenti G
- Lawrence A
- Lazanu I
- LaZur R
- Lazzaroni M
- Le T
- Leardini S
- Learned J
- LeBrun P
- LeCompte T
- Lee C
- Lee SY
- Lehnert R
- Leitner M
- Lepin LM
- Li SW
- Li T
- Li Y
- Liao H
- Lin CS
- Lin Q
- Lin S
- Lineros RA
- Ling J
- LisbĂŽa AFS
- Lister A
- Littlejohn BR
- Liu J
- Lockwitz S
- Loew T
- Lokajicek M
- Lomidze I
- Long K
- Lord T
- LoSecco JM
- Louis WC
- Lu X-G
- Luk KB
- Lunday B
- Luo X
- Luppi E
- Lurgio PD
- Lux T
- Luzio VP
- MacFarlane D
- Machado AA
- Machado P
- Macias CT
- Macier JR
- Maddalena A
- Madera A
- Madigan P
- Magill S
- Mahn K
- Maio A
- Major A
- Maloney JA
- Mandrioli G
- Mandujano RC
- Maneira J
- Manenti L
- Manly S
- Mann A
- Manolopoulos K
- Manyam VN
- Manzanillas L
- Marchan M
- Marchionni A
- Marciano W
- Marfatia D
- Mariani C
- Maricic J
- Marie R
- Marinho F
- Marino AD
- Marsden D
- Marshak M
- Marshall CM
- Marshall J
- Marteau J
- Martin-Albo J
- Martinez N
- Martynenko S
- Mascagna V
- Mason K
- Mastbaum A
- Matichard F
- Matsuno S
- Matthews J
- Mauger C
- Mauri N
- Mavrokoridis K
- Mawby I
- Mazza R
- Mazzacane A
- Mazzucato E
- McAskill T
- McCluskey E
- McConkey N
- McFarland KS
- McGrew C
- McNab A
- Mefodiev A
- Mehta P
- Melas P
- Mena O
- Mendez H
- Mendez P
- Menegolli A
- Menendez PF
- Meng G
- Messier MD
- Metcalf W
- Mettler T
- Mewes M
- Meyer H
- Miao T
- Michna G
- Miedema T
- Mikola V
- Milincic R
- Miller G
- Miller W
- Mills J
- Milne C
- Mineev O
- Minotti A
- Miotto GL
- Miranda OG
- Miravé PM
- Miryala S
- Mishra CS
- Mishra SR
- Mislivec A
- Mladenov D
- Mocioiu I
- Moffat K
- Moggi N
- Mohanta R
- Mohayai TA
- Mokhov N
- Molina J
- Monarca JB
- Monsalve SA
- Montagna E
- Montanari A
- Montanari C
- Montanari D
- Montiel CB
- Moon J
- Moon SH
- Mooney M
- Moor AF
- Morales MF
- Moreno D
- Morquecho MAH
- Morris C
- Mossey C
- Motta HD
- Motuk E
- Moura CA
- Mousseau J
- Mouster G
- Mu W
- Mualem L
- Mueller J
- Muether M
- Mufson S
- Muheim F
- Muir A
- Mulhearn M
- Munford D
- Muramatsu H
- Murphy S
- Musser J
- MĂ©ndez DP
- Nachtman J
- Nagu S
- Nalbandyan M
- Nandakumar R
- Naples D
- Narita S
- Nath A
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The Deep Underground Neutrino Experiment (DUNE) will produce world-leading neutrino oscillation measurements over the lifetime of the experiment. In this work, we explore DUNE's sensitivity to observe charge-parity violation (CPV) in the neutrino sector, and to resolve the mass ordering, for exposures of up to 100 kiloton-megawatt-years (kt-MW-yr). The analysis includes detailed uncertainties on the flux prediction, the neutrino interaction model, and detector effects. We demonstrate that DUNE will be able to unambiguously resolve the neutrino mass ordering at a 3Ï (5Ï) level, with a 66 (100) kt-MW-yr far detector exposure, and has the ability to make strong statements at significantly shorter exposures depending on the true value of other oscillation parameters. We also show that DUNE has the potential to make a robust measurement of CPV at a 3Ï level with a 100 kt-MW-yr exposure for the maximally CP-violating values \delta_{\rm CP}} = \pm\pi/2. Additionally, the dependence of DUNE's sensitivity on the exposure taken in neutrino-enhanced and antineutrino-enhanced running is discussed. An equal fraction of exposure taken in each beam mode is found to be close to optimal when considered over the entire space of interest
First French live-birth after oocyte vitrification performed before chemotherapy for fertility preservation
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