Human anti-60 kD heat shock protein autoantibodies are characterized by basic features of natural autoantibodies

Anti-human Hsp60 autoantibodies--known risk factor of atherosclerosis--were investigated in a mouse model and in samples of healthy subjects: polyreactivity, presence in cord blood samples of healthy newborns and life-long stability were tested. In IgM hybridoma panel from mouse spleens, polyreactivity of anti-Hsp60 autoantibodies was studied. In healthy pregnant women, umbilical vein and maternal blood samples were collected after childbirth, anti-Hsp-60 and -65 IgM and IgG levels were measured. Life-long stability of anti-Hsp-60 levels was studied on healthy patients during 5 years. ELISA was used in all studies. Polyreactivity of IgM clones of newborn mice and lifelong stability of these autoantibodies in healthy adults were established. IgM anti-Hsp60 autoantibodies in cord blood of healthy human infants were present, however, there was no correlation between maternal and cord blood IgM anti-Hsp60 concentrations. It is proposed that presence of anti-Hsp60 autoantibodies--as part of the natural autoantibody repertoire--may be an inherited trait. Level of anti-Hsp60 autoantibodies may be an independent, innate risk factor of atherosclerosis for the adulthood

First Search for Dyons with the Full MoEDAL Trapping Detector in 13 TeV pp Collisions

The MoEDAL trapping detector consists of approximately 800 kg of aluminum volumes. It was exposed during run 2 of the LHC program to 6.46  fb−1 of 13 TeV proton-proton collisions at the LHCb interaction point. Evidence for dyons (particles with electric and magnetic charge) captured in the trapping detector was sought by passing the aluminum volumes comprising the detector through a superconducting quantum interference device (SQUID) magnetometer. The presence of a trapped dyon would be signaled by a persistent current induced in the SQUID magnetometer. On the basis of a Drell-Yan production model, we exclude dyons with a magnetic charge ranging up to five Dirac charges (5gD) and an electric charge up to 200 times the fundamental electric charge for mass limits in the range 870–3120 GeV and also monopoles with magnetic charge up to and including 5gD with mass limits in the range 870–2040 GeV.Peer reviewe

Search for Highly-Ionizing Particles in pp Collisions During LHC Run-2 Using the Full MoEDAL Detector

International audienceThis search for Magnetic Monopoles (MMs) and High Electric Charge Objects (HECOs) with spins 0, 1/2 and 1, uses for the first time the full MoEDAL detector, exposed to 6.6 fb^-1 proton-proton collisions at 13 TeV. The results are interpreted in terms of Drell-Yan and photon-fusion pair production. Mass limits on direct production of MMs of up to 10 Dirac magnetic charges and HECOs with electric charge in the range 5e to 350e were achieved. The charge limits placed on MM and HECO production are currently the strongest in the world. MoEDAL is the only LHC experiment capable of being directly calibrated for highly-ionizing particles using heavy ions and with a detector system dedicated to definitively measuring magnetic charge

Search for Highly-Ionizing Particles in pp Collisions During LHC Run-2 Using the Full MoEDAL Detector

International audienceThis search for Magnetic Monopoles (MMs) and High Electric Charge Objects (HECOs) with spins 0, 1/2 and 1, uses for the first time the full MoEDAL detector, exposed to 6.6 fb^-1 proton-proton collisions at 13 TeV. The results are interpreted in terms of Drell-Yan and photon-fusion pair production. Mass limits on direct production of MMs of up to 10 Dirac magnetic charges and HECOs with electric charge in the range 5e to 350e were achieved. The charge limits placed on MM and HECO production are currently the strongest in the world. MoEDAL is the only LHC experiment capable of being directly calibrated for highly-ionizing particles using heavy ions and with a detector system dedicated to definitively measuring magnetic charge

MoEDAL search in the CMS beam pipe for magnetic monopoles produced via the Schwinger effect

We report on a search for magnetic monopoles (MMs) produced in ultraperipheral Pb--Pb collisions during Run-1 of the LHC. The beam pipe surrounding the interaction region of the CMS experiment was exposed to 174.29 $\mathrm{\mu}$b$^{-1}$ of Pb--Pb collisions at 2.76 TeV center-of-mass energy per collision in December 2011. It was scanned by the MoEDAL experiment using a SQUID magnetometer to search for trapped MMs. No MM signal was observed. The two distinctive features of this search are the use of a trapping volume very close to the collision point and ultra-high magnetic fields generated during the heavy-ion run that could produce MMs via the Schwinger effect. These two advantages allowed setting the first reliable, world-leading mass limits on MMs with high magnetic charge. In particular, the established limits are the strongest available in the range between 2 and 45 Dirac units, excluding MMs with masses of up to 80 GeV at 95% confidence level

Search for Highly-Ionizing Particles in pp Collisions During LHC Run-2 Using the Full MoEDAL Detector

This search for Magnetic Monopoles (MMs) and High Electric Charge Objects (HECOs) with spins 0, 1/2 and 1, uses for the first time the full MoEDAL detector, exposed to 6.6 fb^-1 proton-proton collisions at 13 TeV. The results are interpreted in terms of Drell-Yan and photon-fusion pair production. Mass limits on direct production of MMs of up to 10 Dirac magnetic charges and HECOs with electric charge in the range 5e to 350e were achieved. The charge limits placed on MM and HECO production are currently the strongest in the world. MoEDAL is the only LHC experiment capable of being directly calibrated for highly-ionizing particles using heavy ions and with a detector system dedicated to definitively measuring magnetic charge