279 research outputs found
Drug-induced renal Fanconi syndrome
A number of therapeutic drugs are toxic to the kidney proximal tubule (PT) and can cause the renal Fanconi syndrome (FS). The most frequently implicated drugs are cisplatin, ifosfamide, tenofovir, sodium valproate and aminoglycoside antibiotics, and the new oral iron chelator deferasirox has also recently been associated with FS. The incidence of full or partial FS is almost certainly under-estimated due to a lack of appropriate systematic studies, variations in definitions of tubular dysfunction and under-reporting of adverse events. The clinical features of FS are amino aciduria, low molecular weight proteinuria, hypophosphataemia, metabolic acidosis and glycosuria. The most serious complications are bone demineralization from urinary phosphate wasting and progressive decline in kidney function. Commonly used tests for kidney function such as estimated glomerular filtration rate and urine albumin/creatinine ratio are not sensitive markers of PT toxicity; patients at risk should thus be monitored with more appropriate tests, and drugs should be stopped or reduced in dose if toxicity occurs. Substantial recovery of PT function can occur after withdrawal of therapy, but this can take months and chronic damage may persist in some case
A liquid helium target system for a measurement of parity violation in neutron spin rotation
A liquid helium target system was designed and built to perform a precision
measurement of the parity-violating neutron spin rotation in helium due to the
nucleon-nucleon weak interaction. The measurement employed a beam of low energy
neutrons that passed through a crossed neutron polarizer--analyzer pair with
the liquid helium target system located between them. Changes between the
target states generated differences in the beam transmission through the
polarizer--analyzer pair. The amount of parity-violating spin rotation was
determined from the measured beam transmission asymmetries. The expected
parity-violating spin rotation of order rad placed severe constraints
on the target design. In particular, isolation of the parity-odd component of
the spin rotation from a much larger background rotation caused by magnetic
fields required that a nonmagnetic cryostat and target system be supported
inside the magnetic shielding, while allowing nonmagnetic motion of liquid
helium between separated target chambers. This paper provides a detailed
description of the design, function, and performance of the liquid helium
target system.Comment: V2: 29 pages, 14 figues, submitted to Nucl. Instrum. Meth. B. Revised
to address reviewer comment
On Proper Polynomial Maps of
Two proper polynomial maps are said to be \emph{equivalent} if there exist such that .
We investigate proper polynomial maps of arbitrary topological degree up to equivalence. Under the further assumption that the maps are Galois
coverings we also provide the complete description of equivalence classes. This
widely extends previous results obtained by Lamy in the case .Comment: 15 pages. Final version, to appear in Journal of Geometric Analysi
Azimuthal Correlations in the Target Fragmentation Region of High Energy Nuclear Collisions
Results on the target mass dependence of proton and pion pseudorapidity
distributions and of their azimuthal correlations in the target rapidity range
are presented. The data have been taken with the
Plastic-Ball detector set-up for 4.9 GeV p + Au collisions at the Berkeley
BEVALAC and for 200 GeV/ p-, O-, and S-induced reactions on
different nuclei at the CERN-SPS. The yield of protons at backward rapidities
is found to be proportional to the target mass. Although protons show a typical
``back-to-back'' correlations, a ``side-by-side'' correlation is observed for
positive pions, which increases both with target mass and with impact parameter
of a collision. The data can consistently be described by assuming strong
rescattering phenomena including pion absorption effects in the entire excited
target nucleus.Comment: 7 pages, figures included, complete postscript available at
ftp://qgp.uni-muenster.de/pub/paper/azi-correlations.ps submitted to Phys.
Lett.
Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking
Sustained directional fibroblast migration requires both polarized activation of the protrusive signal, Rac1, and redistribution of inactive Rac1 from the rear of the cell so that it can be redistributed or degraded. In this work, we determine how alternative endocytic mechanisms dictate the fate of Rac1 in response to the extracellular matrix environment. We discover that both coronin-1C and caveolin retrieve Rac1 from similar locations at the rear and sides of the cell. We find that coronin-1C-mediated extraction, which is responsible for Rac1 recycling, is a constitutive process that maintains Rac1 protein levels within the cell. In the absence of coronin-1C, the effect of caveolin-mediated endocytosis, which targets Rac1 for proteasomal degradation, becomes apparent. Unlike constitutive coronin-1C-mediated trafficking, caveolin-mediated Rac1 endocytosis is induced by engagement of the fibronectin receptor syndecan-4. Such an inducible endocytic/degradation mechanism would predict that, in the presence of fibronectin, caveolin defines regions of the cell that are resistant to Rac1 activation but, in the absence of fibronectin leaves more of the membrane susceptible to Rac1 activation and protrusion. Indeed, we demonstrate that fibronectin-stimulated activation of Rac1 is accelerated in the absence of caveolin and that, when caveolin is knocked down, polarization of active Rac1 is lost in FRET experiments and culminates in shunting migration in a fibrous fibronectin matrix. Although the concept of polarized Rac1 activity in response to chemoattractants has always been apparent, our understanding of the balance between recycling and degradation explains how polarity can be maintained when the chemotactic gradient has faded
High-energy physics with particles carrying non-zero orbital angular momentum
Thanks to progress in optics in the past two decades, it is possible to
create photons carrying well-defined non-zero orbital angular momentum (OAM).
Boosting these photons into high-energy range preserving their OAM seems
feasible. Intermediate energy electrons with OAM have also been produced
recently. One can, therefore, view OAM as a new degree of freedom in
high-energy collisions and ask what novel insights into particles' structure
and interactions it can bring. Here we discuss generic features of scattering
processes involving particles with OAM in the initial state. We show that they
make it possible to perform a Fourier analysis of a plane wave cross section
with respect to the azimuthal angles of the initial particles, and to probe the
autocorrelation function of the amplitude, a quantity inaccessible in plane
wave collisions.Comment: 7 pages, 1 figure, talk given at the workshop "30 years of strong
interactions", Spa, Belgium, 6-8 April 201
The systematic study of the influence of neutron excess on the fusion cross sections using different proximity-type potentials
Using different types of proximity potentials, we have examined the trend of
variations of barrier characteristics (barrier height and its position) as well
as fusion cross sections for 50 isotopic systems including various collisions
of C, O, Mg, Si, S, Ca, Ar, Ti and Ni nuclei with condition
for compound systems. The results of our studies reveal that the relationships
between increase of barrier positions and decrease of barrier heights are both
linear with increase of ratio. Moreover, fusion cross sections also
enhance linearly with increase of this ratio.Comment: 28 pages, 7 figures, 5 Table
The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration
Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3's role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the β3-dependent adhesome. We show that depletion of β3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2-driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when β3-integrin levels are reduced
Heavy ion event generator HYDJET++ (HYDrodynamics plus JETs)
HYDJET++ is a Monte-Carlo event generator for simulation of relativistic
heavy ion AA collisions considered as a superposition of the soft, hydro-type
state and the hard state resulting from multi-parton fragmentation. This model
is the development and continuation of HYDJET event generator (Lokhtin &
Snigirev, 2006, EPJC, 45, 211). The main program is written in the
object-oriented C++ language under the ROOT environment. The hard part of
HYDJET++ is identical to the hard part of Fortran-written HYDJET and it is
included in the generator structure as a separate directory. The soft part of
HYDJET++ event is the "thermal" hadronic state generated on the chemical and
thermal freeze-out hypersurfaces obtained from the parameterization of
relativistic hydrodynamics with preset freeze-out conditions. It includes the
longitudinal, radial and elliptic flow effects and the decays of hadronic
resonances. The corresponding fast Monte-Carlo simulation procedure, C++ code
FAST MC (Amelin et al., 2006, PRC, 74, 064901; 2008, PRC, 77, 014903) is
adapted to HYDJET++. It is designed for studying the multi-particle production
in a wide energy range of heavy ion experimental facilities: from FAIR and NICA
to RHIC and LHC.Comment: 44 pages including 6 figures as EPS-files; prepared using LaTeX
package for publication in Computer Physics Communication
Differential Transverse Flow in Central C-Ne and C-Cu Collisions at 3.7 GeV/nucleon
Differential transverse flow of protons and pions in central C-Ne and C-Cu
collisions at a beam energy of 3.7 GeV/nucleon was measured as a function of
transverse momentum at the SKM-200-GIBS setup of JINR. In agreement with
predictions of a transversely moving thermal model, the strength of proton
differential transverse flow is found to first increase gradually and then
saturate with the increasing transverse momentum in both systems. While pions
are preferentially emitted in the same direction of the proton transverse flow
in the reaction of C-Ne, they exhibit an anti-flow to the opposote direction of
the proton transverse flow in the reaction of C-Cu due to stronger shadowing
effects of the heavier target in thr whole range of transverse momentum.Comment: 15 pages, 5 figure
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