515 research outputs found
Primary care summary of the British Thoracic Society Guidelines for the management of community acquired pneumonia in adults:2009 update. Endorsed by the Royal College of General Practitioners and the Primary Care Respiratory Society UK
Magnetic resonance imaging allows early noninvasive assessment of left ventricular remodelling after myocardial infarction in rats
A Comparison of Algorithms for the Construction of SZ Cluster Catalogues
We evaluate the construction methodology of an all-sky catalogue of galaxy
clusters detected through the Sunyaev-Zel'dovich (SZ) effect. We perform an
extensive comparison of twelve algorithms applied to the same detailed
simulations of the millimeter and submillimeter sky based on a Planck-like
case. We present the results of this "SZ Challenge" in terms of catalogue
completeness, purity, astrometric and photometric reconstruction. Our results
provide a comparison of a representative sample of SZ detection algorithms and
highlight important issues in their application. In our study case, we show
that the exact expected number of clusters remains uncertain (about a thousand
cluster candidates at |b|> 20 deg with 90% purity) and that it depends on the
SZ model and on the detailed sky simulations, and on algorithmic implementation
of the detection methods. We also estimate the astrometric precision of the
cluster candidates which is found of the order of ~2 arcmins on average, and
the photometric uncertainty of order ~30%, depending on flux.Comment: Accepted for publication in A&A: 14 pages, 7 figures. Detailed
figures added in Appendi
Characterization and detection of experimental rat gliomas using magnetic resonance imaging
Two different experimental rat brain tumours (F98 glioma and 9L glioma) were characterized using T1 and T2, apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR). Even though both tumours appeared homogenous at the early stage of growth, significant differences were measured for all parametric images between tumours and normal brain tissue. Irrespective of the sequence used, tumour lesion/normal parenchyma contrast for the non-infiltrative 9L was twice that of the infiltrative F98 glioma. The use of spin preparation via an inversion pulse in a fast spin echo sequence increases contrast by a factor of 20-30
The pre-launch Planck Sky Model: a model of sky emission at submillimetre to centimetre wavelengths
We present the Planck Sky Model (PSM), a parametric model for the generation
of all-sky, few arcminute resolution maps of sky emission at submillimetre to
centimetre wavelengths, in both intensity and polarisation. Several options are
implemented to model the cosmic microwave background, Galactic diffuse emission
(synchrotron, free-free, thermal and spinning dust, CO lines), Galactic H-II
regions, extragalactic radio sources, dusty galaxies, and thermal and kinetic
Sunyaev-Zeldovich signals from clusters of galaxies. Each component is
simulated by means of educated interpolations/extrapolations of data sets
available at the time of the launch of the Planck mission, complemented by
state-of-the-art models of the emission. Distinctive features of the
simulations are: spatially varying spectral properties of synchrotron and dust;
different spectral parameters for each point source; modeling of the clustering
properties of extragalactic sources and of the power spectrum of fluctuations
in the cosmic infrared background. The PSM enables the production of random
realizations of the sky emission, constrained to match observational data
within their uncertainties, and is implemented in a software package that is
regularly updated with incoming information from observations. The model is
expected to serve as a useful tool for optimizing planned microwave and
sub-millimetre surveys and to test data processing and analysis pipelines. It
is, in particular, used for the development and validation of data analysis
pipelines within the planck collaboration. A version of the software that can
be used for simulating the observations for a variety of experiments is made
available on a dedicated website.Comment: 35 pages, 31 figure
Observation of the Three-Mode Parametric Instability
Three-mode parametric interactions occur in triply-resonant optomechanical
systems: photons from an optical pump mode are coherently scattered to a
high-order mode by mechanical motion of the cavity mirrors, and these modes
resonantly interact via radiation pressure force when certain conditions are
met. Such effects are predicted to occur in long baseline advanced
gravitational-wave detectors. They can pump energy into acoustic modes, leading
to parametric instability, but they can also extract acoustic energy, leading
to optomechanical cooling. We develop a large amplitude model of three-mode
interactions that explains the ring-up amplitude saturation after instability
occurs. We also demonstrate both radiation-pressure cooling and mechanical
amplification in two different three-mode optomechanical systems, including the
first observation of the three-mode parametric instability in a free-space
Fabry-Perot cavity. The experimental data agrees well with the theoretical
model. Contrary to expectations, parametric instability does not lead to loss
of cavity lock, a fact which may make it easier to implement control techniques
to overcome instability.Comment: 11 pages, 14 figure
The bolometric focal plane array of the Polarbear CMB experiment
The Polarbear Cosmic Microwave Background (CMB) polarization experiment is
currently observing from the Atacama Desert in Northern Chile. It will
characterize the expected B-mode polarization due to gravitational lensing of
the CMB, and search for the possible B-mode signature of inflationary
gravitational waves. Its 250 mK focal plane detector array consists of 1,274
polarization-sensitive antenna-coupled bolometers, each with an associated
lithographed band-defining filter. Each detector's planar antenna structure is
coupled to the telescope's optical system through a contacting dielectric
lenslet, an architecture unique in current CMB experiments. We present the
initial characterization of this focal plane
Development and characterization of the readout system for POLARBEAR-2
POLARBEAR-2 is a next-generation receiver for precision measurements of the
polarization of the cosmic microwave background (Cosmic Microwave Background
(CMB)). Scheduled to deploy in early 2015, it will observe alongside the
existing POLARBEAR-1 receiver, on a new telescope in the Simons Array on Cerro
Toco in the Atacama desert of Chile. For increased sensitivity, it will feature
a larger area focal plane, with a total of 7,588 polarization sensitive
antenna-coupled Transition Edge Sensor (TES) bolometers, with a design
sensitivity of 4.1 uKrt(s). The focal plane will be cooled to 250 milliKelvin,
and the bolometers will be read-out with 40x frequency domain multiplexing,
with 36 optical bolometers on a single SQUID amplifier, along with 2 dark
bolometers and 2 calibration resistors. To increase the multiplexing factor
from 8x for POLARBEAR-1 to 40x for POLARBEAR-2 requires additional bandwidth
for SQUID readout and well-defined frequency channel spacing. Extending to
these higher frequencies requires new components and design for the LC filters
which define channel spacing. The LC filters are cold resonant circuits with an
inductor and capacitor in series with each bolometer, and stray inductance in
the wiring and equivalent series resistance from the capacitors can affect
bolometer operation. We present results from characterizing these new readout
components. Integration of the readout system is being done first on a small
scale, to ensure that the readout system does not affect bolometer sensitivity
or stability, and to validate the overall system before expansion into the full
receiver. We present the status of readout integration, and the initial results
and status of components for the full array.Comment: Presented at SPIE Astronomical Telescopes and Instrumentation 2014:
Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for
Astronomy VII. Published in Proceedings of SPIE Volume 915
Planck Intermediate Results. IV. The XMM-Newton validation programme for new Planck galaxy clusters
We present the final results from the XMM-Newton validation follow-up of new
Planck galaxy cluster candidates. We observed 15 new candidates, detected with
signal-to-noise ratios between 4.0 and 6.1 in the 15.5-month nominal Planck
survey. The candidates were selected using ancillary data flags derived from
the ROSAT All Sky Survey (RASS) and Digitized Sky Survey all-sky maps, with the
aim of pushing into the low SZ flux, high-z regime and testing RASS flags as
indicators of candidate reliability. 14 new clusters were detected by XMM,
including 2 double systems. Redshifts lie in the range 0.2 to 0.9, with 6
clusters at z>0.5. Estimated M500 range from 2.5 10^14 to 8 10^14 Msun. We
discuss our results in the context of the full XMM validation programme, in
which 51 new clusters have been detected. This includes 4 double and 2 triple
systems, some of which are chance projections on the sky of clusters at
different z. We find that association with a RASS-BSC source is a robust
indicator of the reliability of a candidate, whereas association with a FSC
source does not guarantee that the SZ candidate is a bona fide cluster.
Nevertheless, most Planck clusters appear in RASS maps, with a significance
greater than 2 sigma being a good indication that the candidate is a real
cluster. The full sample gives a Planck sensitivity threshold of Y500 ~ 4 10^-4
arcmin^2, with indication for Malmquist bias in the YX-Y500 relation below this
level. The corresponding mass threshold depends on z. Systems with M500 > 5
10^14 Msun at z > 0.5 are easily detectable with Planck. The newly-detected
clusters follow the YX-Y500 relation derived from X-ray selected samples.
Compared to X-ray selected clusters, the new SZ clusters have a lower X-ray
luminosity on average for their mass. There is no indication of departure from
standard self-similar evolution in the X-ray versus SZ scaling properties.
(abridged)Comment: accepted by A&
Component separation methods for the Planck mission
The Planck satellite will map the full sky at nine frequencies from 30 to 857
GHz. The CMB intensity and polarization that are its prime targets are
contaminated by foreground emission. The goal of this paper is to compare
proposed methods for separating CMB from foregrounds based on their different
spectral and spatial characteristics, and to separate the foregrounds into
components of different physical origin. A component separation challenge has
been organized, based on a set of realistically complex simulations of sky
emission. Several methods including those based on internal template
subtraction, maximum entropy method, parametric method, spatial and harmonic
cross correlation methods, and independent component analysis have been tested.
Different methods proved to be effective in cleaning the CMB maps from
foreground contamination, in reconstructing maps of diffuse Galactic emissions,
and in detecting point sources and thermal Sunyaev-Zeldovich signals. The power
spectrum of the residuals is, on the largest scales, four orders of magnitude
lower than that of the input Galaxy power spectrum at the foreground minimum.
The CMB power spectrum was accurately recovered up to the sixth acoustic peak.
The point source detection limit reaches 100 mJy, and about 2300 clusters are
detected via the thermal SZ effect on two thirds of the sky. We have found that
no single method performs best for all scientific objectives. We foresee that
the final component separation pipeline for Planck will involve a combination
of methods and iterations between processing steps targeted at different
objectives such as diffuse component separation, spectral estimation and
compact source extraction.Comment: Matches version accepted by A&A. A version with high resolution
figures is available at http://people.sissa.it/~leach/compsepcomp.pd
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