Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs

Search for the standard model Higgs boson decaying to a bbˉb\bar{b} pair in events with no charged leptons and large missing transverse energy using the full CDF data set

We report on a search for the standard model Higgs boson produced in association with a vector boson in the full data set of proton-antiproton collisions at $\sqrt{s} = 1.96$ TeV recorded by the CDF II detector at the Tevatron, corresponding to an integrated luminosity of 9.45 fb$^{-1}$. We consider events having no identified charged lepton, a transverse energy imbalance, and two or three jets, of which at least one is consistent with originating from the decay of a $b$ quark. We place 95% credibility level upper limits on the production cross section times standard model branching fraction for several mass hypotheses between 90 and $150 \mathrm{GeV}/c^2$. For a Higgs boson mass of $125 \mathrm{GeV}/c^2$, the observed (expected) limit is 6.7 (3.6) times the standard model prediction.Comment: Accepted by Phys. Rev. Let

On the Interference Alignment Designs for Secure Multiuser MIMO Systems

In this paper, we propose two secure multiuser multiple-input multiple-output transmission approaches based on interference alignment (IA) in the presence of an eavesdropper. To deal with the information leakage to the eavesdropper as well as the interference signals from undesired transmitters (Txs) at desired receivers (Rxs), our approaches aim to design the transmit precoding and receive subspace matrices to minimize both the total inter-main-link interference and the wiretapped signals (WSs). The first proposed IA scheme focuses on aligning the WSs into proper subspaces while the second one imposes a new structure on the precoding matrices to force the WSs to zero. When the channel state information is perfectly known at all Txs, in each proposed IA scheme, the precoding matrices at Txs and the receive subspaces at Rxs or the eavesdropper are alternatively selected to minimize the cost function of an convex optimization problem for every iteration. We provide the feasible conditions and the proofs of convergence for both IA approaches. The simulation results indicate that our two IA approaches outperform the conventional IA algorithm in terms of average secrecy sum rate.Comment: Updated version, updated author list, accepted to be appear in IEICE Transaction

Galactic and Cosmic Type Ia SN rates: is it possible to impose constraints on SNIa progenitors?

We compute the Type Ia supernova rates in typical elliptical galaxies by varying the progenitor models for Type Ia supernovae. To do that a formalism which takes into account the delay distribution function (DTD) of the explosion times and a given star formation history is adopted. Then the chemical evolution for ellipticals with baryonic initial masses $10^{10}$, $10^{11}$ and $10^{12} M_{\odot}$ is computed, and the mass of Fe produced by each galaxy is precisely estimated. We also compute the expected Fe mass ejected by ellipticals in typical galaxy clusters (e.g. Coma and Virgo), under different assumptions about Type Ia SN progenitors. As a last step, we compute the cosmic Type Ia SN rate in an unitary volume of the Universe by adopting several cosmic star formation rates and compare it with the available and recent observational data. Unfortunately, no firm conclusions can be derived only from the cosmic SNIa rate, neither on SNIa progenitors nor on the cosmic star formation rate. Finally, by analysing all our results together, and by taking into account previous chemical evolution results, we try to constrain the best Type Ia progenitor model. We conclude that the best progenitor models for Type Ia SNe are still the single degenerate model, the double degenerate wide model, and the empirical bimodal model. All these models require the existence of prompt Type Ia supernovae, exploding in the first 100 Myr since the beginning of star formation, although their fraction should not exceed 15-20% in order to fit chemical abundances in galaxies.Comment: 17 pages, 11 figures, Submitted to MNRA

Swift UVOT Grism Observations of Nearby Type Ia Supernovae - I. Observations and Data Reduction

Ultraviolet (UV) observations of Type Ia supernovae (SNe Ia) are useful tools for understanding progenitor systems and explosion physics. In particular, UV spectra of SNe Ia, which probe the outermost layers, are strongly affected by the progenitor metallicity. In this work, we present 120 Neil Gehrels Swift Observatory UV spectra of 39 nearby SNe Ia. This sample is the largest UV (lambda < 2900 A) spectroscopic sample of SNe Ia to date, doubling the number of UV spectra and tripling the number of SNe with UV spectra. The sample spans nearly the full range of SN Ia light-curve shapes (delta m(B) ~ 0.6-1.8 mag). The fast turnaround of Swift allows us to obtain UV spectra at very early times, with 13 out of 39 SNe having their first spectra observed >~ 1 week before peak brightness and the earliest epoch being 16.5 days before peak brightness. The slitless design of the Swift UV grism complicates the data reduction, which requires separating SN light from underlying host-galaxy light and occasional overlapping stellar light. We present a new data-reduction procedure to mitigate these issues, producing spectra that are significantly improved over those of standard methods. For a subset of the spectra we have nearly simultaneous Hubble Space Telescope UV spectra; the Swift spectra are consistent with these comparison data.Comment: Accepted for publication in MNRA