2,198 research outputs found
Artroplastia total de cadera Mittelmeier: estudio multicéntrico
—Hemos revisado 150 artroplastias de Mittelmeier implantadas hasta 1987 en
tres hospitales. El periodo de seguimiento medio ha sido de 12,5 años (límites: 8-15). Entre las
complicaciones inmediatas aparecieron dos infecciones profundas y cinco luxaciones. El 16%
presentaron malos resultados clínicos y el 26% refieren dolor en el muslo. En el vástago femoral
se apreció en 33 casos una esclerosis reactiva distal y en 69 se produjo algún grado de hundimiento.
Fueron reintervenidos el 18% de los pacientes; en ocho por movilizaciones del
vástago y en cuatro por deslizamientos cotiloideos. La artroplastia de Mittelmeier en evaluaciones
a largo plazo presenta un elevado número de complicaciones sobre todo a nivel femoral lo
que desaconseja su utilización.We have reviewed 150 arthroplasties of Mittelmeier implanted until 1987 in
three hospitals. The mean follow-up has been 12,5 years (range: 8-15). Among the inmediate
complications appeared two deep infections and five dislocations. A 16% of cases presented
poor clinical results and 26% referred pain in the thigh. Distal sclerosis at the femoral stem
was appreciated in 33 cases and in 69 some degree of collapse was produced. In 18% of the
patients was necessary revision surgery; in eight by mobilizations of the stem and in four by
socket displacements. The arthroplasty of Mittelmeier in long-term follow-up presents a high
number of complications above all at femoral level what dissuades their utilization
Evaluation of synthesis time in the growth of vertical-aligned MWCNTs by spray pyrolysis
Multi-Wall Carbon Nanotubes (MWCNTs) were analyzed on crystalline silicon substrates (type P) under optimal temperature conditions, using different synthesis times (2, 3, 4, 5, 10, 20, 30, 60, 120, and 180 min) in order to examine the effect on the structural quality and length of the CNTs produced by ultrasonic spray pyrolysis, using pure toluene and ferrocene as precursor solutions under argon flow. Structural, optical, and morphological differences of the MWCNTs grown were analyzed. Raman spectroscopy evidenced the MWCNTs' high quality, noted by the ID/IG (from 0.41 to 0.68) and I2D/IG intensity ratios around 0.75. Morphological differences of the MWCNTs grow evaluated by Field Emission Scanning Electron Microscopy (FE-SEM); the micrographs examined the thickness of CNTs' layers. High-Resolution Transmission Electron Microscopy (HRTEM) technique was used to determine the diameters of CNTs, which were found from 15 to 140 nm. X-Ray Diffraction (XRD) showed two characteristic peaks around 26° and 44°, which corroborated that the MWCNTs were well-graphitized. The influence of the time in these CNTs demonstrated that the final length of these nanotubes could easily reach micrometers. The alienation was better as time increased, and the graphitization extent is good in most cases compared to other more expensive synthesis methods.We thank Technician Adrian Gómez Herrero, Technician Cristina Moral Gil and Hugo Solera for the TEM, SEM and Raman characterization, respectively. This work has been supported by the thematic network "Nanostructure advanced materials and applications in Mexico" between Spain and Mexico sponsoring this international collaboration. This work has been financially supported by Comunidad de Madrid, Spain (S2018/NMT-4411) and Ministry of Economia, Industría y Competividad (PID2019-106631GB-C43)
Docker security in web simulation tools: a layered approach
International Conference on Wireless Networks and Mobile Communication (EUIWNMC), 26/08/2021-27/08/2021, Marrakesh, Marruecos.In this work, container security issues and strengths are studied using Docker as the main implementation. First,
the container infrastructure is described and compared against the traditional approach of virtual machines. Secondly, the
Docker containers security is discussed by the different infrastructure layers that compose them and different solutions are
proposed to try to decrease the attack surface over this kind of applications.Universidad de Alcal
Identifying and preventing burnout in young oncologists, an overwhelming challenge in the COVID-19 era: a study of the Spanish Society of Medical Oncology (SEOM)
COVID-19; Esgotament professional; Oncòlegs jovesCOVID-19; Agotamiento profesional; Oncólogos jóvenesCOVID-19; Professional burnout; Young oncologistsBackground
Young oncologists are at particular risk of professional burnout, and this could have a significant impact on their health and care of their patients. The coronavirus disease 2019 (COVID-19) pandemic has forced rapid changes in professionals' jobs and training, with the consequent physical and psychological effects. We aimed to characterize burnout levels and determinants in young oncologists, and the effects of the pandemic on their training and health.
Methods
Two online surveys were conducted among oncology residents and young oncology specialists in Spain. The first addressed professional burnout and its determinants before the COVID-19 pandemic, while the second analyzed the impact of the pandemic on health care organization, training, and physical and psychological health in the same population.
Results
In total, 243 respondents completed the first survey, and 263 the second; 25.1% reported significant levels of professional burnout. Burnout was more common among medical oncology residents (28.2%), mainly in their second year of training. It was significantly associated with a poor work–life balance, inadequate vacation time, and the burnout score. Nearly three-quarters of respondents (72%) were reassigned to COVID-19 care and 84.3% of residents missed part of their training rotations. Overall, 17.2% of this population reported that they had contracted COVID-19, 37.3% had scores indicating anxiety, and 30.4% moderate to severe depression. Almost a quarter of young oncologists (23.3%) had doubts about their medical vocation.
Conclusions
Burnout affects a considerable number of young oncologists. The COVID-19 pandemic has had a profound impact on causes of burnout, making it even more necessary to periodically monitor it to define appropriate detection and prevention strategies.This project received funding from the Spanish Society of Medical Oncology (SEOM)
The ALHAMBRA Survey: Bayesian Photometric Redshifts with 23 bands for 3 squared degrees
The ALHAMBRA (Advance Large Homogeneous Area Medium Band Redshift
Astronomical) survey has observed 8 different regions of the sky, including
sections of the COSMOS, DEEP2, ELAIS, GOODS-N, SDSS and Groth fields using a
new photometric system with 20 contiguous ~ filters covering the
optical range, combining them with deep imaging. The observations,
carried out with the Calar Alto 3.5m telescope using the wide field (0.25 sq.
deg FOV) optical camera LAICA and the NIR instrument Omega-2000, correspond to
~700hrs on-target science images. The photometric system was designed to
maximize the effective depth of the survey in terms of accurate spectral-type
and photo-zs estimation along with the capability of identification of
relatively faint emission lines. Here we present multicolor photometry and
photo-zs for ~438k galaxies, detected in synthetic F814W images, complete down
to I~24.5 AB, taking into account realistic noise estimates, and correcting by
PSF and aperture effects with the ColorPro software. The photometric ZP have
been calibrated using stellar transformation equations and refined internally,
using a new technique based on the highly robust photometric redshifts measured
for emission line galaxies. We calculate photometric redshifts with the BPZ2
code, which includes new empirically calibrated templates and priors. Our
photo-zs have a precision of for I<22.5 and 1.4% for
22.5<I<24.5. Precisions of less than 0.5% are reached for the brighter
spectroscopic sample, showing the potential of medium-band photometric surveys.
The global shows a mean redshift =0.56 for I=0.86 for
I<24.5 AB. The data presented here covers an effective area of 2.79 sq. deg,
split into 14 strips of 58.5'x15.5' and represents ~32 hrs of on-target.Comment: The catalog data and a full resolution version of this paper is
available at https://cloud.iaa.csic.es/alhambra
MILP method for objective reduction in multi-objective optimization
A procedure for reducing objectives in a multi-objective optimization problem given a set of Pareto solutions is presented. Three different models are detailed, which achieve three different degrees of objective reduction. These models are based on maintaining the dominance structure of the problem. To compare the performance of the proposed models, these are tested with pure mathematical cases and with actual data from previous works in the field of multi-objective optimization. The first model provides the reduced subset of objectives that do not alter the dominance structure of the problem at all. The second model determines the minimum subset of objectives that alters the dominance structure with an upper predefined limit for the error. The last model provides the subset of objectives with a previously defined cardinality, which achieves the minimum error. The possibility of different inputs introduces flexibility into the models, which accounts for the preferences of the decision-maker.The authors acknowledge financial support from the Spanish “Ministerio de Economía, Industria y Competitividad” (CTQ2016-77968-C3-2-P, AEI/FEDER, UE)
Mapping photodissociation and shocks in the vicinity of Sgr A*
We have obtained maps of the molecular emission within the central five
arcminutes (12 pc) of the Galactic center (GC) in selected molecular tracers:
SiO(2-1), HNCO(5_{0,5}-4_{0,4}), and the J=1-->0 transition of H^{13}CO+,
HN^{13}C, and C^{18}O at an angular resolution of 30" (1.2 pc). The mapped
region includes the circumnuclear disk (CND) and the two surrounding giant
molecular clouds (GMCs) of the Sgr A complex, known as the 20 and 50 km s^{-1}
molecular clouds.Additionally, we simultaneously observed the J=2-1 and 3-2
transitions of SiO toward selected positions to estimate the physical
conditions of the molecular gas. The SiO(2-1) and H^{13}CO+(1-0) emission
covers the same velocity range and presents a similar distribution. In
contrast, HNCO(5-4) emission appears in a narrow velocity range mostly
concentrated in the 20 and 50 km s^{-1} GMCs. The HNCO column densities and
fractional abundances present the highest contrast, with difference factors of
60 and 28, respectively. Their highest values are found toward the cores
of the GMCs, whereas the lowest ones are measured at the CND. SiO abundances do
not follow this trend, with high values found toward the CND, as well as the
GMCs. By comparing our abundances with those of prototypical Galactic sources
we conclude that HNCO, similar to SiO, is ejected from grain mantles into
gas-phase by nondissociative C-shocks. This results in the high abundances
measured toward the CND and the GMCs. However, the strong UV radiation from the
Central cluster utterly photodissociates HNCO as we get closer to the center,
whereas SiO seems to be more resistant against UV-photons or it is produced
more efficiently by the strong shocks in the CND. Finally, we discuss the
possible connections between the molecular gas at the CND and the GMCs using
the HNCO/SiO, SiO/CS, and HNCO/CS intensity ratios as probes of distance to the
Central cluster.Comment: 26 pages plus 2 appendixes with additional figures. 17 figures in
total. Accepted for publication in A&
Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism
[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders;
therefore, topical administration may be an attractive alternative to the management of local pain in order to
avoid these side effects. However, previous studies have shown that DCF, in combination with sunlight, displays
capability to induce photosensitivity disorders. In humans, DCF is biotransformed into hydroxylated metabolites
at positions 4¿ and 5 (4¿OH-DCF and 5OH-DCF), and this chemical change produces non negligible alterations of
the drug chromophore, resulting in a significant modification of its light-absorbing properties. In the present
work, 5OH-DCF exhibited higher photo(geno)toxic potential than the parent drug, as shown by several in vitro
assays (3T3 NRU phototoxicity, DNA ssb gel electrophoresis and COMET), whereas 4¿OH-DCF did not display
significant photo(geno)toxicity. This could be associated, at least partially with their more efficient UV-light
absorption by 5OH-DCF metabolite and with a higher photoreactivity. Interestingly, most of the cellular DNA
damage photosensitized by DCF and 5OH-DCF was repaired by the cells after several hours, although this effect
was not complete in the case of 5OH-DCF.This work was supported by the Carlos III Institute of Health (Grants: RD16/0006/0030, PI16/01877), by the MINECO (Grants: CTQ2013-47872, CTQ2016-78875), and by the Generalitat Valenciana (Prometeo 2017/075).García -Laínez, G.; Ana M Marínez-Reig; Limones Herrero, D.; Jiménez Molero, MC.; Miranda Alonso, MÁ.; Andreu Ros, MI. (2018). Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism. Toxicology and Applied Pharmacology. 341:51-55. https://doi.org/10.1016/j.taap.2018.01.005S515534
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