Clustering on very small scales from a large sample of confirmed quasar pairs: Does quasar clustering track from Mpc to kpc scales?

We present the most precise estimate to date of the clustering of quasars on very small scales, based on a sample of 47 binary quasars with magnitudes of $g<20.85$ and proper transverse separations of $\sim 25\,h^{-1}$\,kpc. Our sample of binary quasars, which is about 6 times larger than any previous spectroscopically confirmed sample on these scales, is targeted using a Kernel Density Estimation technique (KDE) applied to Sloan Digital Sky Survey (SDSS) imaging over most of the SDSS area. Our sample is "complete" in that all of the KDE target pairs with $17.0 \lesssim R \lesssim 36.2\,h^{-1}$\,kpc in our area of interest have been spectroscopically confirmed from a combination of previous surveys and our own long-slit observational campaign. We catalogue 230 candidate quasar pairs with angular separations of <8\arcsec, from which our binary quasars were identified. We determine the projected correlation function of quasars ($\bar W_{\rm p}$) in four bins of proper transverse scale over the range $17.0 \lesssim R \lesssim 36.2\,h^{-1}$\,kpc. The implied small-scale quasar clustering amplitude from the projected correlation function, integrated across our entire redshift range, is $A=24.1\pm3.6$ at $\sim 26.6 ~h^{-1}$\,kpc. Our sample is the first spectroscopically confirmed sample of quasar pairs that is sufficiently large to study how quasar clustering evolves with redshift at $\sim 25 ~h^{-1}$ kpc. We find that empirical descriptions of how quasar clustering evolves with redshift at $\sim 25 ~h^{-1}$ Mpc also adequately describe the evolution of quasar clustering at $\sim 25 ~h^{-1}$ kpc.Comment: 16 pages, 8 figures, 6 tables, Accepted for publication in MNRA

The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer�s disease

Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of � amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer�s disease in rat model. © 2015, Iranian Journal of Basic Medical Sciences. All rights reserved

Quasars at intermediate redshift are not special; but they are often satellites

Understanding the links between the activity of supermassive black holes (SMBH) at the centres of galaxies and their host dark matter haloes is a key question in modern astrophysics. The final data release of the SDSS-IV eBOSS provides the largest contemporary spectroscopic sample of galaxies and QSOs. Using this sample and covering the redshift interval $z=0.7-1.1$, we have measured the clustering properties of the eBOSS QSOs, Emission Line Galaxies (ELGs) and Luminous Red Galaxies (LRGs). We have also measured the fraction of QSOs as a function of the overdensity defined by the galaxy population. Using these measurements, we investigate how QSOs populate and sample the galaxy population, and how the host dark-matter haloes of QSOs sample the underlying halo distribution. We find that the probability of a galaxy hosting a QSO is independent of the host dark matter halo mass of the galaxy. We also find that about 60\% of eBOSS QSOs are hosted by LRGs and about 20-40\% of QSOs are hosted by satellite galaxies. We find a slight preference for QSOs to populate satellite galaxies over central galaxies. This is connected to the host halo mass distribution of different types of galaxies. Based on our analysis, QSOs should be hosted by a very broad distribution of haloes, and their occurrence should be modulated only by the efficiency of galaxy formation processes.Comment: 15 pages, 6 Figures, Data and code from this analysis is available at https://www.roe.ac.uk/~salam/GQOD/ , submitted to MNRAS, comments and suggestions are welcom

Remarks on the Formulation of Quantum Mechanics on Noncommutative Phase Spaces

We consider the probabilistic description of nonrelativistic, spinless one-particle classical mechanics, and immerse the particle in a deformed noncommutative phase space in which position coordinates do not commute among themselves and also with canonically conjugate momenta. With a postulated normalized distribution function in the quantum domain, the square of the Dirac delta density distribution in the classical case is properly realised in noncommutative phase space and it serves as the quantum condition. With only these inputs, we pull out the entire formalisms of noncommutative quantum mechanics in phase space and in Hilbert space, and elegantly establish the link between classical and quantum formalisms and between Hilbert space and phase space formalisms of noncommutative quantum mechanics. Also, we show that the distribution function in this case possesses 'twisted' Galilean symmetry.Comment: 25 pages, JHEP3 style; minor changes; Published in JHE

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential therapeutic targets for these pathologies there is great interest in characterizing the conformations that they adopt and in understanding how their aggregation behavior is influenced by the sequences flanking them. We used solution NMR to study at single-residue resolution a 156-residue proteolytic fragment of the androgen receptor that contains a polyQ tract associated with the disease spinobulbar muscular atrophy, also known as Kennedy disease. Our findings indicate that a Leu-rich region preceding the polyQ tract causes it to become α-helical and appears to protect the protein against aggregation, which represents a new, to our knowledge, mechanism by which sequence context can minimize the deleterious properties of these repetitive regions. Our results have implications for drug discovery for polyQ diseases because they suggest that the residues flanking these repetitive sequences may represent viable therapeutic targets

Noise kernel for a quantum field in Schwarzschild spacetime under the Gaussian approximation

A method is given to compute an approximation to the noise kernel, defined as the symmetrized connected 2-point function of the stress tensor, for the conformally invariant scalar field in any spacetime conformal to an ultra-static spacetime for the case in which the field is in a thermal state at an arbitrary temperature. The most useful applications of the method are flat space where the approximation is exact and Schwarzschild spacetime where the approximation is better than it is in most other spacetimes. The two points are assumed to be separated in a timelike or spacelike direction. The method involves the use of a Gaussian approximation which is of the same type as that used by Page to compute an approximate form of the stress tensor for this field in Schwarzschild spacetime. All components of the noise kernel have been computed exactly for hot flat space and one component is explicitly displayed. Several components have also been computed for Schwarzschild spacetime and again one component is explicitly displayed.Comment: 34 pages, no figures. Substantial revisions in Secs. I, IV, and V; minor revisions elsewhere; new results include computation of the exact noise kernel for hot flat space and an approximate computation of the noise kernel for a thermal state at an arbitrary temperature in Schwarzschild spacetime when the points are split in the time directio

Exponentially growing bubbles around early super massive black holes

We addressed the so far unexplored issue of outflows induced by exponentially growing power sources, focusing on early supermassive black holes (BHs). We assumed that these objects grow to $10^9\;M_{\odot}$ by z=6 by Eddington-limited accretion and convert 5% of their bolometric output into a wind. We first considered the case of energy-driven and momentum-driven outflows expanding in a region where the gas and total mass densities are uniform and equal to the average values in the Universe at $z>6$. We derived analytic solutions for the evolution of the outflow, finding that, for an exponentially growing power with e-folding time $t_{Sal}$, the late time expansion of the outflow radius is also exponential, with e-folding time of $5t_{Sal}$ and $4t_{Sal}$ in the energy-driven and momentum-driven limit, respectively. We then considered energy-driven outflows produced by QSOs at the center of early dark matter halos of different masses and powered by BHs growing from different seeds. We followed the evolution of the source power and of the gas and dark matter density profiles in the halos from the beginning of the accretion until $z=6$. The final bubble radius and velocity do not depend on the seed BH mass but are instead smaller for larger halo masses. At z=6, bubble radii in the range 50-180 kpc and velocities in the range 400-1000 km s$^{-1}$ are expected for QSOs hosted by halos in the mass range $3\times10^{11}-10^{13}\;M_{\odot}$. By the time the QSO is observed, we found that the total thermal energy injected within the bubble in the case of an energy-driven outflow is $E_{th}\sim5 \times 10^{60}$ erg. This is in excellent agreement with the value of $E_{th}=(6.2\pm 1.7)\times 10^{60}$ erg measured through the detection of the thermal Sunyaev-Zeldovich effect around a large population of luminous QSOs at lower redshift. [abridged]Comment: 17 pages and 14 figures. Typos corrected. It matches the version published in A&

The Sloan Digital Sky Survey Reverberation Mapping Project: Technical Overview

The Sloan Digital Sky Survey Reverberation Mapping project (SDSS-RM) is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg$^2$ field with the SDSS-III BOSS spectrograph. The RM quasar sample is flux-limited to i_psf=21.7 mag, and covers a redshift range of 0.1<z<4.5. Optical spectroscopy was performed during 2014 Jan-Jul dark/grey time, with an average cadence of ~4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bands was conducted at multiple facilities including the CFHT and the Steward Observatory Bok telescopes in 2014, with a cadence of ~2 days and covering all lunar phases. The RM field (RA, DEC=14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM 6-month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ~10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z>0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science.Comment: 25 pages, submitted to ApJS; project website at http://www.sdssrm.or