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The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer�s disease
Authors
A. Alizadeh
B. Behnam
+7 more
M. Eftekharzadeh
M. Hajghasem
M. Nobakht
N.K. Osguei
A. Samadikuchaksaraei
B.K. Shargh
M. Soleimani
Publication date
1 January 2015
Publisher
Abstract
Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of � amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer�s disease in rat model. © 2015, Iranian Journal of Basic Medical Sciences. All rights reserved
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Last time updated on 10/10/2019