A nanoflare model of quiet Sun EUV emission

Nanoflares have been proposed as the main source of heating of the solar corona. However, detecting them directly has so far proved elusive, and extrapolating to them from the properties of larger brightenings gives unreliable estimates of the power-law exponent $\alpha$ characterising their distribution. Here we take the approach of statistically modelling light curves representative of the quiet Sun as seen in EUV radiation. The basic assumption is that all quiet-Sun EUV emission is due to micro- and nanoflares, whose radiative energies display a power-law distribution. Radiance values in the quiet Sun follow a lognormal distribution. This is irrespective of whether the distribution is made over a spatial scan or over a time series. We show that these distributions can be reproduced by our simple model.Comment: 13 pages, 18 figures, accepted for publication by A&

The VLA-COSMOS Survey: V. 324 MHz continuum observations

We present 90 cm VLA imaging of the COSMOS field, comprising a circular area of 3.14 square degrees at 8.0"x6.0" angular resolution with an average rms of 0.5 mJy/beam. The extracted catalog contains 182 sources (down to 5.5sigma), 30 of which are multi-component sources. Using Monte Carlo artificial source simulations we derive the completeness of the catalog, and we show that our 90 cm source counts agree very well with those from previous studies. Using X-ray, NUV-NIR and radio COSMOS data to investigate the population mix of our 90 cm radio sample, we find that our sample is dominated by active galactic nuclei (AGN). The average 90-20 cm spectral index (S_nu~nu**alpha, where S_nu is the flux density at frequency nu, and alpha the spectral index) of our 90 cm selected sources is -0.70, with an interquartile range of -0.90 to -0.53. Only a few ultra-steep-spectrum sources are present in our sample, consistent with results in the literature for similar fields. Our data do not show clear steepening of the spectral index with redshift. Nevertheless, our sample suggests that sources with spectral indices steeper than -1 all lie at z>1, in agreement with the idea that ultra-steep-spectrum radio sources may trace intermediate-redshift galaxies (z>1).Comment: 10 pages, 12 figures, accepted for publication in MNRA

Energy Distribution of Micro-events in the Quiet Solar Corona

Recent imaging observations of EUV line emissions have shown evidence for frequent flare-like events in a majority of the pixels in quiet regions of the solar corona. The changes in coronal emission measure indicate impulsive heating of new material to coronal temperatures. These heating or evaporation events are candidate signatures of "nanoflares" or "microflares" proposed to interpret the high temperature and the very existence of the corona. The energy distribution of these micro-events reported in the literature differ widely, and so do the estimates of their total energy input into the corona. Here we analyze the assumptions of the different methods, compare them by using the same data set and discuss their results. We also estimate the different forms of energy input and output, keeping in mind that the observed brightenings are most likely secondary phenomena. A rough estimate of the energy input observed by EIT on the SoHO satellite is of the order of 10% of the total radiative output in the same region. It is considerably smaller for the two reported TRACE observations. The discrepancy can be explained partially by different thresholds for flare detection. There is agreement on the slope and the absolute value of the distribution if the same method were used and a numerical error corrected. The extrapolation of the power law to unobserved energies that are many orders of magnitude smaller remains questionable. Nevertheless, these micro-events and unresolved smaller events are currently the best source of information on the heating process of the corona

Endovascular control of haemorrhagic urological emergencies: an observational study

BACKGROUND: Transarterial embolisation (TAE) is an effective method in control of haemorrhage irrespective of the nature of urological emergency. As the technique and technology have evolved, it is now possible to perform highly selective embolisation. The aim of this study was to critically appraise feasibility and efficacy of therapeutic TAE in control of haemorrhagic urological emergencies using selective and non-selective embolisation. Specifically, we aimed to assess the impact of timing of embolisation on the requirement of blood transfusion and long-term morphological and functional follow-up of embolised organs. METHODS: This is a single institutional observational study carried out between March 1992 and March 2006. Records of all patients who underwent selective and non-selective angioembolisation to control bleeding in urological emergencies were reviewed. Data on success rate, periprocedural complications, timing of embolisation, requirement of blood transfusion and the long-term morphological and functional outcomes of embolised organs was recorded. RESULTS: Fourteen patients underwent endovascular control of bleeding as a result of trauma, iatrogenic injury and spontaneous perinephric haemorrhage during a period of 14 years. All these patients would have required emergency open surgery without the option of embolisation procedure. The mean time between the first presentation and embolisation was 22 hours (range 30 minutes to 60 hours). Mean pre-embolisation transfusion requirement was 6.8 units (range 0–22 units). None of the patients with successful embolisation required post-procedural blood transfusion. Permanent haemostasis was achieved in all but one patient, who required emergency nephrectomy. There were no serious procedure related post-embolisation complications. CONCLUSION: Endovascular control using transarterial angioembolisation is an effective method for managing haematuria or haemorrhage in urological emergencies. Wherever and whenever indicated, this option should be considered early in the management of these cases

HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomas

Angiogenic switch marks the beginning of tumor’s strategy to acquire independent blood supply. In some subtypes of non-Hodgkin’s lymphomas, higher local vascular endothelial growth factor (VEGF) expression correlates with increased microvessel density. However, this local VEGF expression is higher only in tumors with elevated expression of the receptors of the growth factor, suggesting an autocrine growth-promoting feedback loop. Several studies have indicated that VEGF receptors are also targeted by Tat protein from the HIV-1-infected cells. Given the similarity of the basic region of Tat to the angiogenic factors (basic fibroblast growth factor, VEGF), Tat mimics these proteins and binds to their receptors. We evaluated the role of HIV-1 Tat in regulating the level of VEGF expression and microvessel density in the AIDS-related diffuse large B-cell (DLBCL) and Burkitt lymphomas (BL). By luciferase assay, we showed that VEGF promoter activity was downregulated in vitro in cells transfected with Tat. Reduced VEGF protein expression in primary HIV-1 positive BL and DLBCL, compared to the negative cases, supported the findings of promoter downregulation from the cell lines. Microvascular density assessed by CD34 expression was, however, higher in HIV-1 positive than in HIV-1 negative tumors. These results suggest that Tat has a wider angiogenic role, besides the regulation of VEGF expression. Thus, targeting Tat protein itself and stabilizing transient silencing of VEGF expression or use of monoclonal antibodies against their receptors in the AIDS-associated tumors will open a window for future explorable pathways in the management of angiogenic phenotypes in the AIDS-associated non-Hodgkin’s lymphomas

Real-Time Visualization and Quantitation of Vascular Permeability In Vivo: Implications for Drug Delivery

The leaky, heterogeneous vasculature of human tumors prevents the even distribution of systemic drugs within cancer tissues. However, techniques for studying vascular delivery systems in vivo often require complex mammalian models and time-consuming, surgical protocols. The developing chicken embryo is a well-established model for human cancer that is easily accessible for tumor imaging. To assess this model for the in vivo analysis of tumor permeability, human tumors were grown on the chorioallantoic membrane (CAM), a thin vascular membrane which overlays the growing chick embryo. The real-time movement of small fluorescent dextrans through the tumor vasculature and surrounding tissues were used to measure vascular leak within tumor xenografts. Dextran extravasation within tumor sites was selectively enhanced an interleukin-2 (IL-2) peptide fragment or vascular endothelial growth factor (VEGF). VEGF treatment increased vascular leak in the tumor core relative to surrounding normal tissue and increased doxorubicin uptake in human tumor xenografts. This new system easily visualizes vascular permeability changes in vivo and suggests that vascular permeability may be manipulated to improve chemotherapeutic targeting to tumors

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.

The vascular endothelial growth factor (VEGF) isoform VEGF165 stimulates vascular growth and hyperpermeability. Whereas blood vessel growth is essential to sustain organ health, chronic hyperpermeability causes damaging tissue edema. By combining in vivo and tissue culture models, we show here that VEGF165-induced vascular leakage requires both VEGFR2 and NRP1, including the VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interactor GIPC1. In the VEGF165-bound receptor complex, the NCD promotes ABL kinase activation, which in turn is required to activate VEGFR2-recruited SRC family kinases (SFKs). These results elucidate the receptor complex and signaling hierarchy of downstream kinases that transduce the permeability response to VEGF165. In a mouse model with choroidal neovascularisation akin to age-related macular degeneration, NCD loss attenuated vessel leakage without affecting neovascularisation. These findings raise the possibility that targeting NRP1 or its NCD interactors may be a useful therapeutic strategy in neovascular disease to reduce VEGF165-induced edema without compromising vessel growth

Interplane cross-saturation in multiphase machines

The use of electrical machines in electric vehicles and high-power drives frequently requires multiphase machines and multiphase inverters. While appropriate mathematical models under the linear magnetic conditions are readily available for multiphase machines, the same cannot be said for the models of the saturated multiphase machines. This paper examines the saturation in an asymmetrical six-phase induction machine under different supply conditions and addresses the applicability of the existing saturated three-phase machine models for representation of saturated multiphase machines. Specifically, the mutual coupling between different sequence planes in the vector space decomposed model under saturated conditions is analyzed. The paper relies on analytical considerations, finite element analysis and experimental results. It is shown that the saturation of the main flux path is influenced by the current components in the orthogonal (non-fundamental) sequence plane. This implies the need to develop new multiphase machine models which take this effect into account