44,430,829 research outputs found
Dilution of seawater affects the Ca2 + transport in the outer mantle epithelium of crassostrea gigas
Varying salinities of coastal waters are likely to affect the physiology and ion transport capabilities of calcifying marine organisms such as bivalves. To investigate the physiological effect of decreased environmental salinity in bivalves, adult oysters (Crassostrea gigas) were exposed for 14 days to 50% seawater (14) and the effects on mantle ion transport, electrophysiology and the expression of Ca2+ transporters and channels relative to animals maintained in full strength sea water (28) was evaluated. Exposure of oysters to a salinity of 14 decreased the active mantle transepithelial ion transport and specifically affected Ca2+ transfer. Gene expression of the Na+/K+-ATPase and the sarco(endo)plasmic reticulum Ca2+-ATPase was decreased whereas the expression of the T-type voltage-gated Ca channel and the Na+/Ca2+-exchanger increased compared to animals maintained in full SW. The results indicate that decreased environmental salinities will most likely affect not only osmoregulation but also bivalve biomineralization and shell formation.Funding Agency
European Union (EU)
605051
Swedish Mariculture Research Center, SWEMARC, University of Gothenburg
Herbert & Karin Jacobssons Stiftelse
15/h17
Helge Ax:son Johnsons Stiftelse
F18-0128
Portuguese Foundation for Science and Technology
UID/Multi/04326/2019
Portuguese Foundation for Science and Technology
UID/Multi/04326/2019
FCT, under the "Norma Transitoria"
DL57/2016/CP1361/CT0020
DL57/2016/CP1361/CT0011info:eu-repo/semantics/publishedVersio
Motor control retraining exercises for shoulder impingement: effects on function, muscle activation, and biomechanics in young adults
Objective: Evidence for effective management of shoulder impingement is limited. The present study aimed to quantify the clinical, neurophysiological, and biomechanical effects of a scapular motor control retraining for young individuals with shoulder impingement signs.Method: Sixteen adults with shoulder impingement signs (mean age 22 ? 1.6 years) underwent the intervention and 16 healthy participants (24.8 ? 3.1years) provided reference data. Shoulder function and pain were assessed using the Shoulder Pain and Disability Index (SPADI) and other questionnaires. Electromyography (EMG) and 3 dimensional motion analysis was used to record muscle activation and kinematic data during arm elevation to 90? and lowering in 3 planes. Patients were assessed pre and post a 10-week motor control based intervention, utilizing scapular orientation retraining.Results: Pre-intervention, patients reported pain and reduced function compared to the healthy participants (SPADI in patients 20 ? 9.2; healthy 0 ? 0). Post intervention, the SPADI scores reduced significantly (P < .001) by a mean of 10 points (?4). EMG showed delayed onset and early termination of serratus anterior and lower trapezius muscle activity pre-intervention, which improved significantly post-intervention (P < .05). Pre intervention, patients exhibited on average 4.6-7.4? less posterior tilt, which was significantly lower in 2 arm elevation planes (P < .05) than healthy participants. Postintervention, upward rotation and posterior tilt increased significantly (P <.05) during 2 arm movements, approaching the healthy values.Conclusion: A 10-week motor control intervention for shoulder impingement increased function and reduced pain. Recovery mechanisms were indicated by changes in muscle recruitment andscapular kinematics. The efficacy of the intervention requires further examined in a randomizedcontrol trial
On Approximating the Number of -cliques in Sublinear Time
We study the problem of approximating the number of -cliques in a graph
when given query access to the graph.
We consider the standard query model for general graphs via (1) degree
queries, (2) neighbor queries and (3) pair queries. Let denote the number
of vertices in the graph, the number of edges, and the number of
-cliques. We design an algorithm that outputs a
-approximation (with high probability) for , whose
expected query complexity and running time are
O\left(\frac{n}{C_k^{1/k}}+\frac{m^{k/2}}{C_k}\right)\poly(\log
n,1/\varepsilon,k).
Hence, the complexity of the algorithm is sublinear in the size of the graph
for . Furthermore, we prove a lower bound showing that
the query complexity of our algorithm is essentially optimal (up to the
dependence on , and ).
The previous results in this vein are by Feige (SICOMP 06) and by Goldreich
and Ron (RSA 08) for edge counting () and by Eden et al. (FOCS 2015) for
triangle counting (). Our result matches the complexities of these
results.
The previous result by Eden et al. hinges on a certain amortization technique
that works only for triangle counting, and does not generalize for larger
cliques. We obtain a general algorithm that works for any by
designing a procedure that samples each -clique incident to a given set
of vertices with approximately equal probability. The primary difficulty is in
finding cliques incident to purely high-degree vertices, since random sampling
within neighbors has a low success probability. This is achieved by an
algorithm that samples uniform random high degree vertices and a careful
tradeoff between estimating cliques incident purely to high-degree vertices and
those that include a low-degree vertex
The tongue, the mouth and safeguard of freedom: towards a governmental reading of Vondel’s Palamedes (1625)
Quantum singular value transformation and beyond: exponential improvements for quantum matrix arithmetics
Quantum computing is powerful because unitary operators describing the
time-evolution of a quantum system have exponential size in terms of the number
of qubits present in the system. We develop a new "Singular value
transformation" algorithm capable of harnessing this exponential advantage,
that can apply polynomial transformations to the singular values of a block of
a unitary, generalizing the optimal Hamiltonian simulation results of Low and
Chuang. The proposed quantum circuits have a very simple structure, often give
rise to optimal algorithms and have appealing constant factors, while usually
only use a constant number of ancilla qubits. We show that singular value
transformation leads to novel algorithms. We give an efficient solution to a
certain "non-commutative" measurement problem and propose a new method for
singular value estimation. We also show how to exponentially improve the
complexity of implementing fractional queries to unitaries with a gapped
spectrum. Finally, as a quantum machine learning application we show how to
efficiently implement principal component regression. "Singular value
transformation" is conceptually simple and efficient, and leads to a unified
framework of quantum algorithms incorporating a variety of quantum speed-ups.
We illustrate this by showing how it generalizes a number of prominent quantum
algorithms, including: optimal Hamiltonian simulation, implementing the
Moore-Penrose pseudoinverse with exponential precision, fixed-point amplitude
amplification, robust oblivious amplitude amplification, fast QMA
amplification, fast quantum OR lemma, certain quantum walk results and several
quantum machine learning algorithms. In order to exploit the strengths of the
presented method it is useful to know its limitations too, therefore we also
prove a lower bound on the efficiency of singular value transformation, which
often gives optimal bounds.Comment: 67 pages, 1 figur
Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays.
Campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, but source attribution of the organism is difficult. Previously, DNA microarrays were used to investigate isolate source, which suggested a non-livestock source of infection. In this study we analysed the genome content of 162 clinical, livestock and water and wildlife (WW) associated isolates combined with the previous study. Isolates were grouped by genotypes into nine clusters (C1 to C9). Multilocus sequence typing (MLST) data demonstrated that livestock associated clonal complexes dominated clusters C1-C6. The majority of WW isolates were present in the C9 cluster. Analysis of previously reported genomic variable regions demonstrated that these regions were linked to specific clusters. Two novel variable regions were identified. A six gene multiplex PCR (mPCR) assay, designed to effectively differentiated strains into clusters, was validated with 30 isolates. A further five WW isolates were tested by mPCR and were assigned to the C7-C9 group of clusters. The predictive mPCR test could be used to indicate if a clinical case has come from domesticated or WW sources. Our findings provide further evidence that WW C. jejuni subtypes show niche adaptation and may be important in causing human infection
Electronic, vibrational and magnetic properties of a novel C_{48}N_{12} aza-fullerene
We study the structural, electronic, vibrational and magnetic properties of a
novel aza-fullerene using density functional theory
and restricted Hartree-Fock theory. Optimized geometries and total energy of
this fullerene have been calculated. We find that for the total ground state energy is about -67617 eV, the HOMO-LUMO gap is
about 1.9 eV, five strong IR spectral lines are located at the vibrational
frequencies, 461.5 , 568.4 , 579.3 , 1236.1 , 1338.9 , the Raman scattering
activities and depolarization ratios are zero, and 10 NMR spectral signals are
predicted. Calculations of diamagnetic shielding factor, static dipole
polarizabilities and hyperpolarizabilities of are
performed and discussed.Comment: published in Chem.Phys.Let
Discovering the roots: Uniform closure results for algebraic classes under factoring
Newton iteration (NI) is an almost 350 years old recursive formula that
approximates a simple root of a polynomial quite rapidly. We generalize it to a
matrix recurrence (allRootsNI) that approximates all the roots simultaneously.
In this form, the process yields a better circuit complexity in the case when
the number of roots is small but the multiplicities are exponentially
large. Our method sets up a linear system in unknowns and iteratively
builds the roots as formal power series. For an algebraic circuit
of size we prove that each factor has size at most a
polynomial in: and the degree of the squarefree part of . Consequently,
if is a -hard polynomial then any nonzero multiple
is equally hard for arbitrary positive 's, assuming
that is at most .
It is an old open question whether the class of poly()-sized formulas
(resp. algebraic branching programs) is closed under factoring. We show that
given a polynomial of degree and formula (resp. ABP) size
we can find a similar size formula (resp. ABP) factor in
randomized poly()-time. Consequently, if determinant requires
size formula, then the same can be said about any of its
nonzero multiples.
As part of our proofs, we identify a new property of multivariate polynomial
factorization. We show that under a random linear transformation ,
completely factors via power series roots. Moreover, the
factorization adapts well to circuit complexity analysis. This with allRootsNI
are the techniques that help us make progress towards the old open problems,
supplementing the large body of classical results and concepts in algebraic
circuit factorization (eg. Zassenhaus, J.NT 1969, Kaltofen, STOC 1985-7 \&
Burgisser, FOCS 2001).Comment: 33 Pages, No figure
Perfil de autocuidado do doente em tratamentos com hemodiálise: estudo descritivo transversal
This study aimed to explore the self-care theory proposed by Orem and to perform a detailed
categorization of the related profiles. The performed research enabled the identification of four
profiles and goals were set to establish a correlation between self-care profiles and self-management
of the therapeutic regimen; to establish a relationship between demographic characteristics and selfcare profiles and to establish a correlation between self-care profiles and obstacles to an effective
management of the therapeutic regimen.
The design was cross-sectional, descriptive and correlational. Interviews were conducted with 122
patients undergoing haemodialysis in a healthcare unit. Clinical outcomes were extracted from medical recordsThe results show that patients with the highest scores in the responsible self-care profile are those with
improved knowledge (liquid - R=.250; p=.006; medication – R=.246; p=.006); who take better care of
their vascular access (R=.186; p=.042); who manage their diet better (R=.247; p=.006); and who face
fewer obstacles than the others (R=-.207; p=.022).
The research findings show that the implementation of successful nursing treatment plans depends on
the knowledge and understanding of patients perceptions regarding self-care and that this indicator will
be of the utmost importance when helping patients in the transition to a new health condition and to
experience a better quality of life.Estudo explóratorio transversal, descritivo e correlacional sobre a teoria do autocuidado
proposta por Orem. A pesquisa realizada permitiu a identificação de quatro dimensões: definição dos
perfis para estabelecer a correlação entre o autocuidado e o autogestão do regime terapêutico; estudo
da relação entre as características demográficas e autocuidado; estudar a correlação entre os perfis
de autocuidado e os obstáculos ao regime terapêutico.
Entrevistas realizadas a 122 doentes em hemodiálise numa unidade de saúde. Os resultados clínicos
foram extraídos a partir dos registos e mostram que os doentes com os maiores scores no perfil autocuidado responsável são aqueles com melhor conhecimento (liquid. - R = 0,250; p = 0,006; medicação
- R = 0,246; p = 0,006); quem cuida melhor de acesso vascular (R = 0,186; p = 0,042); quem melhor
administra a dieta (R = 0,267; p = 0,006); e quem enfrenta menos obstáculos (R = 0,207; p = 0,022).
Os resultados da pesquisa mostram que a implementação de planos de tratamento depende do conhecimento e compreensão dos doentes sobre o autocuidado e que este indicador é de maior importância
na ajuda do doente na transição para uma nova condição de saúde e melhor qualidade de vidainfo:eu-repo/semantics/publishedVersio
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