Perspectiva y expectativa de la población de Portmán sobre el desarrollo turístico de la bahía

El presente estudio tiene como finalidad principal analizar la perspectiva de los vecinos de Portmán sobre el desarrollo turístico de la bahía. Un espacio fuertemente afectado por la actividad minera desarrollada entre 1957 y 1990 y que en la actualidad es defendido por sus habitantes, los cuales desean una regeneración de la bahía y su puesta en valor. La metodología se basa en entrevistas con los residentes que han permitido la obtención de datos cualitativos sobre sus percepciones y expectativas respecto a la situación medioambiental y el desarrollo del turismo de este espacio. También se revisan las acciones administrativas para la recuperación de la bahía y se contextualiza históricamente el desastre ecológico. Como resultado de la investigación, se presentan propuestas para un desarrollo turístico sostenible en Portmán, alineadas con las expectativas de los vecinos. Estas incluyen estrategias para equilibrar el desarrollo económico con la conservación ambiental, contribuyendo a la regeneración y revitalización de la bahía y la comunidad local

Conocimientos, actitudes y prácticas sobre el uso del dispositivo intrauterino en mujeres atendidas en el programa de planificación familiar, del Centro de Salud Francisco Buitrago-Managua, durante Diciembre 2016 a Febrero 2017

La presente investigación tiene como objetivo Evaluar los conocimientos, actitudes y prácticas sobre el DIU en un centro de salud de Managua durante diciembre 2016-febrero 2017. Es un estudio descriptivo, retrospectivo, de corte transversal, tipo CAP, la muestra estuvo constituida por 42 Mujeres en Edad Fértil que acuden al programa de planificación familiar del Centro de Salud Francisco Buitrago, el tipo de muestreo fue no probabilístico por conveniencia. Dentro de los principales resultados se encontró en cuanto al nivel de conocimientos el 45.2%(19) son buenos, en relación a las actitudes el 54.8%(23) son desfavorables y con respecto a las prácticas son malas en el 52.4%(22). Entré las principales conclusiones, la mayoría de las mujeres que participaron en él estudió se encuentran en edades de 31 a más años, de procedencia urbana, nivel académico secundaria, estado civil casada y unión libre de igual manera, religión católica e iniciaron su vida sexual entre 15 a 19 años, el mayor porcentaje de las participantes tienen con buenos conocimientos generales sobre el DIU, actitudes desfavorables hacia el mismo y las prácticas son malas ante la utilización del dispositivo intrauterino. Dentro de las recomendaciones están dirigidas principalmente al ministerio de salud con énfasis en fortalecer la educación sexual a nivel primario y secundario para mejorar las consejerías en cuanto a la planificación familiar. Palabras claves: Conocimientos, actitudes, prácticas, DIU, Mujeres planificando, Centro de salud Francisco Buitrago-Managua

Effects of Nutritional Supplements on Judo‐Related Performance: A Review.

The potential ergogenic effect of nutritional supplements depends on their dosage and the type of exercise executed. Aiming at reviewing the research literature regarding sport supplements utilized in judo in order to improve performance, a literature search was performed at the following databases: Dialnet, PubMed, Scielo, Scopus and SportDiscus. A total of 11 articles met the inclusion criteria and were selected. Evidence revised indicates that supplementation with caffeine, β-alanine, sodium bicarbonate, creatine, and β-hydroxy-β-methylbutyrate has a positive effect on judo-related performance. Moreover, there is evidence suggesting that combining some of these nutritional supplements may produce an additive effect.post-print412 K

Chloroperoxidase-catalyzed aminoalcohol oxidation : substrate specificity and novel strategy for the synthesis of N-Cbz-3-aminopropanal

The ability of chloroperoxidase (CPO) to catalyze amino alcohol oxidations was investigated. The oxidations of compounds with different configurations with respect to the amine position towards hydroxyl - using H₂O₂ and tert-butyl hydroperoxide (t-BuOOH) - were analyzed in terms of the initial reaction rate, substrate conversion, and CPO operational stability. It was observed that the further the amino group from the hydroxyl, the lower the initial reaction rate. The effect of the amino-protecting group and other substituents (i.e., methyl and hydroxyl) was also examined, revealing an increase in steric hindrance due to the effect of bulky substituents. The observed reaction rates were higher with t-BuOOH, whereas CPO was more stable with H₂O₂. Moreover, CPO stability had to be determined case by case as the enzyme activity was modulated by the substrate. The oxidation of N-Cbz-3-aminopropanol (Cbz, carboxybenzyl) to N-Cbz-3-aminopropanal was investigated. Main operational conditions such as the reaction medium, initial amino alcohol concentration, and peroxide nature were studied. The reaction kinetics was determined, and no substrate inhibition was observed. By-products from a chemical reaction between the formed amino aldehyde and the peroxide were identified, and a novel reaction mechanism was proposed. Finally, the biotransformation was achieved by reducing side reactions and identifying the key factors to be addressed to further optimize the product yield

A Systematic Review on the Genetic Contribution to Tinnitus

Purpose To assess the available evidence to support a genetic contribution and define the role of common and rare variants in tinnitus. Methods After a systematic search and quality assessment, 31 records including 383,063 patients were selected (14 epidemiological studies and 17 genetic association studies). General information on the sample size, age, sex, tinnitus prevalence, severe tinnitus distribution, and sensorineural hearing loss was retrieved. Studies that did not include data on hearing assessment were excluded. Relative frequencies were used for qualitative variables to compare different studies and to obtain average values. Genetic variants and genes were listed and clustered according to their potential role in tinnitus development. Results The average prevalence of tinnitus estimated from population-based studies was 26.3% for any tinnitus, and 20% of patients with tinnitus reported it as an annoying symptom. One study has reported population-specific differences in the prevalence of tinnitus, the white ancestry being the population with a higher prevalence. Genome-wide association studies have identified and replicated two common variants in the Chinese population (rs2846071; rs4149577) in the intron of TNFRSF1A, associated with noise-induced tinnitus. Moreover, gene burden analyses in sequencing data from Spanish and Swede patients with severe tinnitus have identified and replicated ANK2, AKAP9, and TSC2 genes. Conclusions The genetic contribution to tinnitus is starting to be revealed and it shows population-specific effects in European and Asian populations. The common allelic variants associated with tinnitus that showed replication are associated with noise-induced tinnitus. Although severe tinnitus has been associated with rare variants with large effect, their role on hearing or hyperacusis has not been established.Open Access funding enabled and organized by CAUL and its Member Institutions PP-C is funded by the Andalusian Health Government (Grant RH-0150–2020).GNP-182 GENDER-Net Co-Plus Fund“La Caixa” Foundation (ID 100010434), under agreement LCF/PR/DE18/52010002European Union’s Horizon 2020 Research and Innovation Programme, Grant Agreement No. 848261The University of Sydney to support research on genetics of Meniere disease (K7013_B3413 Grant)Andalusian Health Government (Grant DOC_01677

Frequency multipliers based on hybrid technology with high harmonic suppression

A wideband frequency multipliers using SiGe bipolar transistors are proposed in this paper. The main circuit of these frequency multipliers consists of an attenuator followed by a bias network and a band pass filter which selects the desired harmonic at the output. The designed doubler can convert a 2–3 GHz input signal to a 4–6 GHz signal, with high suppressions of 59 dB, and 41 dB on the fundamental, and the third harmonic respectively. The tripler can convert a 2.3−2.7 GHz input signal to a 7–8 GHz signal, with suppressions of 68 dB, 52 dB, and 43 dB on the fundamental, the second, and fourth harmonics respectively.This work has been realized thanks to the service provide in the research project “Support and Consulting in the TTC&RF Active Area” from Thales Alenia Space in Spain. This work was also supported by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (ERDF/FEDER) under research projects TEC2014-60283-C3-1-R and TEC2017-88242-C3-1-R

Plant microRNAs and their role in defense against viruses: a bioinformatics approach

<p>Abstract</p> <p>Background</p> <p>microRNAs (miRNAs) are non-coding short RNAs that regulate gene expression in eukaryotes by translational inhibition or cleavage of complementary mRNAs. In plants, miRNAs are known to target mostly transcription factors and are implicated in diverse aspects of plant growth and development. A role has been suggested for the miRNA pathway in antiviral defense in plants. In this work, a bioinformatics approach was taken to test whether plant miRNAs from six species could have antiviral activity by targeting the genomes of plant infecting viruses.</p> <p>Results</p> <p>All plants showed a repertoire of miRNAs with potential for targeting viral genomes. The viruses were targeted by abundant and conserved miRNA families in regions coding for cylindrical inclusion proteins, capsid proteins, and nuclear inclusion body proteins. The parameters for our predicted miRNA:target pairings in the viral genomes were similar to those for validated targets in the plant genomes, indicating that our predicted pairings might behave <it>in-vivo </it>as natural miRNa-target pairings. Our screening was compared with negative controls comprising randomly generated miRNAs, animal miRNAs, and genomes of animal-infecting viruses. We found that plant miRNAs target plant viruses more efficiently than any other sequences, but also, miRNAs can either preferentially target plant-infecting viruses or target any virus without preference.</p> <p>Conclusions</p> <p>Our results show a strong potential for antiviral activity of plant miRNAs and suggest that the miRNA pathway may be a support mechanism to the siRNA pathway in antiviral defense.</p

Paralelización de un algoritmo de cálculo de la rspuesta impulsional de un canal IR difuso en interiores

Peer Reviewe

Artificial micrornas and their applications in plant molecular biology

Artificial microRNAs (amiRNAs) are modified endogenous microRNA precursors in which the miRNA:miRNA* duplex is replaced with sequences designed to silence any desired gene. amiRNAs are used as part of new genetic transformation techniques in eukaryotes and have proven to be effective and to excel over other RNA-mediated gene silencing methods in both specificity and stability. amiRNAs can be designed to silence single or multiple genes, it is also possible to construct dimeric amiRNA precursors to silence two non-related genes simultaneously. amiRNA expression is quantitative and allows using constitutive, inducible, or tissue-specific promoters. One main application of amiRNAs is gene functional validation and to this end they have been mostly used in model plants; however, their use can be extended to any species or variety. amiRNA-mediated antiviral defense is another important application with great potential for plant molecular biology and crop improvement, but it still needs to be optimized to prevent the escape of viruses from the silencing mechanism. Furthermore, amiRNAs have propelled research in related areas allowing the development of similar tools like artificial trans-acting small interference RNAs (tasiARNs) and artificial target mimicry. In this review, some applications and advantages of amiRNAs in plant molecular biology are analyzed

Personajes de animación con discapacidad a través de una perspectiva educativa

En un momento donde tristemente el acoso escolar se encuentra de latente actualidad y donde hay niñas y niños que sufren el rechazo en el ámbito educativo. Este trabajo pretende utilizar el cine de animación a través de una serie de personajes que tienen algún tipo de discapacidad para trabajar la exclusión y la inclusión en el aula. Utilizando este recurso audiovisual como una herramienta didáctica. El cine de animación se contempla igualmente como un recurso creativo para trabajar los valores y contravalores, y para lograr una mejora en el cambio de actitud y conducta desde edades tempranas. En una etapa clave en su formación, donde se pueden establecer conclusiones antes de poseer un conocimiento de lo que se juzga y hacer que se sientan partícipes y críticos