Detección de anomalías en radio espectrómetros solares mediante métodos estadísticos

La organización científica e-CALLISTO es una cadena de estaciones de observación solar que siguen al Sol 24 horas al día. Estas estaciones detectan ráfagas de radio solar mediante espectrómetros solares. En la primera parte del trabajo, se desarrollará una serie de programas en lenguaje Python en la que se descargará y analizará todos los espectrogramas resultantes de esta organización. En la segunda parte del trabajo, mediante métodos estadísticos se buscará tendencias o patrones de las ráfagas solares para mejorar y aumentar la detección de ráfagas solares de las estaciones de esta organización, en especial, las que se encuentran en España.The scientific organization e-CALLISTO is a chain of solar observation stations that follow the Sun 24 hours a day. These stations detect solar radio bursts using solar spectrometers. In the first part of the work, a series of programs will be developed in Python language in which all the spectrograms resulting from this organization will be downloaded and analyzed. In the second part of the work, by means of statistical methods, trends or patterns of solar bursts will be sought to improve and increase the detection of solar bursts from the stations of this organization, especially those located in Spain.Grado en Ingeniería en Electrónica y Automática Industria

Erythropoietin as a protective factor in rat CNS cells receiving radiotherapy: An in vitro study

Objetivo. Investigar el efecto de la eritropoyetina en cultivos celulares de corteza cerebral de ratas cuando se administra radioterapia. Materiales y métodos. El estudio se desarrolla con la obtención de corteza cerebral de embriones de 17 días de preñez de ratas Wistar. Las células cultivadas después de 72 horas de la extracción de la corteza se dividieron en dos grupos, a uno de ellos se le administró eritropoyetina alfa a una concentración de 30 pM y el otro era el grupo control. A los dos grupos de células se les radió con 6 Gy mediante un aparato Phoenix. Tras la radioterapia permanecieron 24 horas en la incubadora antes de fijarlas. Las células fueron fijadas con formaldehído al 4%. A continuación, con la técnica de TUNEL, se valoró el número de células apoptóticas en los cultivos radiados. Resultados. Se observó un porcentaje de apoptosis del 25,22% del grupo de cultivo sin eritropoyetina, mientras que en el grupo de células radiadas con eritropoyetina fue del 15,5%. Las variables cuantitativas se analizaron mediante el test t de Student y el resultado de la comparación entre los dos grupos fue estadísticamente significativo (p < 0,0001). Conclusión. En nuestro modelo experimental in vitro se comprobó que la eritropoyetina es eficaz en la prevención de la apoptosis en células del sistema nervioso central de ratas por radiación. Esto abre nuevos campos para la investigación del efecto protector del sistema nerviosoAim. To investigate the effect of erythropoietin in cultured rat cerebral cortex cells receiving radiotherapy. Materials and methods. Cerebral cortex was taken from 17-day-old Wistar rat embryos and placed in culture. At 72 hours, the cultures were divided into two groups, one receiving 30 pM erythropoietin alpha and the other was the control group. Both groups received 6 Gy from a Phoenix apparatus and were incubated for another 24 hours before fixation in 4% formaldehyde. TUNEL technique was employed to calculate the number of apoptotic cells in the irradiated cultures. 206 www.neurologia.com Rev Neurol 2014; 58 (5): 199-206 A. Gómez-De la Riva, et al Results. Apoptosis affected 25.22% of the cells cultured without erythropoietin and 15.5% in the group receiving erithropoyetin. Student’s t-test was used to analyse quantitative variables and showed a significant difference in apoptosis between the two groups (p < 0.0001). Conclusion. Our in vitro experimental model demonstrated that erythropoietin effectively prevents apoptosis in irradiated rat SNC cells, opening new fields for investigation into protective agents for the nervous syste

Dual band circular polarization selector using asymmetric SRR mirrors

In this work we aim to design circularly polarized flat mirror/reflectarray to work at a dual frequency. The design approach uses a unit cell made by four assymetrical split-ring resonators with an opposite rotation plus an element size variation, a seen in Fig.1 Fig. 1. Proposed structure (unit cell). The SRRs are made on copper on a FR4 substrate. There is a metallic (copper) plane mirror behind the structure. The inner rings have a radius of 5.8 mm (1st and 3rd quadrant) and 5mm (2nd and 4th quadrant). The outer rings have a radius of 10.2mm and 10mm, respectively. As we may see in Fig.2, the proposed structure presents a dual-band circular polarization selection: in the band around 2.97 GHz it absorbs LHCP incident waves while reflecting LHCP incident waves, doing the opposite around 3.28 GHz Fig. 2. Reflection coefficient for a circularly polarized wave normally incident on a structure as shown in Fig.1. The superindexes +/- stand for right-handed/left-handed circular polarized waves

Personajes de animación con discapacidad a través de una perspectiva educativa

En un momento donde tristemente el acoso escolar se encuentra de latente actualidad y donde hay niñas y niños que sufren el rechazo en el ámbito educativo. Este trabajo pretende utilizar el cine de animación a través de una serie de personajes que tienen algún tipo de discapacidad para trabajar la exclusión y la inclusión en el aula. Utilizando este recurso audiovisual como una herramienta didáctica. El cine de animación se contempla igualmente como un recurso creativo para trabajar los valores y contravalores, y para lograr una mejora en el cambio de actitud y conducta desde edades tempranas. En una etapa clave en su formación, donde se pueden establecer conclusiones antes de poseer un conocimiento de lo que se juzga y hacer que se sientan partícipes y críticos

Analysis of chiral effects in non-planar metamaterials with oblique incidence

One of the main research lines of the Grupo de Electromagnetismo of the Universidad de Cantabria is focused on the study and characterization of planar chiral metamaterial (CMM) structures implemented on printed circuit board technology. The objective of this communication is to analyze the influence of the angle of incidence on the chiral behavior of metamaterial structures. A variation of the split ring resonator (SRR) particle has been used as unit cell of the periodic metamaterials analyzed. From this structure, the effect of the angle of incidence on the chiral response is analyzed, evaluating variations in the geometry that provide different types of interaction between unit cells or between the incident wave and the structure. The SRRs are printed only on one side of the printed circuit board. Fig.1. This way, with normal incidence the structure is achiral. The obtained results show that the angle of incidence is a key parameter for the structure in order to present a chiral behavior. In this case, the chiral behavior is shown as a high difference between the transmission levels of the two eigenwaves (left handed and right handed circular polarized waves), i.e., circular dichroism

META 2016

Producción CientíficaA planar complementary metamaterial, as well as its corresponding inverse structure, has been designed and characterized. Numerical results (using commercial software) are presented here. The structure shows a giant gyrotropy (chirality) as well as very low losses.Ministerio de Economía, Industria y Competitividad (Project TEC2014-55463-C3-2-P

A complementary chiral metamaterial with giant electromagnetic activity and low losses

A planar complementary metamaterial, as well as its corresponding inverse structure, has been designed and characterized. Numerical results (using commercial software) are presented here. The structure shows a giant gyrotropy (chirality) as well as very low losses.This work has been supported by the Spanish Government (MINECO) through the Research Projects TEC2014-55463-C3-1-P, TEC2014-55463-C3-2-P, and TEC2014-55463-C3-3-P and also by the European Commission (ERDF)

Darunavir/cobicistat maintains the effectiveness of darunavir/ritonavir in HIV-infected patients under mono or dual therapy

[Abstract] OBJECTIVES: Darunavir/ritonavir (DRV/r) in mono or dual therapy has proven efficacy in selected patients. The aim of this study was to evaluate the efficacy of switching from DRV/r to DRV/cobicistat (DRV/c) in patients under mono or dual therapy. METHODS: This was a prospective multicenter cohort study of patients using DRV/r under mono or dual therapy plus lamivudine who changed to DRV/c maintaining the previous regimen. All patients had a controlled HIV viral load (<50 copies/ml) when switched and were examined every 12 weeks. The primary end-point was the percentage of participants without virological failure (VF) at week 48 in the intent-to-treat analysis. The CD4 cell count and concentrations of cholesterol, triglyceride, and creatinine were measured from baseline to week 48. RESULTS: A total of 162 patients were included: 68.5% were men, and their mean age was 46 ± 12 years. Seventy (43.2%) patients were treated with DRV/r monotherapy, and 92 (56.8%) were treated with DRV/r plus lamivudine. The efficacy at week 48 was 95.1% (95% CI: 90.6%-97.5%) in the intent-to-treat analysis and 98.7% (95.5-99.6%) in the on-treatment analysis. Two VFs were documented but without development of resistance mutations. No significant changes were found in the lipid profile. Creatinine concentration increased significantly by 0.07 mg/dl (0.04-0.10, P < 0.001). CONCLUSIONS: Switching from DRV/r to DRV/c in patients under mono or dual therapy is safe and effective.Instituto de Salud Carlos III; JR17/0002

Binding Potassium to Improve Treatment With Renin-Angiotensin-Aldosterone System Inhibitors: Results From Multiple One-Stage Pairwise and Network Meta-Analyses of Clinical Trials

This manuscript presents findings from the first dichotomous data pooling analysis on clinical trials (CT) regarding the effectiveness of binding potassium. The results emanated from pairwise and network meta-analyses aiming evaluation of response to commercial potassium-binding polymers, that is, to achieve and maintain normal serum potassium (n = 1,722), and the association between this response and an optimal dosing of renin-angiotensin-aldosterone system inhibitors (RAASi) needing individuals affected by heart failure (HF) or resistant hypertension, who may be consuming other hyperkalemia-inducing drugs (HKID) (e.g., b-blockers, heparin, etc.), and frequently are affected by chronic kidney disease (CKD) (n = 1,044): According to the surface under the cumulative ranking area (SUCRA), sodium zirconium cyclosilicate (SZC) (SUCRA >0.78), patiromer (SUCRA >0.58) and sodium polystyrene sulfonate (SPS) (SUCRA 5.1 mEq/L), and, when normokalemia is achieved, patiromer 16.8–25.2 g/day (SUCRA = 0.94) and patiromer 8.4–16.8 g/day (SUCRA = 0.41) can allow to increase the dose of spironolactone up to 50 mg/day in subjects affected by heart failure (HF) or with resistant hypertension needing treatment with other RAASi. The potential of zirconium cyclosilicate should be explored further, as no data exists to assess properly its capacity to optimize dosing of RAASi, contrarily as it occurs with patiromer. More research is also necessary to discern between benefits of binding potassium among all type of hyperkalemic patients, for example, patients with DM who may need treatment for proteinuria, patients with early hypertension, etc.Fil: Lizaraso Soto, Frank. Universidad de Valladolid; EspañaFil: Gutiérrez Abejón, Eduardo. Universidad de Valladolid; EspañaFil: Bustamante Munguira, Juan. Universidad de Valladolid; EspañaFil: Martín García, Débora. Universidad de Valladolid; EspañaFil: Chimeno, María Montserrat. Hospital Virgen de la Concha; EspañaFil: Nava Rebollo, Álvaro. Hospital Virgen de la Concha; EspañaFil: Maurtua Briseño Meiggs, Álvaro. Woodland Medical Practicenhs; Reino UnidoFil: Fernández, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Cuyo; Argentina. Universidad de Burgos. Departamento de Didácticas Específicas; EspañaFil: Bustamante Munguira, Elena. Universidad de Valladolid; EspañaFil: de Paz, Félix Jesús. Universidad de Valladolid; EspañaFil: Grande Villoria, Jesús. Universidad de Valladolid; España. Universite de Lausanne; SuizaFil: Ochoa Sangrador, Carlos. Sanidad de Castilla y León; EspañaFil: Pascual, Manuel. Universite de Lausanne; SuizaFil: Álvarez, F. Javier. Universidad de Valladolid; EspañaFil: Herrera Gómez, Francisco. Universite de Lausanne; Suiza. Universidad de Valladolid; Españ

Enfermedad celíaca: experiencia en un hospital de tercer nivel (2003-2005)

Los autores de este artículo pretenden analizar las características clínicas y analíticas de presentación en los pacientes pediátricos diagnosticados de enfermedad celíaca en la provincia de Salamanca, así como la evolución de estos parámetros seis meses y un año tras el diagnóstico