Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organization

Combining genome-wide structural models with phenomenological data is at the forefront of efforts to understand the organizational principles regulating the human genome. Here, we use chromosome-chromosome contact data as knowledge-based constraints for large-scale three-dimensional models of the human diploid genome. The resulting models remain minimally entangled and acquire several functional features that are observed in vivo and that were never used as input for the model. We find, for instance, that gene-rich, active regions are drawn towards the nuclear center, while gene poor and lamina associated domains are pushed to the periphery. These and other properties persist upon adding local contact constraints, suggesting their compatibility with non-local constraints for the genome organization. The results show that suitable combinations of data analysis and physical modelling can expose the unexpectedly rich functionally-related properties implicit in chromosome-chromosome contact data. Specific directions are suggested for further developments based on combining experimental data analysis and genomic structural modelling

On systematic approaches for interpreted information transfer of inspection data from bridge models to structural analysis

In conjunction with the improved methods of monitoring damage and degradation processes, the interest in reliability assessment of reinforced concrete bridges is increasing in recent years. Automated imagebased inspections of the structural surface provide valuable data to extract quantitative information about deteriorations, such as crack patterns. However, the knowledge gain results from processing this information in a structural context, i.e. relating the damage artifacts to building components. This way, transformation to structural analysis is enabled. This approach sets two further requirements: availability of structural bridge information and a standardized storage for interoperability with subsequent analysis tools. Since the involved large datasets are only efficiently processed in an automated manner, the implementation of the complete workflow from damage and building data to structural analysis is targeted in this work. First, domain concepts are derived from the back-end tasks: structural analysis, damage modeling, and life-cycle assessment. The common interoperability format, the Industry Foundation Class (IFC), and processes in these domains are further assessed. The need for usercontrolled interpretation steps is identified and the developed prototype thus allows interaction at subsequent model stages. The latter has the advantage that interpretation steps can be individually separated into either a structural analysis or a damage information model or a combination of both. This approach to damage information processing from the perspective of structural analysis is then validated in different case studies

A survey on 3D CAD model quality assurance and testing

[EN] A new taxonomy of issues related to CAD model quality is presented, which distinguishes between explicit and procedural models. For each type of model, morphologic, syntactic, and semantic errors are characterized. The taxonomy was validated successfully when used to classify quality testing tools, which are aimed at detecting and repairing data errors that may affect the simplification, interoperability, and reusability of CAD models. The study shows that low semantic level errors that hamper simplification are reasonably covered in explicit representations, although many CAD quality testers are still unaffordable for Small and Medium Enterprises, both in terms of cost and training time. Interoperability has been reasonably solved by standards like STEP AP 203 and AP214, but model reusability is not feasible in explicit representations. Procedural representations are promising, as interactive modeling editors automatically prevent most morphologic errors derived from unsuitable modeling strategies. Interoperability problems between procedural representations are expected to decrease dramatically with STEP AP242. Higher semantic aspects of quality such as assurance of design intent, however, are hardly supported by current CAD quality testers. (C) 2016 Elsevier Ltd. All rights reserved.This work was supported by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund, through the ANNOTA project (Ref. TIN2013-46036-C3-1-R).González-Lluch, C.; Company, P.; Contero, M.; Camba, J.; Plumed, R. (2017). A survey on 3D CAD model quality assurance and testing. Computer-Aided Design. 83:64-79. https://doi.org/10.1016/j.cad.2016.10.003S64798

The role of strategic groups in understanding strategic human resource management

Purpose – This article explores how understanding the challenges faced by companies’ attempts to create competitive advantage through their human resources and HRM practices can be enhanced by insights into the concept of strategic groups within industries. Based within the international hotel industry this study identifies how strategic groups emerge in the analysis of HRM practices and approaches. It sheds light on the value of strategic groups as a way of readdressing the focus on firm and industry level analyses. Design Methodology/Approach – Senior human resource executives and their teams across eight international hotel companies (IHCs) were interviewed in corporate and regional headquarters, with observations and the collection of company documentation complementing the interviews. Findings – The findings demonstrate that strategic groups emerge from analysis of the HRM practices and strategies used to develop hotel general managers (HGMs) as strategic human resources in the international hotel industry. The value of understanding industry structures, dynamics and intermediary levels of analysis are apparent where specific industries place occupational constraints on their managerial resources and limit the range of strategies and expansion modes companies can adopt. Research limitations/implications - This study indicates that further research on strategic groups will enhance the theoretical understanding of strategic human resource management (SHRM) and specifically the forces that act to constrain the achievement of competitive advantage through human resources. A limitation of this study is the dependence on the human resource divisions’ perspectives of realising international expansion ambitions in the hotel industry. Practical implications - This study has implications for companies’ engagement with their executives’ perceptions of opportunities and threats, and suggests companies will struggle to achieve competitive advantage where such perceptions are consistent with their competitors. Originality/value - Developments in strategic human resource management have relied upon the conceptual and theoretical developments in strategic management, however, an understanding of the impact of strategic groups and their shaping of SHRM has not been previously explored

Computational Techniques to Predict Orthopaedic Implant Alignment and Fit in Bone

Among the broad palette of surgical techniques employed in the current orthopaedic practice, joint replacement represents one of the most difficult and costliest surgical procedures. While numerous recent advances suggest that computer assistance can dramatically improve the precision and long term outcomes of joint arthroplasty even in the hands of experienced surgeons, many of the joint replacement protocols continue to rely almost exclusively on an empirical basis that often entail a succession of trial and error maneuvers that can only be performed intraoperatively. Although the surgeon is generally unable to accurately and reliably predict a priori what the final malalignment will be or even what implant size should be used for a certain patient, the overarching goal of all arthroplastic procedures is to ensure that an appropriate match exists between the native and prosthetic axes of the articulation. To address this relative lack of knowledge, the main objective of this thesis was to develop a comprehensive library of numerical techniques capable to: 1) accurately reconstruct the outer and inner geometry of the bone to be implanted; 2) determine the location of the native articular axis to be replicated by the implant; 3) assess the insertability of a certain implant within the endosteal canal of the bone to be implanted; 4) propose customized implant geometries capable to ensure minimal malalignments between native and prosthetic axes. The accuracy of the developed algorithms was validated through comparisons performed against conventional methods involving either contact-acquired data or navigated implantation approaches, while various customized implant designs proposed were tested with an original numerical implantation method. It is anticipated that the proposed computer-based approaches will eliminate or at least diminish the need for undesirable trial and error implantation procedures in a sense that present error-prone intraoperative implant insertion decisions will be at least augmented if not even replaced by optimal computer-based solutions to offer reliable virtual “previews” of the future surgical procedure. While the entire thesis is focused on the elbow as the most challenging joint replacement surgery, many of the developed approaches are equally applicable to other upper or lower limb articulations

The Effects of Computer Aided Draughting on Architectural Practice

This thesis argues that computer aided draughting (CAD) can be introduced successfully into an organization and can benefit all those engaged in the construction process. It concludes that CAD is the single most important tool to be introduced into the practice of architecture in recent times and, whilst the foregoing proposition is true, there is a cost to the organizations and individuals involved. The study begins with the author's interest in the research as a Chartered Quantity Surveyor working professionally with a firm of architects who installed a CAD system. It identifies several difficulties with the research and justifies the case study research methodology

Development of Bridge Information Model (BrIM) for digital twinning and management using TLS technology

In the current modern era of information and technology, the concept of Building Information Model (BIM), has made revolutionary changes in different aspects of engineering design, construction, and management of infrastructure assets, especially bridges. In the field of bridge engineering, Bridge Information Model (BrIM), as a specific form of BIM, includes digital twining of the physical asset associated with geometrical inspections and non-geometrical data, which has eliminated the use of traditional paper-based documentation and hand-written reports, enabling professionals and managers to operate more efficiently and effectively. However, concerns remain about the quality of the acquired inspection data and utilizing BrIM information for remedial decisions in a reliable Bridge Management System (BMS) which are still reliant on the knowledge and experience of the involved inspectors, or asset manager, and are susceptible to a certain degree of subjectivity. Therefore, this research study aims not only to introduce the valuable benefits of Terrestrial Laser Scanning (TLS) as a precise, rapid, and qualitative inspection method, but also to serve a novel sliced-based approach for bridge geometric Computer-Aided Design (CAD) model extraction using TLS-based point cloud, and to contribute to BrIM development. Moreover, this study presents a comprehensive methodology for incorporating generated BrIM in a redeveloped element-based condition assessment model while integrating a Decision Support System (DSS) to propose an innovative BMS. This methodology was further implemented in a designed software plugin and validated by a real case study on the Werrington Bridge, a cable-stayed bridge in New South Wales, Australia. The finding of this research confirms the reliability of the TLS-derived 3D model in terms of quality of acquired data and accuracy of the proposed novel slice-based method, as well as BrIM implementation, and integration of the proposed BMS into the developed BrIM. Furthermore, the results of this study showed that the proposed integrated model addresses the subjective nature of decision-making by conducting a risk assessment and utilising structured decision-making tools for priority ranking of remedial actions. The findings demonstrated acceptable agreement in utilizing the proposed BMS for priority ranking of structural elements that require more attention, as well as efficient optimisation of remedial actions to preserve bridge health and safety