A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The mechanisms by which type I and II keratins contribute to these functions remain incompletely understood. Here, we report that mice lacking all type I or type II keratins display severe barrier defects and fragile skin, leading to perinatal mortality with full penetrance. Comparative proteomics of cornified envelopes (CEs) from prenatal KtyI(-/-) and KtyII(-/-)(K8) mice demonstrates that absence of KIF causes dysregulation of many CE constituents, including downregulation of desmoglein 1. Despite persistence of loricrin expression and upregulation of many Nrf2 targets, including CE components Sprr2d and Sprr2h, extensive barrier defects persist, identifying keratins as essential CE scaffolds. Furthermore, we show that KIFs control mitochondrial lipid composition and activity in a cell-intrinsic manner. Therefore, our study explains the complexity of keratinopathies accompanied by barrier disorders by linking keratin scaffolds to mitochondria, adhesion, and CE formation

Knowledge-based life event model for e-government service integration with illustrative examples

The advancement of information and communications technology and web services offers an opportunity for e-government service integration, which can help improve the availability and quality of services offered. However, few of the potential service integration applications have been adopted by governments to increase the accessibility of and satisfaction with government services and information for citizens. Recently, the 'life event' concept was introduced as the core element of integrating complexity of service delivery to improve the efficiency and reusability of e-government services, web-based information management systems. In addition, a semantic web-based ontology is considered to be the most powerful conceptual approach for dealing with challenges associated with developing seamless systems in distributed environments. Among these challenges are interoperability, which can be loosely defined as the technical capability for interoperation. Despite the conceptual emergence of semantic web-based ontology for life events, the question remains of what methodology to use when designing a semantic web-based ontology for life events. This paper proposes a semantic web-based ontology model for life events for e-government service integration created using a methodology that implements the model using the ontology modelling tool Protégé and evaluates the model using Pellet Reasoner and the SPARQL query language. In addition, this model is illustrated by two examples, the Saudi Arabia King Abdullah Scholarship and Hafiz, to show the advantages of integrated systems compared with standalone systems. These examples show that the new model can effectively support the integration of standalone e-government services automatically so that citizens do not need to manually execute individual services. This can significantly improve the accessibility of e-government services and citizen's satisfaction. © 2014-IOS Press

Verification of knowledge shared across design and manufacture using a foundation ontology

Seamless computer-based knowledge sharing between departments of a manufacturing enterprise is useful in preventing unnecessary design revisions. A lack of interoperability between independently developed knowledge bases, however, is a major impediment in the development of a seamless knowledge sharing system. Interoperability, being an ability to overcome semantic and syntactic differences during computer-based knowledge sharing can be enhanced through the use of ontologies. Ontologies in computer science terms are hierarchical structures of knowledge stored in a computer-based knowledge base. Ontologies have been accepted by all as an interoperable medium to provide a non-subjective way of storing and sharing knowledge across diverse domains. Some semantic and syntactic differences, however, still crop up when these ontological knowledge bases are developed independently. A case study in an aerospace components manufacturing company suggests that shape features of a component are perceived differently by the designing and manufacturing departments. These differences cause further misunderstanding and misinterpretation when computer-based knowledge sharing systems are used across the two domains. Foundation or core ontologies can be used to overcome these differences and to ensure a seamless sharing of knowledge. This is because these ontologies provide a common grounding for domain ontologies to be used by individual domains or department. This common grounding can be used by the mediation and knowledge verification systems to authenticate the meaning of knowledge understood across different domains. For this reason, this research proposes a knowledge verification framework for developing a system capable of verifying knowledge between those domain ontologies which are developed out of a common core or foundation ontology. This framework makes use of ontology logic to standardize the way concepts from a foundation and core-concepts ontology are used in domain ontologies and then by using the same principles the knowledge being shared is verified. The Knowledge Frame Language which is based on Common Logic is used for formalizing example ontologies. The ontology editor used for browsing and querying ontologies is the Integrated Ontology Development Environment (IODE) by Highfleet Inc. An ontological product modelling technique is also developed in this research, to test the proposed framework in the scenario of manufacturability analysis. The proposed framework is then validated through a Java API specially developed for this purpose. Real industrial examples experienced during the case study are used for validation

A framework for the analysis and evaluation of enterprise models

Bibliography: leaves 264-288.The purpose of this study is the development and validation of a comprehensive framework for the analysis and evaluation of enterprise models. The study starts with an extensive literature review of modelling concepts and an overview of the various reference disciplines concerned with enterprise modelling. This overview is more extensive than usual in order to accommodate readers from different backgrounds. The proposed framework is based on the distinction between the syntactic, semantic and pragmatic model aspects and populated with evaluation criteria drawn from an extensive literature survey. In order to operationalize and empirically validate the framework, an exhaustive survey of enterprise models was conducted. From this survey, an XML database of more than twenty relatively large, publicly available enterprise models was constructed. A strong emphasis was placed on the interdisciplinary nature of this database and models were drawn from ontology research, linguistics, analysis patterns as well as the traditional fields of data modelling, data warehousing and enterprise systems. The resultant database forms the test bed for the detailed framework-based analysis and its public availability should constitute a useful contribution to the modelling research community. The bulk of the research is dedicated to implementing and validating specific analysis techniques to quantify the various model evaluation criteria of the framework. The aim for each of the analysis techniques is that it can, where possible, be automated and generalised to other modelling domains. The syntactic measures and analysis techniques originate largely from the disciplines of systems engineering, graph theory and computer science. Various metrics to measure model hierarchy, architecture and complexity are tested and discussed. It is found that many are not particularly useful or valid for enterprise models. Hence some new measures are proposed to assist with model visualization and an original "model signature" consisting of three key metrics is proposed.Perhaps the most significant contribution ofthe research lies in the development and validation of a significant number of semantic analysis techniques, drawing heavily on current developments in lexicography, linguistics and ontology research. Some novel and interesting techniques are proposed to measure, inter alia, domain coverage, model genericity, quality of documentation, perspicuity and model similarity. Especially model similarity is explored in depth by means of various similarity and clustering algorithms as well as ways to visualize the similarity between models. Finally, a number of pragmatic analyses techniques are applied to the models. These include face validity, degree of use, authority of model author, availability, cost, flexibility, adaptability, model currency, maturity and degree of support. This analysis relies mostly on the searching for and ranking of certain specific information details, often involving a degree of subjective interpretation, although more specific quantitative procedures are suggested for some of the criteria. To aid future researchers, a separate chapter lists some promising analysis techniques that were investigated but found to be problematic from methodological perspective. More interestingly, this chapter also presents a very strong conceptual case on how the proposed framework and the analysis techniques associated vrith its various criteria can be applied to many other information systems research areas. The case is presented on the grounds of the underlying isomorphism between the various research areas and illustrated by suggesting the application of the framework to evaluate web sites, algorithms, software applications, programming languages, system development methodologies and user interfaces

Knowledge management technology for integrated decision support systems in process industries

Premi extraordinari doctorat curs 2011-2012, àmbit d’Enginyeria IndustrialNowadays, factors such as globalization of trade, market uncertainty and fierce competition involve dwindling error margins in enterprises. Two key aspects for achieve it are the viability and the competitiveness of enterprises, which highly depend on the effectiveness for taking their decisions related to their manufacturing characteristics, such as economic efficiency, product quality, flexibility or reliability. For this reason, companies have taken the task, for many years, of develop better management information systems in order to help the decision makers to exploit data and models, with the final objective of discussing and improving decision-making. In this sense, decision support systems must be improved in order to deal with the large amount of available data and the heterogeneity of existing modeling approaches along the hierarchical levels in the enterprise structure. Hence, this thesis proposes the application of ontologies as a decision support tool, since they are increasingly seen as a key semantic technology for addressing heterogeneities and mitigating the problems they create and for enabling data mining by semantics-driven the knowledge processing. The aim of this thesis is to contribute to the development of decision support tools for the enterprise process industry. As a decision support tool, must be capable of become a robust model which interacts among the different decision hierarchical levels, providing a unified framework of data and information levels integration. On the other hand, this thesis also aims the improvement in the development of the ontologies. Firstly, a detailed state of the art about the different production process systems, knowledge management base on ontologies, as well as decision support systems is carried out. Based on this review, the specific thesis objectives are posed. Next, a methodology is proposed for the development and use of ontologies, based on the analysis and adaptation of previously existing methodologies. Such methodology is based on the improvement cycle (PSDA), allowing a better way to design, construct and apply domain ontologies. The second part of this thesis is devoted to the application of the different parts of the previously proposed methodology for the development of an ontological framework in the process industry domain concerning the strategic, tactical and operational decision levels. Next, the description of the decision areas in which the ontological framework is applied is presented. Namely, in the process control decision level, the coordination control is considered. Regarding scheduling decisions level, mathematical optimization approaches are applied. Finally, the distributed hierarchical decision level considers the mathematical optimization for decentralized supply chain networks is adopted. These decision areas and the performance of the proposed framework interaction are studied along the different case studies presented in the thesis. On the whole, this thesis represents a step forward toward the integration among the enterprise hierarchical levels, the process and enterprise standardization and improved procedures for decision-making. The aforementioned achievements are boosted by the application of semantic models, which are currently increasingly used.En la actualidad, factores como la globalización del comercio, la incertidumbre del mercado y la feroz competencia implican la disminución de los márgenes de error en las empresas. Dos aspectos claves para lograrlo son la viabilidad y la competitividad de las enterprisesm, que dependen en gran medida la eficacia para la toma de sus decisiones relacionadas con sus características de fabricación, tales como eficiencia económica, la calidad del producto, la flexibilidad y fiabilidad. Por esta razón, las empresas han dado a la tarea, desde hace muchos años, de desarrollar mejores sistemas de gestión de la información con el fin de ayudar a los tomadores de decisiones de explotación de datos y modelos, con el objetivo final de la discusión y mejorar la toma de decisiones. En este sentido, los sistemas de apoyo a las decisiones deben ser mejorados con el fin de hacer frente a la gran cantidad de datos disponibles y la heterogeneidad de los métodos de modelización existentes a lo largo de los niveles jerárquicos en la estructura de la empresa. Por lo tanto, esta tesis se propone la aplicación de ontologías como herramienta de apoyo a la decisión, ya que son cada vez más como una tecnología clave semántica para hacer frente a las heterogeneidades y la mitigación de los problemas que crean y para permitir la extracción de datos por la semántica impulsado la elaboración del conocimiento. El objetivo de esta tesis es contribuir al desarrollo de herramientas de apoyo para la industria de procesos empresariales. Como una herramienta de apoyo a la decisión, debe ser capaz de convertirse en un modelo sólido que interactúa entre los diferentes niveles de decisión jerárquica, proporcionando un marco unificado de datos e integración de los niveles de información. Por otra parte, esta tesis también tiene como objetivo la mejora en el desarrollo del área de ingeniería ontológica. En primer lugar, un estado detallado de la técnica sobre los diferentes sistemas de procesos de producción, la base de la gestión del conocimiento en ontologías, así como los sistemas de soporte de decisiones se ha llevado a cabo. Basado en esa revision, los objetivos específicos de la tesis se plantean. A continuación, se propone una metodología para el desarrollo y uso de ontologías, con base en el análisis y adaptación de las metodologías ya existentes. Dicha metodología se basa en el ciclo de mejora (PSDA), lo que permite una mejor manera de diseñar, construir y aplicar las ontologías de dominio. La segunda parte de esta tesis se dedica a la aplicación de las diferentes partes de la metodología propuesta anteriormente para el desarrollo de un marco ontológico en el ámbito de la industria de procesos relativos a los niveles de decisiones estratégicas, tácticas y operativas. A continuación, la descripción de las áreas de decisión en la que se aplica el marco ontológico se presenta. Es decir, en el nivel de decision de proceso de control, el control de la coordinación se considera. En cuanto al nivel de decisiones de programación de la producción, los métodos matemáticos de optimización se aplican. Finalmente, el nivel jerárquico distribuido decisión considera la optimización matemática de las redes descentralizadas de la cadena de suministro que se adopte. Estas áreas de decisión y el desempeño de la interacción marco propuesto se estudian a lo largo de los diferentes casos de estudio presentados en la tesis. En general, esta tesis supone un paso hacia adelante en la integración entre los niveles jerárquicos de la empresa, el proceso y la estandarización de la empresa y mejorar los procedimientos de toma de decisiones. Los logros mencionados se potencian mediante la aplicación de modelos semánticos, que actualmente se utilizan cada vez más.Award-winningPostprint (published version

A process model in platform independent and neutral formal representation for design engineering automation

An engineering design process as part of product development (PD) needs to satisfy ever-changing customer demands by striking a balance between time, cost and quality. In order to achieve a faster lead-time, improved quality and reduced PD costs for increased profits, automation methods have been developed with the help of virtual engineering. There are various methods of achieving Design Engineering Automation (DEA) with Computer-Aided (CAx) tools such as CAD/CAE/CAM, Product Lifecycle Management (PLM) and Knowledge Based Engineering (KBE). For example, Computer Aided Design (CAD) tools enable Geometry Automation (GA), PLM systems allow for sharing and exchange of product knowledge throughout the PD lifecycle. Traditional automation methods are specific to individual products and are hard-coded and bound by the proprietary tool format. Also, existing CAx tools and PLM systems offer bespoke islands of automation as compared to KBE. KBE as a design method incorporates complete design intent by including re-usable geometric, non-geometric product knowledge as well as engineering process knowledge for DEA including various processes such as mechanical design, analysis and manufacturing. It has been recognised, through an extensive literature review, that a research gap exists in the form of a generic and structured method of knowledge modelling, both informal and formal modelling, of mechanical design process with manufacturing knowledge (DFM/DFA) as part of model based systems engineering (MBSE) for DEA with a KBE approach. There is a lack of a structured technique for knowledge modelling, which can provide a standardised method to use platform independent and neutral formal standards for DEA with generative modelling for mechanical product design process and DFM with preserved semantics. The neutral formal representation through computer or machine understandable format provides open standard usage. This thesis provides a contribution to knowledge by addressing this gap in two-steps: • In the first step, a coherent process model, GPM-DEA is developed as part of MBSE which can be used for modelling of mechanical design with manufacturing knowledge utilising hybrid approach, based on strengths of existing modelling standards such as IDEF0, UML, SysML and addition of constructs as per author’s Metamodel. The structured process model is highly granular with complex interdependencies such as activities, object, function, rule association and includes the effect of the process model on the product at both component and geometric attributes. • In the second step, a method is provided to map the schema of the process model to equivalent platform independent and neutral formal standards using OWL/SWRL ontology for system development using Protégé tool, enabling machine interpretability with semantic clarity for DEA with generative modelling by building queries and reasoning on set of generic SWRL functions developed by the author. Model development has been performed with the aid of literature analysis and pilot use-cases. Experimental verification with test use-cases has confirmed the reasoning and querying capability on formal axioms in generating accurate results. Some of the other key strengths are that knowledgebase is generic, scalable and extensible, hence provides re-usability and wider design space exploration. The generative modelling capability allows the model to generate activities and objects based on functional requirements of the mechanical design process with DFM/DFA and rules based on logic. With the help of application programming interface, a platform specific DEA system such as a KBE tool or a CAD tool enabling GA and a web page incorporating engineering knowledge for decision support can consume relevant part of the knowledgebase

The Impact of Technology on the Strategic Management of a Knowledge-Intensive Project Organization: Action Design Research of a Competence Management System

The combination of digitalization and globalization will have a dramatic impact on organizations and the way people work. Demographic upheavals and societal changes, as well as the inevitable focus on environmental issues, will amplify the effect of these trends. As a result, business executives around the world will face new challenges with business models on one hand and organizational practices on the other hand. There is now a great opportunity for information systems and human resources scientists and practitioners to work together in order to improve understanding of how technology can be utilized to make organizations more effective and inspiring. The “future of work” is already affecting strategic management, HR organizations, and technology in practice. As a result, this has created many exciting research opportunities, identified by scholars looking at human resource information systems, human resource management, enterprise systems, competence management systems, knowledge management, information management, agile software development, or design science. In this action design research I build on top of existing design science research on competence management systems and aim at 1) gaining more understanding about the organizational and technological aspects of enterprise systems design, especially regarding competence development, and 2) increasing understanding of the design of competence management as a strategic capability. In this action design research project we participated in the design, development, and evaluation of a particular organizational instantiation and a management system instantiation that both address important, previously unsolved problems. This study contributes to the existing body of scientific knowledge on information systems. The theoretical contribution is the improved design principles for competence management systems. The practical contribution of the study builds upon the guidance provided to system designers and managers through several frameworks, IT artifacts, and management practices for information systems design processes. In conclusion, this research provides new evidence of how action design research can lead to significant business benefits by integrating theory and practice in a real business context