247 research outputs found
Multi-modality cardiac image computing: a survey
Multi-modality cardiac imaging plays a key role in the management of patients with cardiovascular diseases. It allows a combination of complementary anatomical, morphological and functional information, increases diagnosis accuracy, and improves the efficacy of cardiovascular interventions and clinical outcomes. Fully-automated processing and quantitative analysis of multi-modality cardiac images could have a direct impact on clinical research and evidence-based patient management. However, these require overcoming significant challenges including inter-modality misalignment and finding optimal methods to integrate information from different modalities.
This paper aims to provide a comprehensive review of multi-modality imaging in cardiology, the computing methods, the validation strategies, the related clinical workflows and future perspectives. For the computing methodologies, we have a favored focus on the three tasks, i.e., registration, fusion and segmentation, which generally involve multi-modality imaging data, either combining information from different modalities or transferring information across modalities. The review highlights that multi-modality cardiac imaging data has the potential of wide applicability in the clinic, such as trans-aortic valve implantation guidance, myocardial viability assessment, and catheter ablation therapy and its patient selection. Nevertheless, many challenges remain unsolved, such as missing modality, modality selection, combination of imaging and non-imaging data, and uniform analysis and representation of different modalities. There is also work to do in defining how the well-developed techniques fit in clinical workflows and how much additional and relevant information they introduce. These problems are likely to continue to be an active field of research and the questions to be answered in the future
A Bayesian constitutive model selection framework for biaxial mechanical testing of planar soft tissues: Application to porcine aortic valves
A variety of constitutive models have been developed for soft tissue mechanics. However, there is no established criterion to select a suitable model for a specific application. Although the model that best fits the experimental data can be deemed the most suitable model, this practice often can be insufficient given the inter-sample variability of experimental observations. Herein, we present a Bayesian approach to calculate the relative probabilities of constitutive models based on biaxial mechanical testing of tissue samples. 46 samples of porcine aortic valve tissue were tested using a biaxial stretching setup. For each sample, seven ratios of stresses along and perpendicular to the fiber direction were applied. The probabilities of eight invariant-based constitutive models were calculated based on the experimental data using the proposed model selection framework. The calculated probabilities showed that, out of the considered models and based on the information available through the utilized experimental dataset, the May–Newman model was the most probable model for the porcine aortic valve data. When the samples were grouped into different cusp types, the May–Newman model remained the most probable for the left- and right-coronary cusps, whereas for non-coronary cusps two models were found to be equally probable: the Lee–Sacks model and the May–Newman model. This difference between cusp types was found to be associated with the first principal component analysis (PCA) mode, where this mode’s amplitudes of the non-coronary and right-coronary cusps were found to be significantly different. Our results show that a PCA-based statistical model can capture significant variations in the mechanical properties of soft tissues. The presented framework is applicable to any tissue type, and has the potential to provide a structured and rational way of making simulations population-based
Immersed boundary-finite element model of fluid-structure interaction in the aortic root
It has long been recognized that aortic root elasticity helps to ensure
efficient aortic valve closure, but our understanding of the functional
importance of the elasticity and geometry of the aortic root continues to
evolve as increasingly detailed in vivo imaging data become available. Herein,
we describe fluid-structure interaction models of the aortic root, including
the aortic valve leaflets, the sinuses of Valsalva, the aortic annulus, and the
sinotubular junction, that employ a version of Peskin's immersed boundary (IB)
method with a finite element (FE) description of the structural elasticity. We
develop both an idealized model of the root with three-fold symmetry of the
aortic sinuses and valve leaflets, and a more realistic model that accounts for
the differences in the sizes of the left, right, and noncoronary sinuses and
corresponding valve cusps. As in earlier work, we use fiber-based models of the
valve leaflets, but this study extends earlier IB models of the aortic root by
employing incompressible hyperelastic models of the mechanics of the sinuses
and ascending aorta using a constitutive law fit to experimental data from
human aortic root tissue. In vivo pressure loading is accounted for by a
backwards displacement method that determines the unloaded configurations of
the root models. Our models yield realistic cardiac output at physiological
pressures, with low transvalvular pressure differences during forward flow,
minimal regurgitation during valve closure, and realistic pressure loads when
the valve is closed during diastole. Further, results from high-resolution
computations demonstrate that IB models of the aortic valve are able to produce
essentially grid-converged dynamics at practical grid spacings for the
high-Reynolds number flows of the aortic root
Integrated Heart - Coupling multiscale and multiphysics models for the simulation of the cardiac function
Mathematical modelling of the human heart and its function can expand our understanding of various cardiac
diseases, which remain the most common cause of death in the developed world. Like other physiological
systems, the heart can be understood as a complex multiscale system involving interacting phenomena at the
molecular, cellular, tissue, and organ levels. This article addresses the numerical modelling of many aspects
of heart function, including the interaction of the cardiac electrophysiology system with contractile muscle
tissue, the sub-cellular activation-contraction mechanisms, as well as the hemodynamics inside the heart
chambers. Resolution of each of these sub-systems requires separate mathematical analysis and specially
developed numerical algorithms, which we review in detail. By using specific sub-systems as examples, we
also look at systemic stability, and explain for example how physiological concepts such as microscopic force
generation in cardiac muscle cells, translate to coupled systems of differential equations, and how their stability
properties influence the choice of numerical coupling algorithms. Several numerical examples illustrate
three fundamental challenges of developing multiphysics and multiscale numerical models for simulating
heart function, namely: (i) the correct upscaling from single-cell models to the entire cardiac muscle, (ii) the
proper coupling of electrophysiology and tissue mechanics to simulate electromechanical feedback, and (iii)
the stable simulation of ventricular hemodynamics during rapid valve opening and closure
A Reduced Order Model formulation for left atrium flow: an Atrial Fibrillation case
A data-driven Reduced Order Model (ROM) based on a Proper Orthogonal
Decomposition - Radial Basis Function (POD-RBF) approach is adopted in this
paper for the analysis of blood flow dynamics in a patient-specific case of
Atrial Fibrillation (AF). The Full Order Model (FOM) is represented by
incompressible Navier-Stokes equations, discretized with a Finite Volume (FV)
approach. Both the Newtonian and the Casson's constitutive laws are employed.
The aim is to build a computational tool able to efficiently and accurately
reconstruct the patterns of relevant hemodynamics indices related to the stasis
of the blood in a physical parametrization framework including the cardiac
output in the Newtonian case and also the plasma viscosity and the hematocrit
in the non-Newtonian one. Many FOM-ROM comparisons are shown to analyze the
performance of our approach as regards errors and computational speed-up.Comment: 21 pages, 14 figure
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A Bayesian constitutive model selection framework for biaxial mechanical testing of planar soft tissues: application to porcine aortic valves
A variety of constitutive models have been developed for soft tissue mechanics. However, there is no established criterion to select a suitable model for a specific application. Although the model that best fits the experimental data can be deemed the most suitable model, this practice often can be insufficient given the inter-sample variability of experimental observations. Herein, we present a Bayesian approach to calculate the relative probabilities of constitutive models based on biaxial mechanical testing of tissue samples. 46 samples of porcine aortic valve tissue were tested using a biaxial stretching setup. For each sample, seven ratios of stresses along and perpendicular to the fiber direction were applied. The probabilities of eight invariant-based constitutive models were calculated based on the experimental data using the proposed model selection framework. The calculated probabilities showed that, out of the considered models and based on the information available through the utilized experimental dataset, the May–Newman model was the most probable model for the porcine aortic valve data. When the samples were grouped into different cusp types, the May–Newman model remained the most probable for the left- and right-coronary cusps, whereas for non-coronary cusps two models were found to be equally probable: the Lee–Sacks model and the May–Newman model. This difference between cusp types was found to be associated with the first principal component analysis (PCA) mode, where this mode’s amplitudes of the non-coronary and right-coronary cusps were found to be significantly different. Our results show that a PCA-based statistical model can capture significant variations in the mechanical properties of soft tissues. The presented framework is applicable to any tissue type, and has the potential to provide a structured and rational way of making simulations population-based
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