Individual Differences in Amygdala and Ventromedial Prefrontal Cortex Activity are Associated with Evaluation Speed and Psychological Well-being

Using functional magnetic resonance imaging, we examined whether individual differences in amygdala activation in response to negative relative to neutral information are related to differences in the speed with which such information is evaluated, the extent to which such differences are associated with medial prefrontal cortex function, and their relationship with measures of trait anxiety and psychological well-being (PWB). Results indicated that faster judgments of negative relative to neutral information were associated with increased left and right amygdala activation. In the prefrontal cortex, faster judgment time was associated with relative decreased activation in a cluster in the ventral anterior cingulate cortex (ACC, BA 24). Furthermore, people who were slower to evaluate negative versus neutral information reported higher PWB. Importantly, higher PWB was strongly associated with increased activation in the ventral ACC for negative relative to neutral information. Individual differences in trait anxiety did not predict variation in judgment time or in amygdala or ventral ACC activity. These findings suggest that people high in PWB effectively recruit the ventral ACC when confronted with potentially aversive stimuli, manifest reduced activity in subcortical regions such as the amygdala, and appraise such information as less salient as reflected in slower evaluative speed

Emotion regulation meets emotional attention: the influence of emotion suppression on emotional attention depends on the nature of the distracters

Recent evidence has suggested a crucial role of people’s current goals in attention to emotional information. This asks for research investigating how and what kinds of goals shape emotional attention. The present study investigated how the goal to suppress a negative emotional state influences attention to emotion-congruent events. After inducing disgust, we instructed participants to suppress all feelings of disgust during a subsequent dot probe task. Attention to disgusting images was modulated by the sort of distracter that was presented in parallel with disgusting imagery. When disgusting images were presented together with neutral images, emotion suppression was accompanied by a tendency to attend to disgusting images. However, when disgusting images were shown with positive images that allow coping with disgust (i.e., images representing cleanliness), attention tended away from disgusting images and toward images representing cleanliness. These findings show that emotion suppression influences the allocation of attention but that the successful avoidance of emotion-congruent events depends on the availability of effective distracters

Aging is associated with positive responding to neutral information but reduced recovery from negative information

Studies on aging and emotion suggest an increase in reported positive affect, a processing bias of positive over negative information, as well as increasingly adaptive regulation in response to negative events with advancing age. These findings imply that older individuals evaluate information differently, resulting in lowered reactivity to, and/or faster recovery from, negative information, while maintaining more positive responding to positive information. We examined this hypothesis in an ongoing study on Midlife in the US (MIDUS II) where emotional reactivity and recovery were assessed in a large number of respondents (N = 159) from a wide age range (36–84 years). We recorded eye-blink startle magnitudes and corrugator activity during and after the presentation of positive, neutral and negative pictures. The most robust age effect was found in response to neutral stimuli, where increasing age is associated with a decreased corrugator and eyeblink startle response to neutral stimuli. These data suggest that an age-related positivity effect does not essentially alter the response to emotion-laden information, but is reflected in a more positive interpretation of affectively ambiguous information. Furthermore, older women showed reduced corrugator recovery from negative pictures relative to the younger women and men, suggesting that an age-related prioritization of well-being is not necessarily reflected in adaptive regulation of negative affect

Determinants of subjective well-being in representative samples of nations

Background: Maximising the happiness and life satisfaction [i.e. subjective well-being (SWB)] of citizens is a fundamental goal of international governmental organizations’ policies. In order to decide what policies should be pursued in order to improve SWB there is a need to identify what the key drivers of SWB are. However, to date most studies have been conducted in unrepresentative samples of largely ‘developed’ nations. Methods: Data from the latest World Value Survey (2010–14) and gathered 85 070 respondents from 59 countries (Age 16–99 years, Mean = 42, SD = 16.54; 52.29% females) were pooled for the analysis. A cross-sectional multilevel random effects model was performed where respondents were nested by country. Results: The average levels of SWB varied across countries and geographical regions. Among the lowest 10 SWB countries are nations from: Eastern Europe and Former Soviet Union and Middle East and North Africa. Factors driving SWB include state of health, financial satisfaction, freedom of choice, GDP per capita, income scale, importance of friends, leisure, being females, weekly religious attendance, unemployment and income inequality. Nevertheless, according to Cohen’s rules of thumb, most of these factors have ‘small’ effect sizes. Thus, the main factors that possibly will improve the SWB of people across the globe are: state of health, household’s financial satisfaction and freedom of choice. Conclusions: To maximize the well-being of the population, policy makers may focus on health status, household’s financial satisfaction and emancipative values. The levels of prosperity and political stability appear to positively improve the SWB of people

Relating stress, anxiety and depression among flood victims’ quality of life in Malaysia: A theoretical perspective

Flood disaster is one of the events that have an impact on the lives of the individuals involved in Malaysia. Destruction and loss make a person feels depressed besides being worried.Even worse when the victims become depressed as a result of the incident. Flood events can be seen as a threat to the well-being of individuals both physically and emotionally.This article will discuss how stress, anxiety and depression are related to the quality of life and well-being of flood victims.The discussion is based on the Stressful Life Events Theory, Freud’s Anxiety Theory, Beck's Cognitive Theory of Depression and the Quality of Life Conceptual Model

Purpose in life predicts better emotional recovery from negative stimuli

Purpose in life predicts both health and longevity suggesting that the ability to find meaning from life’s experiences, especially when confronting life’s challenges, may be a mechanism underlying resilience. Having purpose in life may motivate reframing stressful situations to deal with them more productively, thereby facilitating recovery from stress and trauma. In turn, enhanced ability to recover from negative events may allow a person to achieve or maintain a feeling of greater purpose in life over time. In a large sample of adults (aged 36-84 years) from the MIDUS study (Midlife in the U.S., http://www.midus.wisc.edu/), we tested whether purpose in life was associated with better emotional recovery following exposure to negative picture stimuli indexed by the magnitude of the eyeblink startle reflex (EBR), a measure sensitive to emotional state. We differentiated between initial emotional reactivity (during stimulus presentation) and emotional recovery (occurring after stimulus offset). Greater purpose in life, assessed over two years prior, predicted better recovery from negative stimuli indexed by a smaller eyeblink after negative pictures offset, even after controlling for initial reactivity to the stimuli during the picture presentation, gender, age, trait affect, and other well-being dimensions. These data suggest a proximal mechanism by which purpose in life may afford protection from negative events and confer resilience is through enhanced automatic emotion regulation after negative emotional provocation

Online networks and subjective well-being

We argue that the use of online networks may threaten subjective well-being in several ways, due to the inherent attributes of Internet-mediated interaction and through its effects on social trust and sociability. We test our hypotheses on a representative sample of the Italian population. We find a significantly negative correlation between online networking and well-being. This result is partially confirmed after accounting for endogeneity. We explore the direct and indirect effects of the use of social networking sites (SNS) on well-being in a SEM analysis. We find that online networking plays a positive role in subjective well-being through its impact on physical interactions, whereas SNS use is associated with lower social trust. The overall effect of networking on individual welfare is significantly negative.Comment: 40 page

Heart rate variability is associated with amygdala functional connectivity with MPFC across younger and older adults

The ability to regulate emotion is crucial to promote well-being. Evidence suggests that the medial prefrontal cortex (mPFC) and adjacent anterior cingulate (ACC) modulate amygdala activity during emotion regulation. Yet less is known about whether the amygdala-mPFC circuit is linked with regulation of the autonomic nervous system and whether the relationship differs across the adult lifespan. The current study tested the hypothesis that heart rate variability (HRV) reflects the strength of mPFC-amygdala interaction across younger and older adults. We recorded participants’ heart rates at baseline and examined whether baseline HRV was associated with amygdala-mPFC functional connectivity during rest. We found that higher HRV was associated with stronger functional connectivity between the amygdala and the mPFC during rest across younger and older adults. In addition to this age-invariant pattern, there was an age-related change, such that greater HRV was linked with stronger functional connectivity between amygdala and ventrolateral PFC (vlPFC) in younger than in older adults. These results are in line with past evidence that vlPFC is involved in emotion regulation especially in younger adults. Taken together, our results support the neurovisceral integration model and suggest that higher heart rate variability is associated with neural mechanisms that support successful emotional regulation across the adult lifespan

Differences in the Central Neural Activation under Emotional Stress across the Menstrual Cycle

The present study had several goals. First, we aimed to investigate the potential differences in the activation of the corticolimbic structures during emotional stress in healthy women across the menstrual cycle using stress imagery. Second, we searched for differences in the subjective anxiety under emotional stress across the menstrual cycle and tried to correlate the perceived level of anxiety to activation of the specific corticolimbic structures. Third, we attempted to compare central neural activation of women in follicular and in luteal phases of the menstrual cycle separately to that of men during emotional stress to investigate potential differences in neural response. We used perfusion based functional magnetic resonance imaging (MRI) and blood oxygen level dependent (BOLD) contrast to measure cerebral blood flow response to the emotional stress using stress imagery in 29 healthy volunteers (9 women in follicular phase, 10 women in luteal phase, and 10 men). Cycle-dependent comparison of the stress response in women revealed that women in the follicular phase had greater activation in the areas of the ventro-medial prefrontal cortex (VMPFC), with levels of activation comparable to those of men, and anterior insula, while women in the luteal phase of their menstrual cycle demonstrated increase blood flow in the areas of the anterior cingulate and hippocampus at P = 0.01. Males showed overall greater degree of corticolimbic activation, specifically in the bilateral hippocampi and right prefrontal cortex regardless of which group of women they were compared to. When compared to women in different phases of the menstrual cycle specifically, men showed greater cerebral blood flow in bilateral cingulate cortices and right hippocampus compared to women in the follicular phase, and bilateral striatum, amygdala, bilateral hippocampi when compared to women in the luteal phase. We did not observe different levels of self-reported anxiety during stress imagery across the menstrual cycle, however, women in their luteal phase showed a positive correlation of the self-reported anxiety levels and cerebral blood flow in the posterior insula at the threshold level of P = 0.05. The results of our study are consistent with the previously available information regarding the differences in the corticolimbic activation across the menstrual cycle in women and in women vs. men. In addition to that, our data supports the correlation of the levels of anxiety and insular activation in the luteal phase of the menstrual cycle and could represent an initial step in uncovering the mechanisms regulating stress response, anxiety and their relation to the hormonal status

Whole-brain white matter correlates of personality profiles predictive of subjective well-being.

We investigated the white matter correlates of personality profiles predictive of subjective well-being. Using principal component analysis to first determine the possible personality profiles onto which core personality measures would load, we subsequently searched for whole-brain white matter correlations with these profiles. We found three personality profiles that correlated with the integrity of white matter tracts. The correlates of an "optimistic" personality profile suggest (a) an intricate network for self-referential processing that helps regulate negative affect and maintain a positive outlook on life, (b) a sustained capacity for visually tracking rewards in the environment and (c) a motor readiness to act upon the conviction that desired rewards are imminent. The correlates of a "short-term approach behavior" profile was indicative of minimal loss of integrity in white matter tracts supportive of lifting certain behavioral barriers, possibly allowing individuals to act more outgoing and carefree in approaching people and rewards. Lastly, a "long-term approach behavior" profile's association with white matter tracts suggests lowered sensitivity to transient updates of stimulus-based associations of rewards and setbacks, thus facilitating the successful long-term pursuit of goals. Together, our findings yield convincing evidence that subjective well-being has its manifestations in the brain