Henry Tyne, Virginie André, Christophe Benzitoun, Alex Boulton et Yan Greub (éd.), French through corpora : ecological and data-driven perspectives in French language studies. Newcastle upon Tyne UK : Cambridge Scholars Publishing, 2014, 343 p.

Cet ouvrage vise à montrer comment la méthodologie de corpus fait fructifier plusieurs domaines linguistiques. Il importe donc de démontrer les liens entre les outils, les méthodes et les analyses. Comme le titre l’indique clairement, l’approche adoptée se veut inductive (corpus-driven) et écologique. Autrement dit, le corpus y est utilisé comme point de départ pour élaborer une théorie linguistique et les données sont authentiques tant dans leur origine que dans leur traitement. Le volume se..

Virginia Woolf and Victoria Sackville-West: Orlando as a reflection of their relationship

Virginia Woolf belongs to one of the most significant and original writers of the twentieth century. She was known for her feministic attitudes and denial of traditional gender roles as the social construct. She often criticized the unequal position of women in the patriarchal society and its homophobic tendencies. She used experimental approaches towards literature and writing such as so-called "stream of consciousness" in a form of inner monologue, thus she became the leading figure of the modernistic movement in Britain. The theoretical part of this paper deals with the person of Virginia Woolf as a writer and an intellectual. Her opinions about feminism, gender and androgyny are compared with the general atmosphere of the early twentieth century society. Further, the paper describes the relationship between Virginia Woolf and Victoria Sackville-West which was the impulse for writing the novel Orlando (1928). This novel was inspired by Sackville-West and the story of her life and partially reflected their relationship. The last chapter deals with the novel Orlando itself and how it reflects not only the affinity between Woolf and Sackville-West, but also Virginia Woolf's own thoughts and viewpoints concerning the ambiguity and complexity of gender and other topics such as artistic creativity, inspiration, importance of fame and meaning of human life in general.Teoretická část této práce se zaměřuje na postavu Virginie Woolf jako spisovatelky a intelektuálky. Její názory na feminismus, pohlaví a androgynii jsou srovnávány s obecnou atmosférou ve společnosti na počátku dvacátého století. Dále práce popisuje vztah Virginie Woolf s Victorií Sackville-West, který byl podnětem k napsání románu Orlando (1928). Tento román byl inspirován Sackville-West a jejím životem a částečně odráží jejich vztah. Poslední kapitola se zabývá románem Orlando samotným a jak odráží nejen náklonnost Woolf a Sackville-West, ale také myšlenky a stanoviska samotné Virginie Woolf týkající se nejednoznačnosti a složitosti pohlaví a dalších témat jako je například umělecká kreativita, inspirace, důležitost slávy a význam života člověka vůbec.Katedra anglistiky a amerikanistikyDokončená práce s úspěšnou obhajobo

Présentation

L’existence de corpus a transformé notre rapport à la langue. Ils permettent d’appréhender de très nombreuses questions posées en linguistique, qu’elle soit appliquée ou non. Les corpus offrent la possibilité, par exemple, de comparer les utilisations et les distributions de certaines occurrences lexicales ou constructions syntaxiques, de nous interroger sur les catégories grammaticales, sur les processus de changement linguistique, sur les mécanismes des interactions verbales, sur les effets..

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

Background: In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers. Methods: We have genotyped rs744154 in 9408 BRCA1 and 5632 BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and assessed its association with breast cancer risk using a retrospective weighted cohort approach. Results: We found no evidence of association with breast cancer risk for BRCA1 (per-allele HR: 0.98, 95% CI: 0.93–1.04, P=0.5) or BRCA2 (per-allele HR: 0.97, 95% CI: 0.89–1.06, P=0.5) mutation carriers. Conclusion: This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out. A Osorio1, R L Milne2, G Pita3, P Peterlongo4,5, T Heikkinen6, J Simard7, G Chenevix-Trench8, A B Spurdle8, J Beesley8, X Chen8, S Healey8, KConFab9, S L Neuhausen10, Y C Ding10, F J Couch11,12, X Wang11, N Lindor13, S Manoukian4, M Barile14, A Viel15, L Tizzoni5,16, C I Szabo17, L Foretova18, M Zikan19, K Claes20, M H Greene21, P Mai21, G Rennert22, F Lejbkowicz22, O Barnett-Griness22, I L Andrulis23,24, H Ozcelik24, N Weerasooriya23, OCGN23, A-M Gerdes25, M Thomassen25, D G Cruger26, M A Caligo27, E Friedman28,29, B Kaufman28,29, Y Laitman28, S Cohen28, T Kontorovich28, R Gershoni-Baruch30, E Dagan31,32, H Jernström33, M S Askmalm34, B Arver35, B Malmer36, SWE-BRCA37, S M Domchek38, K L Nathanson38, J Brunet39, T Ramón y Cajal40, D Yannoukakos41, U Hamann42, HEBON37, F B L Hogervorst43, S Verhoef43, EB Gómez García44,45, J T Wijnen46,47, A van den Ouweland48, EMBRACE37, D F Easton49, S Peock49, M Cook49, C T Oliver49, D Frost49, C Luccarini50, D G Evans51, F Lalloo51, R Eeles52, G Pichert53, J Cook54, S Hodgson55, P J Morrison56, F Douglas57, A K Godwin58, GEMO59,60,61, O M Sinilnikova59,60, L Barjhoux59,60, D Stoppa-Lyonnet61, V Moncoutier61, S Giraud59, C Cassini62,63, L Olivier-Faivre62,63, F Révillion64, J-P Peyrat64, D Muller65, J-P Fricker65, H T Lynch66, E M John67, S Buys68, M Daly69, J L Hopper70, M B Terry71, A Miron72, Y Yassin72, D Goldgar73, Breast Cancer Family Registry37, C F Singer74, D Gschwantler-Kaulich74, G Pfeiler74, A-C Spiess74, Thomas v O Hansen75, O T Johannsson76, T Kirchhoff77, K Offit77, K Kosarin77, M Piedmonte78, G C Rodriguez79, K Wakeley80, J F Boggess81, J Basil82, P E Schwartz83, S V Blank84, A E Toland85, M Montagna86, C Casella87, E N Imyanitov88, A Allavena89, R K Schmutzler90, B Versmold90, C Engel91, A Meindl92, N Ditsch93, N Arnold94, D Niederacher95, H Deißler96, B Fiebig97, R Varon-Mateeva98, D Schaefer99, U G Froster100, T Caldes101, M de la Hoya101, L McGuffog49, A C Antoniou49, H Nevanlinna6, P Radice4,5 and J Benítez1,3 on behalf of CIMB

Correction:Solving unsolved rare neurological diseases—a Solve-RD viewpoint (European Journal of Human Genetics, (2021), 29, 9, (1332-1336), 10.1038/s41431-021-00901-1)

In the original publication of the article, consortium author lists were missing in the article

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Peer reviewedPublisher PD

Parallellism in French art and literature during the first half of the nineteenth century

Thesis (M.A.)--Boston University, 1931. This item was digitized by the Internet Archive

L’éveil à la variation phonétique en didactique du français langue étrangère : enjeux et outils

Cet article se donne pour objectif de réfléchir aux raisons pour lesquelles la phonétique est le parent pauvre de la didactique du FLE. Il propose d’intégrer des indices phoniques de la variation stylistique à l’enseignement du français. À partir d’une expérience issue d’un terrain didactique, l’auteur se penche sur le « transcodage » en tant qu’outil d’éveil à la variation phonétique en FLE.This paper attempts to understand why pronunciation is the poor relative of the teaching of French as a foreign language. It examines how phonetic indices of stylistic variation could be integrated in the French language teaching. On the basis of a field study, the author discusses “transcoding” as a tool for awakening phonetic variation in French as a foreign language

Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

PurposeBRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigatedfor the first time to our knowledgeassociations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/2 mutations and implications for cancer risk prediction.Materials and MethodsWe genotyped 1,802 male carriers of BRCA1/2 mutations from the Consortium of Investigators of Modifiers of BRCA1/2 by using the custom Illumina OncoArray. We investigated the combined effects of established breast and prostate cancer susceptibility variants on cancer risks for male carriers of BRCA1/2 mutations by constructing weighted polygenic risk scores (PRSs) using published effect estimates as weights.ResultsIn male carriers of BRCA1/2 mutations, PRS that was based on 88 female breast cancer susceptibility variants was associated with breast cancer risk (odds ratio per standard deviation of PRS, 1.36; 95% CI, 1.19 to 1.56; P = 8.6 x 10(-6)). Similarly, PRS that was based on 103 prostate cancer susceptibility variants was associated with prostate cancer risk (odds ratio per SD of PRS, 1.56; 95% CI, 1.35 to 1.81; P = 3.2 x 10(-9)). Large differences in absolute cancer risks were observed at the extremes of the PRS distribution. For example, prostate cancer risk by age 80 years at the 5th and 95th percentiles of the PRS varies from 7% to 26% for carriers of BRCA1 mutations and from 19% to 61% for carriers of BRCA2 mutations, respectively.ConclusionPRSs may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.Peer reviewe