Advanced machine learning models for online travel-time prediction on freeways

The objective of the research described in this dissertation is to improve the travel-time prediction process using machine learning methods for the Advanced Traffic In-formation Systems (ATIS). Travel-time prediction has gained significance over the years especially in urban areas due to increasing traffic congestion. The increased demand of the traffic flow has motivated the need for development of improved applications and frameworks, which could alleviate the problems arising due to traffic flow, without the need of addition to the roadway infrastructure. In this thesis, the basic building blocks of the travel-time prediction models are discussed, with a review of the significant prior art. The problem of travel-time prediction was addressed by different perspectives in the past. Mainly the data-driven approach and the traffic flow modeling approach are the two main paths adopted viz. a viz. travel-time prediction from the methodology perspective. This dissertation, works towards the im-provement of the data-driven method. The data-driven model, presented in this dissertation, for the travel-time predic-tion on freeways was based on wavelet packet decomposition and support vector regres-sion (WPSVR), which uses the multi-resolution and equivalent frequency distribution ability of the wavelet transform to train the support vector machines. The results are compared against the classical support vector regression (SVR) method. Our results indi-cate that the wavelet reconstructed coefficients when used as an input to the support vec-tor machine for regression (WPSVR) give better performance (with selected wavelets on-ly), when compared against the support vector regression (without wavelet decomposi-tion). The data used in the model is downloaded from California Department of Trans-portation (Caltrans) of District 12 with a detector density of 2.73, experiencing daily peak hours except most weekends. The data was stored for a period of 214 days accumulated over 5 minute intervals over a distance of 9.13 miles. The results indicate an improvement in accuracy when compared against the classical SVR method. The basic criteria for selection of wavelet basis for preprocessing the inputs of support vector machines are also explored to filter the set of wavelet families for the WDSVR model. Finally, a configuration of travel-time prediction on freeways is present-ed with interchangeable prediction methods along with the details of the Matlab applica-tion used to implement the WPSVR algorithm. The initial results are computed over the set of 42 wavelets. To reduce the compu-tational cost involved in transforming the travel-time data into the set of wavelet packets using all possible mother wavelets available, a methodology of filtering the wavelets is devised, which measures the cross-correlation and redundancy properties of consecutive wavelet transformed values of same frequency band. An alternate configuration of travel-time prediction on freeways using the con-cepts of cloud computation is also presented, which has the ability to interchange the pre-diction modules with an alternate method using the same time-series data. Finally, a graphical user interface is described to connect the Matlab environment with the Caltrans data server for online travel-time prediction using both SVR and WPSVR modules and display the errors and plots of predicted values for both methods. The GUI also has the ability to compute forecast of custom travel-time data in the offline mode.Ph.D

Human Dynamics of Street Administration: A Study on Traffic Wardens in Karachi

The study investigated the myriad of psychological and physical stress factors affecting traffic wardens in Karachi. It was hypothesized that traffic wardens do not feel satisfied or stressed with their jobs and also that job tenure has no relation to their job satisfaction and stress. A mixed method approach with 15 semi-structured interviews and 50 survey form was adopted using convenient sampling. Job stress and satisfaction was measured using a self-made questionnaire (a =.797 & .582). Analysis indicated that traffic wardens were satisfied with their jobs and employment duration was not found to be associated with job satisfaction and stress.  

Surface analysis of conversion coating of ASTM A 516

Surface engineering is a vital aspect of manufacturing industries owing to its benefits both in surface protection and aesthetics. It has been extensively used in various industries to guard against corrosion which is a naturally occurring and highly undesirable phenomenon. Present research has endeavored to analyze protection of ASTM A516 (Grade 70) from corrosion through surface engineering. Different methods of surface treatment and conversion coating were carried out to efficiently enhance corrosive protection. Comparative analysis of various samples was conducted to analyze their ability to resist corrosion. Samples with surface treatment followed by conversion coating were found to be effective even against 0.7% aqueous sulfuric acid with no significant cracks in the coating layer. On the other hand, conversion coated only samples showed protection against 0.35% acid. The coating of conversion coated only samples was found to have gaps/ cracks as indicated by 3% Cupric Sulfate whereas no such gaps were found in surface treated samples. Optical microscopy identified a more uniform coating thickness for surface treated samples in comparison with conversion coated only samples. In depth morphology analysis using SEM highlighted that surface treated samples had low porosity preventing the corrosion elements to reach the substrate thereby implementing higher corrosion potential

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124. Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98). Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Addressing the looming epidemic of metabolic dysfunction-associated steatotic liver disease in Pakistan: A call for action

The term metabolic dysfunction-associated steatotic liver disease (MASLD), which evolved from its predecessor, nonalcoholic fatty liver disease (NAFLD),[1

Effect of fin width ratio on thermal performance of fin based-heat sink with phase change materials

The rapid development of electronics, coupled with need of miniaturization in the design and manufacture, makes heat dissipation, which is critical for the performance, lifetime, and reliability of the components extremely challenging. To achieve higher heat dissipation rates, novel fin geometry with variable cross-section considering melting behaviour in medium is presented for PCM-based heat sink beyond previous efforts in literature. In this experimental study, effect of different variable cross-section, which refer different fin width ratio (s = 1, 0.5, 0.2 and 0) values are performed on the thermal performance of plate fin-based heat sink with PCM to enhance melting heat transfer. Decreasing fin width ratios point out increasing heat transfer surface area downwardly. N-eicosane is used. The constant input power is provided at the heat sink base. Thermal performance of novel fin design is evaluated by time-dependent temperature distributions, solid–liquid interface tracking photographs, reliable operating time, enhancement ratio, and thermal conductance. The results reveal that the proposed plate-fin geometry has a significant effect on the cooling performance of PCM-based heat sink. With the decrease of fin width ratio, higher temperature profile with more uniformity of 52% in the PCM medium, and so lower temperature distribution of 4.5% on the heat sink base are provided. Reliable operating time and thermal conductance values go up 15 % and 38%, respectively, for proposed fin geometry. The improvement on the thermal performance is achieved by the form of the plate-fin, which has increased surface area downward. This provides a great contribution to the conduction and convection heat transfer mechanisms at the lower half of the enclosure. Further, in this study, nearly the same reliable operating time is figured out with proposed fin geometry and fin number of s = 0 compared to higher fin number installation of s = 1 previously reported