Is America Ready for a Humane Feral Pig Toxicant?

In 2005 the Invasive Animals Cooperative Research Centre undertook an extensive literature review in an attempt to discover possible pharmacological weaknesses of pigs that could be inherently targeted with specific chemicals. For a chemical to have utility it ideally had to be: safe for human operators, highly toxic to pigs, bait deliverable, target specific, humane, residue-less, reversible, inexpensive, already registered for other purposes, patentable, acceptable to trading partners, and have a well documented toxicological profile. Numerous weaknesses and associated candidate chemicals were discovered, but only one, sodium nitrite, proved appropriate in gavage and bait delivery proof-of-concept pen trials. This paper details the discovery process, two years of research towards formulating an article-of-commerce, and three years of development and registration. Discussed is what is required in relation to lobbying and funding, dealing with bureaucracy, intellectual property protection, formulation, target-specificity and nontarget safety, humaneness, ground and aerial baiting field efficacy, product stability, environmental fate and residue data in order to register a commonly available human food preservative as a new vertebrate pesticide in Australia. Also discussed is the development of a novel bait delivery device that increases the target-specificity and cost-efficiency of feral pig control

Altered metabolism in cancer

Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs

Analisis Penerapan Sistem Akuntansi Penjualan Kredit Dan Penerimaan Kas Dalam Mendukung Pengendalian Intern Perusahaan (Studi Kasus PT. Smart Tbk Refinery Surabaya)

System of selling credit accounting and system of cash receiving from account receivable is the source of life to achieving company goals. This research on the system of credit sales and cash receipts to support the company internal control. This research was conducted at PT. SMART Tbk Refinery Surabaya. PT. SMART Tbk Refinery Surabaya only selling cooking oil in the form of branded product and trading product on credit. PT. SMART Tbk Refinery Surabaya still has any weakness on system of selling credit accounting and system of cash receiving from account receivable, some of the sales transaction activity that occurred less supportive of the company\u27s internal control. This study aims to provide information to companies about the advantages and weakness of credit sales accounting system and cash receipts that have been applied by the company

Semienzymatic cyclization of disulfide-rich peptides using sortase A

Background: Sortase A (SrtA) is a transpeptidase capable of catalyzing the formation of amide bonds. Results: SrtA was used to backbone-cyclize disulfide-rich peptides, including kalata B1, -conotoxin Vc1.1, and SFTI-1. Conclusion: SrtA-mediated cyclization is applicable to small disulfide-rich peptides. Significance: SrtA-mediated cyclization is an alternative to native chemical ligation for the cyclization of small peptides of therapeutic interest