A Critical Approach to Multiliteracy: Automates Intelligents

In this paper we present and analyse a website with a complex rhyzomatic structure in connection with the results of a cybertask in which students were asked to read various information sources by navigating a range of websites. The results and discussion include issues such as: a) culture of learning and students’ task representation; b) possible relationships between learning styles and ways of navigating and managing information to solve a task; c) criteria students use to evaluate their navigation practice

Interculturalité et fonctionnement des flux d’information dans l’écriture hypertextuelle. Réflexions pour une approche pédagogique

En este estudio describimos cómo se teje la estructura interna de dos sitios web (uno francés y otro inglés) al mismo tiempo que formulamos hipótesis sobre el funcionamiento de los flujos de información que aparecen en ellos. Mostramos los aspectos plurilingües y multiculturales sobre los que se sustentan y avanzamos algunas hipótesis sobre las relaciones entre los modelos ideológicos y los modelos discursivos que emanan de los flujos de información que se ofrecen a los visitantes- lectores de dichos sitios. De este análisis se deriva una serie de reflexiones que nos permitirán elaborar propuestas pedagógicas para la enseñanza-aprendizaje de lenguas.This study describes how the internal structure of two websites (in English and French) is interwoven, and formulates a series of hypotheses on the operation of the information flows extant in each of them. Apart from showing the multilingual and multicultural issues upon which these hypotheses are built, this study puts forward a series of discourse models derived from the information flows presented to the visitorsreaders of those sites. This analysis yields a series of reflections that will allow researchers to elaborate pedagogic proposals focused on the teaching and learning of languages

Are Spanish TTOs Prepared to Innovation in a COVID Context?

The analysis of the characteristics of Technology Transfer Offices (TTOs) is particularly important as they constitute mediating units in the relationship between the market and university research. They are responsible for the transfer and exploitation of knowledge arising in the university context. Previous studies have been inconclusive as to the importance that the size, professionalisation or age of TTOs might have on the transfer process. However, the need to explore new markets, recognise new opportunities and identify potential customers points to the importance of TTOs having a dual exploitative and exploratory orientation and an extensive relational network. More recent research in the literature, based on ambidexterity and network theory, points to the impact that these variables could have on change management and innovation in uncertain and changing environments, such as those faced by TTOs in the current pandemic context. Therefore, the aim of this paper is to analyse whether Spanish TTOs, due to their ambidextrous orientation at the organisational and individual level, and their relational network with academic and market actors, are prepared to promote innovation in a COVID-19 context. Based on a cluster analysis of 29 Spanish TTOs, our results show that just a few of the Spanish TTOs surveyed would be prepared, from the perspective of ambidexterity and their relational capital, to promote innovation in a COVID-19 context. In conclusion, Spanish TTOs and their employees should focus more on ambidexterity and building extensive relational capital so that, through mentoring, training, incubation or the provision of various resources, they can help academics take advantage of the innovation opportunities offered by the changing and uncertain environment.This work has been co-financed by the 2014-2020 ERDF Operational Programme and by the Department of Economy, Knowledge, Enterprise and Universities of the Regional Government of Andalusia. Project reference: FEDER-UCA18-107689. The translation was made possible with the help of INDESS (University Institute for Sustainable Social Development, of the University of Cadiz)

The impact of human, social, and psychological capital on academic spin-off internationalization

Academic spin-offs (ASOs) are companies with a strong international vocation for two main reasons: first, they market their products and services in global market niches to profit from their high investment in R&D, characteristic of the sectors in which ASOs operate; and second, as a consequence of the international training and experience and of the international networks that the founding academic entrepreneurs of these companies tend to enjoy, derived from their scientific activity. Despite this natural tendency to internationalize, ASOs and specifically the founding academic entrepreneurs of these companies present certain difficulties in accessing resources for internationalization and in achieving credibility in foreign markets due to their university origins. Based on the resource-based view (RBV), and network theory (NT), this work proposes that the human capital, the social capital, and the psychological capital of the academic entrepreneur could compensate for these obstacles, providing key resources for the internationalization of their companies. The results contribute to the RBV, NT, and academic entrepreneurship and internationalization literature since they show that human capital, in terms of the international experience and training of the academic entrepreneur, their networks of relationships with international academic agents, and their psychological capital, are all antecedents of the internationalization of ASOs. However, the networks of academic entrepreneur relationships with international market agents appear to be irrelevant in the process of international expansion of ASOs.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work has been co-financed by the 2020-2023 ERDF Operational Programme and by the Department of Economy, Knowledge, Business and University of the Regional Government of Andalusia. Project reference: FEDER-UCA18-107689 titled "Analysis of the influence of the Andalusian, Spanish and European entrepreneurial ecosystems on the internationalization process of Andalusian academic spin-offs, and its impact on innovation results"

The international orientation of academic entrepreneurship: the role of relational, human and psychological capital

Purpose Scholars have emphasized intellectual capital's importance for universities in obtaining competitive advantages and creating value. The purpose of this paper is to identify the influences of two components of intellectual capital, relational and human capital at the international level, and psychological capital on international orientation of academic entrepreneurs, and the mediating effects of international relational and human capital. Design/methodology/approach On the basis of a literature review, a theoretical model is proposed to explain the relationship between the studied variables. Our hypotheses are tested on a sample of 173 academic spin-offs of Spanish universities using bootstrapping methodology. Findings The results show that the international market relational capital and international human capital of academic entrepreneurs influence their international orientation, and that their psychological capital is directly, and indirectly, related to international orientation through international human capital and international market relational capital. Practical implications This study provides a better understanding of the antecedents of the international orientation of academic entrepreneurs, which would provide an important contribution to the literature on intellectual capital, academic entrepreneurship and internationalization. The achieved results highlight important implications for training of academic entrepreneurs and for managers and management teams of companies willing to enter, or even those already operating in, international markets. Originality/value In this study, the international orientation of academic entrepreneurs is explained through the psychological capital that is studied jointly with two components of intellectual capital, relational and human capital at the international level. Although some recent work has focused on the study of the internationalization of academic spin-off, this line of research is still incipient

Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells

Controlled delivery of multiple chemotherapeutics can improve the effectiveness of treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold nanoclusters modified with doxorubicin and SN38 (AuNCs-DS) as combined therapy for cancer. The chemotherapeutics are conjugated to the nanostructures using linkers that release them when exposed to different internal stimuli (Glutathione and pH). This system has shown potent antitumor activity against breast and pancreatic cancer cells. Our studies indicate that the antineoplastic activity observed may be related to the reinforced DNA damage generated by the combination of the drugs. Moreover, this system presented antineoplastic activity against mammospheres, a culturing model for cancer stem cells, leading to an efficient reduction of the number of oncospheres and their size. In summary, the nanostructures reported here are promising carriers for combination therapy against cancer and particularly to cancer stem cells.This research was funded by the Spanish Ministry of Economy and Competitiveness (CTQ2016-78454-C2-2-R, SAF2014-56763-R, and SAF2017-87305-R), Comunidad de Madrid (S2013/MIT-2850), Asociación Española Contra el Cáncer, and IMDEA Nanociencia IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686

Impact of Nursing Methodology training sessions on completion of the Virginia Henderson assessment record

Producción CientíficaThe Virginia Henderson model, integrated in the computer application GACELA Care, helps to standardise the nursing assessment and establish precise and personalised nursing diagnoses. The aim was to determine the extent of completion of the initial patient assessment record after nurses following a training programme on nursing methodology. A quasi-experimental, retrospective, randomised, observational, single-group study was performed in two stages: pre-training and post-training. Voluntary training sessions were held for the nurses that work with GACELA Care. The completion of the initial patient assessment using the needs of Virginia Henderson and the Norton scale was evaluated before and after the training sessions. Completion of the needs of Virginia Henderson in the initial patient assessment increased from 94.2% to 100% (p = 0.014). Completion of “hygiene/skin” increased significantly from 83.3% to 95.8% (pre-training and post-training, respectively). The remaining needs did not show statistical significance. Recording of the Norton scale increased from 63.13% to 92.5% (p < 0.001). The training sessions on nursing methodology have improved the completion of records and inclusion of normal characteristics, defining characteristics and risk factors, and improving pressure ulcer risk assessment through the Norton scale

Analysis of burnout syndrome and resilience in nurses throughout the COVID-19 pandemic: A cross-sectional study

Producción CientíficaBackground: The COVID-19 pandemic has contributed to the occurrence of work-related stress on nursing staff. Being resilience an essential element to countering adversity. The aim of the study was to assess burnout syndrome as well as resilience in hospital-care nurses during the first outbreak of the COVID-19 pandemic. Methods: A cross-sectional descriptive study of burnout syndrome and resilience of 101 nurses during the first COVID-19 outbreak. The Maslach Burnout Inventory and the Scale of Resilience of Connor-Davidson were used. Results: The burnout average score was 74.35 ± 12.78 points, and resilience was 27.94 ± 5.84. Temporary nurses reached a lower average score for the emotional fatigue dimension (23.80 ± 10.39 points) p < 0.05. The emotional fatigue dimension correlated adversely with the average score of resilience (r = −0.271; p < 0.001). Conclusions: The level of burnout in nurses was high, being higher on those who took care of COVID-19 patients. Resilient nurses were able to better cope with stressful situations

Diseño, desarrollo, experimentación y evaluación de aplicaciones Android para la enseñanza de la estadística

Memoria ID-0100. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017

3-Hydroxykynurenic acid: Physicochemical properties and fluorescence labeling

Quinoline is one of the most important heterocyclic systems in life sciences. Some derivatives are normal metabolites, and others are used as antibacterial, antimalarial, and anticancer agents. In this work, we describe the synthesis, physicochemical properties, and fluorescence features of a new 4-quinolinone fluorophore, 3-hydroxykynurenic acid (3-HOKA). 3-HOKA was obtained by alkoxide-induced rearrangement of ethyl isatinacetate followed by acidification and then alkaline hydrolysis. The fluorescent compound was characterized by NMR, MS, IR, and UV–Vis spectra. 3-HOKA can exist under a keto-enol equilibrium, but the 4-quinolinone form is the predominant tautomer. In PBS (pH = 7.4), the anionic keto form of 3-HOKA showed a maximum absorption at 368 nm, a fluorescence peak at 474 nm, and a fluorescence quantum yield (ΦF): 0.73. 3-HOKA is photostable and is a moderately weak oxygen generator. Viability assays on HeLa cells indicated that 3-HOKA did not induce significative cytotoxic effects. Under UV excitation, a bright blue fluorescence was selectively found in a singular body within the cytoplasm, a labeling pattern that suggests the possible localization of the probe in the centriole or related structures. Therefore, this novel fluorophore represents a promising prototype compound owing to its biocompatibility and potential biological applications.Fil: Shmidt, María Sol. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Garcia Vior, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Ezquerra Riega, Sergio Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Abasolo, María I.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Lazaro Carrillo, Ana. Universidad Autónoma de Madrid; EspañaFil: Tabero, Andrea. Universidad Autónoma de Madrid; EspañaFil: Villanueva, Angeles. Universidad Autónoma de Madrid; España. Instituto Madrileño de Estudios Avanzados en Nanociencia; EspañaFil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: del Blanco, María Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Stockert Cossu, Juan Carlos. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigacion y Tecnología en Reproducción Animal; Argentin