Everyday visual function and the visual experience in dry age-related macular degeneration

Dry age-related macular degeneration (AMD) is a common eye condition, which causes progressive loss of central vision; there is currently no treatment. The live studies presented in this thesis aimed to explore different aspects of everyday visual function and the experience of living with dry AMD. In the first study, a systematic review of the literature surrounding quality of life and “real-world” visual ability in AMD was conducted. Several domains of everyday life affected by AMD were identified; these had been investigated using a wide variety of study designs. However, only 4% of studies meeting inclusion criteria specifically investigated individuals with dry AMD. In the second and third studies, people (>60 years, logMAR binocular visual acuity of 0.7 or better) categorised with varying severities of dry AMD performed two previously validated computer-based real-world visual tasks. Comparisons for both tasks were made against a 90% normative limit for the outcome measures established in age-related peers with healthy vision. In a search task, participants were instructed to find items within digital photographs of everyday indoor and outdoor scenes. Sixty-one percent of participants with dry AMD, (including all of those with late dry AMD) exceeded the 90% normative limits for average search time; this was statistically significant (Fisher’s exact test, p < 0.0001). In a face recognition task, participants completed a modified version of the Cambridge Face Memory Test. Percentage of correctly identified faces was used as an outcome measure. Five (17%) participants with dry AMD scored worse than the 90% limit (Fisher's exact test, p=0.46); four of these had fovea-involving geographic atrophy. In the fourth study, volunteers with dry AMD described their visual symptoms in an interview and were asked to comment on the realism of a photograph typically used to simulate vision in AMD. Interview transcripts underwent content analysis. The most frequently used visual symptom was blur (n=13) followed by missing part/s (n=10) and distortion (n=7). Seventy-six percent (95% confidence interval 53-92%) of the participants rejected the realism of a popular image often used to portray the visual symptoms of AMD. In a fifth study, a novel test measuring mobility anxiety was introduced. Participants were shown a series of short movies of navigation through real-world mobility scenarios and were asked to press on a button during scenes which would cause them anxiety or discomfort. Pressure on the button was recorded throughout the test and this was used as an outcome measure. People with intermediate and late AMD applied more pressure to the button, on average, than those with early and no AMD (Kruskal-Wallis test, p=0.04). Situations involving negotiating stairs were identified as particularly problematic. To conclude, these studies spotlight the problems people with dry AMD have with visual tasks. In addition, the tests described in this thesis may have potential to be used as patient- based outcome measures for clinical trials for future treatments for dry AMD. Moreover, findings reported in this thesis may help clinicians with patient management and expectations, and should inform future patient, public and professional education about dry AMD

Quantifying nanoparticle dispersion: application of the Delaunay network for objective analysis of sample micrographs

Measuring quantitatively the nanoparticle dispersion of a composite material requires more than choosing a particular parameter and determining its correspondence to good and bad dispersion. It additionally requires anticipation of the measure’s behaviour towards imperfect experimental data, such as that which can be obtained from a limited number of samples. It should be recognised that different samples from a common parent population can give statistically different responses due to sample variation alone and a measure of the likelihood of this occurring allows a decision on the dispersion to be made. It is also important to factor into the analysis the quality of the data in the micrograph with it: (a) being incomplete because some of the particles present in the micrograph are indistinguishable or go unseen; (b) including additional responses which are false. With the use of our preferred method, this article investigates the effects on the measured dispersion quality of nanoparticles of the micrograph’s magnification settings, the role of the fraction of nanoparticles visible and the number of micrographs used. It is demonstrated that the best choice of magnification, which gives the clearest indication of dispersion type, is dependent on the type of nanoparticle structure present. Furthermore, it is found that the measured dispersion can be modified by particle loss, through the limitations of micrograph construction, and material/microscope imperfections such as cut marks and optical aberrations which could lead to the wrong conclusions being drawn. The article finishes by showing the versatility of the dispersion measure by characterising various different spatial features. <br/

The response of the magnetosphere to the passage of a coronal mass ejection on March 20-21 1990

International audienceThe geomagnetic response to the passage of a coronal mass ejection (CME) is studied. The passage of the CME resulted in a storm sudden commencement (SSC) at 2243 UT on March 20 1990 with disturbed magnetic activity during the following 24 h. The auroral, sub-auroral and equatorial magnetic response to the southward turning at 1314 (±5) UT on March 21 and the equatorial response to the southward turning associated with the SSC on 20 March are discussed in terms of existing models. It is found that the auroral and sub-auroral response to the southward turning associated with the SSC is a factor 2 or more quicker than normal due to the shock in the solar wind dynamic pressure. The low-latitude response time to the southward turning, characterised by Dst and the magnetopause current corrected Dst*, is unaffected by the shock. Dst and Dst*, characteristic of the equatorial magnetic field, responded to the 1314 (±5) UT southward turning prior to the first observed substorm expansion phase onset, suggesting that a dayside loading process was responsible for the initial enhancement in the ring current rather than nightside particle injection. The response time of the auroral and sub-auroral magnetic field to the southward turning at 1314 (±5) UT on March 21 is measured at a variety of longitudes and latitudes. The azimuthal propagation velocity of the response to the southward turning varied considerably with latitude, ranging from ~8 km s?1 at 67°N to ~4 km s?1 at 55°N. The southward velocity of the equatorward boundary of the northern polar convection pattern has been measured. This velocity was ~1.2 km s?1 at 1600 MLT, although there was evidence that this may vary at different local times

Gastric intramucosal pH predicts outcome after surgery for ruptured abdominal aortic aneurysm

Objective:The mortality associated with repair of ruptured abdominal aortic aneurysms (RAAA) remains obstinately high and many deaths result from multiple organ failure which is likely to be related to splanchnic ischaemia. The aim of this study is to investigate the importance of splanchnic ischaemia in determining outcome from RAAA by comparing gastric intramucosal pH with other methods of assessing the adequacy of splanchnic oxygenation.Design and setting:Prospective cohort of patients following surgery for RAAA admitted to the Intensive Care Unit of Guy's Hospital, London.Outcome measures:Gastric intramucosal pH (pHim) and global haemodynamic, oxygen transport and metabolic variables were measured on admission, at 12 h and at 24 h after admission. Results were compared between survivors and non-survivors and Receiver Operating Characteristic (ROC) curves were constructed to assess the ability of each measurement to predict outcome.Results:The median 24 h APACHE II was 18 and the ICU mortality 45.5%. Gastric pHim was significantly higher in survivors than non-survivors at 24 h (7.42 vs. 7.24, p < 0.01). In survivors who had a low intramucosal pH (pHim) on admission there was a significant improvement over the first 24 h (7.26 to 7.40, p < 0.05), whereas in patients who subsequently died, and had a normal pHim on admission, there was a significant fall in pHim (7.35 to 7.16, p < 0.05). ROC curves showed that gastric pHim was the most sensitive measurement for predicting outcome in these patients.Conclusions:Gastric intramucosal pH is the most reliable indicator of adequacy of tissue oxygenation in patients with RAAA, suggesting that splanchnic ischaemia may have played an important role in determining survival

Cost Assignments In A Managerial Accounting Contract Logging Context

This case describes a firm where the controller is planning to use his expertise in accounting for company-owned timber to consider logging on a contract basis for others. To develop the contract strategy, the controller must understand the firm’s costs so that he can prepare competitive bids and provide an adequate profit margin. This case requires students to engage in the first steps of developing a cost management system for a contracting situation. Students must: (1) identify management’s information needs, (2) identify cost objects, (3) identify appropriate costs to assign to cost objects, (4) identify potential allocation bases for indirect costs, and (5) describe cost behavior

Effect of Density Inhomogeneity on YORP: The case of Itokawa

The effect of density inhomogeneity on the YORP effect for a given shape model is investigated. A density inhomogeneity will cause an offset between the center of figure and the center of mass and a re-orientation of the principal axes away from those associated with the shape alone. Both of these effects can alter the predicted YORP rate of change in angular velocity and obliquity. We apply these corrections to the Itokawa shape model and find that its YORP angular velocity rate is sensitive to offsets between its center of mass and center of figure, with a shift on the order of 10 meters being able to change the sign of the YORP effect for that asteroid. Given the non-detection of YORP for Itokawa as of 2008, this can shed light on the density distribution within that body. The theory supports a shift of the asteroid center of mass towards Itokawa's neck region, where there is an accumulation of finer gravels. Detection of the YORP effect for Itokawa should provide some strong constraints on its density distribution. This theory could also be applied to asteroids visited by future spacecraft to constrain density inhomogeneities.Comment: 23 pages, 3 figure

Indestructibility of Vopenka's Principle

We show that Vopenka's Principle and Vopenka cardinals are indestructible under reverse Easton forcing iterations of increasingly directed-closed partial orders, without the need for any preparatory forcing. As a consequence, we are able to prove the relative consistency of these large cardinal axioms with a variety of statements known to be independent of ZFC, such as the generalised continuum hypothesis, the existence of a definable well-order of the universe, and the existence of morasses at many cardinals.Comment: 15 pages, submitted to Israel Journal of Mathematic

Comments on Schnabl's analytic solution for tachyon condensation in Witten's open string field theory

Schnabl recently constructed an analytic solution for tachyon condensation in Witten's open string field theory. The solution consists of two pieces. Only the first piece is involved in proving that the solution satisfies the equation of motion when contracted with any state in the Fock space. On the other hand, both pieces contribute in evaluating the kinetic term to reproduce the value predicted by Sen's conjecture. We therefore need to understand why the second piece is necessary. We evaluate the cubic term of the string field theory action for Schnabl's solution and use it to show that the second piece is necessary for the equation of motion contracted with the solution itself to be satisfied. We also present the solution in various forms including a pure-gauge configuration and provide simpler proofs that it satisfies the equation of motion.Comment: 33 pages, 4 figures, LaTeX2e; v2: minor changes, version published in JHE

Constraining the role of early land plants in Palaeozoic weathering and global cooling

How the colonization of terrestrial environments by early land plants over 400 Ma influenced rock weathering, the biogeochemical cycling of carbon and phosphorus, and climate in the Palaeozoic is uncertain. Here we show experimentally that mineral weathering by liverworts—an extant lineage of early land plants—partnering arbuscular mycorrhizal (AM) fungi, like those in 410 Ma-old early land plant fossils, amplified calcium weathering from basalt grains threefold to sevenfold, relative to plant-free controls. Phosphate weathering by mycorrhizal liverworts was amplified 9–13-fold over plant-free controls, compared with fivefold to sevenfold amplification by liverworts lacking fungal symbionts. Etching and trenching of phyllosilicate minerals increased with AM fungal network size and atmospheric CO2 concentration. Integration of grain-scale weathering rates over the depths of liverwort rhizoids and mycelia (0.1 m), or tree roots and mycelia (0.75 m), indicate early land plants with shallow anchorage systems were probably at least 10-fold less effective at enhancing the total weathering flux than later-evolving trees. This work challenges the suggestion that early land plants significantly enhanced total weathering and land-to-ocean fluxes of calcium and phosphorus, which have been proposed as a trigger for transient dramatic atmospheric CO2 sequestration and glaciations in the Ordovician