Hyperonic crystallization in hadronic matter

Published in Hadrons, Nuclei and Applications, World Scientific, Singapore, Proc.of the Conference Bologna2000. Structure of the Nucleus at the Dawn of the Century, G. Bonsignori, M. Bruno, A. Ventura, D. Vretenar Editors, pag. 319.Comment: 4 pages, 2figure

Mode stability in delta Scuti stars: linear analysis versus observations in open clusters

A comparison between linear stability analysis and observations of pulsation modes in five delta Scuti stars, belonging to the same cluster, is presented. The study is based on the work by Michel et al. (1999), in which such a comparison was performed for a representative set of model solutions obtained independently for each individual star considered. In this paper we revisit the work by Michel et al. (1999) following, however, a new approach which consists in the search for a single, complete, and coherent solution for all the selected stars, in order to constrain and test the assumed physics describing these objects. To do so, refined descriptions for the effects of rotation on the determination of the global stellar parameters and on the adiabatic oscillation frequency computations are used. In addition, a crude attempt is made to study the role of rotation on the prediction of mode instabilities.The present results are found to be comparable with those reported by Michel et al. (1999). Within the temperature range log T_eff = 3.87-3.88 agreement between observations and model computations of unstable modes is restricted to values for the mixing-length parameter alpha_nl less or equal to 1.50. This indicates that for these stars a smaller value for alpha_nl is required than suggested from a calibrated solar model. We stress the point that the linear stability analysis used in this work still assumes stellar models without rotation and that further developments are required for a proper description of the interaction between rotation and pulsation dynamics.Comment: 8 pages, 4 figures, 3 tables. (MNRAS, in press

Cis-regulation of IRF5 expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines

INTRODUCTION: Interferon regulatory factor 5 gene (IRF5) polymorphisms are strongly associated with several diseases, including systemic lupus erythematosus (SLE). The association includes risk and protective components. They could be due to combinations of functional polymorphisms and related to cis-regulation of IRF5 expression, but their mechanisms are still uncertain. We hypothesised that thorough testing of the relationships between IRF5 polymorphisms, expression data from multiple experiments and SLE-associated haplotypes might provide useful new information. METHODS: Expression data from four published microarray hybridisation experiments with lymphoblastoid cell lines (57 to 181 cell lines) were retrieved. Genotypes of 109 IRF5 polymorphisms, including four known functional polymorphisms, were considered. The best linear regression models accounting for the IRF5 expression data were selected by using a forward entry procedure. SLE-associated IRF5 haplotypes were correlated with the expression data and with the best cis-regulatory models. RESULTS: A large fraction of variability in IRF5 expression was accounted for by linear regression models with IRF5 polymorphisms, but at a different level in each expression data set. Also, the best models from each expression data set were different, although there was overlap between them. The SNP introducing an early polyadenylation signal, rs10954213, was included in the best models for two of the expression data sets and in good models for the other two data sets. The SLE risk haplotype was associated with high IRF5 expression in the four expression data sets. However, there was also a trend towards high IRF5 expression with some protective and neutral haplotypes, and the protective haplotypes were not associated with IRF5 expression. As a consequence, correlation between the cis-regulatory best models and SLE-associated haplotypes, regarding either the risk or protective component, was poor. CONCLUSIONS: Our analysis indicates that although the SLE risk haplotype of IRF5 is associated with high expression of the gene, cis-regulation of IRF5 expression is not enough to fully account for IRF5 association with SLE susceptibility, which indicates the need to identify additional functional changes in this gene

Liberalism, lack and living the dream : re-considering youth, consumer sovereignty and the attractions of night-time leisure in Magaluf

Much of the academic literature on alcohol-based leisure focuses on the pleasures of hedonism and youthful cultural exploration in environments free from the prescriptions, pressures and routines of everyday life. In this article – in which we present data from our ongoing ethnographic research exploring the experiences and attitudes of young British tourists in the Spanish resort of Magaluf on the island of Majorca – we argue that the standard liberal social-scientific image of youth leisure is naive and misrepresents its variegated reality. Our research indicates that many young British tourists gain little contentment from their holiday in the sun. Rather than embarking on a leisure experience composed of boundless freedom, choice, indulgence, excess and that is indicative of personal consumer sovereignty, many of our interviewees could identify the regimented and commodified nature of alcohol-based tourism. Rather than satisfaction, they felt an imprecise dissatisfaction. Drawing upon elements of psychoanalytic theory, we argue that underneath our interviewees’ accounts of drunkenness and promiscuity lies an obdurate but imprecise sense of lack. Yet, it is precisely this absence which only recharges their motivation to do more of the same the year after in similar destinations, thus confirming the presence, power and domination of consumer sovereignty

Lignin-Based Polyols with Controlled Microstructure by Cationic Ring Opening Polymerization

Lignin-based polyols (LBPs) with controlled microstructure were obtained by cationic ring opening polymerization (CROP) of oxiranes in an organosolv lignin (OL) tetrahydrofuran (THF) solution. The control on the microstructure and consequently on the properties of the LBPs such as hydroxyl number, average molecular weight, melting, crystallization and decomposition temperatures, are crucial to determine the performance and application of the derived-products. The influence of key parameters, for example, molar ratio between the oxirane and the hydroxyl groups content in OLO, initial OL concentration in THF, temperature, specific flow rate and oxirane nature has been investigated. LBPs with hydroxyl numbers from 35 to 217 mg KOH/g, apparent average Mw between 5517 and 52,900 g/mol and melting temperatures from −8.4 to 18.4 °C were obtained. The CROP procedure allows obtaining of tailor-made LBPs for specific applications in a very simple way, opening the way to introduce LBPs as a solid alternative to substitute currently used fossil-based polyols.Basque Government (grant KK-2019/00097

Symphony on strong field approximation

This paper has been prepared by the Symphony collaboration (University of Warsaw, Uniwersytet Jagiellonski, DESY/CNR and ICFO) on the occasion of the 25th anniversary of the 'simple man's models' which underlie most of the phenomena that occur when intense ultrashort laser pulses interact with matter. The phenomena in question include high-harmonic generation (HHG), above-threshold ionization (ATI), and non-sequential multielectron ionization (NSMI). 'Simple man's models' provide both an intuitive basis for understanding the numerical solutions of the time-dependent Schrodinger equation and the motivation for the powerful analytic approximations generally known as the strong field approximation (SFA). In this paper we first review the SFA in the form developed by us in the last 25 years. In this approach the SFA is a method to solve the TDSE, in which the non-perturbative interactions are described by including continuum-continuum interactions in a systematic perturbation-like theory. In this review we focus on recent applications of the SFA to HHG, ATI and NSMI from multi-electron atoms and from multi-atom molecules. The main novel part of the presented theory concerns generalizations of the SFA to: (i) time-dependent treatment of two-electron atoms, allowing for studies of an interplay between electron impact ionization and resonant excitation with subsequent ionization; (ii) time-dependent treatment in the single active electron approximation of 'large' molecules and targets which are themselves undergoing dynamics during the HHG or ATI processes. In particular, we formulate the general expressions for the case of arbitrary molecules, combining input from quantum chemistry and quantum dynamics. We formulate also theory of time-dependent separable molecular potentials to model analytically the dynamics of realistic electronic wave packets for molecules in strong laser fields. We dedicate this work to the memory of Bertrand Carre, who passed away in March 2018 at the age of 60

Wannier-Bloch Approach to Localization in High-Harmonics Generation in Solids

Emission of high-order harmonics from solids provides a new avenue in attosecond science. On the one hand, it allows us to investigate fundamental processes of the nonlinear response of electrons driven by a strong laser pulse in a periodic crystal lattice. On the other hand, it opens new paths toward efficient attosecond pulse generation, novel imaging of electronic wave functions, and enhancement of high-order harmonic-generation (HHG) intensity. A key feature of HHG in a solid (as compared to the well-understood phenomenon of HHG in an atomic gas) is the delocalization of the process, whereby an electron ionized from one site in the periodic lattice may recombine in any other. Here, we develop an analytic model, based on the localized Wannier wave functions in the valence band and delocalized Bloch functions in the conduction band. This Wannier-Bloch approach assesses the contributions of individual lattice sites to the HHG process and hence precisely addresses the question of localization of harmonic emission in solids. We apply this model to investigate HHG in a ZnO crystal for two different orientations, corresponding to wider and narrower valence and conduction bands, respectively. Interestingly, for narrower bands, the HHG process shows significant localization, similar to harmonic generation in atoms. For all cases, the delocalized contributions to HHG emission are highest near the band-gap energy. Our results pave the way to controlling localized contributions to HHG in a solid crystal

Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophy

Copyright \ua9 2024 Fern\ue1ndez-Sim\uf3n, Pi\uf1ol-Jurado, Gokul-Nath, Unsworth, Alonso-P\ue9rez, Schiava, Nascimento, Tasca, Queen, Cox, Suarez-Calvet and D\uedaz-Manera.Background: Duchenne muscular dystrophy is a genetic disease produced by mutations in the dystrophin gene characterized by early onset muscle weakness leading to severe and irreversible disability. Muscle degeneration involves a complex interplay between multiple cell lineages spatially located within areas of damage, termed the degenerative niche, including inflammatory cells, satellite cells (SCs) and fibro-adipogenic precursor cells (FAPs). FAPs are mesenchymal stem cell which have a pivotal role in muscle homeostasis as they can either promote muscle regeneration or contribute to muscle degeneration by expanding fibrotic and fatty tissue. Although it has been described that FAPs could have a different behavior in DMD patients than in healthy controls, the molecular pathways regulating their function as well as their gene expression profile are unknown. Methods: We used single-cell RNA sequencing (scRNAseq) with 10X Genomics and Illumina technology to elucidate the differences in the transcriptional profile of isolated FAPs from healthy and DMD patients. Results: Gene signatures in FAPs from both groups revealed transcriptional differences. Seurat analysis categorized cell clusters as proliferative FAPs, regulatory FAPs, inflammatory FAPs, and myofibroblasts. Differentially expressed genes (DEGs) between healthy and DMD FAPs included upregulated genes CHI3L1, EFEMP1, MFAP5, and TGFBR2 in DMD. Functional analysis highlighted distinctions in system development, wound healing, and cytoskeletal organization in control FAPs, while extracellular organization, degradation, and collagen degradation were upregulated in DMD FAPs. Validation of DEGs in additional samples (n = 9) using qPCR reinforced the specific impact of pathological settings on FAP heterogeneity, reflecting their distinct contribution to fibro or fatty degeneration in vivo. Conclusion: Using the single-cell RNA seq from human samples provide new opportunities to study cellular coordination to further understand the regulation of muscle homeostasis and degeneration that occurs in muscular dystrophies