189 research outputs found
The Attitudes and Awareness of Sexual Assault, Relationship Violence, and Bystander Intervention of Undergraduate Students
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Student Perceptions of the University of North Texas Campus Police
Numerous studies have been conducted to determine predictors of perceptions and attitudes toward police. Less effort has been spent on determining university and college students' perceptions of campus police departments. The purpose of this thesis was to fill this gap in the literature with an added emphasis on exploring potential differences in perceptions between students involved in Greek Life organizations and students not involved in Greek Life organizations. Prior literature found that Greek Life students engage in risk-taking behaviors at higher rates than their counterparts, so it was hypothesized that Greek Life students would have higher levels of distrust in the campus police due to their increased engagement in risk-taking behaviors. The survey questionnaire measuring trust and procedural justice/legitimacy perceptions of campus police was distributed through convenience sampling to university students. Descriptive statistics, bivariate analyses, and multivariate analyses were utilized to analyze the data. The results showed that students overall had positive perceptions of campus police, that Greek Life students had more negative perceptions of the campus police than non-Greek Life students, and that students with prior interactions with the campus police were more likely to perceive the police to be less procedurally just/legitimate. Race/ethnicity was not found to be a predictor in perceptions of trust or procedural justice/legitimacy of the campus police. Limitations, policy implications, and suggestions for future research concerning student perceptions of campus police were also discussed
The Use of Prasugrel and Ticagrelor in Pipeline Flow Diversion
Background:
Despite the routine clopidogrel/aspirin anti-platelet therapy, complications like thromboembolism, continue to be encountered with PED. We studied the safety and the efficacy of prasugrel in the management of clopidogrel non-responders treated for intracranial aneurysms.
Methods:
437 consecutive neurosurgery patients were identified between January 2011 and May 2016. Patients allergic or having \u3c30% platelet-inhibition with a daily 75mg of clopidogrel were dispensed 10mg of prasugrel daily (n=20) or 90mg of ticagrelor twice daily (n=2). The average follow-up was 15.8 months (SD=12.4 months). Patient clinical well being was evaluated with the modified Rankin Scale (mRS) registered before the discharge and at each follow-up visit. To control confounding we used multivariable mixed-effects logistic regression and propensity score conditioning.
Results:
26 of 437(5.9%) patients (mean of age 56.3 years; 62 women [14,2%]) presented with a sub-arachnoid hemorrhage. 1 patient was allergic to clopidogrel and prasugrel simultaneously. All the patients receiving prasugrel (n=22) had a mRS\u3c2 on their latest follow-up visit (mean=0.67; SD=1.15). In a multivariate analysis, clopidogrel did not affect the mRS on last follow-up, p=0.14. Multivariable logistic regression showed that clopidogrel was not associated with an increased long-term recurrence rate (odds ratio[OR], 0.17; 95%Confidence Interval [CI95%], 0.01-2.70; p=0.21) neither with an increased thromboembolic accident rate (OR, 0.46; CI95%, 0.12-1.67; p=0.36) nor with an increased hemorrhagic event rate (OR, 0.39; CI95%,0.91-1.64; p=0.20). None of the patients receiving prasugrel deceased or had a long-term recurrence nor a hemorrhagic event, only 1 patient suffered from mild aphasia subsequent to a thromboembolic event. 3 patients on clopidogrel passed during the study: (2) from acute SAH and (1) from intra-parenchymal hemorrhage. Clopidogrel was not associated with an increased mortality rate (OR, 2.18; CI95%,0.11-43.27; p=0.61). The same associations were present in propensity score adjusted models.
Conclusion:
In a cohort of patients treated with PED for their intracranial aneurysms, prasugrel (10mg/day) is a safe alternative to clopidogrel resistant, allergic or non-responders
Aneurysm Coil Embolization Using a 1.5-Fr Distal Outer Diameter Microcatheter
The current assortment of microcatheters widely used for aneurysm coil embolization may not be well suited for several anatomic variants, including excessive vascular tortuosity and small aneurysms less than 3 mm. Longer microcatheters designed with a smaller caliber that can accommodate and deliver coils may be of use in these situations. This case series and literature review illustrates the advantages and limitations of the Marathon microcatheter (Covidien, Irvine, CA, USA) when used for coil embolization of cerebral aneurysms. Despite some technical compromises including the distal marker, length, and the risk of buckling, the Marathon microcatheter was able to adequately deliver coils to achieve satisfactory occlusion of cerebral aneurysms. We found unique advantages with regards to length and smaller distal outer diameter (OD). These results may serve as a guide for the further development of a microcatheter used for coil embolization that has the features of a smaller distal OD and longer length
Stochastic partial differential equation based modelling of large space-time data sets
Increasingly larger data sets of processes in space and time ask for
statistical models and methods that can cope with such data. We show that the
solution of a stochastic advection-diffusion partial differential equation
provides a flexible model class for spatio-temporal processes which is
computationally feasible also for large data sets. The Gaussian process defined
through the stochastic partial differential equation has in general a
nonseparable covariance structure. Furthermore, its parameters can be
physically interpreted as explicitly modeling phenomena such as transport and
diffusion that occur in many natural processes in diverse fields ranging from
environmental sciences to ecology. In order to obtain computationally efficient
statistical algorithms we use spectral methods to solve the stochastic partial
differential equation. This has the advantage that approximation errors do not
accumulate over time, and that in the spectral space the computational cost
grows linearly with the dimension, the total computational costs of Bayesian or
frequentist inference being dominated by the fast Fourier transform. The
proposed model is applied to postprocessing of precipitation forecasts from a
numerical weather prediction model for northern Switzerland. In contrast to the
raw forecasts from the numerical model, the postprocessed forecasts are
calibrated and quantify prediction uncertainty. Moreover, they outperform the
raw forecasts, in the sense that they have a lower mean absolute error
Carboniferous plant physiology breaks the mold
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155970/1/nph16460-sup-0001-SupInfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155970/2/nph16460_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155970/3/nph16460.pd
The anatomical distance of functional connections predicts brain network topology in health and schizophrenia.
The human brain is a topologically complex network embedded in anatomical space. Here, we systematically explored relationships between functional connectivity, complex network topology, and anatomical (Euclidean) distance between connected brain regions, in the resting-state functional magnetic resonance imaging brain networks of 20 healthy volunteers and 19 patients with childhood-onset schizophrenia (COS). Normal between-subject differences in average distance of connected edges in brain graphs were strongly associated with variation in topological properties of functional networks. In addition, a club or subset of connector hubs was identified, in lateral temporal, parietal, dorsal prefrontal, and medial prefrontal/cingulate cortical regions. In COS, there was reduced strength of functional connectivity over short distances especially, and therefore, global mean connection distance of thresholded graphs was significantly greater than normal. As predicted from relationships between spatial and topological properties of normal networks, this disorder-related proportional increase in connection distance was associated with reduced clustering and modularity and increased global efficiency of COS networks. Between-group differences in connection distance were localized specifically to connector hubs of multimodal association cortex. In relation to the neurodevelopmental pathogenesis of schizophrenia, we argue that the data are consistent with the interpretation that spatial and topological disturbances of functional network organization could arise from excessive "pruning" of short-distance functional connections in schizophrenia.PEV is supported by the Medical Research Council (grant number MR/K020706/1). This
work was supported by the Neuroscience in Psychiatry Network (NSPN) which is funded by a Wellcome Trust strategy award to the University of Cambridge and University College London. ETB is employed half-time by the University of Cambridge and half-time by GlaxoSmithKline; he holds stock in GSK.This is the final published version. It first appeared at http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12365/full
Modelling precipitation in Sweden using multiple step markov chains and a composite model
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