142 research outputs found
Synthesis and asymmetric hydrogenation of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dione
The synthesis of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dione 4 from N-benzylglutarimide was achieved in three steps. The asymmetric hydrogenation of 4 gave either the product of partial reduction (10) or full reduction (13), depending on the catalyst which was employed, in high ee in each case. Attempts at asymmetric transfer hydrogenation (ATH) of 4 resulted in formation of a racemic product
Pd-catalysed amidation of 2,6-dihalopurine nucleosides. Replacement of iodine at 0 ºC
Pd-catalysed reactions of 2-Cl, 2-Br and 2-I derivatives of a 6-chloropurine nucleoside with benzamide have been compared, using Pd2dba3, Xantphos and Cs2CO3 in toluene, between 20 and 80 °C. The reactivity order was 2-I > 2-Br > 6-Cl ≫ 2-Cl. The 2-I substituent could be replaced even at 0 °C, under conditions disclosed here for the first time. On the other hand, the replacement of the chlorine atom at position 2 (2-Cl) required 110 °C
ChemInform Abstract: Stereoselective Organozinc Addition Reactions to 1,2-Dihydropyrans for the Assembly of Complex Pyran Structures.
Synthesis of N-Arylated Sultams: Palladium- and Copper-Catalyzed Cross-Coupling of Aryl Halides with 1,4-Butane and 1,3-Propanesultams.
Synthesis and Characterization of (Aminotroponiminato)titanium(IV) Dialkyl Complexes:Â Control of Reactivity by Ligand Design
Synthesis of Unsymmetrical Diolate, Oxametallacyclopentene, Amido-Alkoxide and Thiolato-Alkoxide Complexes Using Dialkyl and Diaryl Titanium Aminotroponiminate Complexes:Â A Route to Unsymmetrical Vicinal Diols
Synthesis of Unsymmetrical Vicinal Diols Using Titanium Aminotroponiminate Alkyl Complexes
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