Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Measurement of forward charged hadron flow harmonics in peripheral PbPb collisions at √sNN = 5.02 TeV with the LHCb detector

Flow harmonic coefficients, v n , which are the key to studying the hydrodynamics of the quark-gluon plasma (QGP) created in heavy-ion collisions, have been measured in various collision systems and kinematic regions and using various particle species. The study of flow harmonics in a wide pseudorapidity range is particularly valuable to understand the temperature dependence of the shear viscosity to entropy density ratio of the QGP. This paper presents the first LHCb results of the second- and the third-order flow harmonic coefficients of charged hadrons as a function of transverse momentum in the forward region, corresponding to pseudorapidities between 2.0 and 4.9, using the data collected from PbPb collisions in 2018 at a center-of-mass energy of 5.02 TeV . The coefficients measured using the two-particle angular correlation analysis method are smaller than the central-pseudorapidity measurements at ALICE and ATLAS from the same collision system but share similar features

Helium identification with LHCb

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using pp collision data at √(s) = 13 TeV recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of 5.5 fb-1. A total of around 105 helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately 50% with a corresponding background rejection rate of up to O(10^12). These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei

Curvature-bias corrections using a pseudomass method

Momentum measurements for very high momentum charged particles, such as muons from electroweak vector boson decays, are particularly susceptible to charge-dependent curvature biases that arise from misalignments of tracking detectors. Low momentum charged particles used in alignment procedures have limited sensitivity to coherent displacements of such detectors, and therefore are unable to fully constrain these misalignments to the precision necessary for studies of electroweak physics. Additional approaches are therefore required to understand and correct for these effects. In this paper the curvature biases present at the LHCb detector are studied using the pseudomass method in proton-proton collision data recorded at centre of mass energy √(s)=13 TeV during 2016, 2017 and 2018. The biases are determined using Z→μ + μ - decays in intervals defined by the data-taking period, magnet polarity and muon direction. Correcting for these biases, which are typically at the 10-4 GeV-1 level, improves the Z→μ + μ - mass resolution by roughly 18% and eliminates several pathological trends in the kinematic-dependence of the mean dimuon invariant mass

Study of CP violation in B0 → DK⋆(892)0 decays with D → Kπ(ππ), ππ(ππ), and KK final states

A measurement of CP-violating observables associated with the interference of B0 → D0K⋆ (892)0 and B0 → D¯ 0K⋆ (892)0 decay amplitudes is performed in the D0 → K∓π ±(π +π −), D0 → π +π −(π +π −), and D0 → K+K− fnal states using data collected by the LHCb experiment corresponding to an integrated luminosity of 9 fb−1 . CP-violating observables related to the interference of B0 s → D0K¯ ⋆ (892)0 and B0 s → D¯ 0K¯ ⋆ (892)0 are also measured, but no evidence for interference is found. The B0 observables are used to constrain the parameter space of the CKM angle γ and the hadronic parameters r DK⋆ B0 and δ DK⋆ B0 with inputs from other measurements. In a combined analysis, these measurements allow for four solutions in the parameter space, only one of which is consistent with the world average

Structural and ultrastructural observations on the pericapsular duct of the adrenal gland in chicken (Gallus Domesticus)

In this paper, the structure and ultraestructure of the pericapsular duct are studied, in adrenal glands of chicken (Gallus domesticus). This duct is made of a ciliated cuboid-cyl.indroceliular epithelium, that has relatioshiips with the adrenal gland, and it presents morphological signs offuncional activity.En el presente trabajo se estudia la estructura y la ultraestructura del conducto pericapsular de las glándulas adrenales de pollo (Gallus domesticus). El conducto esta constituido por un epitelio cúbico-cilíndrico ciliado, que parece relacionarse con la glándula adrenal y presenta signos morfológicos de funcionalidad

Kidney morphological alterations in Gumboro disease

In the presente work we have studied the electornic microscope the alterations that occur in the renal oarenchyma of a day-old male chicken, of the Leghorn breed, innoculated ocularly with 0,1 ml of the Gumboro diasease virus (country virus), strain 52/70. It has been tried in a total of 73 chickens divided into 20 batches, 19 of them experimental and one control. The most important lesions hav been found in the capillary vessels and in the proximal convoluted tubules where degenerative phenomena appear.En el presente trabajo hemos estudiado con el microscopio electónico las alteraciones que ocurren en el parénquima renal de pollos machos de raza Leghorn de un día de edad, inoculados por cía ocular con un 0,1 ml dl virus productor de la enfermedad de Gumboro ("virus campo", cepa 52/70). Se ha utilizado un total de 73 pollos, divididos en 20 lotes; 19 de ellos, experimentales y uno, testigo. Las lesiones de mayor importancia las hemos encontrado en los vasos capilares y en los túbulos contorneados proximale en los que se presentan fenómenos degenerativos

Follicular cavities in adrenal medulla of the Wistar rat

In this follicular cavities in adrenal medulla of the rat were studied. They are formed by A and NA cells. This cavities present an homogeneous contents, moderately dense, in no-stressed rats, and collapsed cavities in stressed rats. We think that this cavities are follicular cavities.En el presente trabajo describimos cavidades foliculares en medula adrenal de ratas Wistar, constituidas por células A, NA o por ambas, respectivamente. Estas cavidades se han observado con contenido homogéneo escasamente osmi6filo en ratas no estresadas, y otras veces con laces colapsadas en ratas estresadas. Pensamos que estas cavidades pudieran tener un significado de cavidades foliculares

Alterations of the mammary gland capillary net in mammitis by E. coli in cattle

The alterations present in the capillary net of the mammary gland with inflamatory processes produced by E. coli have been examined. As more important lesions we have observed: endothelial tumefaction, increase of the endothelial surface on account of abundant microvilli and caverns, and increase of the plates of the basal membrans.Hemos estudiado las alteraciones que se presentan en la red capilar de las glandulas mamarias afectas por procesos de tipo inflamatorio pro¬ducido por E. coli. Como lesiones mas importantes hemos observado la presencia de tumefaccion endotelial, aumento de la superficie endotelial, debido a abundantes microvellosidades y cavernas, y aumento de las laminas de la membrana basal