68 research outputs found
Community-Clinical Integration in the Connecticut Medicaid Context
- Publication venue
- EliScholar – A Digital Platform for Scholarly Publishing at Yale
- Publication date
- 01/04/2019
- Field of study
It is well established that interventions that address social determinants of health (SDHs) are an optimal strategy to improve health equity, however the efficacy of these interventions is limited by the challenges of addressing SDHs in clinical care. As a result, building linkages between clinical providers and community-based providers of social services, formally known as community-clinical integration, is crucial to helping vulnerable populations achieve holistic, long-term health. Our team employed a mixed-methods design to understand community-clinical integration in the Connecticut Medicaid context. We conducted a realist literature review to identify models of community-clinical integration throughout the United States. We supplemented our literature review with 7 semi-structured interviews with staff from federally qualified health centers to identify best practices for and barriers to integrating community-based services into clinical care. Using insights gained from our literature review and qualitative interviews, we provide a set of recommendations to improve community-clinical integration implementation for Medicaid enrolled children and families throughout Connecticut.https://elischolar.library.yale.edu/ysph_pbchrr/1025/thumbnail.jp
Using multi-modal neuroimaging to characterise social brain specialisation in infants
- Author
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 03/11/2023
- Field of study
The specialised regional functionality of the mature human cortex partly emerges
through experience-dependent specialisation during early development. Our existing understanding
of functional specialisation in the infant brain is based on evidence from unitary imaging modalities
and has thus focused on isolated estimates of spatial or temporal selectivity of neural or haemodynamic activation, giving an incomplete picture. We speculate that functional specialisation will
be underpinned by better coordinated haemodynamic and metabolic changes in a broadly orchestrated physiological response. To enable researchers to track this process through development, we
develop new tools that allow the simultaneous measurement of coordinated neural activity (EEG),
metabolic rate, and oxygenated blood supply (broadband near-infrared spectroscopy) in the awake
infant. In 4- to 7-month-old infants, we use these new tools to show that social processing is accompanied by spatially and temporally specific increases in coupled activation in the temporal-parietal
junction, a core hub region of the adult social brain. During non-social processing, coupled activation decreased in the same region, indicating specificity to social processing. Coupling was strongest
with high-frequency brain activity (beta and gamma), consistent with the greater energetic requirements and more localised action of high-frequency brain activity. The development of simultaneous
multimodal neural measures will enable future researchers to open new vistas in understanding functional specialisation of the brain
Time series analysis of electric energy consumption using autoregressive integrated moving average model and Holt Winters model
- Author
- Publication venue
- 'Universitas Ahmad Dahlan'
- Publication date
- 01/06/2021
- Field of study
With the increasing demand of energy, the energy production is not that much sufficient and that’s why it has become an important issue to make accurate prediction of energy consumption for efficient management of energy. Hence appropriate demand side forecasting has a great economical worth. Objective of our paper is to render representations of a suitable time series forecasting model using autoregressive integrated moving average (ARIMA) and Holt Winters model for the energy consumption of Ohio/Kentucky and also predict the accuracy considering different periods (daily, weekly, monthly). We apply these two models and observe that Holt Winters model outperforms ARIMA model in each (daily, weekly and monthly observations) of the cases. We also make a comparison among few other existing analyses of time series forecasting and find out that the mean absolute percentage error (MASE) of Holt Winters model is least considering the monthly data
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
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- V. Sarathy
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- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
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- Babbage Sarah
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- Badri Hummy
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- Bajorek Eva
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- Baker M.
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- Baldwin Jennifer
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- Banerjee Ruby
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- Bao Qiyu
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- Barbe Valérie
- Bardill Simon
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- Barker Darren
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- Baron Laurent
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- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
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- Birditt Brian
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- Bissell Helen
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- Bituin Aleksandr
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- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
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- Blomstrom David B.
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- Bonnin David
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- Borzym Katja
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- Bowen Eric
- Bradley Amanda
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- Brandriff Brigitte F.
- Brannon Wade
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- Bray Jason
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- Bridgers Michael
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- Brooking Shane
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- Chen Xiaoyun
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- Chen Yiyu
- Chen Zhu
- Chen Zhu
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- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
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- Clarke Laura
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- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
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- Collings Simon
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- Comstock Robin
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- Connolly Anthony
- Connolly Karen
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- Constance Doug
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- Cook Leanna
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- Corby Nicole
- Cordes Matt
- Cordray Rebecca
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- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
- Dean Peter
- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
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- Degusta David
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- Detter John C.
- Devlin Laurie
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- Ding Hao
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- Dixon Kami
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- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
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- Dong Wei
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- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
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- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
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- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
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- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
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- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
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- Edwards Carol
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- Engle David
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- Evans Gareth
- Evans John
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- Footman Simon
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- Fujiyama Asao
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- Fuller Liam
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- Fulton Lucinda A.
- Fulton Robert S.
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- Garnes Jeffrey A.
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- Gonzales Eidelyn
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- Gordon Seth
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- Griffiths Coline
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- Hamza Khalid
- Han Guiqing
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- Hancock Julie
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- Harding Adam
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- Harley Joanne
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- Hillyard Guy
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- Hitchens Matthew Edward
- Ho Issac
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- Hoffman Susan M.G.
- Hoffs Michael
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- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Inoue Shuuji
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- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
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- Jia Jia
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- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kruchowski Scott S.
- Kube Michael
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- Nair Seema R.
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- Nakato Eriko
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- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
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- Nwokenkwo Stanley
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- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
- Orantes Jerry
- Orbell Helena
- Osada Misuzu
- Osborn Anthony
- Osborne Joan
- Osman Sahal
- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
- Pack Elizabeth
- Padki Anuradha
- Pahlavan Shane
- Palaniappan Krishnaveni
- Palazzolo Michael
- Palmeiri Anthony
- Palmer Sophie
- Pan Jiaofeng
- Pan Sisu
- Panasenko Vladimir
- Pandian Richard
- Parker Adrian
- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
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- Paulson Edward
- Payton Brett A.
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- Pearman Charlene
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- Perez Agapito
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- Petit Jean-Louis
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- Phillips Samantha
- Phulchung Tenzin
- Phunkang Pema
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- Pitluck Sam
- Plajzer-Frick Ingrid
- Platt Darren
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- Tabor Paul E.
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- Tam Serena
- Tamerisa Kavitha S.
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- Tan Xinyu
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- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
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- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
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- Taylor Ruth
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- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
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- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
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- Urban Jeremy B.
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- Usmani Kamran
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- Uyama Nozomi
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- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
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- Williamson Helen
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- Wilson Nyree
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- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
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- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The impact of the COVID-19 pandemic on the education of medical, dental and non-medical healthcare professionals in Bangladesh : findings and connotation
- Author
- Adnan Nihad
- Ahammed Ferdaus
- Ahmad Rahnuma
- Ahmed Tarafder Shahniam
- Akhtar Gulshan
- Akter Farhana
- Alim Rumana
- Andalib Sofia
- ARM Lutful Kabir
- Bashar Mohammad Abul
- Basu Kamalesh Chandra
- Begum Firoza
- Begum Mahamuda
- Biswas Nirmal Kanti
- Chowdhury Chand Sultana
- Chowdhury Kona
- Chowdhury Shajia
- Etando Ayukafangha
- Ferdousy Sybilla
- Godman Brian
- Halder Kakali
- Haque Mainul
- Hassan Mahmuda
- Islam Mohammad Ataul
- Islam Salequl
- Jahan Fauzia
- Kabir Fuad Reajwan
- Kabir Rumana
- Khan Jahangir Alam
- Khan Naurin
- Khan Samia Afreen
- Kumar Santosh
- Lugova Halyna
- Lutfor Afzalunnessa Binte
- Mashrur Abu Rushd Muhammad
- Mou Taslin Jahan
- Munwar Shaila
- Nahar Shamsun
- Noor Neelima Sharmin
- Nusrat Nadia
- Rahaman Md. Arifur
- Sarkar Sajuti
- Sharma Paras
- Sharmin Sabrina
- Siddiqui Tosaddeque Hossain
- Sinha Susmita
- Sultana Irin
- Taher Tania
- Yesmin Farida
- Zaman Taslima
- Publication venue
- Publication date
- 27/05/2023
- Field of study
Lockdown measures in response to the COVID-19 pandemic had an appreciable impact on the education of all medical, dental, and non-medical healthcare professional (HCP) students. These included the closure of universities necessitating a rapid move to e-learning and new approaches to practical’s. However initially, there was a lack of knowledge and expertise regarding e-learning approaches and the affordability of internet bundles and equipment. We initially con-ducted two pilot studies to assess such current challenges, replaced by a two-stage approach including a full investigation involving 32 private and public universities during the early stages of the pandemic followed by a later study assessing the current environment brought about by the forced changes. Top challenges at the start of the pandemic included a lack of familiarity with e-learning approaches, cost of the internet, lack of IT equipment and the quality of the classes. Universities offered support to staff and students to a varying degree to address identified challenges. Since then, e-learning approaches have widened the possibilities for teaching and learning at convenient times. However, challenges remain. In conclusion, there were considerable challenges at the start of them pandemic. Several key issues have been addressed with hybrid learning here to stay. Remaining challenges include a lack of ICT equipment. However, new innovations will continue
Bio-composting oil palm waste for improvement of soil fertility
- Author
- A De Guardia
- A Embrandiri
- AH Molla
- AI Bary
- AN Ma
- AN Ma
- Anon
- AS Baharuddin
- AS Baharuddin
- AZ Yaser
- B Hameeda
- B Kavitha
- B Khamseekhiew
- BD Xi
- BK Souleymane
- C Lazcano
- C Ordonez
- CA Edwards
- CA Edwards
- CA Edwards
- CA Palm
- CF Silva
- CG Golueke
- CG Jones
- CY Yeoh
- DT Sabrina
- DT Sabrina
- DT Sabrina
- E Epstein
- EI Arslan
- Environmental Protection Agency (EPA)
- ES Dias
- FA Gutièrrez-Miceli
- G Evans
- G Longsdon
- H Kamarudin
- HA Hassim
- HH Kayikcioglu
- HS Yang
- I Dahlan
- J Martínez-Blanco
- JA Alburquerque
- JD Kim
- JF Parr
- JJ Thambirajah
- JK Datta
- JL Francis
- JMP Phicot
- JMP Phicot
- KKR Bharadwaj
- KO Lin
- LF Gutiérrez
- M Appelhof
- M Crowe
- M Ishida
- M Islam
- M Misson
- MA Bustamante
- MA Hubbe
- MAB Habib
- MAI Khan
- MAN Tabi
- MHM Zainudin
- MKC Sridhar
- MN Alam
- MN Bari
- MP Bernal
- MS Rosnah
- MS Umar
- MS Umikalsom
- MT Abdelhamid
- MZ Alam
- MZ Alam
- MZ Alam
- NE Stork
- NM Bari
- O Chavalparit
- O Kolade
- OO Kolade
- P Campitelli
- P Castaldi
- P Hand
- P Lavelle
- P Lavelle
- P Partanen
- PF Rupani
- PM Ndegwa
- PO Oviasogie
- R Azarmi
- RHV Corley
- RHV Corley
- RHV Corley
- RP Singh
- RP Singh
- RT Haug
- S Javed
- S Paul
- S Prasertsan
- S Salates
- S Sumathi
- SA Abbasi
- SH Shuit
- SHA Rahman
- SM Shafie
- SMM Mirakalaei
- SMR Bhamidimarri
- T Marche
- T Pare
- U Ipek
- W Parsons
- WD Reynolds
- Y Basiron
- Y Siddiqui
- Y Xiao
- YK Singh
- Z Wei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Sources of bio-compost as agro-industrial wastes includes wide range of oil palm wastes viz. waste, biomass, palm kernels, empty fruit bunch, mill effluent, trunk and frond compost. Various composting processes are summarized in brief with distinct reference of oil–palm composting covering aerated static pile, and co-composting with earthworms (vermicomposting). However, in-vessel composting and windrow composting has meritorious advantages in composting. This review article refers to various significant roles played by microorganisms associated. Noteworthy study of bio-compost applications and procedures are correspondingly glosses framework of ecological, economical and agro-ecosystemic benefits
The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries
- Author
- Abdallah Elhassan
- Abdullahi Shehu U.
- Abdulqader Rula A.
- Abdulrahaman Aminatu A.
- Abouelnaga Sherif
- Ademola-Popoola Dupe S.
- Adio Adedayo
- Afifi Mahmoud A.
- Afshar Armin R.
- Aggarwal Priyanka
- Aghaji Ada E.
- Ahmad Alia
- Akib Indonesia Marliyanti N.R.
- Akinsete Adeseye
- Al Ani Mouroge H.
- Al Harby Lamis
- Al Mesfer Saleh
- Al-Badri Safaa A.F.
- Al-Dahmash Saad A.
- Al-Haddad Christiane E.
- Al-Hussaini Hamoud H.Y.
- Al-Jadiry Mazin F.
- Al-Janabi Allawi N. Hussein
- Al-Jumaily Usama
- Al-Mafrachi Ali A.R.M.
- Al-Shaheen Athar A.S.M.
- Al-Shammary Entissar H.
- Alcasabas Ana Patricia A.
- Aldana David Garcia
- Alejos Amanda
- Alemany-Rubio Ernesto
- Alfa Bio Amadou I.
- Ali Amany M.
- Alia Donjeta B.
- Alkatan Hind M.
- All-Eriksson Charlotta
- Almeida Argentino A.
- Alsawidi Khalifa M.
- Amankwaa-Frempong Doreen
- Amiruddin Primawita O.
- Anchaya Jacqueline Karina Vasquez
- Armytasari Inggar
- Astbury Nicholas J.
- Atalay Hatice T.
- Atchaneeyasakul La-ongsri
- Atsiaya Rose
- Autrata Rudolf
- Balaguer Julia
- Balayeva Ruhengiz
- Barranco Honorio
- Bartoszek Paulina
- Bartuma Katarina
- Bascaran Covadonga
- Bechrakis Nikolaos E.
- Begimkulova Ainura S.
- Benmiloud Sarra
- Berete Rokia C.
- Berry Jesse L.
- Bhaduri Anirban
- Bhat Sunil
- Bhattacharyya Arpita
- Biewald Eva M.
- Binkley Elaine
- Blum Sharon
- Bobrova Nadia
- Boldt H.C.
- Bonanomi Maria Teresa B.C.
- Bouda Gabrielle C.
- Bouguila Hedi
- Bowman Richard
- Bowman Richard
- Brennan Rachel C.
- Brichard Benedicte G.
- Buaboonnam Jassada
- Budiongo Aleine
- Burton Matthew J.
- Calderon-Sotelo Patricia
- Calvo Jesus Peralta
- Camuglia Jayne E.
- Cano Miriam R.
- Capra Michael
- Carreras Yvania Alfonso
- Caspi Shani
- Cassoux Nathalie
- Castela Guilherme
- Castillo Luis
- Catala-Mora Jaume
- Cavieres Isabel
- Chafla Edwin G. Villacis
- Chandramohan Arthika
- Chantada Guillermo L.
- Chantada Guillermo L.
- Chantada Guillermo L.
- Chaudhry Shabana
- Chawla Bhavna
- Chen Wensi
- Chiwanga Faraja S.
- Chuluunbat Tsengelmaa
- Cieslik Krzysztof
- Clark Antony
- Cockcroft Ruellyn L.
- Comsa Codruta
- Coronado Rosdali Y. Díaz
- Corson Timothy W.
- Couitchere Line
- Cowan-Lyn Kristin E.
- Csoka Monika
- Dangboon Wantanee
- Das Anirban
- Das Pranab
- Das Sima
- Davanzo Jacquelyn M.
- Davidson Alan
- De Francesco Sonia
- De Potter Patrick
- Demirci Hakan
- Desjardins Laurence
- Dimaras Helen
- Dod Charlotte Wolley
- Dodgshun Andrew J.
- Dragomir Monica D.
- Du Bruyn Magritha
- Du Plessis Johannes
- Du Yi
- Dudeja Gagan
- Eerme Katrin
- El Kettani Asmaa
- Elbahi Amal M.
- Elder James E.
- Elhaddad Alaa M.
- Elhassan Moawia M.A.
- Elzembely M.
- Ericksen Connor
- Essuman Vera A.
- Evina Ted Grimbert A.
- Ezegwui Ifeoma R.
- Fabian Ido Didi
- Fabian Ido Didi
- Fadoo Zehra
- Fandiño Adriana C.
- Faranoush Mohammad
- Fasina Oluyemi
- Fernandez Delia D.P.G.
- Fernandez-Teijeiro Ana
- Foster Allen
- Frenkel Shahar
- Fu Ligia D.
- Fuentes-Alabi Soad L.
- Garcia Juan L.
- Geel Jennifer A.
- Ghassemi Fariba
- Giron Ana V.
- Goenz Marco A.
- Gold Aaron S.
- Goldberg Hila
- Gomel Nir
- Gonzalez Efren
- Gonzalez-Rodriguez Liudmira
- Gopinathan Nair Akshay
- Gorfine Malka
- Graells Jaime
- Gregersen Pernille A.
- Grigorovski Nathalia D.A.K.
- Groznik Alenka Lavric
- Guedenon Koffi M.
- Gunasekera D. Sanjeeva
- Gupta Himika
- Gupta Sanjiv
- Gupta Vineeta
- Gündüz Ahmet K.
- Hadjistilianou Theodora
- Hamel Patrick
- Hamid Syed A.
- Hamzah Norhafizah
- Hansen Eric D.
- Harbour William
- Hartnett M. Elizabeth
- Hasanreisoglu Murat
- Hassan Muhammad
- Hassan Sadiq
- Hassan Shadab
- Hautz Wojciech
- Haydar Huda
- Hederova Stanislava
- Hessissen Laila
- Hongeng Suradej
- Hordofa Diriba F.
- Hubbard G. Baker
- Hummelen Marlies
- Husakova Kristina
- Ibanga Affiong
- Ida Russo
- Ilic Vesna R.
- Islamia Ispahani
- Islamov Ziyavuddin
- Jairaj Vivekaraj
- Jara Doris A. Calle
- Jeeva Irfan
- Ji Xunda
- Jo Dong Hyun
- Jones Michael M.
- Kabesha Amani Theophile B.
- Kabore Rolande L.
- Kaliki Swathi
- Kalinaki Abubakar
- Kamsang Pius
- Kapelushnik Noa
- Kardava Tamar
- Kebudi Rejin
- Keomisy Jonny
- Kepak Tomas
- Ketteler Petra
- Khan Zohora
- Khaqan Hussain A.
- Khetan Vikas
- Khodabande Alireza
- Khotenashvili Zaza
- Kim Jeong Hun
- Kim Jonathan W.
- Kiratli Hayyam
- Kivela Tero T.
- Klett Artur
- Kosh Komba Palet Jess Elio
- Ko~ Irem
- Krivaitiene Dalia
- Kruger Mariana
- Kulvichit Kittisak
- Kuntorini Mayasari W.
- Kyara Alice
- Lam Geoffrey C.
- Larson Scott A.
- Latinovic Slobodanka
- Laurenti Kelly D.
- Lavy Yotam
- Leiva Fanny F. Tarrillo
- Leverant Amy A.
- Li Cairui
- Li Kaijun
- Limbu Ben
- Liu Chun-Hsiu
- Llano Maria G. Correa
- Lopez Arturo M. Zapata
- Lopez Juan P.
- Lukamba Robert M.
- Luna-Fineman Sandra
- Lutfi Delfitri
- Lysytsia Lesia
- Macedo Carla R. Donato
- Madgar Shiran
- Magrath George N.
- Mahajan Amita
- Maitra Puja
- Maka Erika
- Makimbetov Emil K.
- Maktabi Azza
- Maldonado Carlos
- Mallipatna Ashwin
- Manudhane Rebecca
- Manzhuova Lyazat
- Martin-Begue Nieves
- Masud Sidra
- Matende Ibrahim O.
- Mattosinho Clarissa C.D.S.
- Matua Marchelo
- Mayet Ismail
- Mbumba Freddy B.
- McKenzie John D.
- Mehrvar Azim
- Mengesha Aemero A.
- Menon Vikas
- Mercado Gary John V.
- Mets Marilyn B.
- Midena Edoardo
- Midena Edoardo
- Miller Audra
- Mishra Divyansh K.C.
- Mndeme Furahini G.
- Mohamedani Ahmed A.
- Mohammad Mona T.
- Moll Annette C.
- Montero Margarita M.
- Morales Claudia R. Pascual
- Moreira Claude
- Mruthyunjaya Prithvi
- Msina Mchikirwa S.
- Msukwa Gerald
- Mudaliar Sangeeta S.
- Muma Kangwa I.M.
- Munier Francis L.
- Murray Timothy G.
- Musa Kareem O.
- Mushtaq Asma
- Musika Anne A.
- Mustak Hamzah
- Mustapha Tajudeen
- Muyen Okwen M.
- Myezo Khumo H.
- Naidu Gita
- Naidu Natasha
- Nair Akshay Gopinathan
- Natarajan Sundaram
- Naumenko Larisa
- Nency Yetty M.
- Neroev Vladimir
- Ng Yvonne
- Nikitovic Marina
- Nkanga Elizabeth D.
- Nkumbe Henry E.
- Numbi Marcel N.
- Nummi Kalle
- Nuruddin Murtuza
- Nyaywa Mutale
- Nyirenda Chinsisi
- Obono-Obiang Ghislaine
- Oliver Scott C .
- Oporto Joaquin
- Orozco Alma Janeth Sanchez
- Ortega-Hernández Miriam
- Oscar Alexander H.
- Ossandon Diego
- Pacheco Henry N. Garcia
- Pacheco Sonsoles San Roman
- Paintsil Vivian
- Paiva Luisa
- Palanivelu Mahesh Shanmugam
- Papyan Ruzanna
- Parrozzani Raffaele
- Paton Katherine E.
- Perez Graciela Gonzalez
- Peric Sanja
- Pe’er Jacob
- Pham Chau T.M.
- Philbert Remezo
- Plager David A.
- Pochop Pavel
- Polania Rodrigo A.
- Polyakov Vladimir
- Pompe Manca Tekavcic
- Ponce Jimena
- Popovic Maja Beck
- Portabella Silvia Alarcon
- Qadir Ali O.
- Qayyum Seema
- Qian Jiang
- Quah BoonLong
- Quintero D Karina
- Rahman Ardizal
- Rajkarnikar Purnima
- Ramanjulu Rajesh
- Ramasubramanian Aparna
- Ramirez-Ortiz Marco A.
- Randhawa Jasmeen K.
- Randrianarisoa Hoby Lalaina
- Raobela Lea
- Rashid Riffat
- Reddy M. Ashwin
- Refaeli David
- Renner Lorna A.
- Reynders David
- Ribadu Dahiru
- Ritter-Sovinz Petra
- Rogowska Anna
- Rojanaporn Duangnate
- Romero Livia
- Roth Paule Aida Ndoye
- Roy Soma R.
- Saab Raya H.
- Saakyan Svetlana
- Sabhan Ahmed H.
- Sagoo Mandeep S.
- Said Azza M.A.
- Saiju Rohit
- Salas Beatriz
- Sanchez Gissela L.
- Sayalith Phayvanh
- Scanlan Trish A.
- Schluter Sabrina
- Schwab Christoph
- Sedaghat Ahad
- Seth Rachna
- Sgroi Mariana
- Shah Ankoor S.
- Shakoor Shawkat A.
- Sharma Manoj K.
- Sherief Sadik T.
- Shields Carol L.
- Sia David
- Siddiqui Sorath Noorani
- Sidi cheikh Sidi
- Silva Sonia
- Singh Arun D.
- Singh Usha
- Singha Penny
- Sitorus Rita S.
- Skalet Alison H.
- Soebagjo Hendrian D.
- Sorochynska Tetyana
- Ssali Grace
- Stacey Andrew W.
- Staffieri Sandra E.
- Stahl Erin D.
- Steinberg David M.
- Stones David K.
- Strahlendorf Caron
- Suarez Maria Estela Coleoni
- Sultana Sadia
- Sun Xiantao
- Superstein Rosanne
- Supriyadi Eddy
- Surukrattanaskul Supawan
- Sutyawan I. Wayan Eka
- Suzuki Shigenobu
- Svojgr Karel
- Sylla Fatoumata
- Tamamyan Gevorg
- Tan Deborah
- Tandili Alketa
- Tang Jing
- Tashvighi Maryam
- Tateshi Bekim
- Teh Kok Hoi
- Tehuteru Edi S.
- Teixeira Luiz F.
- Thawaba Abdullah Dahan M.
- Theophile Tuyisabe
- Toledano Helen
- Trang Doan L.
- Traore Fousseyni
- Tripathy Devjyoti
- Tuncer Samuray
- Tyau-Tyau Harba
- Umar Ali B.
- Unal Emel
- Uner Ogul E.
- Urbak Steen F.
- Ushakova Tatiana L.
- Usmanov Rustam H.
- Valeina Sandra
- Valente Paola
- Van Hoefen Wijsard Milo
- Vaughan Leon O.
- Veleva-Krasteva Nevyana V.
- Verma Nishant
- Victor Andi A.
- Viksnins Maris
- Villegas Victor M.
- Vishnevskia-Dai Victoria
- Waddell Keith
- Wali Amina H.
- Wang Yi-Zhuo
- Wangtiraumnuay Nutsuchar
- Wetter Julie
- Widiarti Widiarti
- Wilson Matthew W.
- Wime Amelia D.C.
- Wiwatwongwana Atchareeya
- Wiwatwongwana Damrong
- Wong Emily S.
- Wongwai Phanthipha
- Wu Si-qi
- Xiang Daoman
- Xiao Yishuang
- Xu Bing
- Xue Kang
- Yaghy Antonio
- Yam Jason C.
- Yang Huasheng
- Yanga Jenny M.
- Yarovaya Vera A.
- Yarovoy Andrey A.
- Ye Huijing
- Yee Roberto I.
- Yousef Yacoub A.
- Yuliawati Putu
- Zein Ekhtelbenina
- Zhang Yi
- Zhilyaeva Katsiaryna
- Zia Nida
- Ziko Othman A.O.
- Zondervan Marcia
- Publication venue
- Elsevier
- Publication date
- 23/08/2022
- Field of study
DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
- Broome M
- Brown Ammani
- Brown Angela
- Brown J.
- Brown Jeremy S
- Brown Jo
- Brown M.
- Brown M.
- Brown V.
- Brugha Terry
- Brunskill Nigel
- Buch M.
- Buckley Phil
- Bularga A.
- Bullmore E
- Bunker Jenny
- Burden L.
- Burdett Tracy
- Burn D.
- Burns A.
- Burns G.
- Busby J.
- Butcher Robyn
- Butt Al-Tahoor
- Byrne S.
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- Calder P C
- Calvelo Ellen
- Carborn H
- Card Bethany
- Carr Caitlin
- Carr Liesel
- Carson G
- Carter Penny
- Casey A
- Cassar Mark P.
- Cavanagh J
- Chablani Manish
- Chalder Trudie
- Chalmers James D.
- Chambers R C
- Chan Flora
- Channon K M
- Chapman Kerry
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen Jin
- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
- Chiribiri Amedeo
- Chong-James K.
- Choudhury Gourab
- Choudhury N.
- Chowienczyk P
- Christie C
- Chrystal Melanie
- Clark Cameron
- Clark D
- Clarke Jude
- Clohisey S.
- Coakley G.
- Coburn Zach
- Coetzee S.
- Cole Joby
- Coleman C
- Conneh Florence
- Connell David
- Connolly B.
- Connor Lynda
- Cook Amanda
- Cooper B
- Cooper J
- Cooper Shirley
- Copeland D.
- Cosier Tracey
- Coulding Martina
- Coupland C.
- Cox Eleanor
- Craig T.
- Crisp P
- Cristiano Daniele
- Crooks M.G.
- Cross Andy
- Cruz Isabel
- Cullinan P.
- Cuthbertson Dan J
- Daines L
- Dalton Matthhew
- Daly Patrick
- Daniels Alison
- Dark P
- Dasgin J
- David A
- David C.
- Davies Ellie
- Davies Ffyon
- Davies Gareth
- Davies Gwyneth A
- Davies Kim
- Davies Melanie J
- Dawson Joy
- Daynes E
- De Soyza Anthony
- Deakin B
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- Deas C.
- Deery Joanne
- Defres S.
- Dell Amanda
- Dempsey K.
- Denneny E
- Dennis J
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- Dharmagunawardena R
- Diar Bakerly Nawar
- Dickens C
- Dipper A.
- Diver Sarah
- Diwanji Shalin N
- Dixon Myles
- Djukanovic R
- Dobson H.
- Dobson S.L.
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- Donaldson A.
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- Dougherty Andrew
- Dowling R
- Drain S.
- Draxlbauer K
- Drury Katie
- Dulawan Pearl
- Dunleavy A
- Dunn Sarah
- Dupont Catherine
- Earley Joanne
- Easom Nicholas
- Echevarria Carlos
- Edwards Sarah
- Edwardson C
- El-Taweel Hosni
- Elliott Anne
- Elliott K
- Ellis Y.
- Elmer Anne
- Elneima Omer
- Evans D
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- Evans J
- Evans R
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- Evans Ranuromanana I.
- Evans Teriann
- Evenden Cerys
- Evison Lynsey
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- Fairbairn Sara
- Fairman Alexandra
- Fallon K.
- Faluyi David
- Favager Clair
- Fayzan Tamanah
- Featherstone James
- Felton T.
- Ferreira Vanessa M.
- Finch J
- Finney Selina
- Finnigan J
- Finnigan Lucy
- Fisher Helen
- Fletcher S
- Flockton Rachel
- Flynn Margaret
- Foot H
- Foote David
- Ford Amber
- Forton D
- Fraile Eva
- Francis C.
- Francis R
- Francis Susan
- Frankel A.
- Fraser Emily
- Free Rob
- French N.
- Fu X
- Fuld Jonathan
- Furniss J.
- Garner Lucie
- Gautam N
- Geddes John R.
- George J.
- George P.
- Gibbons M
- Gill Mandy
- Gill Rhyan
- Gilmour L.
- Gleeson Fergus
- Glossop Jodie
- Glover Sarah
- Goodman N
- Goodwin Camelia
- Gooptu Bibek
- Gordon Hussain
- Gorsuch T.
- Greatorex M
- Greenhaff P.L.
- Greenhalf William
- Greenhalgh Alan
- Greening Neil J
- Greenwood John P
- Gregory Heidi
- Gregory Rebecca
- Grieve D.
- Griffin Denise
- Griffiths L
- Guerdette Anne-Marie
- Guillen Guio Beatriz
- Gummadi Mahitha
- Gupta Ayushman
- Gurram Sambasivarao
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- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
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- Young B.
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- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
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- Gmati Aimen
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- Kanatas Anastasios
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- Kapetanakis Emmanouil
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- Katsura Morihiro
- Kauppila Joonas H
- Kaur Amanjot
- Kausar Nabila
- Kavalakat Alfie
- Kavanagh Marcel Marjanović
- Kazan Ozgur
- Kealey Joshua
- Kebede Ephrem
- Kedwany Ahmed
- Kelly Michael
- Ken-Amoah Sebastian
- Kenington Cleo
- Kennerton A.S.
- Kent Alistair J
- Keramati Mohammad Reza
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- Kroon Hidde M.
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- Kusuma Venkata Ramana Murthy
- Kusunoki Munenori
- Kutuzov Vladislav
- Kykalos Stylianos
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- Tousidonis Manuel
- Trabulsi Nora
- Tranca Sebastian
- Trebol Jacobo
- Trejo-Avila Mario
- Triantafyllou Alexandra
- Triantafyllou Tania
- Trifunovski Aleksandar
- Tripathi Manjul
- Tripathi Prashant
- Tripathy Sujit
- Trivik-Barrientos Felipe
- Trostchansky Ivan
- Trulson Alexander
- Trungu Sokol
- Truss Adam
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsiantoula Paraskevi
- Tsironis Dimitrios
- Tsolakidis Alexandros
- Tsoulfas Georgios
- Tucker Olga
- Tuech Jean Jacques
- Turan Alparslan
- Turi Stefano
- Turna Akif
- Turrado-Rodriguez Victor
- Turri Giulia
- Tutino Roberta
- Tuyishime Eugene
- Tzelves Lazaros
- Tzima Ioanna
- Tzimas George
- Ubiali Paolo
- Ubom Akaninyene Eseme
- Ugwu Aloy Okechukwu
- Ugwu Ebere
- Ugwu Ifeanyichukwu
- Ul Huda Maria Noor
- Ulas Ali Bilal
- Uldry Emilie
- Ulgur Hanife Seyda
- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- Ulutaş Mehmet Eşref
- Underwood Kirk
- Unsworth Richard
- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
- Vaassen Lauretta
- Vaccara Vincenzo La
- Vagena Xanthoula
- Vagge Aldo
- Vailas Michail
- Valadez Andrea Estefania Cueto
- Valadez Tania Abigail Cueto
- Valanci Sofia
- Valdespino Cristina Puentes
- Valeanu Liana
- Valioulis Ioannis
- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
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