Preparing Students of the Institute of Physical Education and Sport to Use Distant Learning Technologies in the Course of Pandemic

This study reveals the importance of distance learning for professional students’ training in this innovative activity in regional institute of physical education. The urgency of research is based on the problem of insufficient readiness of physical education teachers and sports coaches in the Republic of Sakha (Yakutia) to implement distance learning. It is also based on the lack of widely used educational programs that are scientifically grounded, well tested in practice and that promote targeted training of physical education teachers to use DL technologies in the course of pandemic. The experiment involved bachelors’ and masters’ degree students in various specialties from the M.K. Ammosov North-Eastern Federal University (NEFU) and the Churapchinsky State Institute of Physical Education and Sport. All the students were majoring in Pedagogical Education and Physical Education. The leading method of research into the problem is the use of mathematical statistics to monitor the dynamics of the process development of training future physical education teachers and sports coaches to use DL technology. Main findings: The research results show that the use of new types of educational activities in the course of pandemic contributes to the effective contemporary professional training of Physical Education teachers and sports coaches.The practical implications of the research may be found in the analysis of future Physical Education teachers’ training to use DL in conditions of remote excess to the educative process of the discipline “Information Technologies in Physical Education and Sports” study. The content of the article will be useful for faculty members of institutions of higher education, institutions of additional education, and physical education teachers. The originality of this study is in providing the facts that the high proficiency and professional capacity of graduates of physical culture institutes, their ability and competence to adjust the accumulated knowledge and skills to new goals and objectives of education, regularly changing conditions of professional activity can be formed and developed through the effective use of DL technologies. adapted to the solution of occupational tasks

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autophagy-lysosome system contributes to this as evidenced by a derangement in key autophagy markers in both mouse and human atherosclerotic plaques. By augmenting macrophage TFEB, the master transcriptional regulator of autophagy-lysosomal biogenesis, we can reverse the autophagy dysfunction of plaques, enhance aggrephagy of p62-enriched protein aggregates and blunt macrophage apoptosis and pro-inflammatory IL-1β levels, leading to reduced atherosclerosis. In order to harness this degradative response therapeutically, we also describe a natural sugar called trehalose as an inducer of macrophage autophagy-lysosomal biogenesis and show trehalose's ability to recapitulate the atheroprotective properties of macrophage TFEB overexpression. Our data support this practical method of enhancing the degradative capacity of macrophages as a therapy for atherosclerotic vascular disease

Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis

Atherosclerosis is a chronic inflammatory disease and a leading cause of human mortality. The lesional microenvironment contains a complex accumulation of variably oxidized lipids and cytokines. Infiltrating monocytes become polarized in response to these stimuli, resulting in a broad spectrum of macrophage phenotypes. The extent of lipid loading in macrophages influences their phenotype and consequently their inflammatory status. In response to excess atherogenic ligands, many normal cell processes become aberrant following a loss of homeostasis. This can have a direct impact upon the inflammatory response, and conversely inflammation can lead to cell dysfunction. Clear evidence for this exists in the lysosomes, endoplasmic reticulum and mitochondria of atherosclerotic macrophages, the principal lesional cell type. Furthermore, several intrinsic cell processes become dysregulated under lipidotic conditions. Therapeutic strategies aimed at restoring cell function under disease conditions are an ongoing coveted aim. Macrophages play a central role in promoting lesional inflammation, with plaque progression and stability being directly proportional to macrophage abundance. Understanding how mixtures or individual lipid species regulate macrophage biology is therefore a major area of atherosclerosis research. In this review, we will discuss how the myriad of lipid and lipoprotein classes and products used to model atherogenic, proinflammatory immune responses has facilitated a greater understanding of some of the intricacies of chronic inflammation and cell function. Despite this, lipid oxidation produces a complex mixture of products and with no single or standard method of derivatization, there exists some variation in the reported effects of certain oxidized lipids. Likewise, differences in the methods used to generate macrophages in vitro may also lead to variable responses when apparently identical lipid ligands are used. Consequently, the complexity of reported macrophage phenotypes has implications for our understanding of the metabolic pathways, processes and shifts underpinning their activation and inflammatory status. Using oxidized low density lipoproteins and its oxidized cholesteryl esters and phospholipid constituents to stimulate macrophage has been hugely valuable, however there is now an argument that only working with low complexity lipid species can deliver the most useful information to guide therapies aimed at controlling atherosclerosis and cardiovascular complications

Correlation of physical development indicators with speed-strength performance in 11-12-year-old boys

© 2019 International Journal of Instruction. The paper is devoted to the issues of improving the methods of physical training. Currently, the method of teaching and training schoolchildren is developed mainly with a focus on a child's age, which does not always correspond to his or her biological maturity. These reasons together with the growing phenomenon of child acceleration reinforce the relevance of the research topic. The purpose of the study is to evaluate the impact of speed-strength exercises on the physical development and speed-strength qualities of schoolchildren aged 11-12. The authors used the measurements of anthropometric and physiometric indicators, as well as the tests that determine the level of development of speed and speed-strength qualities. The results of the research show that the physical indicators of the test group tend to increase, and during the school year, many indicators significantly change

Correlation of physical development indicators with speed-strength performance in 11-12-year-old boys

© 2019 International Journal of Instruction. The paper is devoted to the issues of improving the methods of physical training. Currently, the method of teaching and training schoolchildren is developed mainly with a focus on a child's age, which does not always correspond to his or her biological maturity. These reasons together with the growing phenomenon of child acceleration reinforce the relevance of the research topic. The purpose of the study is to evaluate the impact of speed-strength exercises on the physical development and speed-strength qualities of schoolchildren aged 11-12. The authors used the measurements of anthropometric and physiometric indicators, as well as the tests that determine the level of development of speed and speed-strength qualities. The results of the research show that the physical indicators of the test group tend to increase, and during the school year, many indicators significantly change

Synergistic effect of phosphorus, nitrogen and silicon on flame retardancy properties of cotton fabric treated by sol-gel process

Purpose – The purpose of this paper is to develop the flame retardancy properties of cotton fabrics with treatment of phosphorus and nitrogen containing silane-based nanosol by sol-gel process. Design/methodology/approach – Nanosols containing tetraethoxysilane or (3-aminopropyl) triethoxysilane as precursors, (3-glycidyloxypropyl) trimethoxysilane as cross-linking agent and guanidine phosphate monobasic as flame retarding agent were impregnated on cotton fabrics. Flame retardancy properties of the fabric samples were determined by limited flame spread test and limited oxygen index (LOI) test. In addition, microstructural and surface morphological properties of the fabric samples were characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscope. Findings – Depending on the limited flame spread test, the authors show that the coated fabric samples gain flame retardancy properties and the LOI value of the samples increased as to 45.7 per cent by the synergistic effect of phosphorus-nitrogen-silicon. Originality/value – There have some studies in flame retardancy behaviour of textiles. In this study, flame retardant cotton fabric with very low weight in grams was improved by sol-gel process. Moreover, ecological process was provided thanks to using halogen-free flame retardant. © 2016, © Emerald Group Publishing Limited