Similarity of Prosody Between Speech and Singing: A Methodological Study

Background: People with neurogenic communication disorders such as Parkinson’s Disease and Aphasia have language and speech abilities that are characterized by disturbances in speech prosody: abnormal variations of the intonation, stress, and duration of speech. Singing has been used as a therapeutic approach to help regulate and normalize prosody; however, little is known about how to best use the prosody of singing to meet the speech needs of different neuro pathologies. Objectives: The purpose of this study was to identify how the spoken and musical prosody of simple songs compare on measures of intensity, intonation, and duration as well as establish a method of assessing a song’s efficacy in speech therapy. Methods: An observational study compared the recordings of two singers and two speakers (4 participants total) who sang or read aloud the lyrics of three simple songs: “Row, Row, Row Your Boat”, “Happy Birthday To You”, and “Twinkle, Twinkle Little Star”. Participants were asked to either sing or read aloud each selection three times. Analysis: The acoustic analyses of the recordings were performed using the software Praat and were assessed for the prosodic measures of intonation by the fundamental frequency contour (semitones), intensity by the decibel (dB) contour, and rhythm by syllabic duration (seconds). Results: Comparing the prosodic differences between sung and spoken lyrics, on average the highest similarity between speech and singing occurred for the measure of duration (SCP Row = 92%, SCP Twinkle = 85%, SCP Happy = 83)%, second highest similarity for intensity (SCP Row =65%, SCP Twinkle =56%, SCP Happy =54% ), and the least highest similarity of intonation (SCP Row = 69%, SCP Twinkle = 49% , SCP Happy = 42%). Out of the selections Row, Row, Row Your Boat was most speech like while Happy Birthday to you was least speech like. Conclusions: This methodological study for speech and singing helped to establish a basis for assessing how simple songs can be utilized as a tool in speech therapy

Anxiety symptoms prior to a prostate cancer diagnosis: Associations with knowledge and openness to treatment

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135536/1/bjhp12222.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135536/2/bjhp12222_am.pd

Molecular cytogenetic characterization of a critical region in bands 7q35-q36 commonly deleted in malignant myeloid disorders

Loss of chromosome 7 (-7) or deletion of the long arm (7q-) are recurring chromosome abnormalities in myeloid leukemias. The association of - 7/7q- with myeloid leukemia suggests that these regions contain novel tumor suppressor gene(s), whose loss of function contribute to leukemic transformation or tumor progression. Based on chromosome banding analysis, two critical regions have been identified, one in band q22 and another in bands q32-q35. Presently there are no data available on the molecular delineation of the distal critical region. In this study we analyzed bone marrow and blood samples from 13 patients with myeloid leukemia (de novo myelodysplastic syndrome [MDS], n=3; de novo acute myeloid leukemia [AML], n=9; therapy-related (t-) AML, n=1) which, on chromosome banding analysis, exhibited deletions (n=12) or in one case a balanced translocation involving bands 7q31-qter using fluorescence in situ hybridization (FISH). As probes we used representative clones from a contig map of yeast artificial chromosome (YAC) clones that spans chromosome bands 7q31.1-qter. In the 12 cases with loss of 7q material, we identified a commonly deleted region of approximately 4 to 5 megabasepairs in size encompassing the distal part of 7q35 and the proximal part of 7q36. Furthermore, the breakpoint of the reciprocal translocation from the patient with t-AML was localized to a 1,300-kb sized YAC clone that maps to the proximal boundary of the commonly deleted region. Interestingly, in this case both homologs of chromosome 7 were affected: one was lost (-7) and the second exhibited the t(7q35). The identification and delineation of translocation and deletion breakpoints provides the first step toward the identification of the gene(s) involved in the pathogenesis of 7q35-q36 aberrations in myeloid disorders.link_to_OA_fulltex

Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

Microbial communities feature an immense diversity of species and this diversity is linked with outcomes ranging from ecosystem stability to medical prognoses. Yet the mechanisms underlying microbial diversity are under debate. While simple resource-competition models don't allow for coexistence of a large number of species, it was recently shown that metabolic trade-offs can allow unlimited diversity. Does this diversity persist with more realistic, intermittent nutrient supply? Here, we demonstrate theoretically that in serial dilution culture, metabolic trade-offs allow for high diversity. When a small amount of nutrient is supplied to each batch, the serial dilution dynamics mimic a chemostat-like steady state. If more nutrient is supplied, diversity depends on the amount of nutrient supplied due to an "early-bird" effect. The interplay of this effect with different environmental factors and diversity-supporting mechanisms leads to a variety of relationships between nutrient supply and diversity, suggesting that real ecosystems may not obey a universal nutrient-diversity relationship.Comment: Appendix follows main tex

Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes

For Assembly 20 of the Candida albicans genome, the sequence of each of the eight chromosomes was determined, revealing new insights into gene family creation and dispersion, subtelomere organization, and chromosome evolution

Affective theory of mind inferences contextually influence the recognition of emotional facial expressions

This is an Accepted Manuscript of an article published by Taylor & Francis in Cognition and Emotion on 14-3-18, available online: https://doi.org/10.1080/02699931.2018.1450224The recognition of emotional facial expressions is often subject to contextual influence, particularly when the face and the context convey similar emotions. We investigated whether spontaneous, incidental affective theory of mind inferences made while reading vignettes describing social situations would produce context effects on the identification of same-valenced emotions (Experiment 1) as well as differently-valenced emotions (Experiment 2) conveyed by subsequently presented faces. Crucially, we found an effect of context on reaction times in both experiments while, in line with previous work, we found evidence for a context effect on accuracy only in Experiment 1. This demonstrates that affective theory of mind inferences made at the pragmatic level of a text can automatically, contextually influence the perceptual processing of emotional facial expressions in a separate task even when those emotions are of a distinctive valence. Thus, our novel findings suggest that language acts as a contextual influence to the recognition of emotional facial expressions for both same and different valences

The impact of emotional well-being on long-term recovery and survival in physical illness: a meta-analysis

This meta-analysis synthesized studies on emotional well-being as predictor of the prognosis of physical illness, while in addition evaluating the impact of putative moderators, namely constructs of well-being, health-related outcome, year of publication, follow-up time and methodological quality of the included studies. The search in reference lists and electronic databases (Medline and PsycInfo) identified 17 eligible studies examining the impact of general well-being, positive affect and life satisfaction on recovery and survival in physically ill patients. Meta-analytically combining these studies revealed a Likelihood Ratio of 1.14, indicating a small but significant effect. Higher levels of emotional well-being are beneficial for recovery and survival in physically ill patients. The findings show that emotional well-being predicts long-term prognosis of physical illness. This suggests that enhancement of emotional well-being may improve the prognosis of physical illness, which should be investigated by future research

Clarifying Values: An updated review

Background: Consensus guidelines have recommended that decision aids include a process for helping patients clarify their values. We sought to examine the theoretical and empirical evidence related to the use of values clarification methods in patient decision aids. Methods: Building on the International Patient Decision Aid Standards (IPDAS) Collaboration's 2005 review of values clarification methods in decision aids, we convened a multi-disciplinary expert group to examine key definitions, decision-making process theories, and empirical evidence about the effects of values clarification methods in decision aids. To summarize the current state of theory and evidence about the role of values clarification methods in decision aids, we undertook a process of evidence review and summary. Results: Values clarification methods (VCMs) are best defined as methods to help patients think about the desirability of options or attributes of options within a specific decision context, in order to identify which option he/she prefers. Several decision making process theories were identified that can inform the design of values clarification methods, but no single "best" practice for how such methods should be constructed was determined. Our evidence review found that existing VCMs were used for a variety of different decisions, rarely referenced underlying theory for their design, but generally were well described in regard to their development process. Listing the pros and cons of a decision was the most common method used. The 13 trials that compared decision support with or without VCMs reached mixed results: some found that VCMs improved some decision-making processes, while others found no effect. Conclusions: Values clarification methods may improve decision-making processes and potentially more distal outcomes. However, the small number of evaluations of VCMs and, where evaluations exist, the heterogeneity in outcome measures makes it difficult to determine their overall effectiveness or the specific characteristics that increase effectiveness

Rare copy number variants contribute to congenital left-sided heart disease

Left-sided congenital heart disease (CHD) encompasses a spectrum of malformations that range from bicuspid aortic valve to hypoplastic left heart syndrome. It contributes significantly to infant mortality and has serious implications in adult cardiology. Although left-sided CHD is known to be highly heritable, the underlying genetic determinants are largely unidentified. In this study, we sought to determine the impact of structural genomic variation on left-sided CHD and compared multiplex families (464 individuals with 174 affecteds (37.5%) in 59 multiplex families and 8 trios) to 1,582 well-phenotyped controls. 73 unique inherited or de novo CNVs in 54 individuals were identified in the left-sided CHD cohort. After stringent filtering, our gene inventory reveals 25 new candidates for LS-CHD pathogenesis, such as SMC1A, MFAP4, and CTHRC1, and overlaps with several known syndromic loci. Conservative estimation examining the overlap of the prioritized gene content with CNVs present only in affected individuals in our cohort implies a strong effect for unique CNVs in at least 10% of left-sided CHD cases. Enrichment testing of gene content in all identified CNVs showed a significant association with angiogenesis. In this first family-based CNV study of left-sided CHD, we found that both co-segregating and de novo events associate with disease in a complex fashion at structural genomic level. Often viewed as an anatomically circumscript disease, a subset of left-sided CHD may in fact reflect more general genetic perturbations of angiogenesis and/or vascular biology

Urban multi-model climate projections of intense heat in Switzerland

This paper introduces a straightforward approach to generate multi-model climate projections of intense urban heat, based on an ensemble of state-of-the-art global and regional climate model simulations from EURO-CORDEX. The employed technique entails the empirical-statistical downscaling method quantile mapping (QM), which is applied in two different settings, first for bias correction and downscaling of raw climate model data to rural stations with long-term measurements and second for spatial transfer of bias-corrected and downscaled climate model data to the respective urban target site. The resulting products are daily minimum and maximum temperatures at five urban sites in Switzerland until the end of the 21st century under three emission scenarios (RCP2.6, RCP4.5, RCP8.5). We test the second-step QM approach in an extensive evaluation framework, using long-term observational data of two exemplary weather stations in Zurich. Results indicate remarkably good skill of QM in present-day climate. Comparing the generated urban climate projections with existing climate scenarios of adjacent rural sites allows us to represent the urban heat island (UHI) effect in future temperature-based heat indices, namely tropical nights, summer days and hot days. Urban areas will be more strongly affected by rising temperatures than rural sites in terms of fixed threshold exceedances, especially during nighttime. Projections for the end of the century for Zurich, for instance, suggest more than double the number of tropical nights (Tmin above 20 ºC) at the urban site (45 nights per year, multi-model median) compared to the rural counterpart (20 nights) under RCP8.5.This research has been partly supported by the European Commission (HEAT-SHIELD 668786). EH is supported by the German Research Foundation under project number 40805747