Murder She Wrote: Death and Drama in Nesting Woodpeckers

Woodpeckers serve a vital role as a keystone species in their respective biome by excavating nesting cavities that are in turn used by numerous forest birds and animals. These secondary cavity nesters rely heavily on the success of primary nesters in order to ensure their own reproductive success. Unfortunately numerous woodpeckers, such as the Black-backed (Picoides arcticus) and White-headed Woodpeckers (Picoides albolarvatus), have seen a large decline in numbers and are now considered a threatened species. Inability for these woodpeckers to reproduce creates a top-down trophic cascade in their biome. In an effort to better understand how nesting success is impacted by the behaviors of woodpeckers, predators, and secondary cavity nesters at the nest, sixty-five different nests were filmed for over 15,000 hours in the Eastern Washington Cascades during the 2015 and 2016 breeding seasons. We have watched and scored close to 400 hours of footage and have documented aggressive takeover by secondary cavity nesters, predation of nest chicks, and even human disturbance of nests. By better understanding the ecological pressures woodpeckers face and identifying what factors contribute to successful nesting, proper measures can be taken to maintain healthy levels of woodpecker populations

Murder She Wrote: Death and Drama in Nesting Woodpeckers

Woodpeckers serve as primary cavity excavators in fire-dominated forests. Secondary cavity users (SCU’s) rely heavily on cavities excavated by woodpeckers. Woodpecker species are declining, and some are now locally threatened. Management needs answers. How is woodpecker reproductive success impacted by the behavior of woodpeckers, SCU’s, and predators

“Don’t even get us started on social workers”: Domestic Violence, Social Work and Trust, An Anecdote from Research

This paper explores the concept of trust in relation to social work, child protection and work on domestic abuse. Trust is a complex notion. Borrowing from the arguments of Behnia, that trust is the outcome of a process, the paper uses the talk of women who have experienced social work in the context of domestic abuse and child protection to consider the barriers to trust-building. The evidence is gathered from 3 focus groups which formed part of an evaluation of a ‘Freedom Programme’. The findings highlight issues with trust-building that start with the context of living with abuse and work outwards to considerations of professional power, social work systems and wider inequality, suggesting an ecological approach to the trust-building process. The key argument is that social workers will struggle to gain trust within a system that sees domestic abuse as a hurdle that mothers must overcome, rather than a trauma through which they should be supported. The experiences of the women in this research, however, does show that trust and respect for voluntary service is achievable and that practice which builds alliances with the voluntary sector and service users could develop more trusting relationships

Exercise and Physical Therapy Interventions for Children with Ataxia: a systematic review

The effectiveness of exercise and physical therapy for children with ataxia is poorly understood. The aim of this systematic review was to critically evaluate the range, scope and methodological quality of studies investigating the effectiveness of exercise and physical therapy interventions for children with ataxia. The following databases were searched: AMED, CENTRAL, CDSR, CINAHL, ClinicalTrials.gov, EMBASE, Ovid MEDLINE, PEDro and Web of Science. No limits were placed on language, type of study or year of publication. Two reviewers independently determined whether the studies met the inclusion criteria, extracted all relevant outcomes, and conducted methodological quality assessments. A total of 1988 studies were identified, and 124 full texts were screened. Twenty studies were included in the review. A total of 40 children (aged 5-18 years) with ataxia as a primary impairment participated in the included studies. Data were able to be extracted from eleven studies with a total of 21 children (aged 5-18 years), with a range of cerebellar pathology. The studies reported promising results but were of low methodological quality (no RCTs), used small sample sizes and were heterogeneous in terms of interventions, participants and outcomes. No firm conclusions can be made about the effectiveness of exercise and physical therapy for children with ataxia. There is a need for further high-quality child-centred research

Molecular markers and potential therapeutic targets in non-WNT/non-SHH (group 3 and group 4) medulloblastomas

Childhood medulloblastomas (MB) are heterogeneous and are divided into four molecular subgroups. The provisional non-wingless-activated (WNT)/non-sonic hedgehog-activated (SHH) category combining group 3 and group 4 represents over two thirds of all MBs, coupled with the highest rates of metastases and least understood pathology. The molecular era expanded our knowledge about molecular aberrations involved in MB tumorigenesis, and here, we review processes leading to non-WNT/non-SHH MB formations.The heterogeneous group 3 and group 4 MBs frequently harbor rare individual genetic alterations, yet the emerging profiles suggest that infrequent events converge on common, potentially targetable signaling pathways. A mutual theme is the altered epigenetic regulation, and in vitro approaches targeting epigenetic machinery are promising. Growing evidence indicates the presence of an intermediate, mixed signature group along group 3 and group 4, and future clarifications are imperative for concordant classification, as misidentifying patient samples has serious implications for therapy and clinical trials.To subdue the high MB mortality, we need to discern mechanisms of disease spread and recurrence. Current preclinical models do not represent the full scale of group 3 and group 4 heterogeneity: all of existing group 3 cell lines are MYC-amplified and most mouse models resemble MYC-activated MBs. Clinical samples provide a wealth of information about the genetic divergence between primary tumors and metastatic clones, but recurrent MBs are rarely resected. Molecularly stratified treatment options are limited, and targeted therapies are still in preclinical development. Attacking these aggressive tumors at multiple frontiers will be needed to improve stagnant survival rates

Murder She Wrote: Death and Drama in Nesting Woodpeckers

Woodpeckers serve a vital role as a keystone species in their respective biome by excavating nesting cavities that are in turn used by numerous forest birds and animals. These secondary cavity nesters rely heavily on the success of primary nesters in order to ensure their own reproductive success. Unfortunately numerous woodpeckers, such as the Black-backed (Picoides arcticus) and White-headed Woodpeckers (Picoides albolarvatus), have seen a large decline in numbers and are now considered a threatened species. Inability for these woodpeckers to reproduce creates a top-down trophic cascade in their biome. In an effort to better understand how nesting success is impacted by the behaviors of woodpeckers, predators, and secondary cavity nesters at the nest, sixty-five different nests were filmed for over 15,000 hours in the Eastern Washington Cascades during the 2015 and 2016 breeding seasons. We have watched and scored close to 400 hours of footage and have documented aggressive takeover by secondary cavity nesters, predation of nest chicks, and even human disturbance of nests. By better understanding the ecological pressures woodpeckers face and identifying what factors contribute to successful nesting, proper measures can be taken to maintain healthy levels of woodpecker populations

Woodpecker Nesting Patterns in Eastern Washington Cascades

Woodpeckers serve as primary cavity excavators in fire dominated forests. Secondary cavity users (SCU’s) rely heavily on cavities excavated by woodpeckers. Woodpecker species are declining, and some are nowlocally threatened. Management needs answers. How is woodpecker reproductive success impacted by the behavior of woodpeckers, SCU’s, and predators

Sentinel lymph node biopsy is accurate and prognostic in head and neck melanoma

BACKGROUND: Sentinel lymph node biopsy (SLNB) has emerged as a widely used staging procedure for cutaneous melanoma. However, debate remains around the accuracy and prognostic implications of SLNB for cutaneous melanoma arising in the head and neck, as previous reports have demonstrated inferior results to those in nonhead and neck regions. Through the largest single‐institution series of head and neck melanoma patients, the authors set out to demonstrate that SLNB accuracy and prognostic value in the head and neck region are comparable to other sites. METHODS: A prospectively collected database was queried for cutaneous head and neck melanoma patients who underwent SLNB at the University of Michigan between 1997 and 2007. Primary endpoints included SLNB result, time to recurrence, site of recurrence, and date and cause of death. Multivariate models were constructed for analyses. RESULTS: Three hundred fifty‐three patients were identified. A sentinel lymph node was identified in 352 of 353 patients (99.7%). Sixty‐nine of the 353 (19.6%) patients had a positive SLNB. Seventeen of 68 patients (25%) undergoing completion lymphadenectomy after a positive SLNB result had at least 1 additional positive nonsentinel lymph node. Patients with local control and a negative SLNB failed regionally in 4.2% of cases. Multivariate analysis revealed positive SLNB status to be the most prognostic clinicopathologic predictor of poor outcome; hazard ratio was 4.23 for SLNB status and recurrence‐free survival ( P < .0001) and 3.33 for overall survival ( P < .0001). CONCLUSIONS: SLNB is accurate and its results are of prognostic importance for head and neck melanoma patients. Cancer 2012;. © 2011 American Cancer Society. This is the largest single‐institution series of patients with head and neck melanoma (n = 353) to date. The authors demonstrate sentinel lymph node biopsy to be reliable (99.7% identification rate), accurate (19.7% positive sentinel lymph node biopsy rate and 4.2% false‐omission rate), and strongly prognostic of survival on multivariate analysis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90137/1/26288_ftp.pd