102 research outputs found
Attempts to Transfer Eczematous Contact-Type Allergy with Whole Blood Transfusions**From the Department of Dermatology and Syphilology, New York University Post-Graduate Medical School (Dr. Marion B. Sulzberger, Chairman) and the Skin and Cancer Unit of the University Hospital, New York, N. Y.This study was supported by a grant from the United States Public Health Service (E-1361-(C4)).Presented at the Twenty-first Annual Meeting of The Society for Investigative Dermatology, Inc., Miami Beach, Florida, June 15, 1960.
The Effects of Intradermal Injections of Autologous White Blood Cells on the Level of Eczematous Contact-Type Sensitivity in Man
Sensitization to Simple Chemicals III. Relationship between Chemical Structure and Properties, and Sensitizing Capacities in the Production of Eczematous Sensitivity in Man11From the Department of Dermatology, Montefiore Hospital for Chronic Diseases, New York, N. Y. Director, Dr. Fred Wise.
The Basophile Leukocyte in Urticarial Hypersensitivity to Physical Agents**From the Department of Dermatology, University of Lund, Sweden and the Department of Dermatology (Skin and Cancer Unit) of the New York University Schools of Medicine, New York.
Scabies and Pediculosis Treated with Benzyl Benzoate, DDT, Benzocaine Emulsion1 Including a Comparison with Other Methods used at U. S. Naval Hospital, Brooklyn, N. Y., from November 1943 to May 1945
A Future for the Dead Sea Basin: Water Culture among Israelis, Palestinians and Jordanians
Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites
The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions.
The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness
of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence
were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density
and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that
the wood in the starch composites did not prevent water loss from the samples.Peer reviewe
Polyyne Hybrid Compounds from Notopterygium incisum with Peroxisome Proliferator-Activated Receptor Gamma Agonistic Effects
[Image: see text] In the search for peroxisome proliferator-activated receptor gamma (PPARγ) active constituents from the roots and rhizomes of Notopterygium incisum, 11 new polyacetylene derivatives (1–11) were isolated. Their structures were elucidated by NMR and HRESIMS as new polyyne hybrid molecules of falcarindiol with sesquiterpenoid or phenylpropanoid moieties, named notoethers A–H (1–8) and notoincisols A–C (9–11), respectively. Notoincisol B (10) and notoincisol C (11) represent two new carbon skeletons. When tested for PPARγ activation in a luciferase reporter assay with HEK-293 cells, notoethers A–C (1–3), notoincisol A (9), and notoincisol B (10) showed promising agonistic activity (EC(50) values of 1.7 to 2.3 μM). In addition, notoincisol A (9) exhibited inhibitory activity on NO production of stimulated RAW 264.7 macrophages
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes
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