Propuesta estratégica de mejora en la implementación de los estándares mínimos del Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG- SST) en la empresa Fondar para el segundo semestre del 2019 y principios del 2020

Matriz de evaluación del sistema de gestión de seguridad y salud en el trabajo, diagrama de GanttEl presente proyecto comprende el estudio del decreto 1443 del 31 de julio de 2014; que ordeno las directrices de obligatorio cumplimiento para implementar el Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG-SST) el cual debe cumplir la empresa de economía solidaria FONDAR, a partir de ese momento el Fondo de Empleados direcciono un trabajo detallado para cumplir con lo ordenado por el gobierno; teniendo en cuenta la actualización de los estándares mínimos de acuerdo a la resolución No. 0312 del 13 de febrero de 2019, sin embargo al revisar en la práctica el desarrollo de los estándares mínimos que debe cumplir, se evidencio que FONDAR no ha trabajado de la manera correcta el ítem de capacitación en SST y por ende está fallando en el ítem que detalla su plan anual de trabajo. Es por ello que buscamos guiar a la empresa FONDAR para que logre realizar una buena implementación de estos estándares y de esta manera evitar sanciones en la inspección, vigilancia y control que realizará el Ministerio de Trabajo a partir del mes de Noviembre de 2019; aunque la empresa ya tiene un gran porcentaje del trabajo realizado, es importante en este momento hacer un proceso de seguimiento y plan de mejora de acuerdo a lo que ellos ya tienen planteado, proceso que se ha llevado a cabo generando una autoevaluación conforme a los estándares mínimos y en el cual se observó la problemática anteriormente descrita y de acuerdo a esta misma se generará un plan de mejora para solventar esta situación, es muy importante para la consecución de esta actividad poder contar con todos los colaboradores de FONDAR y para ello se elaborará una propuesta que brinde un cronograma de capacitación el cual se pueda ejecutar y que permita cumplir con el plan anual del Sistema de Gestión de SST. Para alcanzar este proyecto es necesario plantear el problema observado, revisar sus antecedentes y analizar de forma cualitativa que está generando esta falencia, así como también analizar el marco teórico y legal, mostrando una metodología de investigación cualitativa la cual se llevara a cabo de acuerdo al análisis que se realizó de la implementación inicial del SG - SST en la empresa, la implementación de la tabla de valores y calificación de los estándares mínimos de SG -SST, de acuerdo a la matriz utilizada para tal fin logrando describir como fue la transición de la empresa desde el decreto 1443 a la nueva resolución 0312, obteniendo de esta manera un análisis detallado de los resultados obtenidos y generando con estos un plan de mejora y los diferentes cronogramas con los que debe trabajar la empresa para alcanzar a un 100% la implementación y evaluación de su Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG-SST) para ser aplicado a partir del mes de Noviembre, evitando sanciones y demás perjuicios para la organización.This project includes the study of Decree 1443 of July 31, 2014; I order the mandatory compliance guidelines to implement the Occupational Health and Safety Management System (SG-SST) which must be met by the solidarity economy company FONDAR, from that moment the Employee Fund directed a detailed work to comply with the orders of the government; taking into account the update of the minimum standards according to resolution No. 0312 of February 13, 2019, however, when reviewing in practice the development of the minimum standards that must be met, it was evidenced that FONDAR has not worked on the Correctly, the training item in OSH and therefore is failing in the item that details your annual work plan. That is why we seek to guide the company FONDAR to achieve a good implementation of these standards and thus avoid sanctions in the inspection, surveillance and control that will be carried out by the Ministry of Labor from the month of November 2019; Although the company already has a large percentage of the work done, it is important at this time to carry out a monitoring process and improvement plan according to what they have already proposed, a process that has been carried out generating a self-assessment according to the standards minimum and in which the above-described problem was observed and according to this one an improvement plan will be generated to solve this situation, it is very important for the achievement of this activity to be able to count on all the employees of FONDAR and for this it will be prepared a proposal that provides a training schedule which can be executed and that allows to comply with the annual plan of the OSH Management System. To achieve this project it is necessary to raise the observed problem, review its background and analyze in a qualitative way that this flaw is generating, as well as analyze the theoretical and legal framework, showing a qualitative research methodology which will be carried out according to the analysis that was carried out of the initial implementation of the SG-SST in the company, the implementation of the table of values ​​and qualification of the minimum standards of SG-SST, according to the matrix used for this purpose managing to describe how the transition of the company from decree 1443 to the new resolution 0312, thus obtaining a detailed analysis of the results obtained and generating with them an improvement plan and the different schedules with which the company must work to achieve 100% implementation and evaluation of its Occupational Health and Safety Management System (SG-SST) to be applied as of the month November, avoiding penalties and other damages for the organization

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Educación ambiental y sociedad. Saberes locales para el desarrollo y la sustentabilidad

EL LIBRO PERMITE REFLEXIONAR SOBRE LA IMPORTANCIA DE FOMENTAL LA EDUCACIÓN AMBIENTAL PARA RESOLVER LA PROBLEMÁTICA AMBIENTALEL LIBRO PRESENTA DIFERENTES TRABAJOS QUE ESTUDIAN EL TEMA D ELA SUSTENTABILIDAD, ENFATIZANDO LA IMPORTANCIA DE LA EDUCACIÓN AMBIENTAL Y LA TRANSDISCIPLINANINGUN

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Protein ubiquitination is a dynamic and reversibleprocess of adding single ubiquitin molecules orvarious ubiquitin chains to target proteins. Here,using multidimensional omic data of 9,125 tumorsamples across 33 cancer types from The CancerGenome Atlas, we perform comprehensive molecu-lar characterization of 929 ubiquitin-related genesand 95 deubiquitinase genes. Among them, we sys-tematically identify top somatic driver candidates,including mutatedFBXW7with cancer-type-specificpatterns and amplifiedMDM2showing a mutuallyexclusive pattern withBRAFmutations. Ubiquitinpathway genes tend to be upregulated in cancermediated by diverse mechanisms. By integratingpan-cancer multiomic data, we identify a group oftumor samples that exhibit worse prognosis. Thesesamples are consistently associated with the upre-gulation of cell-cycle and DNA repair pathways, char-acterized by mutatedTP53,MYC/TERTamplifica-tion, andAPC/PTENdeletion. Our analysishighlights the importance of the ubiquitin pathwayin cancer development and lays a foundation fordeveloping relevant therapeutic strategies

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men