The Meta-data-Database of a Next Generation Sustainability Web-Platform for Language Resources

Our goal is to provide a web-based platform for the long-term preservation and distribution of a heterogeneous collection of linguistic resources. We discuss the corpus preprocessing and normalisation phase that results in sets of multi-rooted trees. At the same time we transform the original metadata records, just like the corpora annotated using different annotation approaches and exhibiting different levels of granularity, into the all-encompassing and highly flexible format eTEI for which we present editing and parsing tools. We also discuss the architecture of the sustainability platform. Its primary components are an XML database that contains corpus and metadata files and an SQL database that contains user accounts and access control lists. A staging area, whose structure, contents, and consistency can be checked using tools, is used to make sure that new resources about to be imported into the platform have the correct structure

Extensive blood transcriptome analysis reveals cellular signaling networks activated by circulating glycocalyx components reflecting vascular injury in COVID-19

BackgroundDegradation of the endothelial protective glycocalyx layer during COVID-19 infection leads to shedding of major glycocalyx components. These circulating proteins and their degradation products may feedback on immune and endothelial cells and activate molecular signaling cascades in COVID-19 associated microvascular injury. To test this hypothesis, we measured plasma glycocalyx components in patients with SARS-CoV-2 infection of variable disease severity and identified molecular signaling networks activated by glycocalyx components in immune and endothelial cells.MethodsWe studied patients with RT-PCR confirmed COVID-19 pneumonia, patients with COVID-19 Acute Respiratory Distress Syndrome (ARDS) and healthy controls (wildtype, n=20 in each group) and measured syndecan-1, heparan sulfate and hyaluronic acid. The in-silico construction of signaling networks was based on RNA sequencing (RNAseq) of mRNA transcripts derived from blood cells and of miRNAs isolated from extracellular vesicles from the identical cohort. Differentially regulated RNAs between groups were identified by gene expression analysis. Both RNAseq data sets were used for network construction of circulating glycosaminoglycans focusing on immune and endothelial cells.ResultsPlasma concentrations of glycocalyx components were highest in COVID-19 ARDS. Hyaluronic acid plasma levels in patients admitted with COVID-19 pneumonia who later developed ARDS during hospital treatment (n=8) were significantly higher at hospital admission than in patients with an early recovery. RNAseq identified hyaluronic acid as an upregulator of TLR4 in pneumonia and ARDS. In COVID-19 ARDS, syndecan-1 increased IL-6, which was significantly higher than in pneumonia. In ARDS, hyaluronic acid activated NRP1, a co-receptor of activated VEGFA, which is associated with pulmonary vascular hyperpermeability and interacted with VCAN (upregulated), a proteoglycan important for chemokine communication.ConclusionsCirculating glycocalyx components in COVID-19 have distinct biologic feedback effects on immune and endothelial cells and result in upregulation of key regulatory transcripts leading to further immune activation and more severe systemic inflammation. These consequences are most pronounced during the early hospital phase of COVID-19 before pulmonary failure develops. Elevated levels of circulating glycocalyx components may early identify patients at risk for microvascular injury and ARDS. The timely inhibition of glycocalyx degradation could provide a novel therapeutic approach to prevent the development of ARDS in COVID-19

Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx

Acute normovolemic hemodilution (ANH) and volume loading (VL) are standard blood-sparing procedures. However, VL is associated with hypervolemia, which may cause tissue edema, cardiopulmonary complications and a prolonged hospital stay. The body reacts to hypervolemia with release of atrial natriuretic peptide (ANP) from the heart. ANP has been shown to deteriorate the endothelial glycocalyx, a vital part of the vascular permeability barrier. The aim of the present study was to evaluate and compare ANP release and damage to the glycocalyx during ANH and VL

Quantum Angle Generator for Image Generation

The Quantum Angle Generator (QAG) is a new generative model for quantum computers. It consists of a parameterized quantum circuit trained with an objective function. The QAG model utilizes angle encoding for the conversion between the generated quantum data and classical data. Therefore, it requires one qubit per feature or pixel, while the output resolution is adjusted by the number of shots performing the image generation. This approach allows the generation of highly precise images on recent quantum computers. In this paper, the model is optimised for a High Energy Physics (HEP) use case generating simplified one-dimensional images measured by a specific particle detector, a calorimeter. With a reasonable number of shots, the QAG model achieves an elevated level of accuracy. The advantages of the QAG model are lined out - such as simple and stable training, a reasonable amount of qubits, circuit calls, circuit size and computation time compared to other quantum generative models, e.g. quantum GANs (qGANs) and Quantum Circuit Born Machines

Measuring Alcohol-Related Consequences in School Surveys: Alcohol-Attributable Consequences or Consequences With Students' Alcohol Attribution

Contains fulltext : 90134.pdf (publisher's version ) (Closed access)In alcohol epidemiology surveys, there is a tradition of measuring alcohol-related consequences using respondents' attribution of alcohol as the cause. The authors aimed to compare the prevalence and frequency of self-attributed consequences to consequences without self-attribution using alcohol-attributable fractions (AAF). In 2007, a total of 7,174 Swiss school students aged 13-16 years reported the numbers of 6 alcohol-related adverse consequences (e.g., fights, injuries) they had incurred in the past 12 months. Consequences were measured with and without attribution of alcohol as the cause. The alcohol-use measures were frequency and volume of drinking in the past 12 months and number of risky single-occasion (>= 5 drinks) drinking episodes in the past 30 days. Attributable fractions were derived from logistic (>= 1 incident) and Poisson (number of incidents) regression analyses. Although relative risk estimates were higher when alcohol-attributed consequences were compared with nonattributed consequences, the use of AAFs resulted in more alcohol-related consequences (10,422 self-attributed consequences vs. 24,520 nonattributed consequences determined by means of AAFs). The likelihood of underreporting was higher among drinkers with intermediate frequencies than among either rare drinkers or frequent drinkers. Therefore, the extent of alcohol-related adverse consequences among adolescents may be underestimated when using self-attributed consequences, because of differential attribution processes, especially among infrequent drinkers