Caracterización de pacientes con infarto miocárdico con elevación del ST complicados no trombolizados

Introduction: Acute coronary syndrome is the ultimate expression of coronary disease, early diagnosis and proper treatment help to reduce the incidence of fatal complications and mortality associated with it.Material and  methods: an observational, longitudinal and prospective study was conducted in the Intensive Care Unit of cardiology at  “Arnaldo Milián Castro" Clinical Surgical Hospital of Villa Clara from January 2007 to December 2009 in order to characterize patients with myocardial elevation acute myocardial ST segment complicated and not thrombolyzed.Results: electrical complications presented 45.05 % of the patients and cardiogenic shock 22; died 100% of those with mechanical complications and 86.36 % of those with cardiogenic shock.Discussion: in this study the electrical complications were the most common and the most lethal were mechanical, cardiogenic shock and ventricular fibrillation, mechanical were more frequent in females, all generally predominated in older and had a higher representation in acute myocardial infarction of the extensive right ventricle, overall mortality was high and was associated with female sex, advanced age and extensive and lateral previuos topography.Introducción: El síndrome coronario agudo es la máxima expresión de la enfermedad coronaria, su diagnóstico precoz y su tratamiento adecuado contribuyen a disminuir la incidencia de complicaciones letales y la mortalidad asociada al mismo.Material y método: se realizó un estudio observacional, longitudinal y prospectivo en la Unidad de Cuidados Intensivos Cardiológicos del Hospital Clínico Quirúrgico “Arnaldo Milián Castro” de la Ciudad de Santa Clara, Provincia de  Villa Clara, desde enero de 2007 hasta diciembre de 2009 con el propósito de caracterizar a los pacientes con  infarto miocárdico agudo con elevación del segmento ST complicado y no trombolizados.Resultados: presentaron complicaciones eléctricas el 45.05% de los pacientes y el choque cardiogénico 22; fallecieron el 100% de los que presentaron complicaciones mecánicas y el 86.36% de los que tenían choque cardiogénico.Discusión: en este estudio las complicaciones eléctricas fueron las más frecuentes y las más letales resultaron las mecánicas, el choque cardiogénico y la fibrilación ventricular; las mécanicas fueron más frecuentes en el sexo femenino; todas en general predominaron en la edad avanzada y tuvieron una mayor representacion en los infarto miocárdico agudo de ventrículo derecho y anterior extenso; la mortalidad general fue elevada y se relacionó con el sexo femenino, la edad avanzada y la topografía anterior extensa y lateral

Púrpura de Schönlein-Henoch fulminante

A female patient of 51 years old with personal pathological precedent of bronchial asthma, hypertension and ulcerative colitis and infection by chikungunya virus for a month. She incomes with dark pasty diarrhea with mucus and blood, she evolved unfavorably with flaccid paraplegia and recticularis livedo, which became extensive purple; then phlyctena and generalized edema. She remained hypotensive with electrolyte imbalance and impairment of consciousness, complementaries were performed, she was transfused and underwent to hemodialysis; she evolved to coma and death. The pathological findings showed an adult, fulminant and deadly form of anaphylactoid purpura or Henoch-Schönlein. Mesangial proliferation with fushinofílicos mesangial deposits werefound corresponding to immunoglobulin A with immunofluorescence, leukocytoclastic vasculitis and necrotizing vasculitis of small vessels. Purple of Schönlein-Henoch is a peculiar form of vasculitis that tends to spontaneous healing and occasionally may have a fatal course or proceed to a chronic nephritis.Se trata de paciente femenina de 51 años, con antecedentes patológicos personales de asma bronquial, hipertensión arterial y colitis ulcerativa e infección por el virus de la chikungunya desde hacía un mes. Ingresó con diarreas pastosas oscuras con moco y sangre, evolucionó desfavorablemente con paraplejia flácida y livedo reticularis, que se transformó en púrpura extensa; posteriormente flictenas y edema generalizado. Se mantuvo hipotensa con desequilibrio hidroelectrolítico y deterioro del estado de conciencia, se le realizaron complementarios, fue transfundida y se le realizó hemodiálisis; evolucionó al coma y a la muerte. Los hallazgos anatomopatológicos mostraron una forma adulta, fulminante y mortal de púrpura anafilactoide o de Schönlein-Henoch. Se encontró proliferación mesangial con depósitos mesangiales fushinofílicos correspondientes a inmunoglobulina A con inmunofluorescencia, vasculitis leucocitoclástica y vasculitis necrotizante de pequeños vasos. La púrpura de Schönlein-Henoch es una forma peculiar de vasculitis que tiende a la curación espontánea y, ocasionalmente, puede tener un curso mortal o proseguir hacia una nefritis crónica

DarkCideS 1.0, a global database for bats in karsts and caves

Tanalgo, Krizler C., Tabora, John Aries G., de Oliveira, Hernani Fernandes Magalhães, Haelewaters, Danny, Beranek, Chad T., Otálora-Ardila, Aída, Bernard, Enrico, Gonçalves, Fernando, Eriksson, Alan, Donnelly, Melissa, González, Joel Monzón, Ramos, Humberto Fernández, Rivas, Alberto Clark, Webala, Paul W., Deleva, Stanimira, Dalhoumi, Ridha, Maula, Jaycelle, Lizarro, Dennis, Aguirre, Luis F., Bouillard, Nils, Quibod, Ma. Niña Regina M., Barros, Jennifer, Turcios-Casco, Manfredo Alejandro, Martínez, Marcio, Ordoñez-Mazier, Diego Iván, Orellana, José Alejandro Soler, Ordoñez-Trejo, Eduardo J., Ordoñez, Danny, Chornelia, Ada, Lu, Jian Mei, Xing, Chen, Baniya, Sanjeev, Muylaert, Renata L., Dias-Silva, Leonardo Henrique, Ruadreo, Nittaya, Hughes, Alice Catherine (2022): DarkCideS 1.0, a global database for bats in karsts and caves. Scientific Data 9 (1): 155, DOI: 10.1038/s41597-022-01234-4, URL: http://dx.doi.org/10.1038/s41597-022-01234-

Modeling complex metabolic reactions, ecological systems, and financial and legal networks with MIANN models based on Markov-Wiener node descriptors

[Abstract] The use of numerical parameters in Complex Network analysis is expanding to new fields of application. At a molecular level, we can use them to describe the molecular structure of chemical entities, protein interactions, or metabolic networks. However, the applications are not restricted to the world of molecules and can be extended to the study of macroscopic nonliving systems, organisms, or even legal or social networks. On the other hand, the development of the field of Artificial Intelligence has led to the formulation of computational algorithms whose design is based on the structure and functioning of networks of biological neurons. These algorithms, called Artificial Neural Networks (ANNs), can be useful for the study of complex networks, since the numerical parameters that encode information of the network (for example centralities/node descriptors) can be used as inputs for the ANNs. The Wiener index (W) is a graph invariant widely used in chemoinformatics to quantify the molecular structure of drugs and to study complex networks. In this work, we explore for the first time the possibility of using Markov chains to calculate analogues of node distance numbers/W to describe complex networks from the point of view of their nodes. These parameters are called Markov-Wiener node descriptors of order kth (Wk). Please, note that these descriptors are not related to Markov-Wiener stochastic processes. Here, we calculated the Wk(i) values for a very high number of nodes (>100,000) in more than 100 different complex networks using the software MI-NODES. These networks were grouped according to the field of application. Molecular networks include the Metabolic Reaction Networks (MRNs) of 40 different organisms. In addition, we analyzed other biological and legal and social networks. These include the Interaction Web Database Biological Networks (IWDBNs), with 75 food webs or ecological systems and the Spanish Financial Law Network (SFLN). The calculated Wk(i) values were used as inputs for different ANNs in order to discriminate correct node connectivity patterns from incorrect random patterns. The MIANN models obtained present good values of Sensitivity/Specificity (%): MRNs (78/78), IWDBNs (90/88), and SFLN (86/84). These preliminary results are very promising from the point of view of a first exploratory study and suggest that the use of these models could be extended to the high-throughput re-evaluation of connectivity in known complex networks (collation)

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality