ASSESSING DEER DAMAGE IN YOUNG FRUIT ORCHARDS

Evaluations of systematic damage assessments of 5, 10 and 20 percent of all apple trees in 12 orchards were compared. The 10% assessment technique was selected as the most accurate and efficient in estimating summer and fall damage. Analysis of several parameters of tree vigor found significant differences between browsed and unbrowsed trees for tree basal diameter and central leader diameter over 2 successive years. These subtle yet important differences in tree development were felt to severely limit the possibilities of relating browsing to growth and. later, yields. Methods and considerations for making control decisions on a per acre basis are discussed

Comparison of MSIS and Jacchia atmospheric density models for orbit determination and propagation

Two atmospheric density model families that are commonly chosen for orbit determination and propagation, Jacchia and MSIS, are compared for accuracy. The Jacchia 70 model, the MSISE-90 model, and the NRLMSISE-00 model may each be used to determine orbits over fitspans of several days and then to propagate forward. With observations kept over the propagation period, residuals may be computed and the accuracy of each model evaluated. We have performed this analysis for over 4000 cataloged satellites with perigee below 1000km for September-­October 1999, and the 60 HASDM calibration satellites with a large observation set for February 2001. The purpose of this study is to form a picture of the relative merits of the drag models in a comprehensive view, using all satellites in a manner consistent with the operational practice of US space surveillance centers. A further goal is to refine this knowledge to understand the orbital parameter regions where one of the models may be consistently superior

In Silico Metabolic Model and Protein Expression of Haemophilus influenzae Strain Rd KW20 in Rich Medium

The intermediary metabolism of Haemophilus influenzae strain Rd KW20 was studied by a combination of protein expression analysis using a recently developed direct proteomics approach, mutational analysis, and mathematical modeling. Special emphasis was placed on carbon utilization, sugar fermentation, TCA cycle, and electron transport of H. influenzae cells grown microaerobically and anaerobically in a rich medium. The data indicate that several H. influenzae metabolic proteins similar to Escherichia coli proteins, known to be regulated by low concentrations of oxygen, were well expressed in both growth conditions in H. influenzae. An in silico model of the H. influenzae metabolic network was used to study the effects of selective deletion of certain enzymatic steps. This allowed us to define proteins predicted to be essential or non-essential for cell growth and to address numerous unresolved questions about intermediary metabolism of H. influenzae. Comparison of data from in vivo protein expression with the protein list associated with a genome-scale metabolic model showed significant coverage of the known metabolic proteome. This study demonstrates the significance of an integrated approach to the characterization of H. influenzae metabolism.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63406/1/153623104773547471.pd

K 1-6: an asymmetric planetary nebula with a binary central star

We present new imaging data and archival multiwavelength observations of the little studied emission nebula K 1-6 and its central star. Narrow-band images in H-alpha (+ [NII]) and [OIII] taken with the Faulkes Telescope North reveal a stratified, asymmetric, elliptical nebula surrounding a central star which has the colours of a late G- or early K-type subgiant or giant. GALEX ultraviolet images reveal a very hot subdwarf or white dwarf coincident in position with this star. The cooler, optically dominant star is strongly variable with a period of 21.312 +/- 0.008 days, and is possibly a high amplitude member of the RS CVn class, although an FK Com classification is also possible. Archival ROSAT data provide good evidence that the cool star has an active corona. We conclude that K 1-6 is most likely an old bona fide planetary nebula at a distance of ~1.0 kpc, interacting with the interstellar medium, and containing a binary or ternary central star. The observations and data analyses reported in this paper were conducted in conjunction with Year 11 high school students as part of an Australian Research Council Linkage Grant science education project, denoted Space To Grow, conducted jointly by professional astronomers, educational researchers, teachers, and high-school students.Comment: 13 pages, 5 figures, accepted by the Publications of the Astronomical Society of Australia (PASA

Evidence for stratospheric sudden warming effects on the upper thermosphere derived from satellite orbital decay data during 1967–2013

We investigate possible impact of stratospheric sudden warmings (SSWs) on the thermosphere by using long-term data of the global average thermospheric total mass density derived from satellite orbital drag during 1967–2013. Residuals are analyzed between the data and empirical Global Average Mass Density Model (GAMDM) that takes into account density variability due to solar activity, season, geomagnetic activity, and long-term trend. A superposed epoch analysis of 37 SSW events reveals a density reduction of 3–7% at 250–575 km around the time of maximum polar vortex weakening. The relative density perturbation is found to be greater at higher altitudes. The temperature perturbation is estimated to be −7.0 K at 400 km. We show that the density reduction can arise from enhanced wave forcing from the lower atmosphere

Analysis of the African coelacanth genome sheds light on tetrapod evolution

It was a zoological sensation when a living specimen of the coelacanth was first discovered in 1938, as this lineage of lobe-finned fish was thought to have gone extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features . Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain, and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues demonstrate the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Social contexts of production and use of pottery engraved in the Hemphill style at Moundville

Recently there has been considerable debate about the social and political organization of Moundville (AD 1020-1650), a Mississippian ceremonial center with 32 earthen mounds, located in west central Alabama. This complex issue is addressed here using a stylistic analysis of pottery bottles and bowls engraved in the Hemphill style (AD 1325-1450), Moundville's local representational art style, that determines the formal characteristics of religious subjects such as winged serpents, crested birds, raptors, bird tails, hands, and centering symbols. Style will be used to examine Moundville's social and political organization during the 150-year Necropolis stage (AD 1300-1450) of its occupational history, when pottery engraved in the Hemphill style was produced. The concept that style similarity is an index of interaction among artisans and that these interactions are shaped by social forces operating within a society is used to evaluate three alternative models of Moundville's social and political organization, which have been suggested in the literature. The first, which is referred to in this text as a Political Economy model, suggests that Hemphill-style artisans were producing pottery under the control of Moundville's political elite. The second, which is referred to in this text as a Sacred Economy model, suggests that Moundville was dominated by a coherent mortuary ideology during the Necropolis stage and that the pottery was integral to mortuary ceremonies. The third, which is referred to in this text as an Associations model, suggests that sodalities were a key organizing principle of Moundville's society and that possession of a Hemphill-style vessel indicated membership in a particular sodality. Each of these models has different implications for Moundville's social and political organization and implications relating to the diversity of different aspects of the Hemphill style through time. The Hemphill style was seriated to examine changes to the style through time. In addition to style, geographic distributional data indicates where these vessels may have been used and if that use was restricted. Evidence of use-wear was also used, indicating the extent to which these vessels had an extended use-life before they were interred. Finally, iconographic considerations were taken into account when evaluating the models. (Published By University of Alabama Libraries