Magnitude of formative flows in stream potholes

Although it is generally recognized that geomorphic work is tied to bedrock channel reshaping, the importance of low vs. high flow stages that cause the most geomorphic impact remains unclear. The objective of the research is to study the concept of “formative flow” in bedrock channels and determine, through morphological studies, if those flows have any impact on sculpted features such as potholes and how this relationship relates to various inputs such as flow stages (magnitude and frequency), shear stress, and sediment size. Here, we studied the distribution of the main pothole typologies and tried to understand why potholes are found along bedrock river channels. Specifically, we examined stream potholes from three locations along the Spanish Central System: Alberche, Tietar, and Manzanares rivers. We conducted the research by taking precise geometric measurements, classifying potholes, analyzing flow magnitude and frequency, and using a two-dimensional (2D) hydrodynamic model to assess key variables in Manzanares river. This research demonstrated that bankfull depths completely cover all pothole typologies in all the analyzed sites but are not sufficient to achieve its formative flow depth (FFD). Using a detailed 2D hydrodynamic model in Manzanares river, we discovered that dimensions of cylindrical potholes are closely related to bankfull discharge and that this depth is connected to FFD. Other potholes, such as erosive-compound and erosive-lateral, are historical remnants, and their shapes are not related to any particular FFD and are likely associated with rare events and catastrophic breaks. A collection of laterals that exhibit FFD near bankfull flows appear to represent a part of the recent evolution of a knickpoint. To summarize, it can be inferred from the findings that the utility of morphological analysis in conjunction with the 2D hydrodynamic model is to examine the fraction of erosional/active features to determine the degree of senescence and/or change in natural conditions in a river reach.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUERegional Government of Madrid (Spain)pu

Proactive and reactive aggressive behavior in bullying: The role of values

The study of violence and bullying in schools is a line of scientific research that has contributed significantly to knowledge on human aggressiveness, especially in children and adolescents. This article shows that there are two patterns of aggressive behavior: proactive and reactive. Both are present in bullying, as are other psychological aspects pertaining to the individuals involved, such as basic personality traits, self-esteem and values. This study links both proactive and reactive behavioral patterns to involvement and non-involvement in school bullying. The results reveal that basic personality traits, such as neuroticism, have a direct impact on proactive and reactive bullying, as do the social and individual dimensions of self-esteem and social and moral values. These findings confirm that variables relating to personal and social values are, in turn, related to proactive and reactive aggressive behavior in bullying for those involved and not involved in bullying. However, they also highlight that while aggressors engage in more proactive aggressive behavior, reactive aggression is more frequent among victims.

Encrypted CDMA audio network

We present a secure LAN using sound as the physical layer for low speed applications. In particular, we show a real implementation of a point-to-point or point-to-multipoint secure acoustic network, having a short range, consuming a negligible amount of power, and requiring no specific hardware on mobile clients. The present acoustic network provides VPN-like private channels to multiple users sharing the same medium. It is based on Time-hopping CDMA, and makes use of an encrypted Bloom filter. An asymmetrical error-correction is used to supply data integrity, even in the presence of strong interference. Simulations and real experiments show its feasibility. We also provide some theoretical analysis on the principle of operation.Fil: Ortega, Alfredo A.. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Bettachini, Victor. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fierens, Pablo Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Alvarez Hamelin, Jose Ignacio. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Towards an increase of flash flood geomorphic effects due to gravel mining and ground subsidence in Nogalte stream (Murcia, SE Spain)

Transition from endorheic alluvial fan environments to well-channelized fluvial systems in natural conditions may occur in response to base-level fluctuations. However, human-induced changes in semi-arid regions can also be responsible for similar unforeseen modifications. Our results confirm that in-channel gravel mining and aquifer overexploitation over the last 50 years in the case study area have changed the natural stability of the Nogalte stream and, as a result, its geomorphic parameters including channel depth and longitudinal profile have begun to adapt to the new situation. Using interferometric synthetic aperture radar (InSAR) data we obtain maximum values for ground subsidence in the Upper Guadalentín Basin of  ∼ 10 cm yr−1 for the period 2003–2010. In this context of a lowered base level, the river is changing its natural flood model to a more powerful one. A comparison of the 1973 flood event, the most dramatic flood event ever recorded in the area, with the 2012 event, where there was a similar discharge but a sediment load deficit, reveals greater changes and a new flooding pattern and extension. In-channel gravel mining may be responsible for significant local changes in channel incision and profile. This, together with the collateral effects of aquifer overexploitation, can favour increased river velocity and stream power, which intensify the consequences of the flooding. The results obtained here clearly demonstrate an existing transition from the former alluvial pattern to a confined fluvial trend, which may become more pronounced in the future due to the time lag between the drop in aquifer level and ground subsidence, and introduce a new scenario to be taken into consideration in future natural hazard planning in this area.s. This research was partially funded by projects CGL 2011-23857, ESP2013-47780-C2-2-R and CGL2013-47412-C2-1-P (Spanish Ministry of Economy and Competitiveness).Peer reviewe

Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications

SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation. We have determined the structure of the complex between first CD2AP SH3 domain and ubiquitin and performed a structural and mutational analysis to decipher the determinants of the SH3-C binding mode to ubiquitin. We found that the Phe-to-Tyr mutation in CD2AP and in the homologous CIN85 SH3-C domain does not abrogate ubiquitin binding, in contrast to previous hypothesis and our findings for the first two CD2AP SH3 domains. The similar alternative binding mode of the SH3-C domains of these related adaptor proteins is characterised by a higher affinity to C-terminal extended ubiquitin molecules. We conclude that CD2AP/CIN85 SH3-C domain interaction with ubiquitin constitutes a new ubiquitin-binding mode involved in a different cellular function and thus changes the previously established mechanism of EGF-dependent CD2AP/CIN85 mono-ubiquitination. © 2013 Ortega Roldan et al

Vibration-based adaptive novelty detection method for monitoring faults in a kinematic chain

Postprint (published version

COVID-19 pandemic in Panama: lessons of the unique risks and research opportunities for Latin America

The Republic of Panama has the second most unequally distributed wealth in Central America, has recently entered the list of countries affected by the COVID-19 pandemic, and has one of the largest testing rate per inhabitant in the region and consequently the highest incidence rate of COVID-19, making it an ideal location to discuss potential scenarios for assessing epidemic preparedness, and to outline research opportunities in the Region of the Americas. We address two timely important questions: What are the unique risks of COVID-19 in Panama that could help other countries in the Region be better prepared? And what kind of scientific knowledge can Panama contribute to the regional and global study of COVID-19? This paper provides suggestions about how the research community could support local health authorities plan for different scenarios and decrease public anxiety. It also presents basic scientific opportunities about emerging pandemic pathogens towards promoting global health from the perspective of a middle income countryThe Republic of Panama has the second most unequally distributed wealth in Central America, has recently entered the list of countries affected by the COVID-19 pandemic, and has one of the largest testing rate per inhabitant in the region and consequently the highest incidence rate of COVID-19, making it an ideal location to discuss potential scenarios for assessing epidemic preparedness, and to outline research opportunities in the Region of the Americas. We address two timely important questions: What are the unique risks of COVID-19 in Panama that could help other countries in the Region be better prepared? And what kind of scientific knowledge can Panama contribute to the regional and global study of COVID-19? This paper provides suggestions about how the research community could support local health authorities plan for different scenarios and decrease public anxiety. It also presents basic scientific opportunities about emerging pandemic pathogens towards promoting global health from the perspective of a middle income countr

Enhancing a de novo enzyme activity by computationally-focused ultra-low-throughput screening

Directed evolution has revolutionized protein engineering. Still, enzyme optimization by random library screening remains sluggish, in large part due to futile probing of mutations that are catalytically neutral and/or impair stability and folding. FuncLib is a novel approach which uses phylogenetic analysis and Rosetta design to rank enzyme variants with multiple mutations, on the basis of predicted stability. Here, we use it to target the active site region of a minimalist-designed, de novo Kemp eliminase. The similarity between the Michaelis complex and transition state for the enzymatic reaction makes this system particularly challenging to optimize. Yet, experimental screening of a small number of active-site variants at the top of the predicted stability ranking leads to catalytic efficiencies and turnover numbers ( 2 104 M 1 s 1 and 102 s 1) for this anthropogenic reaction that compare favorably to those of modern natural enzymes. This result illustrates the promise of FuncLib as a powerful tool with which to speed up directed evolution, even on scaffolds that were not originally evolved for those functions, by guiding screening to regions of the sequence space that encode stable and catalytically diverse enzymes. Empirical valence bond calculations reproduce the experimental activation energies for the optimized eliminases to within 2 kcal mol 1 and indicate that the enhanced activity is linked to better geometric preorganization of the active site. This raises the possibility of further enhancing the stabilityguidance of FuncLib by computational predictions of catalytic activity, as a generalized approach for computational enzyme designKnut and Alice Wallenberg Foundation (Wallenberg Academy Fellowship) 2018.0140Human Frontier Science Program RGP0041/2017FEDER Funds/Spanish Ministry of Science, Innovation and Universities BIO2015-66426-R RTI2018-097142-B-100FEDER/Junta de Andalucia - Consejeria de Economia y Conocimiento E.FQM.113.UGR18Swedish National Infrastructure for computing (SNAC) 2018/2-3 2019/2-

Evaluación de fallas en un transportador de cangilones. Caso de estudio

A failure in the bottom sheet of a bucket conveyor (KZBQ.AUMUND) during service was investigated. Sheets are coupled to the chain throught a screw connection; they operate in variable load scenarios causing fatigue. A chemical and microstructural analysis was made showing that sheet was built in steel with 0.15 % of Carbone without alloying elements that contribute to the refined grain and resistance increase. Strength calculation, used to determinate safety factor, consider load system and type material. Results concluded that geometry and thickness value do not provide an adequate fatigue resistance coefficient.Es investigada la falla en las láminas del fondo de un transportador de cangilones KZB-Q.AUMUND durante su servicio. Las láminas están acopladas a una cadena a través de uniones atornilladas y operan bajo un régimen de cargas variables causándoles fatiga. Se realiza un análisis químico y microestructural el cual evidencia que las láminas fueron elaboradas de un acero con 0,15 % de carbono sin elementos de aleación que contribuyan al afinamiento del grano y al incremento de la resistencia. Se calculan las tensiones para determinar el coeficiente de seguridad a la fatiga considerando el sistema de cargas y el material de las láminas. Los resultados concluyen que la geometría y los valores de espesor no le proporcionan a las láminas un adecuado coeficiente de resistencia a la fatiga

An Adaptive Observer-Based Controller Design for Active Damping of a DC Network with a Constant Power Load

© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting /republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other worksThis article explores a nonlinear, adaptive controller aimed at increasing the stability margin of a direct-current (dc), small-scale, electrical network containing an unknown constant power load (CPL). Due to its negative incremental impedance, this load reduces the effective damping of the network, which may lead to voltage oscillations and even to voltage collapse. To overcome this drawback, we consider the incorporation of a controlled dc-dc power converter in parallel with the CPL. The design of the control law for the converter is particularly challenging due to the existence of unmeasured states and unknown parameters. We propose a standard input-output linearization stage, to which a suitably tailored adaptive observer is added. The good performance of the controller is validated through experiments on a small-scale network.Peer ReviewedPostprint (author's final draft