Archaeological Monitoring Of The Atmos Energy Corporation Hudgins Street Pipeline Replacement Project #080.53481, City Of Grapevine, Tarrant County, Texas

This report presents the results of archaeological monitoring performed by Raba Kistner Environmental, Inc., on behalf of Atmos Energy Corporation for the Atmos Hudgins Street Replacement Project. The project consists of the replacement of aging pipelines with installation of new 2-inch diameter natural gas pipeline within the city of Grapevine, Tarrant County, Texas. The area of pipeline replacement extends along the north side of Hudgins Street within the city of Grapevine right of way for a length of approximate 1,410 feet. Raba Kistner Environmental, Inc., performed archaeological monitoring of mechanical and hand excavations involving trenching, bore pits, tie-in pits, and utility locate pits during project construction. These excavations were performed to place pipe, provide pits for bore machinery, connect to existing pipelines, located buried utilities, or connect to local commercial and residential users. The archaeological monitoring investigations were conducted in accordance with the Antiquities Code of Texas under Texas Antiquities Permit #7861. All fieldwork for this project was conducted over a period of five days from 21 February to 7 March 2017. No in situ prehistoric or historic artifacts or cultural features were observed during the monitoring activities. Raba Kistner Environmental, Inc., recommends that construction proceed as planned with no further cultural resources investigations for the Atmos Hudgins Street Replacement Project. All field records generated by this project will be curated in accordance with Texas Archaeology Research Laboratory guidelines

Archaeological Monitoring Of Atoms Natural Gas Pipeline Replacement, Oakwood Cemetery And Adjacent Grand Avenue Public Right Of Way, City Of Fort Worth, Tarrant County, Texas

Red River Archaeology, LLC (RRA) has been contracted by Atmos Energy Corporation (Atmos) to conduct archaeological monitoring of the replacement of a 1.25-inch-diameter natural gas pipeline located within Oakwood Cemetery and extending under adjacent Grand Avenue public right of way (ROW) in Tarrant County. The project area is located within the city limits of Fort Worth, approximately 1.5 miles northwest of the city center and depicted on the Haltom City, Tex. 7.5 minute topographic quadrangle (USGS 1981) (Figure 1). More specifically, the project area is located along Grand Avenue, 160 feet (ft) northeast of the Grand Avenue – Gould Avenue intersection. The purpose of the project is to replace an existing Atmos natural gas pipeline with a new pipeline. The new pipeline will connect to an existing gas meter located at the south façade of a metal maintenance building within Oakwood Cemetery. The existing pipeline will be abandoned in place. The proposed archaeological Area of Potential Effects (APE) coordinated with the THC in the permit application consisted of a 6.12-meter wide (20 ft) Atmos easement beginning in the privately-owned Oakwood Cemetery at the existing meter and extending 21.15 meters (m) (69 ft 4 inches) in a northwesterly direction to the center-line of Grand Avenue. However, during monitoring, the area of impact was modified and shortened by the construction contractor. No excavation was performed within the paved roadway of Grand Avenue as originally anticipated and the trench was excavated only to intersect with the existing gas line and did not extend to the gas meter. The final APE was shortened from the coordinated length of 21.15 m to the 15.66 m of the actual trench excavation. Depth of impact is anticipated to exceed 1 m (3 ft). Although Atmos will be replacing additional gas lines along the north drive lane and right of way of Grand Avenue, this area is beyond the 25 ft buffer area surrounding the cemetery and was not recommended for monitoring per TAC 13 § 26.7 (Figure 2). Oakwood Cemetery is not a public cemetery and does not fall under the statutory requirements of TAC 9.191.093: Protection of publicly owned cemeteries. However, in accordance with the Antiquities Code of Texas, RRA proposed to conduct archaeological construction monitoring of the proposed APE as 0.012 acres is located within City of Fort Worth ROW. The remaining section of the APE (.018 acres) is within privately-owned Oakwood Cemetery and was also monitored during construction. No federal undertaking is anticipated for this project; therefore, consultation under Section 106 of the National Historic Preservation Act (NHPA) is not required. In the event that a burial(s) was encountered, the project would follow the requirements of the Texas Administrative Code Title 13 Part 2 Chapter 22: Cemeteries; the Texas Health and Safety Code Title 8 Subtitle C Chapter 711: General Provisions Related to Cemeteries; the Texas Penal Code Title 9 Chapter 42 Section 42.08: Abuse of Corpse; and Title 7 Chapter 31.03: Thef. The proposed project is located within an historic-age cemetery which is listed as a Registered Texas Historic Landmark (RTHL) and designated TR-CO77. A separate consultation has been submitted to the Architectural Division of the Texas Historical Commission (THC) on 11 March 2015 due to the RTHL designation. In reply dated 26 March 2015, the Architectural Division agreed with the proposed scope of work and stated that the project “will not affect any historic feature or designated landscape elements of the cemetery” provided areas of trenching are returned to pre-construction condition. Fieldwork was conducted under the supervision of Charles D. Neel, and Sarah M. Cole, MA, RPA, served as Principal Investigator for the project. Fieldwork was completed on 12 May 2015. The trench excavation location was subjected to 100 percent monitoring (Figure 2). Two general areas of mixed modern and historic glass, ceramic, brick, metal, and composite material were documented from monitored back-dirt during the excavation of the pipeline trench and were recorded as Isolated Finds (IFs) Locality-1 and Locality-2. No graves, grave shafts, or associated artifacts were encountered during construction monitoring. All records associated with this project will be curated at the Texas Archeological Research Laboratory. It is recommended that artifacts recovered from IF Locality-1 (in City of Fort Worth ROW) be discarded as they are highly redundant and lack historical, cultural, or scientific value. Artifacts recovered from IF Locality-2 are located on private property and will be returned to the landowner

Archaeological Monitoring Of The Atmos Natural Gas Grapevine Franklin Optiman Replacement Project 080.52287, Task 01202, City Of Grapevine, Tarrant County, Texas

This report presents the results of archaeological monitoring performed by Raba Kistner Environmental, Inc., on behalf of Atmos Energy Corporation, for the Atmos Grapevine Franklin Optimain Replacement Project. The project consists of the installation of a 2-, 4-, and 6-inch diameter Polyethylene pipe in Tarrant County, Texas. The proposed pipeline will extend for a length of approximate 4,420 feet, within a 25- to 50-foot-wide easement, located on City of Grapevine road right of way within the Grapevine Commercial Historic District and the Original Town Residential Historic District and immediately adjacent areas of downtown Grapevine. Raba Kistner Environmental, Inc., performed archaeological monitoring of trenching, bore pits, tie-in pits, and service connection mechanical excavations during project construction. These excavations were performed to place pipe, provide pits for bore machinery, connect to existing pipelines, located buried utilities, or connect to local commercial and residential users and are referred to herein as Monitored Locations. The archaeological monitoring investigations were conducted in accordance with the Antiquities Code of Texas under Texas Antiquities Permit #7771. All fieldwork for this project was conducted from 31 January through 16 March 2017 and 28 March 2017. No in situ prehistoric or historic artifacts or cultural or non-cultural features were observed during the monitoring activities. Therefore, Raba Kistner Environmental, Inc., recommends that construction proceed as planned with no further cultural resources investigations for the Atmos Grapevine Franklin Optimain Replacement Project. All field records generated by this project will be curated in accordance with the Texas Archaeology Research Laboratory guidelines

Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial

AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis (NASH). METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin (100 mg daily) (n = 6) or placebo (n = 6) for 24 wk. The primary outcome was improvement in liver fibrosis after 24 wk. Secondary outcomes included evaluation of changes in NAFLD activity score (NAS), individual components of NAS (hepatocyte ballooning, lobular inflammation, and steatosis), glycemic control and insulin resistance [including measurements of glycated hemoglobin (HbA1C) and adipocytokines], lipid profile including free fatty acids, adipose distribution measured using magnetic resonance imaging (MRI), and thrombosis markers (platelet aggregation and plasminogen activator inhibitor 1 levels). We also sought to determine the correlation between changes in hepatic fat fraction (%) [as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation (IDEAL) MRI technique] and changes in hepatic steatosis on liver biopsy. RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy (mean difference between sitagliptin and placebo arms, 0.40, P = 0.82). There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS. Compared to baseline, those patients who received sitagliptin demonstrated improved HbA1C (6.7% ± 0.4% vs 7.9% ± 1.0%, P = 0.02), and trended towards improved adiponectin levels (4.7 ± 3.5 μg/mL vs 3.9 ± 2.7 μg/mL, P = 0.06) and triglyceride levels (1.26 ± 0.43 mmol/L vs 2.80 ± 1.64 mmol/L, P = 0.08). However, when compared with placebo, sitagliptin did not cause a statistically significant improvement in HbA1C (mean difference, -0.7%, P = 0.19) nor triglyceride levels (mean difference -1.10 mmol/L, P = 0.19) but did trend towards improved adiponectin levels only (mean difference, 0.60 μg/mL, P = 0.095). No significant changes in anthropometrics, liver enzymes, other adipocytokines, lipid profile, thrombosis parameters, or adipose distribution were demonstrated. The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment, and the Spearman correlation coefficients ranged from r = 0.819 (baseline) to r = 0.878 (post-treatment), P = 0.002. CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy. The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis

Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade

SummaryThe treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR substituted for the androgen receptor (AR) to activate a similar but distinguishable set of target genes and was necessary for maintenance of the resistant phenotype. The GR agonist dexamethasone was sufficient to confer enzalutamide resistance, whereas a GR antagonist restored sensitivity. Acute AR inhibition resulted in GR upregulation in a subset of prostate cancer cells due to relief of AR-mediated feedback repression of GR expression. These findings establish a mechanism of escape from AR blockade through expansion of cells primed to drive AR target genes via an alternative nuclear receptor upon drug exposure

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations

SummaryThe SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome (NS), which is associated with increased risk of juvenile myelomonocytic leukemia (JMML). Somatic Shp2 mutations occur in sporadic JMML and other leukemias. We found that Shp2 mutants associated with sporadic leukemias transform murine bone marrow cells, whereas NS mutants are less potent in this assay. Transformation requires multiple domains within Shp2 and the Shp2 binding protein Gab2, and is associated with hyperactivation of the Erk, Akt, and Stat5 pathways. Mutant Shp2-transduced BM causes a fatal JMML-like disorder or, less commonly, lymphoproliferation. Shp2 mutants also cause myeloproliferation in Drosophila. Mek or Tor inhibitors potently inhibit transformation, suggesting new approaches to JMML therapy

1955: Abilene Christian College Bible Lectures - Full Text

Delivered in the Auditorium of Abilene Christian College, February, 1955 ABILENE, TEXAS PRICE, $3.00 FIRM FOUNDATION PUBLISHING HOUSE Box 77 Austin 61, Texa

Формирование эмоциональной культуры как компонента инновационной культуры студентов

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p<1 × 10−300, 2.1 × 10−6, 2.5 × 10−10, 1.8 × 10−10). In each case increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing convincing evidence for the first time that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5,6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein (LDL) cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been

Durability of high-frequency 10-kHz spinal cord stimulation for patients with painful diabetic neuropathy refractory to conventional treatments: 12-month results from a randomized controlled trial

No abstract available